The present invention provides an antiobesity composition comprising extract of Melissa as an 
active ingredient, use of Melissa extract, and a method for suppressing 
obesity using the composition. Also, the present invention provides an antiobesity composition comprising extract of Melissa and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract and Mori Folium extract, and a method for suppressing 
obesity using the composition. Further, the present invention provides an antiobesity composition comprising extract of Melissa, extract of 
Artemisia and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract, 
Artemisia extract and Mori Folium extract, and a method for suppressing 
obesity using the composition. When the present compositions are administrated into genetically 
obese mice or 
high fat diet-induced 
obese mice, the present compositions reduced 
body weight, body fat and gonadal fat, and reduce 
blood cholesterol level and obesity-related blood glucose level. Also, the present compositions suppress hypertrophy of adipocytes, and inhibit the accumulation of lipid in the liver by reducing the size and number of lipid vacuoles. Furthermore, in human clinial trial the present compositions show that 
body weight, PIBW, body fat, especially 
visceral fat, apolipoprotin B concentration, ratio of 
total cholesterol / HDL 
cholesterol and ratio of 
LDL cholesterol / HDL 
cholesterol are significantly decreased, and atherogenic index is improved and 
muscle mass is increased. Thus, the present compositions can be usefully applied as antiobesity composition for reduction of 
body weight and suppression of 
abdominal fat, particularly, 
visceral fat.