The invention relates to medicinal
gelatin microspheres and a preparation method thereof, and belongs to the field of
medicine preparation. The
active ingredient of the medicinal
gelatin microspheres is
trimetazidine or a medicinal salt of the
trimetazidine. The preparation of the microspheres adopts a chemical cross-linking method, and comprises steps of emulsification, deoiling and
dewatering, chemical cross-linking, washing and
drying, and the like. According to the preparation method, the particle size, the appearance, the encapsulation efficiency, the
drug loading rate are adopted as indexes to comprehensively optimize the carrier, the
oil phase, the
dewatering and deoiling agent, the cross-linking curing agent, and other reagents added in the process, wherein the carrier, the
oil phase, the
dewatering and deoiling agent, the cross-linking curing agent, and other reagents are suitable for preparation of the microspheres of the present invention. The prepared microspheres have characteristics of
smooth surface, particle size of 50-200 mum,
drug loading rate of 30-35%, and has a slow release effect under the common
dissolution conditions. In addition, the
blood drug level of the microspheres is stable
in vivo, and is better than the
blood drug level of ordinary tablets.