The invention discloses a medicine for treating occupational chronic lead poisoning caused by spleen-stomach disharmony and a preparation method. The medicine comprises the following medicinal materials: valeriana jatamansi, uraria crinita, mentha spicata, camphorwood seed, eupatorium japonicum, gnaphalium tranzschelii, bushy dasiphora flower, diuranthera major, dracontomelon duperreanum, desmodium triquetrum, dendrobe, arisaema intermedium blume, helwingia root, podophyllum hexandrum, polygonum chinense, adiantum capillus-veneris, lithospermum, garden balsam stem, fructus polygoni orientalis, kamuning, herba pyrolae, peperomia blanda, ternate buttercup root, marsdenia tinctoria, acmella ciliate, indian lettuce, creeping violet herb, centella, nude pronephrium rhizome, ovateleaf holly bark and liquorice. According to the medicine disclosed by the invention, the traditional Chinese medicinal materials with different medicine properties are scientifically combined to achieve the effects of detoxifying, regulating vital energy, regulating the middle warmer, calming the adverse-rising energy, accelerating poison discharge and treating both symptoms and root causes; the medicine is safe, effective, relatively few in adverse effects and relatively short in treatment course; the preparation technology of the medicine is simple, convenient and low in cost; and the occupational chronic lead poisoning is not easy to recur after being cured.