221results about "Carbon active ingredients" patented technology

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention relates to the technical field of biomedical materials, in particular to an alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material and a preparation method and application thereof.The alendronate-modified ZIF-8 serves as a carrier, TPP-modified carbon dots are encapsulated in the carrier, citric acid, urea and cerium salt serve as raw materials of the TPP-modified carbon dots, and the alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material is prepared through a one-step method. After cerium-doped carbon quantum dots are synthesized through a hydrothermal method, TPP is grafted through an amide method, alendronate endows the material with a bone targeting function, and TPP modified carbon dots endow the material with antioxidant and mitochondrial targeting functions. According to the invention, the bone targeting property is excellent, and bone focuses are efficiently enriched; the anti-oxidation and anti-inflammatory capacities are high, and the infected microenvironment can be improved; zIF-8 packaging is stable, and functional components can be controllably released; multiple components cooperate to promote bone repair, accumulation of non-target organs is little, and the composition is safe, reliable and suitable for treatment of various bone-related diseases.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention relates to the field of complex bone defect treatment, and discloses a nano material with an efficient antibacterial effect and a preparation method thereof.The preparation method comprises the steps that ammonium bismuth citrate and luteolin are mixed and dissolved in formamide, the mixture is put into a reaction kettle to react, a reaction solution is obtained, and Bi-Lu CDs in formamide is obtained after centrifugation and filtration; mixing the MSN-coated Bi-Lu CDs with amino-modified mesoporous silica microspheres, centrifuging, dispersing in deionized water, and drying in vacuum to obtain pure MSN-coated Bi-Lu CDs powder; the preparation method comprises the following steps: preparing a polyurethane dispersion liquid from polyurethane, spraying the polyurethane dispersion liquid on a quartz plate to form a polyurethane film, and spraying MSN and Bi-Lu CDs powder on the polyurethane film to carry out metal spraying treatment; a second precipitate is obtained; drying in vacuum to obtain J-Bi-LuCDs M (at) Au powder; the problems that in the prior art, due to the fact that a pure carbon dot material lacks active diffusion power, the treatment effect on complex tissue defects and bacterial biofilms is still limited, and a precursor material is poor in biocompatibility, not prone to dissolution and low in bioavailability are solved.

To provide a jelly composition containing spherical adsorptive carbon for improving uremic symptoms and delaying initiation of dialysis of chronic renal failure patients, which has more improved medication compliance than existing therapeutic agents.SOLUTION: The jelly composition contains spherical adsorptive carbon as an active ingredient, a gelling agent, a thickener, and spherical adsorptive carbon containing distilled water.SELECTED DRAWING: Figure 2

The invention relates to the technical field of medicines, in particular to application of green alga-based carbon quantum dots in preparation of chikungunya virus infection resisting drugs or decontamination agents. The green algae-based carbon quantum dots belong to nano materials, and the green algae-based carbon quantum dots prepared by a hydrothermal method are good in water solubility, high in stability and high in biocompatibility. The application of the green alga-based carbon quantum dots in the chikungunya virus infection resisting medicine or decontamination agent is reported, the in-vivo and in-vitro antiviral effect is good, the application is reported for the first time internationally, and a new scheme is provided for prevention and treatment of chikungunya heat.

The application discloses a novel fullerene hydrogel and a preparation method and application thereof. The fullerene hydrogel is formed by chemical cross-linking of a fullerene derivative shown in formula I and oxidized hyaluronic acid (oxHA). The fullerene-hyaluronic acid hydrogel material provided by the application has a porous framework, a large pore size and a cell loading potential.

The invention discloses an anti-biofilm nano composite material added with resveratrol and a preparation method of the anti-biofilm nano composite material. According to the method, ferric trichloride hexahydrate, trisodium citrate, sodium acetate, polyetherimide, resveratrol and hyaluronic acid are used as raw materials, modified magnetic Fe3O4 nanoparticles with positive charges are prepared through a hydrothermal method, carbon dots derived from a resveratrol and hyaluronic acid mixture are introduced, and the magnetic Fe3O4 nanoparticles with positive charges are prepared. The anti-biofilm nano composite material added with the resveratrol is prepared. The nano composite material disclosed by the invention can be attached to a biological membrane, so that the loss is reduced in a transfer process, the effective utilization rate of a medicine is remarkably improved, and excellent magnetic property, antibacterial property and biological membrane resistance are shown.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses an external liquid containing lime and alum for astringing sores and a preparation method of the external liquid. The external liquid containing lime and alum for healing sores is prepared from the following raw materials: lime, alum, water, a thickening agent, a cortex phellodendri extract, carbonized sanguisorba root powder, borneol and a pH regulator. The preparation method comprises the following steps: S1, preparing lime milk; s2, preparing an alum solution; s3, mixing reaction; s4, performing curing treatment; s5, blending; s6, refining: filtering the mixture obtained in S5, adding borneol and ethylparaben into the filtrate before filtering, and uniformly stirring to obtain the external liquid for healing sore. The external liquid containing lime and alum for healing sores can be used for treating various skin injuries such as skin ulcers, wounds, burns, eczema and postoperative wounds, and has the advantages of efficient astringency and hemostasis, antisepsis and anti-inflammation, promotion of wound healing, good system stability, comfort in use and high safety.

The invention provides an anti-biofilm composition based on the synergistic effect of amino fullerene and vancomycin and application of the anti-biofilm composition. The mass ratio of the amino fullerene to the vancomycin is 10: 1. The amino fullerene derivative and vancomycin are combined to have a remarkable synergistic effect in the aspect of inhibiting the formation of the biological membrane for the first time, and the inhibition rate of the biological membrane reaches 93%, so that the amino fullerene derivative and vancomycin have a strong synergistic effect. The composition provided by the invention can effectively remove more than 40% of formed mature biological membranes (24-48-hour biological membranes), which is an effect which cannot be realized by independent use of vancomycin.

The invention relates to application of graphene-(RADA-IKVAV)-pranoprofen, eye drops and a preparation method of the eye drops. The invention relates to graphene-(RADA-IKVAV)-pranoprofen, the graphene-(RADA-IKVAV)-pranoprofen comprises graphene-polyacrylic acid, self-assembled oligopeptide RADA-IKVAV and pranoprofen, the self-assembled oligopeptide RADA-IKVAV is connected with the graphene-polyacrylic acid through a chemical bond, and the pranoprofen is loaded on the surface of the graphene-polyacrylic acid. The eye drops provided by the invention comprise graphene-(RADA-IKVAV)-pranoprofen, so that the drug loading capacity of pranoprofen in the eye drops is increased, the bioavailability of drugs is improved, and the eye drops are used for inhibiting eye inflammation; the coupled oligopeptide RADA-IKVAV simulates an extracellular environment, provides a suitable microenvironment for eyes, promotes nerve repair and regeneration by influencing nerve growth factors, and promotes optic nerve repair.

The invention discloses a rhizoma polygonati derived carbon dot with a Schiff base structure as well as a preparation method and application of the rhizoma polygonati derived carbon dot. The rhizoma polygonati derived carbon dot comprises the Schiff base structure, hydroxyl and carboxyl functional groups, the rhizoma polygonati derived carbon dots are spherical in microstructure and uniform in particle size distribution, the particle size range is 1.5-3.6 nm, and the lattice spacing is 0.20-0.21 nm. The water solubility is good, the emission wavelength is 407 nm under excitation of 330 nm, and the absolute fluorescence quantum yield is 16.2%; the fluorescent probe shows high specific recognition capability on metal ions such as Fe < 3 + >, the detection limit is as low as 1 mu M, and the fluorescence intensity and the ion concentration are in a good linear relationship within the concentration range of 10-100 mu M; good free radical scavenging capacity is achieved, and the scavenging effect on DPPH and ABTS free radicals at the concentration of 100 micrograms / mL reaches 80% or above; and a certain broad-spectrum antibacterial effect is achieved.

The invention discloses a carbon nitride quantum dot as well as a preparation method and application thereof, and the preparation method comprises the following steps: taking formamide as a precursor and a solvent, taking ammonia water as a doping reagent, taking H2O2 as a redox agent, and carrying out solvothermal reaction to obtain the carbon nitride quantum dot. Wherein the temperature of the solvothermal reaction is 160 to 180 DEG C. The preparation method disclosed by the invention is low in raw material cost, short in synthesis time and simple and convenient to operate, efficient batch production is realized, and the generated carbon nitride quantum dot has good stability, shows efficient peroxidase-like activity as a metal-free nano-enzyme, shows excellent catalytic ability in vitro, and has good application prospects. The compound has a great prospect in the aspect of tumor treatment.

A homeopathic mixture for alleviating fatigue symptoms, cancer treatment-related fatigue symptoms, or radiation fatigue symptoms, comprising cadmium sulfide, X-rays, phosphoric acid, radium bromide, and animal char. Each is diluted in a 1:100 ratio, with cadmium sulfide diluted 12 to 200 times, X-rays diluted 3 to 30 times, acidic phosphoric acid diluted 12 to 200 times, radium bromide diluted 12 to 200 times, and animal char diluted 12 to 200 times.

This invention belongs to the field of pharmaceutical technology, specifically relating to biomimetic nanomedicines for treating subcutaneous drug-resistant bacterial infections, their preparation methods, and applications. In this invention, dopamine hydrochloride is added during the synthesis of a metal-organic framework to prepare a dandelion-shaped carbon nanozyme precursor. This precursor is then carbonized to obtain a carbon nanozyme with targeting, photoresponsiveness, and peroxidase activity. Finally, berberine hydrochloride is loaded onto the carbon nanozyme to obtain the biomimetic nanomedicine. The biomimetic nanomedicine provided by this invention firstly possesses good biocompatibility; secondly, it has a unique dandelion-like morphology, which is beneficial for its targeting effect; and finally, it exhibits strong photoresponsiveness in the near-infrared region, enabling synergistic and efficient bactericidal action through the mechanisms of antibacterial drugs, photothermal therapy, and chemokinetics. It has significant application value in the preparation of drugs for treating subcutaneous drug-resistant bacterial infections.

The invention discloses an ROS responsive hydrogel delivery system as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel delivery system is prepared from sulfur-doped ginger carbon dots (SGCDs) and an ROS (reactive oxygen species) responsive sulfhydrylation hyaluronic acid (HS) hydrogel matrix, the SGCDs have excellent antioxidant and anti-inflammatory activity, and can be used for clearing ROS and simulating SOD and CAT enzyme functions; the HS hydrogel matrix triggers gelling in an inflammation part high ROS environment, and targeted drug release and colitis part retention are achieved. Through the synergistic effect of the SGCDs and the HS hydrogel matrix, the delivery system can efficiently remove ROS, promote polarization of macrophages from M1 type to M2 type, up-regulate an anti-inflammatory factor IL-10, down-regulate proinflammatory factors TNF-alpha, IL-1beta and IL-6, repair Occludin and remodel the intestinal flora homeostasis.

The invention belongs to the field of preparation of high-antibacterial carbon dots, and discloses a high-antibacterial carbon dot, a preparation process and application of the high-antibacterial carbon dot in vaginal gel. The prepared carbon dots are prepared by adopting physical shearing and ultrasonic synergistic pretreatment, then cooperating with microwave gradient energy crushing and stripping, and then performing centrifugation, dialysis purification and vacuum freeze drying, the damage of oxidation or acid treatment to a graphite structure is avoided in the whole process, and the carbon dots have excellent antibacterial and antiviral performance, can effectively inactivate various pathogenic microorganisms, and have good application prospects. Comprise herpes simplex virus, human papilloma virus HPV16, staphylococcus aureus, candida albicans and the like. The invention also optimizes application conditions, is suitable for developing efficient and safe vagina antibacterial gel products, and provides an innovative solution for preventing and treating gynecological infection.

The invention discloses liquorice-source fluorescent carbon quantum dots and a preparation method and application thereof.The preparation method comprises the following steps that dried liquorice roots and stems are smashed, water is added according to the proportion of 100 mg: (10-20) mL, a hydrothermal reaction is conducted for 5-6 h at the temperature of 140-180 DEG C, filtration is conducted through a 0.22-micron microfiltration membrane after centrifugation, and a brown-yellow carbon quantum dot aqueous solution with the special fragrance and the fluorescence characteristic is obtained; obtaining the liquorice source fluorescent carbon quantum dots. Compared with a liquorice extract liquid extracted by a traditional method, the liquorice-source fluorescent carbon quantum dot disclosed by the invention has the advantages that the growth of porphyromonas gingivalis and staphylococcus aureus can be remarkably inhibited at low concentration, and the liquorice-source fluorescent carbon quantum dot has a remarkable fluorescence characteristic; the visible real-time visualization of a treatment area can be realized under the excitation of a common handheld ultraviolet light source or a blue light source, so that the administration accuracy is improved, the dental plaque aggregation on the surface of teeth is obviously reduced, and the gingival inflammation is inhibited.

The invention provides a preparation method of fructus aurantii immaturus and paeonia lactiflora powder of a classic famous formula The invention also provides a method for detecting the quality of the fructus aurantii immaturus and paeonia lactiflora powder prepared by the preparation method of the classic famous prescription fructus aurantii immaturus and paeonia lactiflora powder. The invention establishes a preparation process of the immature bitter orange and Chinese herbaceous peony powder preparation, and particularly, a process route and key process parameters obtained through systematic research on immature bitter orange charcoal frying process parameters in the formula not only accord with description of the medicine in ancient books, but also can meet actual equipment conditions of modern large-scale production. Within the determined key process parameter range, the decrease amplitude of three heat-sensitive components, namely catechin, narirutin and naringin, which are easy to decompose after being heated in the immature bitter orange charcoal can be controlled within 10%, so that the effectiveness and the quality controllability of the product are ensured. The UPLC method established by the invention can more quickly realize simultaneous detection of eight components in the immature bitter orange and Chinese herbaceous peony powder, can be used as an evaluation method for the process research, and can also be used for controlling the product quality in the production of the immature bitter orange and Chinese herbaceous peony powder.

The invention relates to a preparation method and application of zinc / cerium double-doped resveratrol carbon dots, resveratrol is used as a carbon source, cerous nitrate is used as a doping agent, and the zinc / cerium double-doped resveratrol carbon dots Zn / Ce-RCDs are synthesized in one step through a controllable hydrothermal method. The prepared zinc / cerium double-doped resveratrol carbon dots Zn / Ce-RCDs have high biocompatibility, antioxidant activity and excellent vascular regeneration promoting performance, and can be used as a biological material or medicine for promoting vascular regeneration.

The present disclosure relates to a composition that includes a compound having Structure I, where, formula (I), X is an anion, Ri includes a hydrogen atom or an alkyl group, R2 includes a hydrogen atom, an ester, a carboxylic acid, and / or a ketone, 0 < m < 5, 1 < n < 5, and a carbonaceous material that includes carbon atoms indicated by 1 and 2.

The invention discloses a novel nanocarbon material with conditioning and treating functions and a preparation method thereof, and belongs to the technical field of health food. According to the novel nano-carbon material, a biological nano-carbon material is organically combined with active magnesium and active silicon, so that a finished product is endowed with unique conditioning and treatment functions. The traditional Chinese medicine composition integrates multiple mechanisms such as sterilization and disinfection, immune enhancement, free radical removal and cell activation, not only has a direct treatment effect on oral inflammation, gastroenteritis, skin inflammation, cyst and the like, but also can fundamentally improve the sub-health state by regulating the acid-base balance of an organism, promoting metabolism and delaying senescence. The whole process is carried out in a 10000-grade clean environment at normal temperature and normal pressure, so that the operation process is simplified, the energy consumption and equipment requirements are reduced, the damage of extreme conditions such as high temperature and high pressure to the activity of the material can be effectively avoided, and the effect of each component is fully exerted.

The present disclosure relates to a graphene oxide-based a composition for preventing hair loss or promoting hair growth, including a graphene oxide. According to embodiments of the present disclosure, a composition for preventing hair loss or promoting hair growth may exhibit excellent effects in promoting the growth or proliferation of human follicle dermal papilla cells, in enhancing the expression or activity of hair growth-promoting factor proteins in human follicle dermal papilla cells, and in improving the expression or activity of Wnt / β-catenin. Also, the composition shows superior suppression of hair loss-inducing gene expression. Thus, the composition exhibits excellent effects in preventing hair loss or promoting hair growth.

The present application relates to the technical field of veterinary pharmaceutical preparations, and more particularly to a high-solubility high-content amoxicillin powder and a preparation method thereof.The raw materials of the amoxicillin powder include, in mass fractions, amoxicillin 30-80 parts, powdered activated carbon 10-65 parts, a pH regulator 1-5 parts, a surfactant 1-5 parts, and an ionic liquid solubilizer 1-5 parts; the ionic liquid solubilizer is preferably 1-butyl-3-methylimidazolium tetrafluoroborate.The preparation process adopts stepwise dissolution, ultrasonic degassing, and spray drying after mixing to obtain the finished product.Through the synergistic effect of activated carbon adsorption drug loading, pH adjustment, interfacial tension control, and ionic strength synergism, the solubility of amoxicillin in water is increased from 1.27 mg / mL to 9.42 mg / mL, about 7 times, and the amoxicillin can be rapidly dissolved within 5 minutes at 40-50 DEG C, which is significantly better than similar products on the market, is suitable for efficient drug administration in large-scale livestock and poultry breeding, and has a good application prospect.

Activated carbon compounds for the detoxification of intoxications, including methods of use thereof are provided. Many embodiments provide an approach to detoxifying individuals, including household pets (e.g., dogs and / or cats) from toxic substances. Many embodiments are directed to compositions including activated carbon compounds that can be used to detoxify toxins and other intoxications in an individual. Many embodiments may use activated carbon spheres for detoxification. Many embodiments of compositions can be administered orally. In numerous embodiments, the individual is a human and / or a non-human animal, such as a household pet, including dogs and / or cats.

The invention relates to a chitosan oligosaccharide-gallic acid carbon dot engineered exosome and a preparation method and application thereof.The preparation method comprises the steps that firstly, chitosan oligosaccharide-gallic acid composite carbon dots (COS / GA-CDs) are synthesized in one step through a hydrothermal method, the COS / GA-CDs engineered exosome (COS / GA-CDs (at) EVs) is constructed by means of the electrostatic self-assembly effect of surface positive charges of the COS / GA-CDs and exosome membrane negative charges, and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs are subjected to According to the exosome disclosed by the invention, the inherent vasoactive substances of the exosome are reserved, the antioxidant / anti-inflammatory function and the endothelial cell uptake enhancement effect are given through carbon dot synergism, and the problems that the natural exosome is limited in biological activity, insufficient in stability and low in cell uptake efficiency are solved.

The invention discloses a synthesis method of a fullerene nano material with glycolipid metabolism regulation capability, and belongs to the technical field of material science and biomedical engineering. The fullerene and the metformin are combined through chemical bonds, the strong oxidation resistance of the fullerene and the hypoglycemic effect of the metformin are exerted at the same time, the synergistic treatment effect is formed, and the drug composition is superior to a single drug; active oxygen in cells can be efficiently removed, oxidative stress is effectively relieved, and the functions of pancreatic beta cells are protected; through structural modification, the problem of low bioavailability caused by hydrophobicity of fullerene and hydrophilicity of metformin is solved, and the solubility and absorption efficiency of the medicine are improved; in conclusion, through chemical combination of the fullerene and the metformin, a dual-mechanism synergistic effect of oxidation resistance and blood sugar reduction is achieved, the treatment effect is remarkably improved, meanwhile, good safety and biocompatibility are achieved, and important application value is achieved in the field of treatment of the type II diabetes mellitus.

The invention relates to the treatment or prevention of disease by modulating the microbiome of the gut using porous carbon particles comprising micropores of diameter 2 nm or less and meso pores / small macropores of diameter 30 nm to 500 nm, but substantially no mesopores of diameter greater than 2 nm and less than 30nm, and substantially no large macropores of diameter greater than 500 nm.