343results about "Carbon active ingredients" patented technology

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention provides a nitrogen-doped biomass-based fluorescent carbon quantum dot, a preparation method and application, and relates to the technical field of carbon nanomaterials, the method comprises the following steps: mixing a biomass material and deionized water under an ultrasonic condition, adding a nitrogen source, and carrying out ultrasonic dispersion to obtain a uniformly dispersed to-be-reacted solution; reacting the to-be-reacted solution at a preset temperature for a preset time to obtain a mixed product solution; and filtering and dialyzing the mixed product solution to obtain the nitrogen-doped biomass-based fluorescent carbon quantum dot solution. The nitrogen-doped biomass-based fluorescent carbon quantum dot prepared by the method shows a stable fluorescent effect and good water solubility, the free radical clearance rate can reach 90% or above, and the antibacterial rate can reach 99% or above. The method can be used in the fields of drug sustained release, bioimaging and the like.

Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

The invention discloses a two-dimensional bionic nanostructure assembled based on receptor-ligand acting force and a preparation method of the two-dimensional bionic nanostructure. The core characteristic of the two-dimensional bionic nanostructure is that the ultrafine particles modified by ligand molecules are anchored on the surface of a cell membrane fragment with a corresponding receptor expressed on the surface through a receptor-ligand effect, so that uniform compounding of the ultrafine particles and the cell membrane is realized; the bottlenecks of low compounding efficiency, functional site masking and the like caused by high surface curvature of small-size particles in the traditional cell membrane complete wrapping technology are broken through. According to the preparation method disclosed by the invention, the binding force between the cell membrane and the ultramicro particles is stronger, the off-target phenomenon of the ultramicro particles in the in-vivo circulation process can be avoided, the response release of the ultramicro particles under the competition effect in a lesion region expressed by a high-abundance receptor can be realized, and the preparation method has a good application prospect in the aspect of precise drug delivery. Meanwhile, the in-vivo circulation time of the ultrafine particles is prolonged by membrane loading, the biocompatibility of the ultrafine particles is improved, and the effectiveness and low toxicity of a drug delivery system are ensured.

The invention discloses a preparation method of ocimum gratissimum carbon dots and application of the ocimum gratissimum carbon dots in antibacterial drugs and food preservation. The preparation method of the ocimum gratissimum carbon dots comprises the following steps: performing steam distillation on ocimum gratissimum leaves to remove essential oil, drying in the shade, and crushing; adding an alcohol solvent into the powder, extracting, filtering, concentrating and drying to obtain an alcohol extract; dispersing the alcohol extract in distilled water, and stirring and pyrolyzing on a heating table; and diluting the pyrolysis product with distilled water, centrifuging, taking supernate, filtering with a filter membrane, dialyzing, and freeze-drying to obtain the carbon dots. The obtained carbon dots have a carbon dot-vesicle coexisting structure, and the average particle size is 5.732 + / -0.5 nm. The prepared ocimum gratissimum carbon dots can be applied to preparation of antibacterial drugs, especially drugs for inhibiting the activity of bacillus cereus and listeria, and the field of food preservation, and have the advantages of being wide in raw material source, simple in preparation method, low in cost, environmentally friendly and the like.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of carbon dots for killing helicobacter pylori and application of the carbon dots in oral pharmaceutical preparations. The preparation method comprises the following steps: mixing microcrystalline cellulose and glycerol, freezing and crushing at an ultralow temperature, and selectively hydrolyzing by combining citric acid-malic acid mixed acid liquor to efficiently prepare a high-crystallinity cellulose nanocrystal template; the controllable synthesis of the carbon dots is realized by utilizing the hydrogen-bond interaction of hydroxyl / carboxyl on the surface of the cellulose nanocrystal and the nitrogen doping effect in the polymerization and carbonization process of citric acid and urea. Besides, when a sodium alginate-chitosan double-layer structure is constructed, carbon dots are introduced into the inner layer to endow the inner layer with special performance, a protein-polysaccharide network is formed on the outer layer through transglutaminase enzymatic crosslinking, and the oxidation resistance and mechanical strength are enhanced through secondary curing of tea polyphenol. According to the invention, food-grade raw materials are used for realizing high-efficiency antibiosis, the oral preparation safety specification is met, and the clinical transformation potential is realized.

The invention relates to the technical field of traditional Chinese medicine carbon dots, in particular to ligusticum wallichii carbon dots, a medicine and application. The ligusticum wallichii carbon dots disclosed by the invention are obtained by carbonizing ligusticum wallichii by a hydrothermal method, wherein the hydrothermal method carbonization is a hydrothermal reaction at 175-195 DEG C for 8-12 hours; research finds that the ligusticum wallichii carbon dots have the characteristic of treating myocardial apoptosis caused by myocardial ischemia reperfusion injury, and compared with ligusticum wallichii carbon dots synthesized by ligustrazine and a pyrolysis method, the ligusticum wallichii carbon dots have the advantage that the heart function can be better recovered. The invention provides a new candidate drug for treating myocardial ischemia reperfusion injury.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention discloses a traditional Chinese medicine composition for treating liver cirrhosis and a preparation method thereof, and belongs to the technical field of anti-liver cirrhosis traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 10g of polyporus umbellatus, 10g of herba artemisiae scopariae, 10g of radix bupleuri, 10g of charred rheum officinale, 10g of rhizoma coptidis, 10g of charred radix scutellariae, 10g of fructus gardeniae, 15g of herba hyperici japonici, 10g of radix curcumae, 10g of rhizoma alismatis, 10g of radix paeoniae rubra, 10g of radix salviae miltiorrhizae, 10g of cortex magnoliae officinalis, 10g of fructus aurantii, 10g of rhizoma cyperi, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of plantain herb, 10g of turtle shell, 10g of pericarpium arecae, 25g of oven earth and 2g of charred colla corii asini. By providing the traditional Chinese medicine composition formula for treating the liver cirrhosis, the effective rate and the cure rate of the medicine for treating the liver cirrhosis are improved.

A method of inhibiting cancer cell viability may include contacting cancer cells and a nanocomposite including graphitic C3N4, Fe2O3, and MgAl2O4 in a mass relationship to each other in a range of 5 to 15:2 to 7:75 to 95. The nanocomposite is in a concentration range of 7.5 micrograms per milliliters (μg / mL) to 500 μg / mL, thereby inhibiting the growth of the cancer cells by at least 85%.

The invention discloses a preparation method and application of a chlorogenic acid carbon quantum dot microsphere capsule, a natural active product chlorogenic acid (CHA) in coffee is used as a raw material, and chlorogenic acid carbon quantum dots (CHA CDs) with anti-inflammatory and antioxidant activity are synthesized through a hydration method; then, the chlorogenic acid carbon quantum dots (CHACDs) are packaged with chitosan, and meanwhile, the chitosan on the outer layer of the capsule is modified with the DNA aptamer, so that the chlorogenic acid carbon quantum dot microsphere capsule Apt-CS (at) CHA CDs are obtained. The chlorogenic acid carbon quantum dot microsphere capsule disclosed by the invention not only has anti-inflammatory and antioxidant activity, but also can regulate intestinal flora, enhance intestinal barrier function and immune conditions; moreover, the microsphere capsule can be retained in the intestinal tract for a long time, so that the microsphere capsule can resist inflammation and remove high-level reactive oxygen species (ROS), can be retained in the intestinal tract for a long time and play a role in regulating intestinal flora, finally, the disease development of IBS is comprehensively relieved, and the microsphere capsule has a very good application prospect.

The invention relates to the technical field of biomedical materials, in particular to an alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material and a preparation method and application thereof.The alendronate-modified ZIF-8 serves as a carrier, TPP-modified carbon dots are encapsulated in the carrier, citric acid, urea and cerium salt serve as raw materials of the TPP-modified carbon dots, and the alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material is prepared through a one-step method. After cerium-doped carbon quantum dots are synthesized through a hydrothermal method, TPP is grafted through an amide method, alendronate endows the material with a bone targeting function, and TPP modified carbon dots endow the material with antioxidant and mitochondrial targeting functions. According to the invention, the bone targeting property is excellent, and bone focuses are efficiently enriched; the anti-oxidation and anti-inflammatory capacities are high, and the infected microenvironment can be improved; zIF-8 packaging is stable, and functional components can be controllably released; multiple components cooperate to promote bone repair, accumulation of non-target organs is little, and the composition is safe, reliable and suitable for treatment of various bone-related diseases.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention discloses a tellurium-doped carbon quantum dot and a preparation method and application thereof, the tellurium-doped carbon quantum dot is obtained by using 2, 2 '-diaminodiphenyl telluride as a precursor, the average particle size is 1.9 nm, the thickness is about 2.1 nm, and the surface is rich in amino groups. And fixing (4-carboxybutyl) triphenylphosphonium bromide, 3-morpholinopropionic acid or 3-((4-methylphenyl) sulfonamide) propionic acid on the surfaces of the tellurium-doped carbon quantum dots to prepare Mito-Te-CDs, Lyso-Te-CDs and ER-Te-CDs with an organelle targeting function. The Mito-Te-CDs, the Lyso-Te-CDs and the ER-Te-CDs are good in biocompatibility, can be used as fluorescent probes for targeted imaging of organelles, can be used for recognition and removal of superoxide anions in specific organelles, have a protection effect on cells and can be used for effectively treating acute kidney injury.

The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and / or congenital erythropoietic porphyria (CEP), and related syndromes thereof.

The invention relates to the field of complex bone defect treatment, and discloses a nano material with an efficient antibacterial effect and a preparation method thereof.The preparation method comprises the steps that ammonium bismuth citrate and luteolin are mixed and dissolved in formamide, the mixture is put into a reaction kettle to react, a reaction solution is obtained, and Bi-Lu CDs in formamide is obtained after centrifugation and filtration; mixing the MSN-coated Bi-Lu CDs with amino-modified mesoporous silica microspheres, centrifuging, dispersing in deionized water, and drying in vacuum to obtain pure MSN-coated Bi-Lu CDs powder; the preparation method comprises the following steps: preparing a polyurethane dispersion liquid from polyurethane, spraying the polyurethane dispersion liquid on a quartz plate to form a polyurethane film, and spraying MSN and Bi-Lu CDs powder on the polyurethane film to carry out metal spraying treatment; a second precipitate is obtained; drying in vacuum to obtain J-Bi-LuCDs M (at) Au powder; the problems that in the prior art, due to the fact that a pure carbon dot material lacks active diffusion power, the treatment effect on complex tissue defects and bacterial biofilms is still limited, and a precursor material is poor in biocompatibility, not prone to dissolution and low in bioavailability are solved.

To provide a jelly composition containing spherical adsorptive carbon for improving uremic symptoms and delaying initiation of dialysis of chronic renal failure patients, which has more improved medication compliance than existing therapeutic agents.SOLUTION: The jelly composition contains spherical adsorptive carbon as an active ingredient, a gelling agent, a thickener, and spherical adsorptive carbon containing distilled water.SELECTED DRAWING: Figure 2

The invention relates to the technical field of medicines, in particular to application of green alga-based carbon quantum dots in preparation of chikungunya virus infection resisting drugs or decontamination agents. The green algae-based carbon quantum dots belong to nano materials, and the green algae-based carbon quantum dots prepared by a hydrothermal method are good in water solubility, high in stability and high in biocompatibility. The application of the green alga-based carbon quantum dots in the chikungunya virus infection resisting medicine or decontamination agent is reported, the in-vivo and in-vitro antiviral effect is good, the application is reported for the first time internationally, and a new scheme is provided for prevention and treatment of chikungunya heat.

The invention belongs to the technical field of nano material preparation, and particularly discloses a copper-containing graphene oxide nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving graphene oxide powder in ultrapure water, and carrying out ultrasonic treatment to obtain a mixed solution; and S2, adding copper nitrate into the mixed solution obtained in S1, uniformly mixing, and carrying out ultrasonic treatment to obtain the copper-containing graphene oxide nanosheet. The invention discloses a copper-containing graphene oxide nanosheet and a preparation method and application thereof.The copper-containing graphene oxide nanosheet has high antibacterial performance, is applied to preparation of antibacterial infection drugs, and can be further functionally modified through active groups on the surface of the nanosheet to achieve targeted delivery and slow release; and the local antibacterial efficiency is improved while the toxicity to normal cells is reduced.

The application discloses a novel fullerene hydrogel and a preparation method and application thereof. The fullerene hydrogel is formed by chemical cross-linking of a fullerene derivative shown in formula I and oxidized hyaluronic acid (oxHA). The fullerene-hyaluronic acid hydrogel material provided by the application has a porous framework, a large pore size and a cell loading potential.

The invention discloses an anti-biofilm nano composite material added with resveratrol and a preparation method of the anti-biofilm nano composite material. According to the method, ferric trichloride hexahydrate, trisodium citrate, sodium acetate, polyetherimide, resveratrol and hyaluronic acid are used as raw materials, modified magnetic Fe3O4 nanoparticles with positive charges are prepared through a hydrothermal method, carbon dots derived from a resveratrol and hyaluronic acid mixture are introduced, and the magnetic Fe3O4 nanoparticles with positive charges are prepared. The anti-biofilm nano composite material added with the resveratrol is prepared. The nano composite material disclosed by the invention can be attached to a biological membrane, so that the loss is reduced in a transfer process, the effective utilization rate of a medicine is remarkably improved, and excellent magnetic property, antibacterial property and biological membrane resistance are shown.

The application discloses antibacterial carbon dots and a low-temperature and normal-pressure preparation method and application thereof. The method is characterized in that ascorbic acid and cetylpyridinium chloride are used as raw materials, and the antibacterial carbon dots are synthesized through a low-temperature and normal-pressure method. The preparation method has the advantages of simple process, low reaction temperature, short reaction time, no need for any functional modification and low cost. The prepared carbon dots have good water solubility and excellent antibacterial activity. In particular, the carbon dots exhibit significant antibacterial activity on drug-resistant bacteria, can inactivate the drug-resistant bacteria through multiple ways such as destroying cell membranes, inducing active oxygen and reducing the surface charge of bacteria, and have a good application prospect in antibacterial aspects.

The invention relates to the technical field of biological medicines, in particular to an anti-tumor compound as well as a preparation method and application thereof. The nano-diamond cannot effectively kill tumor cells due to good biocompatibility, and the ferrocene with an aromatic ring structure is combined with the nano-diamond, so that a good anti-tumor effect can be fully exerted. The TAT-PEG-PLGA has the advantages that the TAT-PEG-PLGA is high in membrane penetrating capability, water solubility, biocompatibility, stability and targeting property; the TAT-PEG-PLGA with adsorption force on the surface is used for loading the ferrocene-nano-diamond and the adriamycin to obtain the anti-tumor compound, so that the ferrocene-nano-diamond and the adriamycin can effectively enter tumor cells to jointly play an anti-tumor effect. The obtained anti-tumor compound can effectively inhibit the activity of melanoma cells A375, is an effective tumor inhibitor, and can provide a new treatment strategy and choice for tumor treatment.

To provide a method for solubilizing a water-insoluble substance that uses a solubilizer having high biocompatibility and low environmental load and is applicable to a wide range of water-insoluble substances by a simple process, offering high versatility, and a composition comprising a solubilized water-insoluble substance.SOLUTION: A water-insoluble substance is solubilized by a method including the steps of: grinding a water-insoluble substance and a solubilizer, which is at least one selected from gelatin, polyglutamic acid and polylysine, using a ball mill, or a mortar and a pestle, to obtain a ground mixture; and adding water to the ground mixture, to obtain aqueous solution of the ground mixture.SELECTED DRAWING: None

The invention relates to a samarium-doped carbon quantum dot as well as a preparation method and application thereof, and belongs to the technical field of nano material synthesis, the preparation method comprises the following steps: carrying out ultrasonic dispersion on 0.01-0.03 g of p-phenylenediamine, 0.05-0.10 g of N-(4-aminophenyl) acetamide and 0.01-0.02 g of samarium chloride (III) hexahydrate in 15-25 mL of ultrapure water to form a mixed solution, carrying out hydrothermal reaction at 160-200 DEG C for 8-12 hours, filtering, washing and drying to obtain the samarium-doped carbon quantum dot. High-speed centrifugation, millipore filtration membrane filtration, 500Da molecular weight interception dialysis and freeze drying processes are sequentially adopted to realize efficient doping of the samarium element and precise purification of the product. The method is easy and convenient to operate, the product uniformity is excellent, and the prepared samarium-doped carbon quantum dots have the strong fluorescence characteristic and chemical stability and can be widely applied to the fields of biomedical imaging, photocatalytic materials and photo-thermal anticancer.

The present invention provides a method for preparing and applying amino acid-derived carbon dot nanozymes, belonging to the field of new biomedical materials technology. The amino acid comprises one of histidine, proline, cysteine, tryptophan, aspartic acid, arginine, lysine, methionine, and phenylalanine; the mass ratio of the amino acid to citric acid monohydrate is 1:1 to 1:5. The amino acid-derived carbon dots proposed in the present invention have free radical scavenging activity and superoxide dismutase-like properties, exhibiting low toxicity and good biosafety at the cellular, nematode, and animal levels. Furthermore, the amino acid-derived carbon dot nanozymes exhibit excellent anti-inflammatory activity, downregulating cellular inflammation, reducing oxidative stress damage to nematodes, improving intestinal flora structure, increasing the richness and diversity of intestinal flora, and alleviating and treating DSS-induced ulcerative colitis in mice. The nanozymes can be further applied to the preparation of drugs for treating inflammatory bowel disease.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses an external liquid containing lime and alum for astringing sores and a preparation method of the external liquid. The external liquid containing lime and alum for healing sores is prepared from the following raw materials: lime, alum, water, a thickening agent, a cortex phellodendri extract, carbonized sanguisorba root powder, borneol and a pH regulator. The preparation method comprises the following steps: S1, preparing lime milk; s2, preparing an alum solution; s3, mixing reaction; s4, performing curing treatment; s5, blending; s6, refining: filtering the mixture obtained in S5, adding borneol and ethylparaben into the filtrate before filtering, and uniformly stirring to obtain the external liquid for healing sore. The external liquid containing lime and alum for healing sores can be used for treating various skin injuries such as skin ulcers, wounds, burns, eczema and postoperative wounds, and has the advantages of efficient astringency and hemostasis, antisepsis and anti-inflammation, promotion of wound healing, good system stability, comfort in use and high safety.

The invention provides an anti-biofilm composition based on the synergistic effect of amino fullerene and vancomycin and application of the anti-biofilm composition. The mass ratio of the amino fullerene to the vancomycin is 10: 1. The amino fullerene derivative and vancomycin are combined to have a remarkable synergistic effect in the aspect of inhibiting the formation of the biological membrane for the first time, and the inhibition rate of the biological membrane reaches 93%, so that the amino fullerene derivative and vancomycin have a strong synergistic effect. The composition provided by the invention can effectively remove more than 40% of formed mature biological membranes (24-48-hour biological membranes), which is an effect which cannot be realized by independent use of vancomycin.

A therapeutic method for catalytically forming persulfide and / or polysulfide from hydrogen sulfide in vitro and in vivo using endogenously or exogenously released hydrogen sulfide is disclosed. That method comprises contacting cells in need including those under oxidative stress, traumatic brain injury (TBI) and hypoxia, or have an excess of hydrogen sulfide or deficiency of protein persulfidation with oxidized carbon nanoparticulate material in which the particles contain a plurality of carbonyl, hydroxyl and carboxyl substituents. Oxidized carbon nanoparticulate (OCN) material can be prepared from any of a variety of sources of which activated charcoal is preferred. A water-dispersible OCN material is described that does not need added hydrophilic polymers to provide dispersibility for at least 7 days at a concentration of about 1-5 mg / mL. These OCN materials also have a UV absorbance maximum in water of about 220 nm and pass through a 0.22 μm pore PES membrane.

The invention relates to application of graphene-(RADA-IKVAV)-pranoprofen, eye drops and a preparation method of the eye drops. The invention relates to graphene-(RADA-IKVAV)-pranoprofen, the graphene-(RADA-IKVAV)-pranoprofen comprises graphene-polyacrylic acid, self-assembled oligopeptide RADA-IKVAV and pranoprofen, the self-assembled oligopeptide RADA-IKVAV is connected with the graphene-polyacrylic acid through a chemical bond, and the pranoprofen is loaded on the surface of the graphene-polyacrylic acid. The eye drops provided by the invention comprise graphene-(RADA-IKVAV)-pranoprofen, so that the drug loading capacity of pranoprofen in the eye drops is increased, the bioavailability of drugs is improved, and the eye drops are used for inhibiting eye inflammation; the coupled oligopeptide RADA-IKVAV simulates an extracellular environment, provides a suitable microenvironment for eyes, promotes nerve repair and regeneration by influencing nerve growth factors, and promotes optic nerve repair.