526results about "Carbon active ingredients" patented technology

The invention discloses a preparation method and application of a zinc-manganese bimetal organic framework derived composite nano-enzyme, and belongs to the technical field of nano-materials. Zinc-manganese bimetal organic framework nanoparticles prepared by reacting ZIF-8 with manganese (III) acetylacetonate are used as a template, and are calcined at different temperatures in a tubular furnace to obtain zinc-manganese bimetal organic framework derivative composite nano-enzymes with different morphologies. The nano enzyme has peroxidase-like activity, glutathione peroxidase-like activity and catalase-like activity, and has a wide application prospect in anti-tumor treatment.

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention provides a nitrogen-doped biomass-based fluorescent carbon quantum dot, a preparation method and application, and relates to the technical field of carbon nanomaterials, the method comprises the following steps: mixing a biomass material and deionized water under an ultrasonic condition, adding a nitrogen source, and carrying out ultrasonic dispersion to obtain a uniformly dispersed to-be-reacted solution; reacting the to-be-reacted solution at a preset temperature for a preset time to obtain a mixed product solution; and filtering and dialyzing the mixed product solution to obtain the nitrogen-doped biomass-based fluorescent carbon quantum dot solution. The nitrogen-doped biomass-based fluorescent carbon quantum dot prepared by the method shows a stable fluorescent effect and good water solubility, the free radical clearance rate can reach 90% or above, and the antibacterial rate can reach 99% or above. The method can be used in the fields of drug sustained release, bioimaging and the like.

Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.

The invention discloses a two-dimensional bionic nanostructure assembled based on receptor-ligand acting force and a preparation method of the two-dimensional bionic nanostructure. The core characteristic of the two-dimensional bionic nanostructure is that the ultrafine particles modified by ligand molecules are anchored on the surface of a cell membrane fragment with a corresponding receptor expressed on the surface through a receptor-ligand effect, so that uniform compounding of the ultrafine particles and the cell membrane is realized; the bottlenecks of low compounding efficiency, functional site masking and the like caused by high surface curvature of small-size particles in the traditional cell membrane complete wrapping technology are broken through. According to the preparation method disclosed by the invention, the binding force between the cell membrane and the ultramicro particles is stronger, the off-target phenomenon of the ultramicro particles in the in-vivo circulation process can be avoided, the response release of the ultramicro particles under the competition effect in a lesion region expressed by a high-abundance receptor can be realized, and the preparation method has a good application prospect in the aspect of precise drug delivery. Meanwhile, the in-vivo circulation time of the ultrafine particles is prolonged by membrane loading, the biocompatibility of the ultrafine particles is improved, and the effectiveness and low toxicity of a drug delivery system are ensured.

The invention belongs to the technical field of medicines, and particularly relates to a bionic nano-drug for resisting subcutaneous drug-resistant bacterial infection as well as a preparation method and application thereof. Dopamine hydrochloride is added in the synthesis process of a metal-organic framework to prepare a dandelion-shaped carbon nano-enzyme precursor, then the nano-enzyme precursor is carbonized to obtain a carbon nano-enzyme with targeting property, photoresponse and peroxidase activity, and finally berberine hydrochloride is loaded on the carbon nano-enzyme to obtain the bionic nano-drug. The bionic nano-drug provided by the invention firstly has good biocompatibility, secondly has a unique dandelion-shaped form, is beneficial to playing a targeting role, and finally has relatively strong light response capability in a near-infrared region, and can synergistically and efficiently sterilize through action mechanisms of antibacterial drugs, photothermal therapy and chemical kinetics, so that the bionic nano-drug has a good application prospect. The compound has an important application value in preparation of drugs for treating subcutaneous drug-resistant bacterium infection.

The invention discloses a preparation method of ocimum gratissimum carbon dots and application of the ocimum gratissimum carbon dots in antibacterial drugs and food preservation. The preparation method of the ocimum gratissimum carbon dots comprises the following steps: performing steam distillation on ocimum gratissimum leaves to remove essential oil, drying in the shade, and crushing; adding an alcohol solvent into the powder, extracting, filtering, concentrating and drying to obtain an alcohol extract; dispersing the alcohol extract in distilled water, and stirring and pyrolyzing on a heating table; and diluting the pyrolysis product with distilled water, centrifuging, taking supernate, filtering with a filter membrane, dialyzing, and freeze-drying to obtain the carbon dots. The obtained carbon dots have a carbon dot-vesicle coexisting structure, and the average particle size is 5.732 + / -0.5 nm. The prepared ocimum gratissimum carbon dots can be applied to preparation of antibacterial drugs, especially drugs for inhibiting the activity of bacillus cereus and listeria, and the field of food preservation, and have the advantages of being wide in raw material source, simple in preparation method, low in cost, environmentally friendly and the like.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of carbon dots for killing helicobacter pylori and application of the carbon dots in oral pharmaceutical preparations. The preparation method comprises the following steps: mixing microcrystalline cellulose and glycerol, freezing and crushing at an ultralow temperature, and selectively hydrolyzing by combining citric acid-malic acid mixed acid liquor to efficiently prepare a high-crystallinity cellulose nanocrystal template; the controllable synthesis of the carbon dots is realized by utilizing the hydrogen-bond interaction of hydroxyl / carboxyl on the surface of the cellulose nanocrystal and the nitrogen doping effect in the polymerization and carbonization process of citric acid and urea. Besides, when a sodium alginate-chitosan double-layer structure is constructed, carbon dots are introduced into the inner layer to endow the inner layer with special performance, a protein-polysaccharide network is formed on the outer layer through transglutaminase enzymatic crosslinking, and the oxidation resistance and mechanical strength are enhanced through secondary curing of tea polyphenol. According to the invention, food-grade raw materials are used for realizing high-efficiency antibiosis, the oral preparation safety specification is met, and the clinical transformation potential is realized.

The invention belongs to the technical field of hepatopathy treatment drugs, and particularly relates to an anti-inflammatory and anti-oxidative stress nano-enzyme Cu5.4O atCNDs with cascade enzyme activity and application of the nano-enzyme Cu5.4O atCNDs. The nano-enzyme Cu5.4O-coated CNDs is prepared by the following steps: dissolving CuCl2 in a carbon dot aqueous solution, reacting for 10-12 minutes at the temperature of 75-80 DEG C, then adding an L-ascorbic acid aqueous solution, regulating the pH value to 7.0-8.0 by using a NaOH solution, reacting for 10-12 hours at the temperature of 75-80 DEG C, after the reaction is finished, centrifuging to remove precipitates, dialyzing supernate, and freeze-drying to obtain the Cu5.4O-coated CNDs. Research results of the invention prove that the nano-enzyme Cu5.4O-coated CNDs has the potential of treating various acute liver injury diseases, and is an intervention strategy with a good clinical application prospect.

The invention relates to the technical field of traditional Chinese medicine carbon dots, in particular to ligusticum wallichii carbon dots, a medicine and application. The ligusticum wallichii carbon dots disclosed by the invention are obtained by carbonizing ligusticum wallichii by a hydrothermal method, wherein the hydrothermal method carbonization is a hydrothermal reaction at 175-195 DEG C for 8-12 hours; research finds that the ligusticum wallichii carbon dots have the characteristic of treating myocardial apoptosis caused by myocardial ischemia reperfusion injury, and compared with ligusticum wallichii carbon dots synthesized by ligustrazine and a pyrolysis method, the ligusticum wallichii carbon dots have the advantage that the heart function can be better recovered. The invention provides a new candidate drug for treating myocardial ischemia reperfusion injury.

The invention relates to armadillidiam vulgare derived carbon quantum dots as well as a preparation method and application thereof, the armadillidiam vulgare derived carbon quantum dots are characterized in that the particle size of the armadillidiam vulgare derived carbon quantum dots is 2.2-6.0 nm, and the armadillidiam vulgare derived carbon quantum dots can inhibit pain response, reduce oxidative stress level and reduce inflammatory factor gene expression level. The armadillidiam vulgare derived analgesic carbon quantum dots inhibit irritant movement and oxidative damage in a pain model, and reduce inflammatory factors and pain pathway gene expression; the oxidative stress level is reduced, and the effects of relieving pain, resisting inflammation and resisting oxidative stress are achieved.

The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.

A graphene acupoint herbal patch (AHP) for warming uterus and relieving pain, and a method of preparation and use thereof are provided, belonging to the technical field of traditional Chinese medicines (TCMs). The graphene AHP for warming uterus and relieving pain includes a TCM, graphene, a hot melt adhesive, a far-infrared ceramic powder, a heat sensitizer, camphor, and menthol. The graphene AHP for warming uterus and relieving pain produces no acute toxicity, has no skin irritation, and does not induce allergies. In the graphene AHP for warming uterus and relieving pain, the release rate of the small drug molecules tetrahydropalmatine, imperatorin, eugenol, and paeoniflorin is higher than that of an ordinary AHP for warming uterus and relieving pain, thus exhibiting a more obvious analgesic effect.

The invention discloses a preparation method of antibacterial dual-oxygen-supply manganese-doped carbon dot-oxygen-carrying microbubbles, and belongs to the field of preparation of medical configuration products, and the preparation method comprises the following steps: attaching biotinylated manganese-doped carbon dots to oxygen-carrying microbubbles by using biotin-avidin connection to prepare micron-level manganese-doped carbon dot-oxygen-carrying microbubbles; the size of the micron-level manganese-doped carbon dot-oxygen-carrying microbubble is 1000-2500nm. The antibacterial dual-oxygen-supply manganese-doped carbon dot-oxygen-carrying microbubble prepared by the invention has the advantages of simple synthesis, clear structure, adjustable size and the like, and the material preparation method is simple, mild in reaction condition and suitable for large-scale production; manganese-doped carbon dot-oxygen-carrying microbubbles provide dual oxygen supply to enhance the sonodynamic therapy effect, so that efficient antibacterial activity is achieved, angiogenesis is promoted, wound healing is accelerated, and the method is a promising wound healing therapy method.

The invention discloses efficient gynecological antibacterial liquid and a preparation method thereof, and belongs to the technical field of medical instruments. The efficient gynecological antibacterial liquid is prepared from active ingredients, auxiliaries and deionized water, the active component is prepared from the following raw materials: zein, a chitosan derivative, metal ions, fullerene and epsilon-polylysine; the efficient gynecological antibacterial liquid does not contain a vitamin B component, and the preparation raw materials do not contain the vitamin B component. The efficient gynecological antibacterial liquid does not contain vitamin B, artificial essence and plant-derived aromatic substances, has no unpleasant smell when in use, and has good antibacterial performance.

The invention discloses a liquid metal-based anti-inflammatory drug as well as a preparation method and application thereof, and relates to the technical field of biomedicine. The preparation method of the liquid metal nanoparticles comprises the steps that liquid metal is placed in a solvent, a dispersing agent is added, ultrasonic dispersion and gradient centrifugation are conducted, and the liquid metal nanoparticle suspension preparation is obtained. The concentration of the liquid metal in the liquid metal nanoparticle suspension preparation is 5-30 mg / mL, and the size of the liquid metal nanoparticles is 50-500 nm; the liquid metal is gallium, indium, tin or alloy thereof; the dispersing agent is ligand molecules for realizing separation of the liquid metal nanoparticles by forming an end-capping layer on newly-generated liquid drops in at least one mode of static electricity, cross-linking and covalent replacement. The liquid metal nanoparticles can be directly used for treating infectious bone defect diseases, and other auxiliary agents can also be added to prepare anti-inflammatory drugs; meanwhile, the antibacterial and osteogenesis characteristics are achieved, and the dual requirements for treating infectious bone defects, inhibiting infection and promoting tissue regeneration are met.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention discloses a traditional Chinese medicine composition for treating liver cirrhosis and a preparation method thereof, and belongs to the technical field of anti-liver cirrhosis traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 10g of polyporus umbellatus, 10g of herba artemisiae scopariae, 10g of radix bupleuri, 10g of charred rheum officinale, 10g of rhizoma coptidis, 10g of charred radix scutellariae, 10g of fructus gardeniae, 15g of herba hyperici japonici, 10g of radix curcumae, 10g of rhizoma alismatis, 10g of radix paeoniae rubra, 10g of radix salviae miltiorrhizae, 10g of cortex magnoliae officinalis, 10g of fructus aurantii, 10g of rhizoma cyperi, 10g of rhizoma sparganii, 10g of rhizoma curcumae, 20g of plantain herb, 10g of turtle shell, 10g of pericarpium arecae, 25g of oven earth and 2g of charred colla corii asini. By providing the traditional Chinese medicine composition formula for treating the liver cirrhosis, the effective rate and the cure rate of the medicine for treating the liver cirrhosis are improved.

The invention belongs to the field of nano material preparation, and particularly relates to a preparation method and application of seaweed biomass derived manganese / nitrogen doped carbon composite nano enzyme. The low-cost manganese nanoparticle / seaweed biomass derived nitrogen-doped carbon composite nano-enzyme is prepared by taking seaweed biomass as a raw material through an impregnation-pyrolysis method. The nano-enzyme has high-efficiency enzyme-like activities such as peroxidase-like activity, glutathione oxide enzyme-like activity, singlet oxygen generation catalysis capability and the like, and shows application prospects in the antibacterial and anti-tumor fields.

A method of inhibiting cancer cell viability may include contacting cancer cells and a nanocomposite including graphitic C3N4, Fe2O3, and MgAl2O4 in a mass relationship to each other in a range of 5 to 15:2 to 7:75 to 95. The nanocomposite is in a concentration range of 7.5 micrograms per milliliters (μg / mL) to 500 μg / mL, thereby inhibiting the growth of the cancer cells by at least 85%.

The invention discloses a preparation method and application of a chlorogenic acid carbon quantum dot microsphere capsule, a natural active product chlorogenic acid (CHA) in coffee is used as a raw material, and chlorogenic acid carbon quantum dots (CHA CDs) with anti-inflammatory and antioxidant activity are synthesized through a hydration method; then, the chlorogenic acid carbon quantum dots (CHACDs) are packaged with chitosan, and meanwhile, the chitosan on the outer layer of the capsule is modified with the DNA aptamer, so that the chlorogenic acid carbon quantum dot microsphere capsule Apt-CS (at) CHA CDs are obtained. The chlorogenic acid carbon quantum dot microsphere capsule disclosed by the invention not only has anti-inflammatory and antioxidant activity, but also can regulate intestinal flora, enhance intestinal barrier function and immune conditions; moreover, the microsphere capsule can be retained in the intestinal tract for a long time, so that the microsphere capsule can resist inflammation and remove high-level reactive oxygen species (ROS), can be retained in the intestinal tract for a long time and play a role in regulating intestinal flora, finally, the disease development of IBS is comprehensively relieved, and the microsphere capsule has a very good application prospect.

The invention discloses a carbon dot capable of remarkably improving the solubility and the biological effect of baicalin, and belongs to the technical field of medicines. The invention relates to application of scutellaria baicalensis carbon dots (nano particles / particles / nano components), the carbon dots can obviously increase the solubility of baicalin in water, and the application comprises the biological effects of improving the solubility and bioavailability of the baicalin in water, resisting inflammation and oxidation, resisting tumors and the like.

The invention relates to the technical field of biomedical materials, in particular to an alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material and a preparation method and application thereof.The alendronate-modified ZIF-8 serves as a carrier, TPP-modified carbon dots are encapsulated in the carrier, citric acid, urea and cerium salt serve as raw materials of the TPP-modified carbon dots, and the alendronate-modified ZIF-8 encapsulated TPP-carbon dot bone targeting nano-material is prepared through a one-step method. After cerium-doped carbon quantum dots are synthesized through a hydrothermal method, TPP is grafted through an amide method, alendronate endows the material with a bone targeting function, and TPP modified carbon dots endow the material with antioxidant and mitochondrial targeting functions. According to the invention, the bone targeting property is excellent, and bone focuses are efficiently enriched; the anti-oxidation and anti-inflammatory capacities are high, and the infected microenvironment can be improved; zIF-8 packaging is stable, and functional components can be controllably released; multiple components cooperate to promote bone repair, accumulation of non-target organs is little, and the composition is safe, reliable and suitable for treatment of various bone-related diseases.

The invention discloses antibacterial gynecological gel and a preparation method thereof, and relates to the field of gynecological products, arginine powder and sorbitol are dissolved in water, a hydrothermal reaction is performed at 130-160 DEG C, cooling is performed to obtain an arginine carbon quantum dot solution, then modified hydrogel and a plant extract are added, vacuum stirring and uniform mixing are performed, ultraviolet irradiation is started while stirring, standing is performed, and the antibacterial gynecological gel is obtained. The bacteriostatic gynecological gel is obtained. The adopted gel matrix releases arginine carbon quantum dots in a weak acid environment, and is compounded with active substances, especially flavonoid substances, in the plant extracting solution, so that a better synergistic antibacterial effect is achieved. Sensitive response of the carbon quantum dots to illumination is combined, so that the carbon quantum dots can be attached to a gel matrix more easily; meanwhile, polar groups, especially oxygen-containing groups, are introduced to the surface of the gel, so that the viscosity and the adhesiveness of the gel material are greatly improved, and the affected part can be better treated.

The invention discloses a fullerene C60 eye fatigue relieving patch and a preparation method thereof, and belongs to the technical field of eye patches. The fullerene C60 eye fatigue relieving patch comprises hydrogel and a non-woven fabric, the hydrogel is prepared from the following raw materials: a traditional Chinese medicine active substance, fullerene and a gelling substance. The fullerene C60 eye fatigue relieving patch is in a hydrogel dosage form, fullerene is further added, and the product is good in moisturizing performance, good in sterilization performance and good in mechanical strength performance.

The invention provides curcumin carbon dot nano-enzyme and application thereof in preparation of medicine for preventing and treating lung injury, a preparation method of the curcumin carbon dot nano-enzyme comprises the following steps: 1) adding tobacco powder, reduced glutathione and curcumin into formamide, stirring, performing ultrasonic treatment, and performing high-temperature reaction; and 2) after the reaction is finished, cooling to room temperature, filtering, collecting filtrate, transferring into a dialysis bag, enabling the dialyzed solution to pass through a water film, and freeze-drying to obtain the curcumin carbon dot nano-enzyme. The invention belongs to the technical field of nano-enzymes, and the curcumin carbon dot nano-enzyme provided by the invention has a dual-wavelength fluorescence emission characteristic, realizes effective utilization of tobacco leaf wastes, and is expected to play an important role in preparation of medicines for preventing and treating lung injury.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The present embodiments are directed to methods of using a glycine transporter inhibitor, e.g., a GlyT1 inhibitor, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a pharmaceutical composition thereof, to prevent or treat erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), and / or congenital erythropoietic porphyria (CEP), and their associated syndromes. The present application provides a method of treating erythropoietic protoporphyria (EPP), X-linked protoporphyria (XLPP), or congenital erythropoietic porphyria (CEP) in a subject, the method comprising administering to the subject a pharmaceutical composition comprising one or more glycine transporter 1 (GlyT1) inhibitors or pharmaceutically acceptable salts thereof, or one or more prodrugs of GlyT1 inhibitors or salts thereof.

The invention discloses a tellurium-doped carbon quantum dot and a preparation method and application thereof, the tellurium-doped carbon quantum dot is obtained by using 2, 2 '-diaminodiphenyl telluride as a precursor, the average particle size is 1.9 nm, the thickness is about 2.1 nm, and the surface is rich in amino groups. And fixing (4-carboxybutyl) triphenylphosphonium bromide, 3-morpholinopropionic acid or 3-((4-methylphenyl) sulfonamide) propionic acid on the surfaces of the tellurium-doped carbon quantum dots to prepare Mito-Te-CDs, Lyso-Te-CDs and ER-Te-CDs with an organelle targeting function. The Mito-Te-CDs, the Lyso-Te-CDs and the ER-Te-CDs are good in biocompatibility, can be used as fluorescent probes for targeted imaging of organelles, can be used for recognition and removal of superoxide anions in specific organelles, have a protection effect on cells and can be used for effectively treating acute kidney injury.

The invention provides antibacterial and anti-inflammatory bio-based carbon dot-photo-crosslinking in-situ adhesion hydrogel, which is prepared by the following steps: preparing bio-based carbon dots from curcumin and carboxymethyl chitosan, mixing the bio-based carbon dots with double-bond collagen and o-nitrobenzene functionalized hyaluronic acid, and carrying out chemical crosslinking under ultraviolet irradiation to prepare the hydrogel. The invention further provides a preparation method and application of the antibacterial and anti-inflammatory bio-based carbon dot-photo-crosslinking in-situ adhesion hydrogel. The invention provides a multifunctional biological enlightenment hydrogel matrix, which not only has strong tissue adhesion, but also has antibacterial, anti-inflammatory and antioxidant characteristics, and can be used for repairing seriously infected cornea wounds. As a cornea substitute, the hydrogel has wound sealing performance, transparency and appropriate mechanical strength, and is the key characteristic of the suture-free hydrogel. In-vitro and in-vivo experiments prove that the hydrogel not only has good biocompatibility, but also can remodel a microenvironment through antibacterial infection, antioxidant and anti-inflammatory effects, so that wound healing is accelerated.