17 results about "Biological effect" patented technology

A phototherapy device is disclosed for irradiating tissues, such as those within a patient's body cavity, with light to induce various biological effects. These biological effects may include at least one of the following: inactivation and / or inhibition of the growth of one or more pathogens, upregulation of local immune responses, increase of endogenous nitric oxide reserves, release of nitric oxide from endogenous reserves, and induction of anti-inflammatory effects. The biological effects may also include upregulation and downregulation of inflammatory immune response molecules within the target tissue. The wavelength of light is selected based on the expected biological effects on one or more of the target tissue type and target pathogens. Whether using light of a single wavelength or light of multiple wavelengths, phototherapy can provide a variety of pathogenic biological effects. A device for phototherapy is disclosed that provides a light dose to induce biological effects on various target pathogens and tissues with enhanced efficacy and reduced cytotoxicity.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

The application provides a veterinary traditional Chinese medicinal material characteristic map efficacy quality correlation determination method, relates to the fields of traditional Chinese medicine analysis and detection and intelligent sensing technology, and the application converts static chemical components in the characteristic map into active node networks with inherent metabolic properties and definite dynamic interaction rules by constructing a chemical component characteristic space based on pharmacological mechanisms, quantifies synergistic or antagonistic inhibitory relationships between key nodes by using data driving and model simulation methods, thereby establishing a dynamic correlation evaluation system from material basis to biological effects, and realizing scientific determination of internal quality and actual efficacy of the veterinary traditional Chinese medicinal material. The application introduces metabolic response disorder degree and physiological stress load index as dynamic feedback variables, and improves the accuracy of the evaluation model in responding to real-time biological state of the body.

The invention provides a quantitative analysis method for physical-biological effects of vortexes with different polarities of an upwelling system, which is characterized in that a systematic vortex and chlorophyll-a concentration (CHL) quantitative analysis technical system is constructed based on multi-source satellite remote sensing data and reanalysis data; a vortex recognition and tracking method based on a complex empirical orthogonal function (CEOF), a vortex geometrical characteristic and dynamic parameter calculation method, a vortex radial CHL gradient calculation method and a vortex enhancement fraction calculation method are integrated, and fine description of dynamic characteristics and space-time distribution differences of gas vortexes (CEs) and anti-cyclonic vortexes (AEs) is achieved. And the regulation and control action mechanism of vortexes with different polarities on the upwelling biological productivity is quantitatively evaluated, so that the coupling relationship between the physical process and the biological response in the upwelling system is revealed, and a scientific basis and a technical support are provided for ecological environment monitoring and water environment management of the upwelling system.

This disclosure relates to a method for determining bioeffective dose, wherein the method includes: detecting the boron concentration C of each voxel in the target at multiple time points. B ; Calculate C B The corresponding biological effect value (RBE) B Determine C B and RBE B The first association relationship, based on the first association relationship, determines the connection through C. B Characterized RBE B ; Calculate C B The corresponding first physical absorbed dose rate D B And other physical absorbed dose rates corresponding to dose components other than boron, and physical dose rate distribution D phy According to RBE B and D B The product of the other dose components and the product of other biological effect values ​​and other physically absorbed dose rates is used to calculate C. B The combined biological effect value (CBE); based on CBE and D phy Calculate the biologically effective dose D bio According to this disclosure, it is beneficial to determine the appropriate irradiation time for different voxels during BNCT in order to obtain better therapeutic effects.

A computer-implemented method and corresponding system for monitoring ultrasound therapy are described. The method dynamically classifies, by a processor, cavitation effects of at least one ultrasound stimulus on microbubbles introduced into in a biological setting for use in the ultrasound therapy. The cavitation effects are observed via an ultrasound receiver and dynamically classified, by the processor, into stable cavitation effects and inertial cavitation effects. The at least one ultrasound stimulus targets biological tissue by causing the stable and inertial cavitation effects during the ultrasound therapy which responsively induce distinct bio-effects on the biological tissue in the biological setting. The method outputs, by the processor, a representation of an action to be taken for the ultrasound therapy. The action is a function of the stable and inertial cavitation effects dynamically classified, thereby enabling controlled ultrasound-based treatments, minimizing unintended effects on surrounding tissue.

This invention discloses a method and system for optimizing hypoxia in carbon ion radiotherapy based on a local effect model, belonging to the field of radiotherapy technology. The method constructs a mapping between dose-average linear energy transfer density (LETd) and oxygen gain ratio (OER), incorporating the OER value corresponding to LETd into the calculation process of the maximum relative biological effect (RBEmax) parameter of the LEM, generating an OER-calibrated hypoxic LEM; acquiring patient images, treatment plans, tumor target volume (GTV), clinical target volume (CTV), and hypoxic regions; calculating voxel LETd and assigning region labels; calling the hypoxic LEM for hypoxic regions, and calling the standard LEM for target voxels and normal tissue voxels outside the hypoxic region; iterative optimization through an objective function including target dose deviation, insufficient LETd in hypoxic regions, insufficient RBE-weighted dose (RBE dose), insufficient OER improvement, and penalties for exceeding organ limits, and recalculating and evaluating using the standard LEM.

The application relates to a kind of electromagnetic wave biological effect safety active prevention and control method, applied to open prevention and control area, the radiation source around the region is divided into two categories of no need to prevent and control and need to prevent and control, and multiple intelligent super surfaces are laid out.The method first opens the radiation source that does not need to prevent and control when, traverses all state vectors of intelligent super surface and detects electromagnetic wave intensity in the region, and filters out feasible solution space;When only the radiation source that needs to be prevented and controlled is opened, traverse the feasible solution space and detect the intensity, determine the state vector that makes the total intensity of the region minimum and configure.The method does not need to limit personnel activity or drug intervention, guarantees normal frequency demand, efficiently weakens harmful electromagnetic influence, and has strong adaptability.

This utility model discloses a home-use prostate phototherapy device, comprising: a shell assembly, a light-emitting component, a heat dissipation component, a power supply component, and a main control module. The light-emitting component is installed on one side of the shell assembly, and the heat dissipation component is tightly fitted to the light-emitting component. The power supply component and the main control module are both installed inside the shell assembly. This utility model provides power by incorporating a battery within the shell assembly, eliminating the need for an external power cord and improving the flexibility of the entire phototherapy device. The shell assembly also includes a fan and heat sink to prevent overheating of the high-energy spectral lamp core through air cooling, extending its lifespan and preventing burns to the patient's skin. During treatment, the tilt angle of the phototherapy device can be adjusted using a support block to irradiate areas such as the perineum, allowing photon energy to be transmitted through the body surface to the tissues, producing a biological effect and achieving the therapeutic purpose.

The application discloses a kind of S wave band high-power microwave biological effect test and evaluation method, comprising: selecting microwave test site satisfying far-field condition and constructing S frequency band high-power microwave biological effect device;According to test scheme, adjust output power, repetition frequency, pulse width and irradiation time to form different irradiation conditions, and apply S wave band high-power microwave irradiation to the biological body to be measured;At the preset time point after irradiation ends, the behavior of the biological body to be measured is tested and blood routine and biochemical index detection is carried out;Based on the obtained behavior characteristic data, blood routine and biochemical index data, a multi-parameter collaborative evaluation model of the three-level mapping relationship between physical stimulation intensity, behavior abnormality and blood markers is established to evaluate the influence of S wave band high-power microwave on the biological body.The application can study the influence of S wave band high-power microwave on the behavior state and blood routine parameters of the biological body under the conditions of output power, repetition frequency, pulse width, irradiation time and other variables.

This invention discloses a device, method, and system for synergistic regulation of flux and energy spectrum in boron neutron capture therapy (BNCT), belonging to the field of radiotherapy technology. It includes a composite modulation unit array, comprising multiple composite modulation rods capable of independent linear motion along a direction parallel to the beam axis. Each composite modulation rod is composed of at least two segments of neutronic materials with different neutron reaction cross sections and moderation capabilities, fixedly connected along its direction of motion. By employing an array of independently linearly moving composite modulation rods, and ensuring that each rod is composed of at least two different neutronic material segments, this invention breaks the traditional paradigm of separating flux regulation and energy spectrum regulation. It achieves synchronous, independent, and dynamic integrated modulation of the flux intensity and energy spectrum characteristics of the output neutron beam in any local region of two-dimensional space, thereby achieving dual optimization of dose and biological effects, significantly improving the personalization level and potential efficacy of BNCT treatment.

The application discloses a kind of particle arc radiotherapy energy layer selection method, device, equipment and medium, to solve the problems of current proton particle arc radiotherapy, such as energy layer redundancy, treatment time may be too long and LET distribution is unreasonable, by obtaining beam arc, beam angle set in particle arc radiotherapy treatment plan;According to the water equivalent thickness of beam, determine the candidate energy layer set, according to the preset objective function, determine the optimal energy layer selection of each beam;Through target area coverage and energy layer switching total time control, make target area dose coverage reach the expected effect and reduce energy layer switching total time, through the degree of energy layer deviation from center, make energy line density hot spot concentrate in target area inside, improve biological effect control precision, reach in the premise of guaranteeing target area coverage high, reduce treatment time, make energy line density hot spot as possible distribute in target area inside.

The application discloses application of Ms4a1 in peripheral blood leukocytes in calculation of high-energy neutron radiation dose, and relates to the technical field of biological detection. The application focuses on the biological effect and damage mechanism of neutron radiation, and potential biomarkers under dose gradient are screened. The LD50 and LD100 of mice under neutron radiation are determined as 8 Gy and 12 Gy respectively. The damage degree of radiation-sensitive organs such as spleen and intestinal tract is aggravated with dose gradient. The number of lymphocytes in the blood system is significantly reduced with dose, and can be used as an evaluation index of radiation damage. Cytokines such as IL-6 and IL-10 are significantly up-regulated, which indicates the inflammation and immune regulation mechanism. Ms4a1 is finally screened as a potential key gene, and the expression amount of Ms4a1 changes significantly before and after irradiation, and has very high sensitivity. The method can realize rapid and objective estimation of the neutron radiation dose by detecting the expression amount of Ms4a1 in peripheral blood leukocytes and substituting the dose-effect function, and has clinical transformation value.

This invention relates to an intelligent building environment control method based on multimodal perception, belonging to the field of environmental control system technology. This invention extracts the characteristics of personnel distribution and activity intensity from visual images and accurately converts them into dynamic metabolic rate parameters at the data layer. This enables the system to adapt to sudden changes in the state of personnel within the building in real time and proactively, greatly improving the adaptability and agility of environmental regulation. Simultaneously, it introduces physiological rhythm model parameters based on system time series to weight and correct the real-time predicted average vote index, effectively compensating for the shortcomings of traditional thermodynamic evaluations that neglect non-visual biological effects of the human body, thus improving the overall comfort of personnel within the space. Guided by the output comprehensive comfort target value, the algorithm coordinates the HVAC, lighting, and shading systems, completely changing the situation where each subsystem operates independently. Under the premise of strictly ensuring dynamic comfort, it achieves a deep reduction in the overall operating energy consumption of the building control system.

This invention discloses the application of Ikzf3 in peripheral blood leukocytes in calculating high-energy neutron radiation dose, belonging to the field of biodetection technology. This invention focuses on the biological effects and damage mechanisms of neutron radiation, screening potential biomarkers under dose gradients. The LD50 and LD100 of neutron radiation in mice were determined to be 8 Gy and 12 Gy, respectively. The degree of damage to radiation-sensitive organs such as the spleen and intestines increased with the dose gradient. The number of lymphocytes in the blood system decreased significantly with dose, which can serve as an indicator for assessing radiation damage. Cytokines such as IL-6 and IL-10 were significantly upregulated, suggesting inflammatory and immune regulatory mechanisms. Finally, Ikzf3 was screened as a potential key gene, and its expression level changed significantly before and after irradiation, exhibiting extremely high sensitivity. This method, by detecting the expression level of Ikzf3 in peripheral blood leukocytes and substituting it into a dose-response function, can achieve rapid and objective estimation of neutron radiation dose, possessing clinical translational value.

The application provides a circRNA circNOP14 and application thereof, through in-depth research on the mechanism of 125I particle action, it is found for the first time that the circRNA circNOP14 (hsa_circ_0006737) is one of the circRNAs with expression difference before and after 125I particle treatment, it is found for the first time that the circNOP14 can inhibit liver cancer growth and metastasis and induce apoptosis, and can enhance the radio-biological effect of 125I particles. And the mechanism of action is found: the circNOP14 can inhibit DNA damage repair by combining with the RBP binding protein XRCC6, and enhance the radiation damage of 125I particles on liver cancer cells. This shows that the circNOP14 can realize the effect of treating liver cancer and the effect of 125I particle radiosensitization, and has wide application prospect.

The application discloses application of a biomarker combination in peripheral blood leukocytes in calculation of high-energy neutron radiation biological dose, and relates to the field of biological detection. The application focuses on neutron radiation biological effect and damage mechanism, and potential biomarkers under a dose gradient are screened. The LD50 and LD100 of mouse neutron radiation are determined as 8 Gy and 12 Gy respectively. The damage degree of radiation-sensitive organs such as spleen and intestinal tract is aggravated with the dose gradient. The number of lymphocytes in the blood system is significantly reduced with the dose, and can be used as a radiation damage evaluation index. Cytokines such as IL-6 and IL-10 are significantly up-regulated, which indicates inflammation and immune regulation mechanism. Finally, the Ms4a1, CD79a and Ikzf3 combination with extremely high sensitivity is screened. The method can realize rapid and objective estimation of the neutron radiation dose by detecting the expression amount of Ms4a1, CD79a and Ikzf3 in peripheral blood leukocytes and substituting the dose-effect function.