94 results about "Biological effect" patented technology

The invention discloses an ultra-high dose rate radiotherapy plan optimization system based on compensator modulation, and relates to the technical field of radiotherapy. A data acquisition module is used for acquiring medical image data of a patient and receiving a clinical target; the clinical target comprises a target region prescription dose, an organ-endangering limit and a minimum dose rate threshold value required for triggering and maintaining a FLASH effect; and the FLASH biological effect evaluation module is used for calculating FLASH biological effective dose distribution corresponding to the physical dose distribution through an embedded biological effect model based on the input physical dose distribution and dose rate distribution. According to the method, the physical dose is converted into the accurate FLASH biological effective dose through the improved linear quadratic model embedded with the FLASH correction factor, the target tumor killing effect is guaranteed, normal tissue protection is enhanced with the help of the tissue differentiation correction factor, the industrial pain point that the physical dose reaches the standard but the biological effect does not reach the expectation is effectively solved, and the application prospect is wide. And the treatment plan better meets the clinical curative effect and safety core requirements.

The invention discloses a therapeutic nano-vesicle preparation rich in mitochondrial functional protein, a preparation method of the therapeutic nano-vesicle preparation and application of the therapeutic nano-vesicle preparation in treatment of radioactive skin injury. The preparation method comprises the following steps: culturing, amplifying and cleaning umbilical cord mesenchymal stem cells, dispersing the umbilical cord mesenchymal stem cells in a suspension, mechanically extruding the umbilical cord mesenchymal stem cells into a crude solution through a multistage aperture polycarbonate membrane, and centrifuging, concentrating and purifying the crude solution to obtain the preparation. The preparation has the remarkable advantages that local administration can be realized, inflammation can be quickly inhibited, oxidative stress is reduced, and a repair pathway is activated, so that the preparation is suitable for treating acute radioactive skin injury; the preparation method is easy to standardize and scale, high in stability and convenient for emergency storage and delivery, and avoids the defects of cell therapy; a plurality of targets such as immune inflammation, oxidative stress and the like can be synergistically regulated, the biological effect of hUMSCs is simulated and partially replaced, and the limitation caused by the cell survival rate and the microenvironment dependency is avoided; the key function of hUMSCs is covered in function, and the clinical feasibility, safety and emergency suitability of the application level are higher.

The invention discloses an alpha nuclide drug in-vitro cellular response prediction method and system based on multi-module mathematical modeling and a medium, and the method comprises the steps: constructing a basic parameter input module, a pharmacokinetic prediction module, a cell absorbed dose calculation module and a biological effect prediction module which are connected in sequence; a three-compartment dynamical model and a micro-dose learning point kernel convolution and DNA damage repair dynamical model are integrated, and full-chain and quantitative simulation from drug distribution, microscopic energy deposition to cell survival is achieved. The method overcomes the defects that an existing empirical model cannot accurately reflect the high LET characteristic of alpha particles, neglects the bystander effect and repair dynamics and the like, and the prediction precision is remarkably improved. According to the method, the curative effects of different drugs, cell lines and dosage schemes can be quickly simulated on a computer, the research and development cost and period are greatly reduced, and an efficient theoretical tool is provided for new drug screening and dosage optimization.

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.

The invention discloses a particle arc radiation therapy energy layer selection method, device, equipment and medium, and aims to solve the problems of energy layer redundancy, too long treatment time, unreasonable LET distribution and the like in current proton particle arc radiation therapy, and the method comprises the following steps: obtaining a beam arc and a beam angle set in a particle arc radiation therapy plan; determining a candidate energy layer set according to the water equivalent thickness of the beam, and determining the optimal energy layer selection of each beam according to a preset objective function; target region dose coverage reaches an expected effect through target region coverage and total energy layer switching time control, the total energy layer switching time is reduced, and the energy transfer linear density hot spots are concentrated in the target region through the degree that the energy layer deviates from the center, so that the biological effect control precision is improved; and the purposes of reducing the treatment time and enabling the energy transfer linear density hot spots to be distributed in the target region as far as possible are achieved on the premise of ensuring high coverage of the target region.

The invention relates to a physical therapy equipment parameter optimization method based on a terahertz technology, which comprises the following steps of: constructing a frequency stepping and pulse width combination mechanism of terahertz irradiation parameters to adapt to microscopic heterogeneity of water molecule distribution in human tissues, and exciting a tissue area which is originally in a low response state by expanding an absorption window range; setting an irradiation duration and duty ratio strategy, enabling a part of the tissue structure to generate reversible conformational deformation under terahertz micro-thermal stimulation, and regulating and controlling a scattering path and an interference state of local terahertz waves by utilizing the conformational deformation; the method has the beneficial effects that the microcosmic non-uniform tissue area is activated by utilizing the high-selectivity absorption characteristic of terahertz waves on water molecules and biological polar groups and through a combined mechanism of frequency stepping and pulse width, and the coupling efficiency and biological effect strength of energy in target tissue are remarkably improved.

The invention relates to a carbon ion radiotherapy relative biological effect prediction method and device, and the method comprises the steps: obtaining carbon ion RBE prediction input data comprising carbon ion physical parameters, tumor cell parameters and equivalent W value database data, enabling the input information to adapt to different tumor characteristics, and enabling the subsequent prediction to be more fit with a specific treatment scene; the input data is substituted into a target RBE prediction model which is constructed based on sodium dosimetry and optimized by an average ionization energy correction factor for processing, on one hand, an equivalent W value database provides corrected basic data, and in combination with a model core of the sodium dosimetry, prediction is closer to the actual action effect of carbon ions from the mechanism level, experience errors are reduced, and the prediction efficiency is improved. And on the other hand, the dual design of nanodosimetry and average ionization energy correction can also accurately associate the physical effect and the biological effect of the carbon ions, and it is guaranteed that the output target carbon ion RBE predicted value is more accurate.

Illumination devices for directing light on tissue to induce one or more biological effects and more particularly phototherapeutic illumination devices with data capturing capabilities are disclosed. Illumination devices for phototherapy include integrated data capturing capabilities while also being capable of delivering phototherapeutic treatments to the scalp. Data capturing capabilities include imaging capabilities where one or more integrated cameras within an illumination device are capable of capturing images of the scalp before, during, and / or after phototherapy. In certain embodiments, data capturing capabilities include the ability to map larger regions of the scalp or the entire scalp. Related systems are disclosed capable of accessing captured data from illumination devices, identifying and characterizing one or more features in the data, such as hair, hair density, and hair follicles, as well as other conditions of the hair and / or scalp.

The invention discloses a terahertz wave irradiation system and method for suspension cells, and belongs to the technical field of terahertz waves. The method comprises a process of assembling and constructing an irradiation system, a step of cleaning the irradiation system before applying terahertz waves, a treatment mode before irradiation of suspension cells, flow rate control of a cell suspension, determination of power density of the terahertz waves, safety detection of the system and an experimental effect evaluation system after irradiation of the suspension cells. Through the methods, the physiological environment of in-vivo circulation of the suspension cells can be simulated to the greatest extent, and the difficulty of irradiating the suspension cells by terahertz waves at present is overcome. According to the method, the biological effect of the terahertz waves on the suspension cells can be explored, and an idea is provided for subsequently exploring more effective specific terahertz frequencies.

The invention discloses a carbon ion radiotherapy biological dose modulation system and method based on energy transfer linear density threshold triggering, and relates to the technical field of tumor radiotherapy, and the system comprises an image and target region data import module, an energy transfer linear density calculation module, a dual-model optimization engine module, and a dose verification module. According to the method, a double-model regional optimization framework with specific energy transfer linear density as a physical threshold value is initiated for the first time, a local effect model is taken as an example, the maximum relative biological effect of a low-energy transfer linear density region is adjusted by introducing a modulation factor, the absorbed dose is deduced by combining a corrected local effect model equation, and the energy transfer linear density is calculated. The method realizes accurate improvement of the biological weighted dose of the region, is compatible with a mainstream relative biological effect model, can guarantee the safety of the high-energy-transfer linear density region and the endangered organ dose only through software upgrading, guarantees accurate calculation of the energy-transfer linear density through standard water model experiment calibration, and is suitable for carbon ion radiotherapy of various hypoxia tumors.

Illumination devices for directing light on tissue to induce one or more biological effects and more particularly phototherapeutic illumination devices with data capturing capabilities are disclosed. Illumination devices for phototherapy include integrated data capturing capabilities while also being capable of delivering phototherapeutic treatments to the scalp. Data capturing capabilities include imaging capabilities where one or more integrated cameras within an illumination device are capable of capturing images of the scalp before, during, and / or after phototherapy. In certain embodiments, data capturing capabilities include the ability to map larger regions of the scalp or the entire scalp. Related systems are disclosed capable of accessing captured data from illumination devices, identifying and characterizing one or more features in the data, such as hair, hair density, and hair follicles, as well as other conditions of the hair and / or scalp.

The invention discloses a drug-coated prostate balloon dilatation catheter control system, relates to the technical field of medical instruments, and aims to solve the technical problems of uncontrollable drug release, extensive dilatation process and lack of quantitative evaluation in existing drug balloon therapy. The system integrates a high-precision pressure sensing module, a micro piezoelectric pump control module, a man-machine interaction module and a data processing module. The system carries out real-time closed-loop control on the internal pressure of the balloon through a self-adaptive PID algorithm, and precise execution of a preset pressure curve is achieved. The innovation of the method lies in that a drug release quantitative estimation model based on pressure-time integration (AUC) is created for the first time, the model can calculate and display the estimated drug release amount in the treatment process in real time, and physical operation parameters are directly associated with biological effects; the device has the effects of realizing accurate and constant control of the dilatation pressure and improving the operation safety.

The disclosed invention is a method for mapping glutathione deficiency and / or mitochondria dysfunction in disease states, utilizing glutathione and its precursors as imaging tracers in conjunction with medical imaging techniques, particularly magnetic resonance imaging. The innovation involves administering glutathione or glutathione-increasing interventions, such as oral liposomal reduced glutathione, to enhance imaging accuracy. The proposed methodology aims to identify and monitor regions of depleted reduced glutathione (GSH) in various organs and tissues. The maps generated through this process provide valuable biomarkers for toxic exposure, early biological effects, and health risks. The approach is versatile, offering applications in mental health, neurological disorders, inflammation, organ dysfunction, and personalized treatment and risk assessments.

The invention provides a plasma dose calibration method and device, and the device comprises a biological reaction module which is used for carrying a biological sample and providing a stable processing environment, and guaranteeing that plasma energy is transmitted to the biological sample; the plasma generation module is connected with the biological reaction module and is used for generating plasmas to the biological reaction module, controlling a discharge mode and energy output according to the discharge parameters and monitoring physical characteristic data of the plasmas; the biological verification module is used for carrying out quantitative detection on biophysical reactions under different plasma release doses to obtain biological effect data; the control center is connected with the biological verification module and the plasma generation module and used for obtaining biological effect data and physical property data of the plasma so as to adjust discharge parameters of the plasma generation module and control the plasma dosage. A closed-loop control system of'parameter regulation and control-biological treatment-effect feedback 'is constructed.

The application discloses a design, verification analysis and optimization method of a bracket-free invisible orthodontic appliance model, and belongs to the technical field of oral orthodontics. The design method of the application adopts a cooling method to simulate and adjust the thermal expansion deformation of a local appliance model, restricts the deformation direction and size, and realizes the design deformation of the appliance model. The analysis verification method of the application comprises iterative simulation of the osteogenesis and osteolysis biological effect under orthodontic treatment force based on computer three-dimensional finite element analysis, simulation of wearing of the appliance, reading of simulation results, and analysis and verification. The optimization method of the application is based on the simulation results. The application creatively adopts a "cooling method" with prestress loading to realize the model deformation simulation of the appliance, and can combine the finite element simulation of the periodontal membrane biological effect of the actual clinical treatment time. The application implements the step-by-step design, analysis verification and optimization of the invisible orthodontic appliance model according to the analysis verification results.

The invention provides a method for calculating micro-dosimetry parameters and statistical errors thereof in alpha radiopharmaceutical radiation biological effect prediction under a microscopic heterogeneity condition. The method comprises the following steps: (1) constructing a stylized cell community model with microstructure heterogeneity, and describing heterogeneity spatial distribution of alpha radiopharmaceutical source items; (2) using a Monte Carlo method to simulate energy deposition information generated by each region source item to a cell nucleus target region; (3) calculating key micro-dosimetry parameters and statistical errors of the cell nucleus and the intranuclear radiation sensitive domain under the complex source item based on a micro-dosimetry principle and a probability method; and (4) predicting the survival score in the cell community based on the microdosimetry radiobiologic effect model, and performing error control and relative biological efficiency calculation. The method is used in the field of alpha radiopharmaceutical dose evaluation, can realize composite analysis and error control of micro-dosimetry parameters in a more real scene model, and provides technical support for research, development and conversion of alpha radiopharmaceuticals.

A phototherapy device is disclosed for irradiating tissues, such as those within a patient's body cavity, with light to induce various biological effects. These biological effects may include at least one of the following: inactivation and / or inhibition of the growth of one or more pathogens, upregulation of local immune responses, increase of endogenous nitric oxide reserves, release of nitric oxide from endogenous reserves, and induction of anti-inflammatory effects. The biological effects may also include upregulation and downregulation of inflammatory immune response molecules within the target tissue. The wavelength of light is selected based on the expected biological effects on one or more of the target tissue type and target pathogens. Whether using light of a single wavelength or light of multiple wavelengths, phototherapy can provide a variety of pathogenic biological effects. A device for phototherapy is disclosed that provides a light dose to induce biological effects on various target pathogens and tissues with enhanced efficacy and reduced cytotoxicity.

Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

The invention discloses a pulse type blood pump heat management control system based on rotation speed modulation. The control system is configured to execute the following steps that an initial state vector is generated according to motor key parameters, blood pump output flow, blood temperature and aorta pressure difference at historical moments; outputting a rotating speed adjustment vector by utilizing a strategy network according to the initial state vector, and further controlling the rotating speed of the motor; according to the motor key parameters, the blood pump output flow, the blood temperature and the aorta pressure difference at the current moment, a state vector at the current moment is generated, and an instant reward is calculated; updating the value network according to the state vectors at the n moments and the instant rewards; and updating the strategy network according to the predicted reward error of the value network. According to the invention, temperature rise minimization is realized under the constraint conditions of blood pump output flow, blood temperature, aorta pressure difference and the like, stable blood flow support can be provided during long-term operation of the blood pump, and bad biological effects can be effectively prevented.

The present application relates to the technical field of biological effect test equipment, and particularly relates to a spatial magnetic field generating device for biological sample test, which comprises a rack, a driving unit arranged on the rack, a magnet assembly rotating driven by the driving unit, and a control system electrically connected with the driving unit, wherein the magnet assembly comprises at least one pair of N-S pole oppositely arranged permanent magnets; the device further comprises a magnetic shielding cover arranged between the driving unit and the magnet assembly. The present application effectively suppresses the eddy current induced by the high-speed rotating permanent magnet in the metal part by introducing the magnetic shielding cover, thereby significantly reducing the operation heat of the device, solving the problem that the stability of the equipment and the environment of the biological sample are affected due to the excessively high temperature rise during long-term continuous work, and simultaneously improving the mechanical stability and the heat dissipation efficiency of the device at high speed through the high-precision dynamic balance calibration and the optimized heat dissipation hole design, so as to provide a more reliable and pure magnetic field environment for biological test.

Provided are multi-layer bioreactors for growing, maintaining, stimulating, monitoring and testing organoids and tissues derived from or representing hollow organs in organoid chambers. Also provided are uses of those bioreactors in modeling a disease process for monitoring disease progress and / or for assessing a biological effect, such as therapeutic efficacy and / or toxicity, e.g., organotoxicity. Also disclosed are bioreactors comprising organoid chambers that are useful as systems for measuring the volume, pressure, contractility, pump function, or electrophysiology of an organoid chamber as well as systems for controlling the pressure experienced by an organoid or tissue in an organoid chamber.

The invention relates to the technical field of medical instruments, and provides an argon-oxygen mixed plasma jet blood coagulation device which comprises a jet reactor, a power module and a gas supply assembly, the jet reactor comprises a discharge electrode, a medium tube and an insulating shell, and the discharge electrode and the medium tube are arranged in the insulating shell; a connecting end and a jet end are formed at the two ends of the discharge electrode respectively, and the jet end penetrates through the insulating shell and is suitable for forming a plasma jet beam; an air flow channel is formed in at least one of the discharge electrode and the dielectric tube; the power module is connected with the connecting end; the gas supply assembly is connected with the gas flow channel and used for supplying argon-oxygen mixed gas with the preset proportion to the gas flow channel. According to the invention, the thermal damage of tissues can be reduced, so that normal tissues around the wound surface can be protected; in addition, the effect of the biological effect in the blood coagulation process is increased, blood coagulation is accelerated, and the blood coagulation efficiency is remarkably improved.

The application provides a veterinary traditional Chinese medicinal material characteristic map efficacy quality correlation determination method, relates to the fields of traditional Chinese medicine analysis and detection and intelligent sensing technology, and the application converts static chemical components in the characteristic map into active node networks with inherent metabolic properties and definite dynamic interaction rules by constructing a chemical component characteristic space based on pharmacological mechanisms, quantifies synergistic or antagonistic inhibitory relationships between key nodes by using data driving and model simulation methods, thereby establishing a dynamic correlation evaluation system from material basis to biological effects, and realizing scientific determination of internal quality and actual efficacy of the veterinary traditional Chinese medicinal material. The application introduces metabolic response disorder degree and physiological stress load index as dynamic feedback variables, and improves the accuracy of the evaluation model in responding to real-time biological state of the body.

According to the radioactive hydrogel and the preparation method and application thereof and the radioactive tumor treatment application, chitosan serves as a matrix and is crosslinked with genipin to construct a three-dimensional network, and stable loading and slow release of radionuclides can be synchronously achieved; the self-antibacterial and adhesion characteristics of the patch can reduce the infection risk and ensure the fixation of the patch, so that a safe, effective and easy-to-operate local treatment platform is provided, the prepared patch can be directly placed on a tumor bed after resection in an operation, beta or alpha rays released by radionuclides accurately and continuously act on an area where tumor cells are most likely to remain, and the effect of treating the tumor cells is achieved. Different from traditional external radiation radiotherapy, the hydrogel can continuously release radiation with a low dosage rate. The mode has a stronger biological effect (such as inhibition of reproliferation) on tumor cells, the radiosensitivity difference of different cell periods and time phases can be overcome, the killing effect is more thorough, and chitosan is proved to have certain antibacterial activity, tumor cell growth inhibition activity and immunomodulatory activity. A synergistic effect can be generated with radionuclide, and a microenvironment which is not beneficial to survival and relapse of tumor cells is constructed together with the radionuclide.

The invention provides a quantitative analysis method for physical-biological effects of vortexes with different polarities of an upwelling system, which is characterized in that a systematic vortex and chlorophyll-a concentration (CHL) quantitative analysis technical system is constructed based on multi-source satellite remote sensing data and reanalysis data; a vortex recognition and tracking method based on a complex empirical orthogonal function (CEOF), a vortex geometrical characteristic and dynamic parameter calculation method, a vortex radial CHL gradient calculation method and a vortex enhancement fraction calculation method are integrated, and fine description of dynamic characteristics and space-time distribution differences of gas vortexes (CEs) and anti-cyclonic vortexes (AEs) is achieved. And the regulation and control action mechanism of vortexes with different polarities on the upwelling biological productivity is quantitatively evaluated, so that the coupling relationship between the physical process and the biological response in the upwelling system is revealed, and a scientific basis and a technical support are provided for ecological environment monitoring and water environment management of the upwelling system.

The application discloses a multifunctional visual acuity prevention and control wearable device based on a sound wave factor, which comprises an eye protection frame body and an adjustable elastic band connected with the eye protection frame body; a control module and a power module are arranged in the eye protection frame body; a plurality of sound wave resonance generators corresponding to the acupoints of the human eyes are arranged outside the eye protection frame body; the power module is electrically connected with the control module and the sound wave resonance generators respectively. The application further comprises a connection sensing and feedback unit and a frequency regulator connected with the control module. The application discloses a use method of the multifunctional visual acuity prevention and control wearable device based on the sound wave factor. Based on the physical characteristics and biological effects of the sound wave resonance and the resonance effect of the sound wave factor, a series of biological effects are generated on the biological cells and tissues of the acupoints around the human eyes, so that the gene expression of the eye tissues is influenced, the sensitivity of the cone cells and the secretion of dopamine are promoted, the visual recognition ability is optimized, the growth of the eye axis is inhibited, and the prevention and control of the naked eye myopia are achieved.

The invention discloses a radiotherapy plan evaluation information processing method and system based on a biological effect dose and a functional image. The method comprises the following steps: acquiring a CT image of a patient, structural contour information of a tumor or a normal tissue region of interest in the CT image, a radiotherapy physical dose distribution matrix and radiotherapy plan prescription information; querying to obtain physical doses corresponding to all pixel points in the region of interest of the tumor or the normal tissue in the CT image, and calculating biological effect doses of all the pixel points; acquiring a functional image reflecting biological characteristics of tumors or normal tissues of the patient; calculating weighted function distribution information of each pixel point in a tumor or normal tissue region of interest in the CT image; and calculating a biological effect dose-function histogram of the region of interest to be evaluated for evaluating the radiotherapy plan. According to the method, the biological effect dose and functional heterogeneity of the region of interest to be evaluated are reflected, and individualization and accuracy of radiotherapy plan evaluation can be improved.

A method for dynamically estimating a biological effect of a variable combination of non-photon radiation in accordance with a relative biological effectiveness, RBE, model including at least one biological effect multiplier δ(T,E) which depends on particle type T and / or particle energy E, the method comprising:obtaining one or more non-photon radiation contributions D(i)(T,E), 1≤i≤N, at least one of said contributions including multiple particle types and / or multiple particle energies;storing per-contribution dose-weighted averages δ(i), 1≤i≤N, of said at least one biological effect multiplier with respect to each of the one or more contributions; andin response to obtaining an assignment Π of the combination, the assignment being in terms of non-negative coefficients k1, k2, . . . , kN≥0 to be applied to the one or more contributions, determining a biological effect of the combination, including computing a combined dose-weighted average δΠ of said at least one biological effect multiplier on the basis of the stored per-contribution dose-weighted averages.

The invention relates to the technical field of medicine screening, in particular to an antidiarrheal medicine screening method based on a neural network, and the method comprises the following steps: setting an ideal adjustment direction of a core peristalsis rhythm phase and an expected enhancement amplitude of a core barrier function rhythm amplitude based on a preset antidiarrheal medicine efficacy demand; refined and operable drug efficacy demand indicators are established by setting an ideal adjustment direction of a core peristalsis rhythm phase and an expected enhancement amplitude of a core barrier function rhythm amplitude. According to the design based on individual physiological rhythm and flora abundance, evaluation of the drug effect in the screening process is more accurate and scientific, and dynamic changes in a living body can be responded in real time. By simulating the influence of each candidate drug molecule on the core rhythm and the expected influence of each candidate drug molecule on the abundance of the probiotic flora, the comprehensive effect of the drug is evaluated, and the process not only improves the screening efficiency, but also ensures the reliability and consistency of the candidate drug molecules on the biological effect.