20777results about How to "Shorten the construction period" patented technology

The present invention provides methods of re-engineering or re-shaping an antibody from a first species, wherein the re-engineered or re-shaped antibody does not elicit undesired immune response in a second species, and the re-engineered or re-shaped antibody retains substantially the same antigen binding-ability of the antibody from the first species. In accordance with the present invention, a combinatorial library comprising the CDRs of the antibody from the first species fused in frame with framework regions derived from a second species can be constructed and screened for the desired modified antibody. In particular, the present invention provides methods utilizing low homology acceptor antibody frameworks for efficiently humanizing an antibody or a fragment thereof. The present invention also provides antibodies produced by the methods of the invention.

A method and system for providing flexible subscriber VCR control of an interactive media system that limits the consumption of bandwidth capacity, the method comprising establishing a viewing time window during which a subscriber can watch an ordered program, enabling the subscriber to freely pause, rewind, and fast-forward the program so long as the end of the program does not exceed the end of the window, automatically tracking the remaining program running time against the time remaining in the window, deactivating the pause and rewind features if the remaining program running time equals the time remaining in the window, and reactivating the pause and rewind features if the program is fast-forwarded such that the time remaining in the window exceeds the remaining program running time. The system of the present invention is any interactive media system that delivers video streams such as an interactive television system that supports services such as pay-per-view and video-on-demand, or an internet-based interactive media system that downloads video streams through the internet to be played on a subscriber's personal computer or other viewing device.

A software platform in communication with networked distributed energy resource energy storage apparatus, configured to deliver various specific applications related to offset demand monitoring, methods of virtual power plant and orchestration, load shaping services, methods of reducing demand at aggregated level, prioritizing computer programs related to virtual energy pool, energy cloud controllers methods, charge discharge orchestration plans of electric vehicles, distributed energy resources, machine learning predictive algorithms, value optimizing algorithms, autonomous sensing event awareness, mode selection methods, capacity reservation monitoring, virtual power plant methods, advanced DER-ES apparatus features, energy management system for governing resources and methods, aggregated energy cloud methods, load shaping methods, marginal cost cycle-life degradation, load shaping API, forward event schedule, on demand request, and load service state request methods. Various rules, constraints of predictive algorithms for signal inputs to determine incremental storage cycles, cycle life degradation marginal cost, iterative and forward event schedule development, and load control.

A method for forming an oxide film by plasma-assisted processing includes: (i) supplying a precursor reactive to none of oxygen, CxOy, and NxOy (x and y are integers) without a plasma to a reaction space wherein a substrate is placed; (ii) exposing the precursor to a plasma of CxOy and / or NxOy in the reaction space; and (iii) forming an oxide film on the substrate using the precursor and the plasma.

A device is disclosed for assisting surgical operations inside a vessel, particularly for the minimally invasive explantation and implantation of cardiac valves, comprising an operating structure adapted to be implanted within the vessel, that is adapted to be fixedly and detachably joined to the inner wall of the vessel and is provided with at least one connector and / or support structure for a further instrument required for the surgical operation.

The present invention relates to a stent including a variable porosity, tubular structure having pores defined by structural surfaces. The tubular structure has a low porosity region in proximity to or at either end of the tubular structure, where the low porosity region is less porous than other regions located on the tubular structure and fully or partially obstructs passage of fluid. Any arcuate path that starts at one point within the low porosity region and goes around the perimeter of the tubular structure to stop at the same point within the low porosity region must have at least a portion that is outside of the low porosity region. Also disclosed is a method of modifying blood flow within and near an opening of an aneurysm in a blood vessel by deploying one or more stents of the present invention near an opening of the aneurysm in a blood vessel.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller in a queue of callers, and jumping or moving the caller to a different position within the queue based on the caller data. The caller data may include one or both of demographic data and psychographic data. The caller can be jumped forward or backward in the queue relative to at least one other caller. Jumping the caller may further be based on comparing the caller data with agent data via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are disclosed for routing callers to agents in a contact center, along with an intelligent routing system. A method for routing callers includes routing a caller, if agents are available, to an agent based on a pattern matching algorithm (which may include performance based matching, pattern matching based on agent and caller data, computer models for predicting outcomes of agent-caller pairs, and so on). Further, if no agents are available for the incoming caller, the method includes holding the caller in a shadow queue, e.g., a set of callers. When an agent becomes available the method includes scanning all of the callers in the shadow queue and matching the agent to the best matching caller within shadow queue.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes routing a caller from a pool of callers based on at least one caller data associated with the caller, where a pool of callers includes, e.g., a set of callers that are not chronologically ordered and routed based on a chronological order or hold time of the callers. The caller may be routed from the pool of callers to an agent, placed in another pool of callers, or placed in a queue of callers. The caller data may include demographic or psychographic data. The caller may be routed from the pool of callers based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller of a plurality of callers in a queue, and routing the caller from the queue out of queue order. For example, a caller that is not at the top of the queue may be routed from the queue based on the identified caller data, out of order with respect to the queue order. The caller may be routed to another queue of callers, a pool of callers, or an agent based on the identified caller data, where the caller data may include one or both of demographic and psychographic data. The caller may be routed from the queue based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Systems and methods are disclosed for routing callers to agents in a contact center, along with an intelligent routing system. An exemplary method includes combining multiple output variables of a pattern matching algorithm (for matching callers and agents) into a single metric for use in the routing system. The pattern matching algorithm may include a neural network architecture, where the exemplary method combines output variables from multiple neural networks. The method may include determining a Z-score of the variable outputs and determining a linear combination of the determined Z-scores for a desired output. Callers may be routed to agents via the pattern matching algorithm to maximize the output value or score of the linear combination. The output variables may include revenue generation, cost, customer satisfaction performance, first call resolution, cancellation, or other variable outputs from the pattern matching algorithm of the system.

Methods and systems are disclosed for routing callers to agents in a contact center with an intelligent routing system. An exemplary method includes routing callers to agents based on a pattern matching algorithm utilizing caller data and agent data, where the agent data includes agent satisfaction data from past agent-caller pairings. The agent satisfaction data may be obtained via surveys of the agents regarding their satisfaction with past agent-caller contacts. The agent satisfaction data may be used by the pattern matching algorithm in an attempt to increase agent satisfaction for future calls, thereby potentially reducing attrition of agents and cost to the call center, increasing morale of the agents, and so on. The agent satisfaction data and output from past agent-caller pairings may be weighted by the contact center against other agent data and caller data for a desired mixing of output variables.

Methods are disclosed for routing callers to agents in a contact center, along with an intelligent routing system. One or more agents are graded on achieving an optimal interaction, such as increasing revenue, decreasing cost, or increasing customer satisfaction. Callers are then preferentially routed to a graded agent to obtain an increased chance at obtaining a chosen optimal interaction. In a more advanced embodiment, caller and agent demographic and psychographic characteristics can also be determined and used in a pattern matching algorithm to preferentially route a caller with certain characteristics to an agent with certain characteristics to increase the chance of an optimal interaction.

Methods are disclosed for routing callers to agents in a contact center, along with an intelligent routing system. One or more agents are graded on achieving an optimal interaction, such as increasing revenue, decreasing cost, or increasing customer satisfaction. Callers are then preferentially routed to a graded agent to obtain an increased chance at obtaining a chosen optimal interaction. In a more advanced embodiment, caller and agent demographic and psychographic characteristics can also be determined and used in a pattern matching algorithm to preferentially route a caller with certain characteristics to an agent with certain characteristics to increase the chance of an optimal interaction.

A preformed, seamless, three-dimensional, anatomically contoured prosthetic device for reinforcing breast tissue and supporting a breast implant includes a flat back wall, a concave front wall and a curved transitional region between the flat back wall and the front wall defining a smoothly curved bottom periphery. A concave receiving space is defined by the back wall and the front wall for at least partially receiving and supporting the breast implant therein. The three-dimensional prosthetic device is free of wrinkles, creases, folds or seams, which may have otherwise caused potential tissue irritation, bacteria hosting, infection and palpability problems.

The present invention includes methods and materials for implantable devices (markers) which are disclosed for permanently marking the location of a biopsy or surgery for the purpose of identification. The devices are remotely delivered, preferably percutaneously. Visualization of the markers is readily accomplished using various state of the art imaging systems. Preferred visualization is through MRI, X-ray and ultrasound. The markers function to provide evidence of the location of the lesion after the procedure is complete for reference during future examinations or procedures.

An assisted guidance and navigation method in intraoral surgeries is a method using computerized tomography (CT) photography and an optical positioning system to track medical appliances, the method including: first providing an optical positioning treatment instrument and an optical positioning device; then obtaining image data of the intraoral tissue receiving treatment through CT photography, precisely displaying actions of the treatment instrument in the image data, and real-time checking an image and guidance and navigation. Therefore, during the surgery, the existing use habits of the physicians are not affected and accurate and convenient auxiliary information is provided, and attention is paid to using the treatment instrument in physical environments such as a patient's tooth or dental model.

Systems, methods, and computer-readable storage media for inter-node data replication while reducing network traffic for remote backup. A system receives a command to duplicate a dataset, located on a source network node, to a remote network node, accesses, on the source network node, signatures of a previous snapshot of the dataset and signatures of a current snapshot of the dataset, performs, at the source network node, a local signature comparison between the previous snapshot and the current snapshot to identify one or more signatures that do not match, sends the signatures that do not match to the remote network node, searches, on the remote network node, for the signatures that do not match, and sends data associated with the signatures that do not match to the remote network node for incorporation within a current remote snapshot if they do not exist on a current remote network node.

A pulsed laser comprises an oscillator and amplifier. An attenuator and / or pre-compressor may be disposed between the oscillator and amplifier to improve performance and possibly the quality of pulses output from the laser. Such pre-compression may be implemented with spectral filters and / or dispersive elements between the oscillator and amplifier. The pulsed laser may have a modular design comprising modular devices that may have Telcordia-graded quality and reliability. Fiber pigtails extending from the device modules can be spliced together to form laser system. In one embodiment, a laser system operating at approximately 1050 nm comprises an oscillator having a spectral bandwidth of approximately 19 nm. This oscillator signal can be manipulated to generate a pulse having a width below approximately 90 fs.

Systems, methods and apparatus for acquiring an image from within a body lumen are provided. Systems embodying features of the invention include an intracorporeal imaging component for acquiring imaging information, an image information recording component, and an image information playback component. Methods for acquiring image information from within a body lumen include steps of acquiring imaging information, storing image information, and playing back imaging information. Imaging information may be played back as acquired, or non-sequentially, or composite images may be formed by combining, filtering, enhancing, or subtracting images and the composite images displayed. Devices embodying features of the invention include optical imaging components such as an optical IGW, an optical imaging recording component, and an optical image playback component. The systems, methods and devices are suitable for use with angiopoplasty, stent delivery, and other intracorporeal clinical procedures.

The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and / or ameliorating diseases and disorders associated with aberrant expression and / or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.