296results about How to "Reduce diversity" patented technology

The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

The present invention provides methods of re-engineering or re-shaping an antibody from a first species, wherein the re-engineered or re-shaped antibody does not elicit undesired immune response in a second species, and the re-engineered or re-shaped antibody retains substantially the same antigen binding-ability of the antibody from the first species. In accordance with the present invention, a combinatorial library comprising the CDRs of the antibody from the first species fused in frame with framework regions derived from a second species can be constructed and screened for the desired modified antibody. In particular, the present invention provides methods utilizing low homology acceptor antibody frameworks for efficiently humanizing an antibody or a fragment thereof. The present invention also provides antibodies produced by the methods of the invention.

Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample.

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.

A circuit breaker system integrated into a package including an input for coupling to an external electrical power source, an output for coupling to an external electrical circuit, and a current path selectively coupling the input and the output. A mechanical circuit breaker mechanism interrupts electrical power flow through the current path in response to a current exceeding a predetermined value. A trip solenoid causes the mechanical circuit breaker mechanism to interrupt electrical power flow through current path in response to a control signal. Voltage and current sensors measure voltage and current values of the electrical power flowing through the current path and a microprocessor selectively generates the control signal in response to the measured voltage and current values, along with and a control profile stored in memory, to energize the solenoid and cause the mechanical circuit breaker mechanism to interrupt the electrical power.

To perform link adaptation at radio interfaces of an enhanced packet data cellular network the system behavior is simulated for different C/I conditions. Two sets of tables are obtained, each table including upgrade and downgrade thresholds expressed in terms of Block Error Rate (BLER). The tables are specialized for taking into account EGPRS type II hybrid ARQ, Incremental Redundancy (IR). Transmitted blocks are checked for FEC and results are sent to the network that continuously updates BLER. A reliability filter output is used to decide the weight between new and old measurements. IR efficiency is tested for each incoming block and an indicative variable IR_status is filtered. Each threshold of BLER to be used is obtained by linear interpolation between the tabulated threshold without IR and with perfect IR, both weighed with filtered IR_status. Filtered BLER is compared with interpolated thresholds for testing the incoming of a MCS switching condition.

The invention provides a method for manufacturing a chromatic filter touch control base plate, in particular that a touch control sensing structure (element) in a touch control panel is integrated to one side where the chromatic filter touch control base plate faces to a thin film transistor base plate, and the surfaces of transparent sensing pads form patterned assistant electrodes to reduce the equivalent resistance value of the touch control sensing structure (element). Besides, because the invention utilizes a transparent conductive layer and an assistant electrode layer which are adjacent to form the transparent sensing pads and the patterned assistant electrodes, a simplified pattern transfer process can be utilized to manufacture the transparent sensing pads and the patterned assistant electrodes, or part of the assistant electrode layer is utilized to form a joint bridging structure which is arranged between parts of the transparent sensing pads to be used as electrical connection, and the goal of process simplification is reduced.

The present invention relates to a microbial composition which is tailored based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from the intestine of secretor individuals. The present invention further relates to a method of tailoring a microbial composition based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from that of secretor blood group status. The present invention relates to use of the secretor status of an individual as a criterion for microbial supplementation tailored based on the differences in the spectra of microbes found between secretor and non-secretor individuals.

The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.

A female snap-on connection is provided for cooperating with a male catching end piece with central barrel and flange ring. The snap-on connection includes a body made of rigid plastic material and a tubular portion with raised parts for connection to a pipe and a portion forming a stepped cylindrical cavity to receive at least the barrel end, and at the front of the body, a lock made of rigid plastic material to be urged to lock the flange ring once the latter is set in plane, the lock and the body are secured together by at least a flexible part so as to form a single piece, at least an annular joint ensuring tightness; the lock tilts on a hinge pin formed by the flexible part(s).

A method, system and apparatus using hybrid automatic repeat-request (HARQ) to enhance a system throughput in a transmit diversity system. Embodiments of the present invention may include a method including receiving a quality-indication signal such as a HARQ from the base station, calculating a complex weighting based on the quality-indication signal, modifying a pre-transmission signal based on the complex weighting to produce a plurality of modified pre-transmission signals, each modified pre-transmission signal from the plurality modified pre-transmission signals being uniquely associated with an antenna element from a plurality antenna elements of a mobile device, and sending the plurality of modified pre-transmission signals from the plurality of antenna elements to produce an effective combined transmitted signal, the complex weighting being associated with a total power of the transmitted signal and at least one from a phase rotation and a power ratio associated with each antenna element from the plurality of antenna elements.

The invention relates to a network data transmission method for a distributed opportunistic relay, belonging to wireless network transmission technical field. In bidirectional wireless network transmission, a plurality of candidate relay nodes select one relay node to participate in cooperation through distributed selection count; the originating nodes decide whether to adopt the direct transmission mode or the relay transmission mode, which satisfies the quality of service of the system and meanwhile reduces power consumption. The relay nodes judge whether to forward the data and calculate the optimized transmitted power of the data and send the data from a plurality of originating nodes to a plurality of destination nodes at the same time after conducting network coding to the data. The destination nodes receive the data through maximum likelihood method and maximum ratio combining method at the receiver terminals and decode the received information. The network data transmission method can carry out combinatorial optimization to the selection, the network coding and the power splitting of the relay nodes through distributed control mechanism under the condition that only part of the information of the channel status is provided, and can be effectively used in an energy-effective bidirectional-transmission wireless network.

Viscoelastic transmission device (100) for a mechanical connection between a shaft (4) of an actuator the axis (XX′) of which defines an axial direction, and a driving wheel (6) of a winding tube (5) of a blind, of a roller shutter or of a roll-up screen, which comprises a first component (10) that has an output profile that complements an input profile of a second component of the device, the first and the second components adhering to an intermediate component (30) made of viscoelastic material.

The present invention is directed to devices with enhanced biocompatibility and methods for generating and utilizing such devices. The present invention is further directed to enhanced biocompatibility utilizing oligonucleotide functionalization. In one aspect, a device for implantation and/or prolonged exposure to the body tissues includes a functionalized surface. The functionalized surface generally enhances the biocompatibility of the device with body tissues. In some embodiments, the functionalized surface includes substances for controlling interaction between the device and the body tissues. Substances for controlling interactions may include, but are not limited to, polymeric materials, biomolecules, ions and/or ion-releasing substances, and/or any other appropriate substance or combination thereof. In exemplary embodiments, the functionalized surface includes oligonucleotides for controlling interaction between the device and the body tissues. In some exemplary embodiments, the oligonucleotides are aptamers.

Methods for non-specifically amplifying a nucleic acid template molecule are provided. The methods may be used to amplify nucleic acid template molecule(s) for sequencing, e.g., for sequencing the genomes of uncultivable microbes or sequencing to identify copy number variation in cancer cells. Aspects of the disclosed methods may include non-specifically amplifying a nucleic acid template molecule, including encapsulating in a microdroplet a nucleic acid template molecule obtained from a biological sample, introducing multiple displacement amplification (MDA) reagents and a plurality of MDA primers into the microdroplet, and incubating the microdroplet under conditions effective for the production of MDA amplification products, wherein the incubating is effective to produce MDA amplification products from the nucleic acid template molecule.

The invention provides a method for tracking a radio frequency tag track. A moving RFID tag is located and tracked in real time at the millimeter level through phase values. The method specifically includes the following steps that A, target space is divided; B, the phase values are collected through an antenna array; C, probability distribution of the position of the tag in the target space is calculated; D, influence on localization from white noise is eliminated; E, influence on localization from diversity is eliminated; F, the maximum probability position is searched for. According to the method, influence from white noise and diversity in RFID localization can be effectively eliminated and under the condition that only a small number of antennas are available, the moving RFID tag is located and tracked with high accuracy in real time through the virtual antenna array established according to the virtual antenna technology and under the condition of a small number of antennas.

The invention discloses a system which can realize cooperated duplex, and it includes the base station that use the FDD ascending spectrum, the FDD descending spectrum and the non-duplex spectrum and several terminals, said base station includes: several launching channels those include the first launching channel using the non-duplex spectrum, the second launching channel using the FDD ascending spectrum and the third launching channel using the FDD descending spectrum; and several receiving channels those include the first receiving channel using the non-duplex spectrum, the second receiving channel using the FDD ascending spectrum; said terminals include: launching channel which can use the FDD ascending spectrum and the non-duplex spectrum; and several receiving channels those can use the first receiving channel which can use the FDD ascending spectrum and the non-duplex spectrum and the second receiving channel which can use the FDD descending spectrum. Using the system of invention, it can solve the intercommunication problems between the non-duplex spectrum systems and the FDD spectrum system, and reduce the complex cost of system greatly.

The invention provides a micro inertial measurement unit screening method and a combined type micro inertial measurement device. In the screening method, according to a multi-position method, an angular speed conversion matrix is calculated, the spinning top z-axis zero-offset data, changing along with temperature, of the combined type micro inertial measurement device is calculated, and micro inertial measurement units are screened with the minimum curve fitting residual error, changing along with temperature, of spinning top x-axis/y-axis/z-axis zero-offset data of the combined type micro inertial measurement device as the standard; the combined type micro inertial measurement device comprises at least two micro inertial measurement units capable of measuring angular speeds of three axes. The micro inertial measurement units are arranged on an installation platform. The combined type micro inertial measurement device has the advantages that the micro inertial measurement units low in price can be combined to establish an inertial measurement system high in performance, cost is saved, higher reliability is achieved, the influences of temperature changes on spinning top zero-offset are reduced, and effective error compensation of the inertial measurement device is achieved.

A proportional pressure control valve includes a valve housing (38) with at least three fluid connections (1, 2, 3). The valve can be connected to a hydraulic drive system with a pre-determinable consumer pressure. The valve can perform reliable valve switching functions even for low-viscous fluid media, and can reduce its susceptibility to disturbance variables. A valve piston (56) actively connected to a pilot seat (5) by an energy accumulator (62) can be controlled by a control device (40). The consumer pressure on a fluid connection (1) acts on the valve piston (56) such that, according to the consumer pressure and the actuating force of the control device (40), a fluid can flow between the two other fluid connections (2 and 3) in both directions inside the valve housing (38).

In order to standardize the structure of a cooling module with and without a main radiator and thus to make a cooling module equally usable for motor vehicles with an internal combustion engine as well as with an electric motor and for hybrid vehicles it is provided to replace the bearing and holding function of a cooling component, in particular of the radiator unit flowed through by air and engine fluid of an internal combustion engine, by two adapter parts.

A cable guide of a cable winch, such as a cable hoisting winch, includes a cable drum having at least one cable groove and a cable guide having at least two base segments expanding into a ring. The two base segments are guided in the cable groove by at least one engaging element and are supported against the cable winch by at least one torque support. Elements for guiding and holding down a cable are arranged on the base segments. To create a simplified and optionally modular design of a cable guide, the base segments may be configured such that at least one torque support and at least one add-on element for guiding and holding down a cable can be secured in a desired arrangement on the base segments.