10results about How to "Reduce diversity" patented technology

The invention relates to the technical field of immune carriers, in particular to immune carrier microspheres loaded with individualized MHC-II binding polypeptide and vaccine preparation and application of the immune carrier microspheres loaded with the individualized MHC-II binding polypeptide. The core microsphere is loaded with individualized MHC-II binding polypeptide, the sequence of the MHC-II binding polypeptide is obtained by predicting and screening based on an HLA genotyping result, and each HLA allele corresponds to at least one high-affinity MHC-II binding polypeptide; and the shell is a glucan or other polymer coating layer. The preparation method has the advantages that the T epitope and the B epitope are separately subjected to immune competitive inhibition inside and outside the microspheres, so that a better immune effect is obtained. The antibody avoids cross reaction side effects; carrier molecule diversity is reduced, and side effects caused by T cell over-activation are avoided; th1 epitopes and Th2 epitopes can be contained in the microspheres, so that antibody immunity and T cell immunity functions are generated; the particle size of the microspheres is controllable, and the immunologic function can be achieved without adjuvants.

The invention discloses a robot navigation method based on reinforcement learning security constraint and danger perception, and relates to the technical field of robots and artificial intelligence, and the robot navigation method comprises the following steps: when a robot is controlled to execute a navigation task in a target area, using a security filter SF to perform security constraint on the execution action of the robot; and when the robot executes the navigation task, the danger perception virtual robot HAVR is utilized to obtain experience in the dangerous area so as to enhance the ability of the robot to explore in the dangerous area. The action generated by reinforcement learning can be dynamically adjusted, so that the action meets the safety constraint, and the safety of the robot in the reinforcement learning training process is further enhanced; by introducing the HAVR with risk-driven rewards, the robot can still obtain experience in a dangerous area while introducing security constraints, and the exploration security of the robot is further enhanced while the performance of the model after convergence is ensured.

The utility model discloses a distance adjusting assembly, a rotor assembly and a magnetic suspension compressor, and relates to the technical field of magnetic suspension compressors, the distance adjusting assembly comprises a first adjusting member, a second adjusting member and a support sleeve; the first adjusting piece and the second adjusting piece are coaxially arranged at an interval; the supporting sleeve is arranged between the first adjusting piece and the second adjusting piece, the two ends of the supporting sleeve abut against the first adjusting piece and the second adjusting piece respectively, and the supporting sleeve is used for being sleeved with the protection bearing. Each of the first adjusting piece and the second adjusting piece comprises a main body ring part and a protruding ring part coaxially arranged with the main body ring part, and the protruding ring parts protrude from the end faces of the main body ring parts to the supporting sleeve so as to abut against the supporting sleeve; the diameter of the protruding ring part is smaller than or equal to that of the supporting sleeve. The protection bearing is used for being installed between the two main body ring parts, and the gap between the protection bearing and the main body ring parts is adjusted by replacing the first adjusting piece and the second adjusting piece which are different in size.

The invention relates to the technical field of analysis of intestinal flora structures, and discloses a method for analyzing an adjusting effect of intestinal flora in a longevity / aging process, which comprises the following steps: step 1, selecting research objects: randomly selecting 30 old people of more than 100 years old, and selecting 30 old people of 60-70 years old as a control group; 2, basic condition investigation and physical examination of a research object; and 3, detecting technical indexes of a research object. According to the invention, the change of intestinal micro-ecology of the 100-year old people is preliminarily discussed, and the dominant flora with longevity characteristics and the biomarkers are determined. The influence of aging on intestinal microecology is obvious, so that the diversity of intestinal flora is obviously reduced, and the structural proportion of the intestinal flora is also changed; the intestinal flora spectrums of the same age group are relatively similar, that is, the core flora exists; the'core flora 'of different age groups has difference. By combining genetic backgrounds, lifestyles and environmental factors of different samples, the influence of different lifestyles and environmental factors on the structure and longevity of intestinal bacteria is determined.

The application discloses a vehicle positioning estimation method, which comprises the following steps: obtaining an initial pose satisfying a switching condition based on a particle filter algorithm; fusing the initial pose of the vehicle satisfying the switching condition, laser point cloud data and wheel odometer data based on an unscented Kalman filter algorithm to estimate the pose of the vehicle and obtain vehicle pose estimation data; calculating the variance of the current pose state estimation to determine whether the current pose is reliable; if the current pose is reliable, updating the current pose as the current pose estimation data and estimating the pose state of the next state of the vehicle based on the unscented Kalman filter; and if the current pose is not reliable, estimating the pose state of the next state of the vehicle based on the particle filter algorithm. The application further discloses a corresponding system, a storage medium and a vehicle. When the positioning estimation is performed, the application can break the dependence on the third source input of the initial pose of the vehicle, and improve the positioning accuracy and stability of the vehicle in a complex nonlinear scene.

The utility model belongs to the technical field of agricultural machinery, and discloses a rechargeable portable green walnut peeling machine which comprises a protection box arranged on a walking vehicle convenient to move. The driving assembly is arranged in the protection box and serves as a power source for green walnut peeling. The arc-shaped peeling channel is arranged in the protection box, a first discharge port and a second discharge port are formed in the lower end of the peeling channel, and the first discharge port and the second discharge port communicate with the outside of the protection box; the peeling mechanism comprises a driving wheel and a cutter assembly which are correspondingly arranged, the driving wheel is in transmission connection with the driving assembly, and the cutter assembly is arranged in an arc shape and elastically installed in the peeling channel. The green walnut peeling device is light and compact in structure, flexible to operate, high in protection performance, convenient to flexibly use in an orchard, wider in application range, higher in peeling efficiency of green walnuts in the orchard and higher in quality of obtained walnuts, and is suitable for large-scale popularization and application.

The invention relates to an assembly (130) for a vehicle seat (10), in particular a floor rail (100) for a pair of seat rails (60), comprising at least one spacer (120) for resting against a vehicle body surface, in particular a vehicle floor (20), wherein the at least one spacer (120) has at least one disc (122). The invention further relates to a pair of seat rails (60) for a vehicle seat (10), a method for manufacturing an assembly (130) for a vehicle seat (10) and a vehicle seat (10).

Certain aspects of the present disclosure provide techniques for generating an output image based on a textual prompt. A method can include receiving a textual prompt, providing a user interface including one or more input elements associated with one or more words of the textual prompt, receiving input corresponding to at least one of the one or more input elements, the input indicating a semantic importance of each of at least one of the one or more words associated with the at least one of the one or more input elements, and generating an output image based on the textual prompt and the input.

The invention relates to a wiper arm device having at least one channel connection unit (10) for interconnecting at least two wiping water channel sections, at least one channel holding unit (14) which can be arranged on at least one wiper arm (12) and at least one additional nozzle unit (16), the channel holding unit being provided for holding at least the channel connection unit (10) on the wiper arm (12). Furthermore, it is proposed that the wiper arm device has a connection unit (18) which is provided for connecting the at least one additional nozzle unit (16) to the channel connection unit (10), in particular non-destructively and releasably.

The invention discloses a multi-objective optimization train driving parking control method, which comprises the following steps of: performing preprocessing based on train real-time operation data to obtain time sequence data; the time sequence data comprises a time sequence state, control instruction data and operation environment data of the train; calculating resultant force according to the time sequence data, establishing a dynamic model, and setting constraint conditions and evaluation indexes; the kinetic model comprises a control curve and a constant, and the evaluation indexes comprise an accurate parking constraint index, an energy consumption index and a stability index; setting an objective function according to the evaluation indexes, optimizing the objective function by using a multi-objective optimization algorithm based on improved NSGA-II, and obtaining an elite individual (an optimal speed control scheme under multi-objective tradeoff); and judging whether the elite individuals meet expectation or not according to the constraint conditions and the evaluation indexes, if so, outputting a planning control curve to the elite individuals, and otherwise, adjusting the control instruction data to update the elite individuals. According to the invention, the parking precision and the system stability of the train in a complex environment are improved.