528 results about "Oxime" patented technology

The invention discloses a preparation method of an oxime ammonia ester modified self-repairing high-gloss hydroxypropyl dispersion. The preparation method comprises the following steps: S1, preparing an oxime ammonia ester modified monomer; s2, adding a solvent into a reaction kettle, and dropwise adding the mixed monomer C, the prepolymer B and an initiator into the reaction kettle; mixing and dropwise adding the mixed monomer D, a carboxyl-containing monomer and an initiator into the reaction kettle; and cooling, adding a neutralizer, adding deionized water for dispersion, and finally preparing the oxime ammonia ester modified self-repairing high-gloss hydroxypropyl dispersion. According to the invention, a two-step method is adopted, a hydroxypropyl dispersion is synthesized in a self-emulsifying manner, and a self-made monomer containing an oxime urethane bond is added, so that the emulsion has a self-repairing capability, can be self-repaired when a workpiece is damaged, and also has high gloss, high weather resistance and excellent chemical resistance; the service time is prolonged, and the maintenance cost is effectively reduced.

The invention relates to the field of caprolactam production, and discloses a green and efficient production process and device. The process comprises the following steps: continuously oximating cyclohexanone and hydroxylamine in a microreactor under the catalysis of mesoporous silica solid acid; carrying out gas phase rearrangement on cyclohexanone-oxime in the presence of a ZSM-5 molecular sieve under the assistance of microwaves; coupling, rectifying and purifying the crude product through a four-stage molecular sieve membrane; and performing catalytic cracking on the by-product to obtain N2 / H2O and recycling. The device comprises a micro-reaction unit, a microwave-radial reactor, a membrane coupling rectifying tower group and a tail gas cracking unit. Zero emission of ammonium sulfate is achieved, the product purity is larger than or equal to 99.95%, and energy consumption is reduced by 45%.

A room-temperature-curing resin composition, which contains in specific ratios(A) an organic polymer in which molecular chain ends are capped by hydrolyzable silyl groups and / or hydroxysilyl groups and(B) a hydrolyzable organosilane compound represented in general formula (1) below and / or a partially hydrolyzed condensate thereof(where R1 is a monovalent hydrocarbon group having a carbon number of 1-10, n is 1-8, and m is 3 or 4),has equivalent or superior curing properties compared to conventional alcohol-release or oxime-release room-temperature-curing resin compositions even if various catalysts are used, can reduce harmful effects on humans and environmental load, and can provide a cured rubber product after curing having favorable rubber properties, adhesion, and durability.

The invention relates to a method for synthesizing trifloxystrobin through a one-pot method, and belongs to the technical field of organic synthesis.The method comprises the following steps that 1, E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester, m-trifluoromethyl acetophenone, hydroxylamine hydrochloride or hydroxylamine sulfate and a solvent are added into a reaction flask, then alkali is added, and after addition is completed, a heat preservation reaction is conducted; and Step 2, after the reaction is finished, filtering to remove salt, and concentrating filtrate under reduced pressure to obtain trifloxystrobin. Compared with a traditional synthesis method of the trifloxystrobin, the synthesis method of the trifloxystrobin has the advantages that the 3-trifluoromethyl acetophenone and the E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester are used as raw materials, the trifloxystrobin is directly synthesized by a one-pot method, the reaction route is short, the raw material cost is low, and the synthesis method of the trifloxystrobin by the one-pot method has the advantages that the synthesis efficiency is high, and the synthesis cost is low. The preparation method has the advantages that the preparation of m-trifluoromethyl acetophenone oxime from m-trifluoromethyl acetophenone is not needed, the whole synthesis process is simpler and more efficient, the reaction conditions are mild, and the preparation method is suitable for industrial large-scale production.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of 5, 5-dimethyl-4, 5-dihydroisoxazole. The method comprises the following steps: (1) reacting isopentenal with an oximation agent to obtain a reaction solution containing isopentenal oxime; (2) dropwise adding the reaction liquid into a mixture containing isopentenal and an acid catalyst for reaction to obtain a product; or when the reaction liquid contains water, performing phase splitting on the reaction liquid to obtain an organic phase, and dropwise adding the organic phase into a mixture containing the isopentenal and the acid catalyst for reaction to obtain a product. The method does not produce ketone by-products, and is good in atom economy, high in reaction yield, good in technological process continuity, low in cost, few in materials, simple to operate, mild in reaction condition, low in requirements on production equipment and suitable for large-scale industrial production.

The invention provides an epoxy adhesive solution composition, a preparation method of an epoxy adhesive solution and a modified cellular board. The epoxy adhesive liquid composition comprises the following components in parts by weight: 53-58 parts of epoxy resin, 2-10 parts of a silane coupling agent, 1-10 parts of a curing agent, 1-5 parts of blocked isocyanate and 60-70 parts of water, wherein a blocking group of the blocked isocyanate is selected from hydroxyl, oximido, acylamino, amino, imidazolyl, pyrazolyl or piperazinyl. By introducing the blocked isocyanate with the specific structure, the epoxy adhesive liquid can be subjected to pre-crosslinking reaction in the early drying treatment process, the modulus and high temperature resistance of a formed dry film are improved, and the phenomenon of glue overflow in the subsequent curing stage is inhibited; therefore, the structural integrity and the bonding strength of the adhesive layer in the modified cellular board under the high-temperature condition are improved.

The present invention relates to a method for preparing a sulfonepyraclostrobin intermediate, comprising the following steps: S1, in a solvent, acetic acid oxime and N-chlorosuccinimide react to obtain a reaction solution containing dichloroformaldehyde oxime; S2, in water, under the action of a catalyst and a base, dichloroformaldehyde oxime and isobutylene in the reaction solution obtained by S1 react, and after the reaction is completed, 3-chloro-5,5-dimethyl-4,5-dihydroisoxazole is obtained by post-treatment. The present invention produces 3-chloro-5,5-dimethyl-4,5-dihydroisoxazole at a higher yield on the basis of using acetic acid oxime, with the advantages of reducing reaction temperature, improving reaction yield, effectively controlling side reactions, and realizing greater economic benefits.

The invention relates to a method for preparing caprolactam, which is characterized in that: a # imgabs0 # acidic compound with temperature control phase transfer catalysis characteristics is adopted as a catalyst to catalyze cyclohexanone-oxime rearrangement reaction to prepare caprolactam, and the catalyst is recycled and reused; the conditions of the rearrangement reaction are as follows: the molar ratio of cyclohexanone-oxime to the catalyst is (10: 1)-(200: 1), the mass ratio of cyclohexanone-oxime to the organic solvent is (1: 1)-(1: 5), the reaction temperature is 40-150 DEG C, and the reaction time is 1-8 hours. The method has the characteristics that the # imgabs 1 # acidic compound with the temperature control phase transfer catalysis characteristic is used as a catalyst to catalyze cyclohexanone-oxime rearrangement reaction to prepare caprolactam, and has the characteristics of high-temperature homogeneous reaction-low-temperature two-phase separation; the reaction conditions are mild, the catalyst has good catalytic activity, the product yield is high, and the solvent and the catalyst are easy to separate and can be used.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

The invention provides an oxime-containing compound and application thereof. The oxime-containing compound provided by the invention has a structure as shown in a formula (I) or enantiomers, diastereoisomers, racemate, tautomers, stereoisomers, geometric isomers, nitrogen oxides, metabolites or pharmaceutically acceptable salts, esters, solvates, hydrates, isotope labeled compounds or prodrugs of the structure as shown in the formula (I). The oxime-containing compound provided by the invention can be used for preventing and / or treating cancers and other hyperproliferative diseases and diseases related to Hippo pathway dysfunction. # imgabs0 #

The invention belongs to the field of herbicides. In particular to a 3-phenylisoxazoline-5-formamide oxime ester compound and application thereof. The 3-phenylisoxazoline-5-formamide oxime ester compound disclosed by the invention is shown as a general formula I: # imgabs0. The compound disclosed by the invention generally has a relatively high control effect on various weeds. Part of the compounds of the general formula I have a good control effect on barnyard grass, digitaria sanguinalis, edible amaranth or piemarker when the application dosage is 150 ga.i. / hm < 2 >.

The present invention provides an oxime ester photoinitiator, a photocurable resin composition and an application. The above-mentioned oxime ester photoinitiator has a structure shown in the general formula (I): compared with the existing oxime ester photoinitiators, the oxime ester photoinitiator with the general formula (I) structure has better stability, so under the irradiation of ultraviolet light, it can effectively suppress the generation and volatilization of small molecule fragments, and almost no overflow gas is generated after curing; at the same time, because the above-mentioned oxime ester photoinitiator has a specific substituent group, it has a strong ultraviolet absorption performance, thereby improving its sensitivity, and the oxime ester photoinitiator also has a high yellowing resistance. In addition, the oxime ester initiator with the structure shown in the general formula (I) can be used in a UV-LED light curing system, and is particularly suitable for initiation under the action of a 365nm light source.

The invention discloses a preparation method of a loose nanofiltration membrane based on reactive polyarylene ether nitrile oxime, and belongs to the technical field of high polymer materials. Starting from a side chain nitrile group of polyarylene ether nitrile (PEN), the nitrile group is converted into an amidoxime group and a carboxyl group with reactivity, so that the originally relatively inert polyarylene ether nitrile has chemical reaction activity. The nanofiltration membrane which is high in flux, high in interception effect and excellent in acid and alkali resistance is prepared by utilizing an active group on a side chain of the modified reactive poly (arylene ether nitrile) (PEA) through a phase inversion method. The nitrile group conversion provides more cross-linking sites in the nanofiltration membrane preparation process, further improves the cross-linking density, can significantly improve the compatibility with other resins, and provides a brand new thought for the development and utilization of the high-molecular side chain nitrile group and the preparation of the nanofiltration membrane.

The present invention belongs to the technical field of artificial boards, and relates to a curing agent for a formaldehyde-free substrate, which is composed of 5-10wt% of methyl ethyl ketone oxime, 20-30wt% of polyacrylamide, and the balance of water by weight percentage. A preparation method and application of the curing agent for the formaldehyde-free substrate are also disclosed. The curing agent for the formaldehyde-free substrate disclosed by the present invention has good sealing property, can reduce the viscosity of isocyanate, extend the application period, and improve the fluidity and dispersibility of spray glue. By sealing the free isocyanate group, the pre-curing during drying is reduced, and the isocyanate is unsealed during high-temperature hot pressing, and the isocyanate is cured quickly, the hot pressing efficiency is improved, the hot pressing time is shortened, and the water loss is reduced; more active isocyanate groups are retained in the adhesive, the bonding performance and water resistance are improved, the amount of isocyanate glue applied is reduced, and the reaction with water is reduced. The present invention can also effectively improve the production capacity of the formaldehyde-free floor substrate and reduce the cost; by increasing the moisture content, the expansion or contraction degree caused by the change of humidity in the external environment is reduced, and the dimensional stability is improved.

The invention belongs to the technical field of photoinitiators, and particularly relates to an oxime ester photoinitiator, a photoresist composition and application of the oxime ester photoinitiator and the photoresist composition. The initiator provided by the invention is an oxime ester compound, the main structure of the photoinitiator molecule has the capability of absorbing light with different wavelengths, the molecular stability is good, meanwhile, the blue light absorption is reduced, and the yellowing risk of the system is inhibited. Through substituent group modification, on the premise that the stability of the photoinitiator is improved, the light absorption activity and initiation efficiency of the photoinitiator can be guaranteed, the photocuring reaction is efficiently promoted, the dual requirements of production for speed and quality are met, and collaborative optimization of absorption wavelength expansion, stability improvement and initiation efficiency guarantee is achieved.

The invention provides a preparation method of a nitrosamine impurity, and belongs to the technical field of heterocyclic compounds. The clarithromycin related nitrosamine impurity is 3 '-N-demethyl-3'-N-nitroso-6-O-methyl erythromycin, and is prepared by carrying out demethylation and nitrosation on clarithromycin. The clarithromycin intermediate erythromycin oxime related nitrosamine impurity is 3 '-N-demethyl-3'-N-nitroso erythromycin A (E)-9-oxime, and the clarithromycin intermediate erythromycin oxime related nitrosamine impurity is prepared from erythromycin A (E)-9-oxime through demethylation, etherification, nitrosation and hydrolysis.

The invention relates to an oxime aryl formyl formate photoinitiator suitable for LED (light-emitting diode) photopolymerization, the photoinitiator has a structure as shown in a general formula (I), and Ar, R1 and R2 are defined in the specification and claims. The invention also relates to a preparation method of the photoinitiator and application of the photoinitiator in an LED photopolymerization system. # imgabs0 #

The invention relates to the field of chemistry or medicinal chemistry, in particular to a synthesis method of isoxazoline anti-parasitic drug lotirasodium. The synthesis method comprises the following steps: firstly, synthesizing an intermediate 1 (1, 2, 3-trichloro-5-(1-trifluoromethyl-vinyl) benzene); then synthesizing an intermediate 2 (5-bromo-4-methyl-2-thiophenecarboxime); the preparation method comprises the following steps: carrying out a 1, 3 dipolar cycloaddition reaction on an intermediate 1 and an intermediate 2 in sequence to obtain an intermediate 3, carrying out a Grignard reaction to obtain racemic acid, and finally carrying out chemical resolution and amide condensation in sequence to obtain lotirasodium. According to the novel synthesis method of the isoxazoline anti-parasitic drug lotirazine, wittig reaction is adopted for the first time to obtain the intermediate 1, operation is simpler and more convenient, and reaction conditions are mild. Besides, the synthesis method of the intermediate 2 is improved, so that the reaction conditions are milder, the operation is simpler, the cost is greatly reduced on the basis of reported reaction conditions, and the method is suitable for industrialization.

The invention relates to a synthesis method of 5, 5-disubstituted 2-isoxazoline, according to the method, oxime of a formula (II) and a carbonyl compound of a formula (I) react in the presence of a boron trifluoride complex and in the presence of an optional organic solvent or no solvent, the reaction conditions are mild, and the product yield is high.

The invention discloses a column [n] arene benzoquinone oxime ortho-position functionalized derivative and a preparation method thereof, and particularly relates to a preparation method for obtaining the column [n] arene benzoquinone oxime ortho-position functionalized derivative by reacting column [n] arene [1] benzoquinone oxime with a Grignard reagent. In the structure of column [n] arene [1] benzoquinone oxime, when alpha, beta-unsaturated ketone and a Grignard reagent are subjected to nucleophilic addition reaction, a 1, 4-addition product with high yield can be obtained, and no 1, 2-addition product exists. The method is mainly characterized in that protons can be removed from hydroxyl of oxime in column [n] arene [1] benzoquinone oxime under an alkaline condition, and oxygen negative ions of the hydroxyl are combined with positively charged metal magnesium atoms in a Grignard reagent to form a six-membered ring transition state, so that R negative ions can attack a No.4 carbon atom of alpha, beta-unsaturated ketone, and a 1, 4-addition reaction is carried out. The preparation method disclosed by the invention is mild in condition and can be carried out without harsh reaction conditions.

In some aspects, the present disclosure provide systems for forming crosslinked reaction products, which comprise (a) a first composition that comprises a first multifunctional molecule that comprises a plurality of first reactive moieties that comprise oxyamine groups and (b) a second composition that comprises a second multifunctional molecule that comprises a plurality of second reactive moieties that comprise aldehyde or ketone groups, wherein at least one of the first and second multifunctional molecules is a multi-arm polymer and wherein at least one of the first and second multifunctional molecules comprises one or more covalently attached iodine groups. Other aspects of the present disclosure pertain to crosslinked networks that are formed using such systems and methods of treatment using such systems.

The invention provides a preparation method of a low-load RuPdPt ternary noble metal electrocatalyst. The preparation method comprises the following steps: etching foamed nickel in a hydrochloric acid solution, and soaking the etched foamed nickel in a mixed solution containing ferric chloride, copper chloride and sodium chloride for 3-12 hours to obtain a NixFeyCuzOOH substrate; ruthenium salt, platinum salt and palladium salt are mixed and then ground, water is added to prepare a mixed solution, then an alcoholic solution of dimethylglyoxime disodium salt octahydrate is added, and a precious metal mixed solution is formed after ultrasonic dispersion; the preparation method comprises the following steps: soaking a NixFeyCuzOOH substrate in a noble metal mixed solution, soaking for 1-6 hours under stirring and heating conditions, washing an obtained product with water, and drying to obtain the RuPdPt-NixFeyCuzOOH composite catalyst. According to the invention, the noble metals Ru, Pd and Pt are combined with the substrate NixFeyCuzOOH nanosheets through M1-M2-O bonds, so that monatomic-cluster sites of the noble metals Ru, Pd and Pt are effectively anchored, and the stability of the catalyst at high current density is greatly improved.

The invention discloses a synthesis method of 9-dichloromethylene-5-amino-benzonorbornene and an intermediate product, the synthesis method comprises the following steps: firstly, synthesizing a cyclization compound 1 as shown in a formula 1 from a cold solution of 6, 6-dichlorofulvene and 1, 4-benzoquinone under the action of a solution of a catalyst I, carrying out oximation reaction on the cyclization compound 1 prepared in the step a and hydroxylamine salt under an alkaline condition, and carrying out post-treatment to obtain the 9-dichloromethylene-5-amino-benzonorbornene. Under the action of a catalyst II, adding the oximate 2 prepared in the step b into a closed container, carrying out hydrogenation reduction to obtain 9-dichloromethylene-5-amino-benzo norbornene, and directly treating the reduction product with acid to obtain 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene. According to the method, the cyclization compound is oximated firstly, then the residual carbonyl and two double bonds on the ring are subjected to one-step reduction through catalytic hydrogenation, the working procedure is optimized, meanwhile, reduction by using expensive sodium borohydride is avoided, the method is short in synthesis route and suitable for industrialization, and the production cost is reduced.

The invention discloses a method for preparing a remote oxyimidization product based on an olefin 1, 5-HAT strategy, the product and application, and belongs to the technical field of organic synthesis.The method comprises the following steps that unactivated olefin containing a benzoyl skeleton, oxime carbonate, a catalyst and an organic solvent are mixed and then stirred to react under the illumination condition, the solvent is removed after the reaction is finished, and the remote oxyimidization product is obtained. And carrying out purification treatment to obtain the remote oxyimidization product. The method provided by the invention not only is simple and convenient to operate, but also is green and environment-friendly, and provides a novel and potential synthesis strategy for constructing a complex compound skeleton containing a C-N bond and a C-O bond and realizing a remote position bifunctionalization reaction.

The invention relates to a preparation method of oxime glucoside. According to the method, unprotected fluoroglycoside and oxime are taken as substrates, alkali is taken as an accelerant, and the substrates and the alkali are stirred to react in a solvent to obtain an oxime glycoside product. The novel preparation method of the oxime glucoside is simple in reaction condition, convenient to operate and wide in substrate applicability, meanwhile, the substrate glucoside does not need to be protected, the problems of upper protection and deprotection processes are avoided, one-step synthesis is achieved, and the yield of the oxime glucoside is remarkably increased. Moreover, the method takes cheap and environment-friendly alkali as an accelerant, has the characteristics of low cost, environment friendliness and the like, and is more suitable for industrial production. Besides, the preparation method disclosed by the invention can be suitable for amplification reaction, a relatively high yield is kept, and a brand-new solution is provided for large-scale industrial production of oxime glucoside.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

This invention provides a dehydrogenation catalyst that enables the production of hydrogen by dehydrogenating formic acid using a continuous process with higher efficiency than conventional methods, as well as a polymer precursor that can optimally form the catalyst and a formic acid dehydrogenation catalyst formed therefrom. [Solution] The polymer precursor has a structure represented by the following general formula (1). TIFF2026073992000060.tif50163 (A and B are independently groups comprising a 5-membered or 6-membered heterocycle or oxime structure which may have substituents, Z is a 5-membered or 6-membered aromatic ligand, M is a Group 8 noble metal element, R 1 R is a hydroxyl group, an alkenyl group or alkynyl group having 1 to 12 carbon atoms, 2 (where is a halogen atom, hydrogen atom, formic acid, or water molecule, X is an anion, and n is a natural number between 1 and 12)

The present application relates to a kind of phenyl-tetrazole oxime derivatives and its preparation method and application, wherein the phenyl-tetrazole oxime derivatives have the structure as shown in formula (I), wherein R 1 , R 2 , T, R a , R b , R c , R d , R e Have the meaning described in the present application;The phenyl-tetrazole oxime derivatives described in the present application have excellent prevention effect on cucumber downy mildew, rice sheath blight, cucumber gray mold, cucumber powdery mildew and the like, and can be further developed as a fungicide for application.

The invention relates to the technical field of organic chemistry, and particularly discloses an amide derivative containing a thiazole oxime structure as shown in a general formula 8 and a preparation method and application of the amide derivative. The derivative shows remarkable antibacterial activity on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and fluoroquinolone-resistant escherichia coli, particularly has a remarkable effect on gram-negative bacteria, has broad-spectrum antibacterial potential and can be used for preparing drugs for treating related bacterial infection, and the activity of part of compounds is superior to that of a control drug.

A method for the iron-catalyzed photoinduced preparation of cyano-inner unsaturated derivatives. The present invention belongs to the field of the synthesis of organic unsaturated bond compounds, and particularly relates to a method for the synthesis of cyano-inner unsaturated derivatives. The present invention aims to solve the technical problem that the current synthesis of cyano-unsaturated compounds uses dangerous inorganic or organic small molecule cyanides as raw materials, resulting in poor preparation safety. Method: Using an iron salt as a catalyst, an unsaturated sulfone reagent and a cyclic oxime acid compound as raw materials, potassium hydroxide as a base, in a toluene solvent, the reaction temperature is 30 °C, and it is placed under a 10W purple LED for photoinduced reaction to obtain the cyano-inner unsaturated compound. The catalyst involved in the synthesis method of the present invention is simple and easily available, the raw materials are green and non-toxic, the functional group compatibility is good, the reaction conditions are mild, and it has good industrial application prospects. The present invention is used for the preparation of cyano-inner unsaturated derivatives.