418 results about "Oxime" patented technology

The invention relates to the field of caprolactam production, and discloses a green and efficient production process and device. The process comprises the following steps: continuously oximating cyclohexanone and hydroxylamine in a microreactor under the catalysis of mesoporous silica solid acid; carrying out gas phase rearrangement on cyclohexanone-oxime in the presence of a ZSM-5 molecular sieve under the assistance of microwaves; coupling, rectifying and purifying the crude product through a four-stage molecular sieve membrane; and performing catalytic cracking on the by-product to obtain N2 / H2O and recycling. The device comprises a micro-reaction unit, a microwave-radial reactor, a membrane coupling rectifying tower group and a tail gas cracking unit. Zero emission of ammonium sulfate is achieved, the product purity is larger than or equal to 99.95%, and energy consumption is reduced by 45%.

The invention relates to a method for synthesizing trifloxystrobin through a one-pot method, and belongs to the technical field of organic synthesis.The method comprises the following steps that 1, E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester, m-trifluoromethyl acetophenone, hydroxylamine hydrochloride or hydroxylamine sulfate and a solvent are added into a reaction flask, then alkali is added, and after addition is completed, a heat preservation reaction is conducted; and Step 2, after the reaction is finished, filtering to remove salt, and concentrating filtrate under reduced pressure to obtain trifloxystrobin. Compared with a traditional synthesis method of the trifloxystrobin, the synthesis method of the trifloxystrobin has the advantages that the 3-trifluoromethyl acetophenone and the E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester are used as raw materials, the trifloxystrobin is directly synthesized by a one-pot method, the reaction route is short, the raw material cost is low, and the synthesis method of the trifloxystrobin by the one-pot method has the advantages that the synthesis efficiency is high, and the synthesis cost is low. The preparation method has the advantages that the preparation of m-trifluoromethyl acetophenone oxime from m-trifluoromethyl acetophenone is not needed, the whole synthesis process is simpler and more efficient, the reaction conditions are mild, and the preparation method is suitable for industrial large-scale production.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of 5, 5-dimethyl-4, 5-dihydroisoxazole. The method comprises the following steps: (1) reacting isopentenal with an oximation agent to obtain a reaction solution containing isopentenal oxime; (2) dropwise adding the reaction liquid into a mixture containing isopentenal and an acid catalyst for reaction to obtain a product; or when the reaction liquid contains water, performing phase splitting on the reaction liquid to obtain an organic phase, and dropwise adding the organic phase into a mixture containing the isopentenal and the acid catalyst for reaction to obtain a product. The method does not produce ketone by-products, and is good in atom economy, high in reaction yield, good in technological process continuity, low in cost, few in materials, simple to operate, mild in reaction condition, low in requirements on production equipment and suitable for large-scale industrial production.

The invention provides an epoxy adhesive solution composition, a preparation method of an epoxy adhesive solution and a modified cellular board. The epoxy adhesive liquid composition comprises the following components in parts by weight: 53-58 parts of epoxy resin, 2-10 parts of a silane coupling agent, 1-10 parts of a curing agent, 1-5 parts of blocked isocyanate and 60-70 parts of water, wherein a blocking group of the blocked isocyanate is selected from hydroxyl, oximido, acylamino, amino, imidazolyl, pyrazolyl or piperazinyl. By introducing the blocked isocyanate with the specific structure, the epoxy adhesive liquid can be subjected to pre-crosslinking reaction in the early drying treatment process, the modulus and high temperature resistance of a formed dry film are improved, and the phenomenon of glue overflow in the subsequent curing stage is inhibited; therefore, the structural integrity and the bonding strength of the adhesive layer in the modified cellular board under the high-temperature condition are improved.

The invention discloses a preparation method of a loose nanofiltration membrane based on reactive polyarylene ether nitrile oxime, and belongs to the technical field of high polymer materials. Starting from a side chain nitrile group of polyarylene ether nitrile (PEN), the nitrile group is converted into an amidoxime group and a carboxyl group with reactivity, so that the originally relatively inert polyarylene ether nitrile has chemical reaction activity. The nanofiltration membrane which is high in flux, high in interception effect and excellent in acid and alkali resistance is prepared by utilizing an active group on a side chain of the modified reactive poly (arylene ether nitrile) (PEA) through a phase inversion method. The nitrile group conversion provides more cross-linking sites in the nanofiltration membrane preparation process, further improves the cross-linking density, can significantly improve the compatibility with other resins, and provides a brand new thought for the development and utilization of the high-molecular side chain nitrile group and the preparation of the nanofiltration membrane.

The invention belongs to the technical field of photoinitiators, and particularly relates to an oxime ester photoinitiator, a photoresist composition and application of the oxime ester photoinitiator and the photoresist composition. The initiator provided by the invention is an oxime ester compound, the main structure of the photoinitiator molecule has the capability of absorbing light with different wavelengths, the molecular stability is good, meanwhile, the blue light absorption is reduced, and the yellowing risk of the system is inhibited. Through substituent group modification, on the premise that the stability of the photoinitiator is improved, the light absorption activity and initiation efficiency of the photoinitiator can be guaranteed, the photocuring reaction is efficiently promoted, the dual requirements of production for speed and quality are met, and collaborative optimization of absorption wavelength expansion, stability improvement and initiation efficiency guarantee is achieved.

The invention relates to a synthesis method of 5, 5-disubstituted 2-isoxazoline, according to the method, oxime of a formula (II) and a carbonyl compound of a formula (I) react in the presence of a boron trifluoride complex and in the presence of an optional organic solvent or no solvent, the reaction conditions are mild, and the product yield is high.

The invention discloses a column [n] arene benzoquinone oxime ortho-position functionalized derivative and a preparation method thereof, and particularly relates to a preparation method for obtaining the column [n] arene benzoquinone oxime ortho-position functionalized derivative by reacting column [n] arene [1] benzoquinone oxime with a Grignard reagent. In the structure of column [n] arene [1] benzoquinone oxime, when alpha, beta-unsaturated ketone and a Grignard reagent are subjected to nucleophilic addition reaction, a 1, 4-addition product with high yield can be obtained, and no 1, 2-addition product exists. The method is mainly characterized in that protons can be removed from hydroxyl of oxime in column [n] arene [1] benzoquinone oxime under an alkaline condition, and oxygen negative ions of the hydroxyl are combined with positively charged metal magnesium atoms in a Grignard reagent to form a six-membered ring transition state, so that R negative ions can attack a No.4 carbon atom of alpha, beta-unsaturated ketone, and a 1, 4-addition reaction is carried out. The preparation method disclosed by the invention is mild in condition and can be carried out without harsh reaction conditions.

In some aspects, the present disclosure provide systems for forming crosslinked reaction products, which comprise (a) a first composition that comprises a first multifunctional molecule that comprises a plurality of first reactive moieties that comprise oxyamine groups and (b) a second composition that comprises a second multifunctional molecule that comprises a plurality of second reactive moieties that comprise aldehyde or ketone groups, wherein at least one of the first and second multifunctional molecules is a multi-arm polymer and wherein at least one of the first and second multifunctional molecules comprises one or more covalently attached iodine groups. Other aspects of the present disclosure pertain to crosslinked networks that are formed using such systems and methods of treatment using such systems.

The invention discloses a synthesis method of 9-dichloromethylene-5-amino-benzonorbornene and an intermediate product, the synthesis method comprises the following steps: firstly, synthesizing a cyclization compound 1 as shown in a formula 1 from a cold solution of 6, 6-dichlorofulvene and 1, 4-benzoquinone under the action of a solution of a catalyst I, carrying out oximation reaction on the cyclization compound 1 prepared in the step a and hydroxylamine salt under an alkaline condition, and carrying out post-treatment to obtain the 9-dichloromethylene-5-amino-benzonorbornene. Under the action of a catalyst II, adding the oximate 2 prepared in the step b into a closed container, carrying out hydrogenation reduction to obtain 9-dichloromethylene-5-amino-benzo norbornene, and directly treating the reduction product with acid to obtain 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene. According to the method, the cyclization compound is oximated firstly, then the residual carbonyl and two double bonds on the ring are subjected to one-step reduction through catalytic hydrogenation, the working procedure is optimized, meanwhile, reduction by using expensive sodium borohydride is avoided, the method is short in synthesis route and suitable for industrialization, and the production cost is reduced.

The invention discloses a method for preparing a remote oxyimidization product based on an olefin 1, 5-HAT strategy, the product and application, and belongs to the technical field of organic synthesis.The method comprises the following steps that unactivated olefin containing a benzoyl skeleton, oxime carbonate, a catalyst and an organic solvent are mixed and then stirred to react under the illumination condition, the solvent is removed after the reaction is finished, and the remote oxyimidization product is obtained. And carrying out purification treatment to obtain the remote oxyimidization product. The method provided by the invention not only is simple and convenient to operate, but also is green and environment-friendly, and provides a novel and potential synthesis strategy for constructing a complex compound skeleton containing a C-N bond and a C-O bond and realizing a remote position bifunctionalization reaction.

The invention relates to a preparation method of oxime glucoside. According to the method, unprotected fluoroglycoside and oxime are taken as substrates, alkali is taken as an accelerant, and the substrates and the alkali are stirred to react in a solvent to obtain an oxime glycoside product. The novel preparation method of the oxime glucoside is simple in reaction condition, convenient to operate and wide in substrate applicability, meanwhile, the substrate glucoside does not need to be protected, the problems of upper protection and deprotection processes are avoided, one-step synthesis is achieved, and the yield of the oxime glucoside is remarkably increased. Moreover, the method takes cheap and environment-friendly alkali as an accelerant, has the characteristics of low cost, environment friendliness and the like, and is more suitable for industrial production. Besides, the preparation method disclosed by the invention can be suitable for amplification reaction, a relatively high yield is kept, and a brand-new solution is provided for large-scale industrial production of oxime glucoside.

Described herein are compounds that reactivate acetylcholinesterase and associated methods of treating organophosphate poisoning.

This invention provides a dehydrogenation catalyst that enables the production of hydrogen by dehydrogenating formic acid using a continuous process with higher efficiency than conventional methods, as well as a polymer precursor that can optimally form the catalyst and a formic acid dehydrogenation catalyst formed therefrom. [Solution] The polymer precursor has a structure represented by the following general formula (1). TIFF2026073992000060.tif50163 (A and B are independently groups comprising a 5-membered or 6-membered heterocycle or oxime structure which may have substituents, Z is a 5-membered or 6-membered aromatic ligand, M is a Group 8 noble metal element, R 1 R is a hydroxyl group, an alkenyl group or alkynyl group having 1 to 12 carbon atoms, 2 (where is a halogen atom, hydrogen atom, formic acid, or water molecule, X is an anion, and n is a natural number between 1 and 12)

The present application relates to a kind of phenyl-tetrazole oxime derivatives and its preparation method and application, wherein the phenyl-tetrazole oxime derivatives have the structure as shown in formula (I), wherein R 1 , R 2 , T, R a , R b , R c , R d , R e Have the meaning described in the present application;The phenyl-tetrazole oxime derivatives described in the present application have excellent prevention effect on cucumber downy mildew, rice sheath blight, cucumber gray mold, cucumber powdery mildew and the like, and can be further developed as a fungicide for application.

The invention relates to the technical field of organic chemistry, and particularly discloses an amide derivative containing a thiazole oxime structure as shown in a general formula 8 and a preparation method and application of the amide derivative. The derivative shows remarkable antibacterial activity on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and fluoroquinolone-resistant escherichia coli, particularly has a remarkable effect on gram-negative bacteria, has broad-spectrum antibacterial potential and can be used for preparing drugs for treating related bacterial infection, and the activity of part of compounds is superior to that of a control drug.

A method for the iron-catalyzed photoinduced preparation of cyano-inner unsaturated derivatives. The present invention belongs to the field of the synthesis of organic unsaturated bond compounds, and particularly relates to a method for the synthesis of cyano-inner unsaturated derivatives. The present invention aims to solve the technical problem that the current synthesis of cyano-unsaturated compounds uses dangerous inorganic or organic small molecule cyanides as raw materials, resulting in poor preparation safety. Method: Using an iron salt as a catalyst, an unsaturated sulfone reagent and a cyclic oxime acid compound as raw materials, potassium hydroxide as a base, in a toluene solvent, the reaction temperature is 30 °C, and it is placed under a 10W purple LED for photoinduced reaction to obtain the cyano-inner unsaturated compound. The catalyst involved in the synthesis method of the present invention is simple and easily available, the raw materials are green and non-toxic, the functional group compatibility is good, the reaction conditions are mild, and it has good industrial application prospects. The present invention is used for the preparation of cyano-inner unsaturated derivatives.

The present invention relates to a composition having low conductivity comprising a hydroxylamine-containing molecule in combination with a yellow metal corrosion inhibitor, such as a triazole, where the weight ratio of the yellow metal corrosion inhibitor to the hydroxylamine-containing molecule is from 1: 20 to 20: 1; and wherein the composition has an electrical conductivity at 25 DEG C of less than 200 [mu] S / cm. These compositions can be effective to provide ferruginous metal corrosion inhibition and maintain low conductivity in low conductivity heat transfer fluids that do not significantly change with aging. They are therefore particularly useful as heat transfer fluids, for example in fuel cell units or battery electric vehicles. The invention further relates to a method for preparing said composition and to the use of said composition.

The invention discloses a liquid phase detection method of an oxime ester photoinitiator, and relates to the field of chemical analysis and detection. According to the method, a standard solution, a reaction solution to be detected and a mobile phase are prepared, a sample to be detected is subjected to pretreatment such as quenching and extraction, a high performance liquid chromatography gradient elution technology is combined to realize detection, the mobile phase adopts a phosphoric acid aqueous solution with the concentration of 0.05-0.1% and acetonitrile, a gradient elution program optimizes the separation effect, and a chromatographic column adopts a C18 stationary phase. According to the method, the separation degree of the impurities such as diester impurities in the oxime ester photoinitiator synthesis reaction is larger than or equal to 1.5, the detection limit is as low as 0.010 mg / L, the quantification limit is as low as 0.032 mg / L, the reaction process can be effectively monitored, and the method has the advantages of being easy and convenient to operate, low in cost and high in accuracy.

The invention provides an aryl alkyl ketoxime derivative as well as a preparation method and application thereof, and relates to the field of aryl oxime derivatives. The preparation method of the aryl alkyl ketoxime derivative comprises the following steps: by taking potassium formate as an additive, carrying out free radical reaction on a compound I and a compound II under ultraviolet irradiation in the presence of tert-butyl nitrite to obtain the aryl alkyl ketoxime derivative, the compound I is substituted iodobenzene or iodopyridine; the compound II is substituted styrene or thienyl ethylene; wherein a hydrogen atom transfer / single electron transfer relay sequence is utilized to activate a compound I, and tert-butyl nitrite is adopted as a bifunctional reagent, and is used as a hydrogen atom transfer reagent and an oxime source. According to the preparation method of the aryl alkyl ketoxime derivative, pre-functionalization is not needed, a reaction substrate is wide in universality and good in compatibility, reaction conditions are mild, operation is easy and convenient, a target product can be efficiently and rapidly prepared on the premise of high yield, and a new way is provided for oxime synthesis.

The present invention belongs to the technical field of pathogen control, and particularly relates to a cinnamic acid oxime ester compound, a preparation method and an application thereof. The cinnamic acid oxime ester compound has a structural formula as shown in Formula I: The preparation method of the compound of the present invention is simple in operation and easy to obtain raw materials. The compound has broad-spectrum bactericidal activity, and particularly has obvious inhibitory effects on Botrytis cinerea of tomato, Valsa mali of apple tree and Gaeumannomyces graminis of wheat, and can be used as a bactericide for the prevention and control of the above plant diseases.

The problem to be solved is to provide a novel herbicide having both high safety for crops and excellent herbicidal activity against weeds in order to resolve the food crisis that is anticipated to come in the near future due to global population growth. The problem is solved by the compound represented by the following general formula (1): or a salt thereof, an agricultural or horticultural herbicide comprising the compound or the salt thereof as an active ingredient, and a method for using the herbicide.

The present invention discloses an N-aryl-N-alkyl-O-allylhydroxylamine compound and its synthesis method. The general structural formula is as follows: The synthesis method includes the following steps: Using cheap and easily available aldehydes or ketones as starting materials, reacting with hydroxylamine hydrochloride to form oximes, and then preparing N-alkylhydroxylamines under the action of a supported metal catalyst; N-alkylhydroxylamines react with (R4-substituted) allyl bromide, etc. in the presence of a weak base to prepare N-alkyl-N-allylhydroxylamines; N-alkyl-N-allylhydroxylamines react with aryl alkyne precursors under the action of an initiator fluoride at room temperature to prepare N-aryl-N-alkyl-O-allylhydroxylamine compounds. The method of the present invention can effectively avoid the use of toxic, harmful, and explosive strong oxidants, and at the same time solve the problems of limited raw material sources, high prices, harsh reaction conditions, and low reaction selectivity in the existing synthesis methods.

The present invention provides a method for synthesizing 3-aminobiphenyl compounds, which relates to the technical field of organic synthesis. The synthesis method comprises the following steps: in acetic anhydride, under an acid promoter and a reducing agent, 4-methyl-4-phenyl-2,5-cyclohexadienone oxime compounds generate 3-aminobiphenyl compounds at a temperature of 100-120 °C. A highly selective acid rearrangement and reduction reaction occur in the mixed system of acetic anhydride / acid promoter / reducing agent, and thus 3-aminobiphenyl compounds can be successfully prepared. The selected 4-methyl-4-phenyl-2,5-cyclohexadienone oxime compounds are easily obtained. The acetic anhydride / acid promoter / reducing agent system used does not contain metal reagents, and the reaction conditions are compatible with a variety of functional groups. The method is simple and easy to operate, has a short reaction time, low cost, and simple post-treatment, and has little impact on environmental pollution.

Provided are new compounds that are free of perfluoromethyl and perfluoromethylene groups, are easily decomposed by light irradiation, and generate sulfonic acid having high acid strength.　The present invention is a compound that is a salt of an anion represented by formula (a-1) or (a-2) and a cation. In the formula, R1 represents a hydrogen atom, a hydrocarbon group, or a heterocyclic group, or a group in which two or more of said groups are bonded via a linking group. R10 represents a fluorine atom, an aromatic hydrocarbon group, or an aromatic heterocyclic group. R20 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or a group having a group in which said group and a linking group are bonded. n is 0 or 1.

The application relates to a method for preparing a beta-heteroaryl ethylamine derivative by utilizing photocatalytic energy transfer, and belongs to the technical field of catalytic synthesis, in particular to a method for preparing a beta-heteroaryl ethylamine derivative by utilizing photocatalytic energy transfer. The application is to solve the technical problems of the existing synthesis method, such as being too complicated, needing pre-activation and expensive metal catalysts. One, an oxime ester compound, an olefin compound and TXT are added into a solvent to obtain a mixed solution; two, the mixed solution obtained in the step one is irradiated by using an LED light source, the solvent is removed by rotary evaporation, and separation and purification are carried out. Compared with the prior art, the application is more green, mild, atom-economical, simple and efficient in a metal-free catalytic energy transfer strategy to construct aryl tertiary amine compounds. The method can be used for preparing a beta-heteroaryl ethylamine derivative.

Disclosed in the present invention are a method and system for preparing an oxime via an ammoximation reaction. The method comprises: (1) mixing a carbonyl compound, ammonia, and a circulating catalyst slurry at a specific feed ratio of the carbonyl compound to the circulating catalyst slurry to obtain a mixed stream, and then bringing the mixed stream into contact with hydrogen peroxide for an ammoximation reaction to obtain a reaction slurry; (2) mixing the reaction slurry with an organic solvent and then performing two-phase separation to obtain an oxime-containing organic phase and a catalyst-containing aqueous phase; (3) optionally, washing the organic phase obtained in step (2) with optional water and then performing separation to obtain an organic solvent and an oxime product; and (4) filtering the aqueous phase obtained in step (2) and then returning same to step (1) to provide at least part of the circulating catalyst slurry. The method and system for preparing an oxime according to the present invention significantly prolong the service life of a catalyst, improve the operating stability of a system, reduce the consumption of catalyst, and improve the quality of the prepared oxime product.

The invention discloses a preparation method of pesticide line thiophene, which comprises the following steps: under protective gas, dissolving benzaldoxime and 2-cyano thiophene in an organic solvent, slowly adding an oxidizing agent at the temperature of 20-30 DEG C, and after the reaction is completed, washing with water, extracting, concentrating and recrystallizing to obtain line thiophene, the oxidizing agent is selected from one or more of diacetoxy iodobenzene, [bis (trifluoroacetoxy) iodine] benzene and potassium peroxymonosulfonate. According to the preparation method of the pesticide line thiophene, the line thiophene is directly and efficiently synthesized through one-step reaction, and the yield is good. Compared with the existing synthesis route, the route is short, the solvent can be recycled and reused, the requirement on equipment is simple and corrosion-free, and a foundation is laid for further pilot scale production.

The application discloses a synthesis method of 5,5-dimethyl 2-isoxazoline. First, isoamyl aldehyde is added with hydrogen chloride to generate chloroisoamyl aldehyde, then under alkaline conditions, the chloroisoamyl aldehyde generated in step one is added with hydroxylamine salt to generate chloroisoamyl aldehyde oxime, finally under alkaline conditions, the chloroisoamyl aldehyde oxime generated in step two is cyclized to generate 5,5-dimethyl 2-isoxazoline, the yield is high, the process is simple and suitable for industrial production; compared with the traditional method, the synthesis method has the characteristics of mild reaction condition, green environmental protection and low cost.