The invention provides an azithromycin production technology. The azithromycin production technology comprises (1), erythromycin oxime synthesis, (2), erythromycin A-6,9-iminoether synthesis, (3), 9-deoxo-9a-aza-9a-homoerythromycin synthesis, (4), azithromycin synthesis and (5), refining. The azithromycin production technology realizes strict control of an acetone-water ratio in erythromycin A-6,9-iminoether synthesis, guarantees dispersibility of erythromycin oxime in a system, is convenient for reaction control, improves a yield and can be industrialized easily. In 9-deoxo-9a-aza-9a-homoerythromycin synthesis, pH is controlled in a range of 1.0-1.5 in reduction product acidolysis so that reduction product hydrolysis is thorough, a yield is improved and post-treatment troubles are reduced. In a methylation reaction for azithromycin synthesis, a crystallization water dropwise addition rate and a dropwise addition total amount are strictly controlled so that crystallization is complete, granularity is uniform and an azithromycin yield is improved.