4097 results about "Tableting" patented technology

Metformin Hydrochloride (herein referred to as metformin HCl) that may be 98.5%-100% pure is a high dose drug capable of being directly compressed with specific excipients into tablets having desired, hardness, disintegrating ability, and acceptable dissolution characteristics. Metformin HCl is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow metformin HCl to be compressed using the direct compression method. The tablets produced provide an acceptable in-vitro dissolution profile.

A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.

The present invention relates to an immediate release solid oral dosage form containing 1-aminocyclohexanes, preferably memantine or neramexane, and optionally a pharmaceutically acceptable coating, wherein the active ingredient exhibits dose proportionality and is released at a dissolution rate of more than about 80% within about the first 60 minutes following entry of said form into a use environment. The dosage form is direct compressed and has a hardness within the range of between about 3 and about 40 Kp, exhibits an average T_max within the range of about 2 to about 8 hours with an active ingredient load within the range of about 2.5 to about 150 mg. The formulation allows for dose-proportional compositions for once daily or b.i.d. dosing, while maintaining a steady average range of T_max.

A catalyst for preparing low-carbon olefins by one-step conversion of synthetic gas and a preparation method thereof relate to catalysts; the catalyst is made from 20-60% of a zirconium-based solid solution,30-70% of a double-micropore zeolite molecular sieve and 0.1-10% of metal oxides; the preparation method comprises: adding salt compounds of at least one element from IA, IIIA, VIIB, IB, IIB and the like into deionized water or alcohol to obtain solution A having a mass concentration of 0.1-15%; adding the zirconium-based solid solution into the solution A, heating, drying by distillation, and drying to obtain solid powder; adding the solid powder and the double-micropore zeolite molecular sieve into ethylene glycol, ultrasonically dispersing, and moving a filtered and washed sample to a vacuum drying box, drying at 50-100 DEG C for 2-24 h, calcining in a muffle furnace, and tableting obtained solid sample to obtain the catalyst.

Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

The present invention provides rapid disintegrating tablets in oral cavity having a shortened disintegration time in oral cavity as well as a sufficient hardness compared to rapid disintegrating tablets of the prior art. The above objective is solved by a composition in which the inorganic excipient and the disintegrating agent are dispersed in the complex particles consisting of mannitol and other saccharide(s) in a specific ratio, and rapid disintegrating tablets in oral cavity obtained by direct compression of the composition.

The invention relates to stomach-nourishing spleen-strengthening chewing tablets and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The chewing tablets comprises the raw materials of, by weight: 6-9 parts of Mongolian milkvetch root, 5-8 parts of pilose asiabell root, 3-5 parts of ligusticum, 7-11 parts of common yam rhizome, 6-8 parts of dried longan, 8-12 parts of medlar, 7-9 parts of red date, 3-7 parts of dried tangerine peel, 8-12 parts of hawthorn fruit, 10-12 parts of stir-fried malt, 60-80 parts of microcrystalline cellulose, 10-20 parts of micro-powder silica gel, 2-10 parts of a hydroxymethyl cellulose, and 1-3 parts of a flavoring agent. The chewing tablets are prepared through three steps which are extraction, granulation, and tableting. The process provided by the invention is simple. The prepared chewing tablets have the advantages of rich nutrients, good taste, convenient application, and long effect. The tablets have the functions of stomach nourishing, spleen strengthening, qi invigorating, and digestion promoting.

The present invention relates to a decorative powder coating. It can be divided into two kinds of non-expansive fire-resisting powder coating and expansive fire-resisting powder coating. Its production process includes the following steps: heating proper quantity of polyester resin and/or epoxy resin to glass state temp., adding fire-resisting agent and/or carbon-forming agent, catalyst and foaming agent, stirring, cooling and pulverizing, mixing them with residual polyester resin and/or epoxy resin and other materials, stirring them, extruding, cooling, tabletting, pulverizing and sieving soas to obtain the invented products.

The invention relates to a tough fusion bonded epoxy powder coating and a preparation method thereof. The tough fusion bonded epoxy powder coating of the invention consists of the following components by mass percentage: linear phenolic epoxy resin, 30 percent to 50 percent; epoxy resin E-12, 0 percent to 20 percent; curing agent, 15 percent to 25 percent; leveling agent, 0 to 2 percent; and filling, 23 percent to 33 percent. The preparation method of the tough fusion bonded epoxy powder coating comprises the following steps: adding the components into a high-speed mixer for mixing according to mixture ratio and later into an extruder for melt extrusion, and then undertaking chip compression, cooling and crushing on a cold crawler type chip compression crusher, and later undertaking grinding, classification, cyclone separation and screening in a grinding machine, and finally obtaining the product. The tough fusion bonded epoxy powder coating of the invention is mainly used in the pipe anti-corrosion field, has the advantages of good toughness, high impact resistance performance, and simple preparation process, and is suitable for mass production.

There is provided a method for preparing a pharmaceutical composition comprising compressible coated, taste-masked and/or controlled-release coated drug-containing particles, rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol, a saccharide, or a mixture thereof, and other optional, pharmaceutically acceptable excipients wherein the orally disintegrating tablet (ODT) or rapidly dispersing tablet (RDT) composition having acceptable tableting, organoleptic, and pharmacokinetic properties.

The present invention discloses formulations for sheeted, baked fruit and vegetable crackers that have a light, crispy texture similar to a potato chip or cracker. Undehydrated ingredients are combined with dry ingredients and oil to make a dough, which is then sheeted and cut into pieces. The pieces are baked to produce vegetable and fruit snack crackers.

The present invention relates to a cordyceps sinensis powder tablet and a preparation method thereof, which pertains to the field of medicines and health products. The technical problem the present invention aims at providing a tablet containing cordyceps sinensis medicinal powder and no auxiliary material; the appearance, shape and harness of the tablet is consistent with the tablet quality standard. The cordyceps sinensis powder tablet only adopts cordyceps sinensis powder with the water content of 8 to 18 percent and the granule diameter of 1 to 150mum; no auxiliary material is added in the preparation process and the cordyceps sinensis powder is the only component. The aim of direct tablet forming can be achieved by controlling the water of the powder or by the process of second tabletting or dry granule tabletting. The process ensures that the tablet appearance is good; pockmark surface rate and fracture rate are low; tablet harness, disintegration rate and friability are consistent with the tablet quality requirement; the harness can also ensure that the tablet can not fracture in the preparation process when coating and film covering is carried out in the later stage.

The invention relates to a process for extracting xanthoxylin and sanshoamides through supercritical carbon dioxide. Firstly, the pricklyash peels are crushed and squashed into pieces, the squashed pricklyash peels are loaded in a supercritical extraction reactor for extraction, the extraction solvent is food-grade carbon dioxide, the extraction liquid sequentially enters a separation reactor I and a separation reactor II for separation, the pressure of the separation reactor I is 6-7 MPa, the temperature thereof is 25-32 DEG C and the time is 20-40 min; the pressure of the separation reactor II is 5-6 MPa, the temperature thereof is 22-26 DEG C and the time is 30-50 min; the products of the separation reactor I and the separation reactor II are respectively collected, the product of the separation reactor I is dehydrated and refined to prepare the sanshoamides, and the product of the separation reactor II is xanthoxylin; the sanshoamides, xanthoxylin and food oil are blended according to weight ratio of 1:1:30-100 to obtain supercritical pepper oil which can be used as flavoring oil for high-grade dinning industry.

The invention discloses a blueberry composite tablet candy capable of relieving visual fatigue and a preparation method thereof. The blueberry composite tablet candy capable of relieving the visual fatigue comprises the following raw materials in percentage by weight: 13.25 percent of a blueberry extract, 0.5 percent of lutein esters, 0.3 percent of beta-carotene, 1.0 percent of citric acid, 64.45 percent of sorbitol, 2 percent of xylooligosaccharide, 3 percent of dextrin and 15 percent of microcrystalline cellulose, wherein the blueberry extract is extracted from a mixture of blackberry pomace dry matter and acid ethanol; the acid ethanol comprises ethanol and water with the volume percentage of 60 percent; the pH value of the acid ethanol is 1.5 to 3.0; the blackberry pomace dry matter and the acid ethanol are in the mass volume ratio of 1:50-1:70; the preparation method of the blueberry composite tablet candy capable of relieving the visual fatigue comprises the following main steps: 1, preparing the blueberry extract; 2, crushing; 3, mixing; 4, granulating; 5, tabletting; 6 packaging. The blueberry composite tablet candy capable of relieving the visual fatigue can effectively relieve the visual fatigue, can improve eyesight after long-term eating, and is convenient to take; a new using way is provided for utilizing fresh blueberry and fully playing intentional physiological and pharmacological efficacies.

Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.

An eyesight-improving and nerves-soothing composition comprises mulberries, downy rosemyrtle roots, boxthorn fruits, chrysanthemum, fleece-flower roots, cassia seeds, gorgon fruits and honey. Preparation steps for the eyesight-improving and nerves-soothing composition are as follows: the mulberries, the downy rosemyrtle roots and the chrysanthemum are respectively ground into powder and then mixed with honey to form an extractive; the boxthorn fruits, the fleece-flower roots, the cassia seeds and the gorgon fruits are ground into particles to be uniformly mixed, then water is added for decocting, the water is added in the proportion of 1 to 20 to 30, decocting is performed for 3 to 5 hours, and after decocting, a decoction solution is filtered for standby; the prepared extractive and the prepared decoction solution are mixed uniformly for standby; the prepared compound is sent to prepare compound powder through spray drying; the prepared compound powder is sent into a tablet machine for tabletting, so as to obtain solid particles with fixed shapes; the solid particles are packed into a sealed aluminium foil bag for boxing, so as to obtain the eyesight-improving and nerves-soothing composition.

PCT No. PCT/CH97/00203 Sec. 371 Date Dec. 28, 1998 Sec. 102(e) Date Dec. 28, 1998 PCT Filed May 23, 1997 PCT Pub. No. WO98/00353 PCT Pub. Date Jan. 8, 1998A device for pressing of tablets from a blister pack. The device has a base plate and a cover plate. When closed, the two plates connected to each other by a hinge are superimposed in such a manner that openings in the cover plate are arranged substantially over openings in the base plate. The base plate is arranged using fins at a distance from a datum plane. Supporting bumps and embossed edges form a support plane on which the blister pack rests with the cover film thereof, for facilitating punching through the cover film when pressure is exerted on bumps of the deep-drawn plastic film of the blister pack. Tabs with corresponding locking noses lock the device. The device also allows disabled patients to remove the tablets required from the blister pack without further assistance.

The invention relates to a compound extraction of refreshing and throat beneficiary effect, comprising essentially 1 to 5 portion of tea extraction, 0.5 to 5 portion of guanala extraction, 0.2 to 5 portion of balloonflower root extraction, 0.2 to 5 portion of Sterculiae Scaphigera extractuibm extraction, 10 to 60 portion of xylitol, 0.2 portion of grosvenor momordica extraction, o.1 to 1 portion of ginger oil, and 0.1 to 1 portion of menthol. The invention still relates to a sugar-free refreshing and throat beneficiary tabletting candy, comprising the compound extraction as the principal agent and medically acceptable accessories.

The invention relates to a preparation method of a cholagogic tablet, which comprises the following steps that: rhubarb is taken and extracted by microwave and is purified by macroporous resin columns to obtain the rhubarb extract; desmodium and honeysuckle are taken and extracted by microwave and are purified by macroporous adsorption resin and ion exchange resin to obtain desmodium-honeysuckle extract; costus root, rhizoma anemarrhenae, dyers woad leaves, radix bupleuri, root of herbaceous peony, radix scutellariae and Herba Artemisiae Capillaris are taken, pulverized and are extracted under a carbon dioxide (CO2) supercritical condition to obtain the supercritical extract; glauber salt is taken, heated and dissolved in the water to be filtered, the filtered liquid is mixed with the rhubarb extract, the desmodium-honeysuckle extract and the supercritical extract as well as dextrine and 70% ethanol to be made into granules, the granules are dried, carried out tabletting, and coated with a membrane. The cholagogic tablet which is prepared through the above method is convenient to take.

The effervescent health beverage table is featured by that it contains functional oligosaccharide, such as oligo-xylose, oligo-fructose, oligo-galactose, oligo-isomaltose, etc., with bifidobacterium proleferating function and may contain medicine, vitamins, minerals, soluble chitin and other functional factors. The tablet is produced through sieving, mixing, drying at 55-65 deg.c and tableting. The effervescent health beverage tablet, when being thrown into water, will be dissolved instantly into homogeneous beverage, health liquid, medicated tea, etc. while producing bubbles and turning up and down.