1828 results about "Tableting" patented technology

The invention discloses a pharmaceutical composition containing melogabalin besylate and a preparation method of the pharmaceutical composition. Belongs to the technical field of pharmaceutical preparations. Comprising melogabalin besylate and pharmaceutically acceptable auxiliary materials, the pharmaceutically acceptable auxiliary materials comprise a filler, a disintegrating agent, an adhesive, an antioxidant and a lubricant, the antioxidant comprises vitamin E succinic acid polyethylene glycol ester, and the lubricant comprises vitamin E succinic acid polyethylene glycol ester. The melogabalin besylate as the active ingredient accounts for 2-15% by weight of the pharmaceutical composition, preferably 2-10% by weight of the pharmaceutical composition. According to the pharmaceutical composition, antioxidant particles are prepared by adopting a fluidized bed granulation process, raw material medicines, the antioxidant particles and other auxiliary materials are mixed, tableted and coated, an antioxidant comprises vitamin E succinic acid polyethylene glycol ester and tartaric acid, and the prepared tablet has good stability.

The invention discloses a melogabalin besylate pharmaceutical composition and a preparation method thereof. The invention provides a pharmaceutical composition. The pharmaceutical composition comprises melogabalin besylate, ascorbyl palmitate, a filling agent and a disintegrating agent. According to the pharmaceutical composition provided by the invention, only one antioxidant is added, the antioxidant effect is better than that of a commercial product TARLIGE, the stability of prepared tablets is better, the process production is simple, and the pharmaceutical composition is more suitable for mixing and tabletting the tablets.

The invention discloses an atorvaquone enteric-coated tablet, the preparation comprises atorvaquone, glyceryl behenate, teloxpol, a filler, an adhesive, a disintegrating agent and an enteric coating, and the particle size D90 of the atorvaquone is 30-50 [mu] m. The atorvaquone enteric-coated tablet disclosed by the invention is stable and continuous in release and high in bioavailability, can be positioned and released in intestinal tracts and reduce liver circulation, so that the occurrence of phenomena such as liver injury is reduced, the phenomena such as sticking and cracking are avoided in a tabletting process, the quality is qualified and stable, and the dissolution performance and the stability of the atorvaquone enteric-coated tablet are also ensured.

The invention provides MAB-phase ceramic powder as well as a preparation method and application thereof, and belongs to the technical field of ceramic materials. Firstly, elementary substance M powder and boron powder serve as raw materials, and MB powder is prepared through ball milling treatment, tabletting, heat treatment and grinding; the simple substance M powder is selected from transition metal powder; the preparation method comprises the following steps: by taking MB powder and aluminum powder as raw materials, carrying out wet ball-milling treatment, compression molding, packaging and sintering treatment to prepare MAB-phase ceramic powder; the packaging is carried out by adopting potassium bromide powder. According to the invention, an MS3-fused salt shielding synthesis / sintering method is adopted, salt is used as a reaction medium and a salt bed, the exterior of a sample is packaged with salt, so that a synthetic product is prevented from being oxidized during high-temperature synthesis in the air, and the preparation method has the characteristics of rapidness, high efficiency, energy conservation, environmental protection, low cost and the like, and is simple, convenient and feasible in the aspect of promotion of large-scale production.

The invention relates to the field of rubber sealing rings, and discloses a refrigerant-resistant HNBR sealing ring and a preparation method thereof. The refrigerant-resistant HNBR sealing ring is prepared from the following raw materials in parts by weight: 100-120 parts of HNBR, 45-55 parts of nano modified magnesium aluminum silicate, 40-50 parts of white carbon black, 10-20 parts of a plasticizer, 6-10 parts of a cross-linking agent, 5-8 parts of an active agent, 5-8 parts of a vulcanizing agent and 1-3 parts of an anti-aging agent, the preparation method comprises the following steps: mixing the raw materials, tabletting and cutting; and carrying out mold pressing vulcanization forming and punching. The preparation process is simple, and the prepared HNBR sealing ring is applied to a new energy automobile air conditioner, is suitable for a cold and heat cycle environment, has relatively good flexibility, and can keep relatively good aging resistance and sealing performance when being in contact with a refrigerant for a long time.

The invention belongs to the field of synthesis of inorganic non-metallic materials, and particularly relates to an equimolar-ratio seven-element high-entropy oxide and a preparation process thereof. The preparation process comprises the following steps: putting seven oxide powder Al2O3, Y2O3, TiO2, ZrO2, NiO, CuO and CeO2 into a ball milling tank according to a molar ratio of 1: 1: 2: 2: 2: 2: 2: 2, adding absolute ethyl alcohol and zirconium oxide grinding balls, performing ball milling in a ball mill, and fully drying and sieving after ball milling to obtain mixed powder; carrying out tabletting treatment on the mixed powder to obtain a to-be-sintered green body; and putting the to-be-sintered green body into an alumina crucible, and putting the alumina crucible into a microwave oven for microwave sintering. According to the method, the equimolar-ratio seven-element high-entropy oxide (AlYTiZrNiCuCe) Ox with good solid solution is obtained, the crystallinity and element uniformity of the seven-element high-entropy oxide are improved, all the raw materials react completely, meanwhile, the process efficiency is high, and energy consumption is low.

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

The invention discloses an abesilil raw material medicine, a composition, a tablet and a preparation method thereof. The particle size distribution of the abesilil raw material medicine is as follows: D10 is more than or equal to 20 microns, D90 is more than or equal to 60 microns and less than or equal to 300 microns, and the span (D90-D10) / D50 is less than or equal to 2.5. According to the present invention, the large raw material particle size within a certain range is provided, the dissolution rate and the dissolution amount of the abelsilil tablet in the pH 6.8 medium can be easily improved, the sticking phenomenon during the tabletting process can be solved, the production process is simple, the production period is short, the production cost is low, the mixing and the tabletting are smooth, and the dissolution end point is high.

The invention discloses a potassium ferrate composite environmental remediation material as well as a preparation method and application thereof. The material comprises the following components in percentage by weight: 40-70% of potassium ferrate; 20-50% of a porous carrier; and 5-10% of a stabilizer. The preparation method comprises the following steps: S1, potassium ferrate synthesis: synthesizing potassium ferrate under the action of an auxiliary catalyst by adopting a sodium hypochlorite oxidation method; s2, modifying a porous carrier: activating the porous carrier with acid, soaking the porous carrier in a stabilizer solution, and drying for later use; and S3, composite loading: mixing the potassium ferrate powder and the porous carrier in proportion, then adding a binder, carrying out ball milling, then carrying out tabletting molding, and then carrying out calcination in an inert atmosphere to obtain porous composite particles, namely the environmental remediation material. The composite structure delays decomposition of potassium ferrate, and the validity period of the material is prolonged to 6 months or above. The porous carrier provides adsorption sites and cooperates with the oxidation-adsorption effect to improve the pollutant removal rate. The calcining process enhances the mechanical strength of the material, and is suitable for flowing water or deep soil injection.

The invention discloses a preparation method of sturgeon roe peptide freeze-dried powder with an anti-aging effect. The preparation method specifically comprises the following steps: (1) unfreezing sturgeon roes, adding water, uniformly stirring, grinding and crushing, and adjusting the pH value; (2) heating and naturally cooling; (3) adding alkaline protease, uniformly stirring, carrying out enzymolysis, and adding starch sodium octenylsuccinate and vitamin E powder; (4) carrying out enzyme inactivation, naturally cooling, and adjusting the pH value; (5) carrying out rough filtration and centrifugal treatment, taking supernate, adsorbing, filtering and taking filtrate; and (6) carrying out plate frame filtration, taking filtrate, carrying out vacuum freeze drying, screening and packaging, thereby obtaining the product. The preparation method disclosed by the invention has the advantages of simplicity and convenience in operation, low cost, high embedding yield and the like, and has important significance in improving the stability and biological activity of the sturgeon roe peptide. Moreover, the sturgeon roe peptide freeze-dried powder has an anti-aging effect, and can be widely applied to oral liquid, solid beverages, tablet candies and the like in common foods.

The invention relates to the technical field of medicines, in particular to a compound amlodipine atorvastatin calcium tablet and a production mixing device. The compound amlodipine atorvastatin calcium tablet is a core-coated tablet and comprises an inner-layer tablet core containing atorvastatin calcium and an outer-layer tablet layer containing amlodipine besylate, the inner-layer tablet core further comprises meglumine and sodium lauryl sulfate, the mass ratio of meglumine to sodium lauryl sulfate is (0.5-5): 1, the mass ratio of meglumine to sodium lauryl sulfate is (0.5-5): 1, and the mass ratio of meglumine to sodium lauryl sulfate is (0.5-5): 1. And the mass of the meglumine accounts for 1-3% of the total mass of the inner-layer tablet core. The amlodipine and atorvastatin calcium are prepared into the coated tablet, so that two active ingredients in the same tablet are effectively isolated, and the compatibility of the atorvastatin calcium and the amlodipine besylate is remarkably improved; meanwhile, the inner layer and the outer layer of the core-coated sheet are separately granulated before tabletting, so that the problem that the mixing uniformity of total mixed particles is relatively poor when conventional tablets are prepared is effectively solved.

The application discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptides, wherein the calcium chelate peptide provided by the application has an amino acid sequence as shown in SEQ ID No.1, and the specific sequence is GETGPA (F21-1), and the calcium binding capacity of the calcium chelate peptide is 4.72±1.06 μg / mg. The bone health tablet candy provided by the application has good calcium absorption promoting activity. The results of a mouse experiment show that the bone health tablet candy does not cause adverse effects on the growth of mice, can reverse high bone conversion caused by osteoporosis, improves the bone biomechanical properties of osteoporotic mice, and thus achieves the effect of enhancing bone density.

The invention relates to the technical field of food processing, in particular to a food processing crusher which comprises a conveying cylinder with the right end inclining downwards, a feeding cylinder is fixedly installed at the left end of the upper side of the conveying cylinder, a discharging port is formed in the right end of the lower side of the conveying cylinder, a shaking-up device is installed in the conveying cylinder, and a driving device is further installed in the conveying cylinder. An impact device and a grinding device are sequentially mounted on the driving device from left to right, and the impact device is used for impacting and crushing candy raw materials; the crushing device is used for crushing candy raw materials, and the candy raw materials are crushed in a manner of impact crushing and grinding crushing of the candy raw materials, so that the hard blocky candy raw materials can be thoroughly crushed, and the processed candy raw materials are uniform in particle size; and meanwhile, large blocky or granular candy raw materials in the candy raw materials can be uniformly distributed, so that the processing efficiency of the candy raw materials is improved.

The invention relates to the technical field of preparation of marine bioactive substances and functional foods, in particular to oyster peptide and application thereof in preparation of products for improving alcoholic liver injury. According to the invention, oyster peptide raw materials rich in natural taurine are adopted, scientific formula design and natural plant alcohol effect dispelling and liver protecting components are adopted, and adverse reactions after drinking, such as hangover, fatigue and alcoholic liver injury, are effectively relieved; according to the oyster peptide tabletted candy formula with the functions of dispelling the effects of alcohol and protecting the liver, provided by the invention, functional components all meet design requirements through detection.

The invention provides a preparation method of a trazodone hydrochloride sustained release tablet, and belongs to the technical field of medicine processing. The preparation method comprises the following steps: (1) mixing a trazodone hydrochloride raw material medicine, cane sugar, povidone and carnauba wax to obtain a mixture; (2) preparing the mixture into molten particles by adopting a hot-melt extrusion technology; and (3) cooling and sieving the molten particles, adding magnesium stearate, uniformly mixing, and tabletting to obtain the trazodone hydrochloride sustained-release tablet. The trazodone hydrochloride sustained release tablet comprises the following components in percentage by mass: 45%-55% of trazodone hydrochloride raw material medicine, 15%-35% of cane sugar, 5%-15% of povidone, 5%-15% of carnauba wax and 1%-5% of magnesium stearate. According to the invention, a hot melt extrusion technology is adopted, so that the raw materials can be highly dispersed within a short heating time, the loss of the raw materials is avoided, the production cost is reduced, and commercialized production is facilitated.

The invention relates to the technical field of medical care, and particularly discloses a preparation method and application of sea cucumber peptide. The preparation method of the sea cucumber peptide provided by the invention comprises the following steps: heating sea cucumber primary pulp for denaturation, and then adding compound protease for enzymolysis treatment to obtain sea cucumber enzymatic hydrolysate; the addition amount of the compound protease is 0.1-0.15 mg / mL, and the compound protease is prepared from papain, ficin and trypsin according to the weight ratio of 1: (0.5-1.5): (2-3); adding activated carbon and diatomite into the sea cucumber enzymatic hydrolysate, and performing enzyme deactivation, filtration and concentration treatment to obtain sea cucumber peptide; the invention also provides application of the sea cucumber peptide obtained by the preparation method in medicines and foods. According to the preparation method of the sea cucumber peptide, the sea cucumber peptide with small molecular weight and good uniformity can be obtained, and the prepared sea cucumber peptide tablet candy has the effects of relieving physical fatigue, resisting aging, resisting oxidation and the like.

The invention provides anhydrous magnesium chloride and a preparation method thereof, and the preparation method comprises the following steps: mixing MgCl2. NH2O and ammonium chloride, carrying out ball milling, tabletting and granulating the mixed material, and heating and sintering the obtained flaky particles to obtain the anhydrous magnesium chloride, wherein n is an integer, and 0 < n < = 6. The water-containing magnesium chloride and the ammonium chloride can form an alternately coated sandwich structure through the pretreatment modes of ball milling and tabletting granulation, so that hydrogen chloride gas and ammonia gas generated during heating decomposition are diffused from the inside of the flaky particles to the outside, and meanwhile, the water-containing magnesium chloride in the particles can be fully exposed in a hydrogen chloride atmosphere; mgO generated in the sintering process is reduced; according to the tabletting and granulating method, large pores can exist among the flaky particles, generated water molecules can be taken away from a heating system from the pores existing among the flaky particles along with gas circulation in the heating and sintering process, and dehydration is better achieved. Meanwhile, the method is more beneficial to model selection of dehydration equipment.

The invention discloses a method for extracting active ingredients of traditional Chinese medicinal materials based on ultralow-temperature crushing and deep eutectic solvent synergy, a tableted candy for dispelling effects of alcohol and protecting liver and a preparation method of the tableted candy. The ultralow-temperature crushing and deep eutectic solvent synergy extraction technology is combined, and the active ingredients of the traditional Chinese medicinal materials with homology of medicine and food are extracted at low temperature; the method comprises the following steps: firstly, quickly freezing a raw material by using liquid nitrogen and mechanically crushing the raw material to improve the cell wall breaking rate, then stirring and mixing a deep eutectic solvent based on choline chloride and glycerol with water to reduce the viscosity of the solvent for extraction, and carrying out ultrasonic extraction, filtration, macroporous adsorption resin recovery and other steps to obtain a high-purity extract. According to the preparation method, the extraction rate of active substances in the traditional Chinese medicinal materials is increased, and extracts of multiple medicinal and edible Chinese herbal medicines such as lucid ganoderma, radix puerariae, hawthorn and olive are compounded into the tablet candy, so that liver injury caused by alcohol is effectively improved, and side effects caused by long-term administration of medicines can be effectively avoided.

According to the preparation method of the high-temperature-resistant durable super-hydrophobic powder coating, integrated powder coating particles are prepared by mixing through a tabletting-crushing-sieving technology, and finally, one end of a solid nano-material in the integrated powder coating particles is embedded into a bottom layer, and the other end of the solid nano-material protrudes out of the surface of the coating, so that a nano-fiber bridging interface strengthening structure is formed. According to the invention, the low surface energy material, the solid nano material and the thermoplastic film-forming resin are effectively combined together to construct firm and stable integrated powder coating particles, so that the overall performance is synergistically enhanced, and the protection capability of a micron-scale structure to a nano-scale structure is greatly improved; the solvent-free durable super-hydrophobic powder coating is directly prepared through electrostatic spraying, so that the technological process is simplified; the solid, solvent-free and environment-friendly super-hydrophobic powder coating is prepared, has excellent high-temperature resistance and super-hydrophobic performance, and has potential advantages in the aspect of anti-corrosion and anti-drag application of a heat distribution pipeline.

The utility model relates to the technical field of tablet processing, in particular to a tablet processing tabletting structure which comprises a machine table, a U-shaped frame is connected to the top of the machine table, a tabletting mechanism is arranged at the top of the U-shaped frame and extends to the bottom of the U-shaped frame, a driving mechanism is arranged on one side of the machine table, and after medicine powder is scattered on a placing assembly, the U-shaped frame is driven by the driving mechanism to rotate. The tabletting mechanism can be started to press down to perform tabletting operation on medicine powder on the placing assembly, then the tabletting mechanism can rise, the driving mechanism is started to drive the placing assembly to turn over, and the tabletting mechanism is started again to press down to be in contact with the placing assembly to generate acting force to discharge tablets and medicine powder formed by tabletting on the placing assembly. By means of the tablet taking-out device, tablets formed after tabletting can be taken out of the mold conveniently, medicine powder remaining in the mold can be discharged and cleaned conveniently, and therefore the tablet tabletting efficiency is improved.

The utility model belongs to the field of probiotics, and particularly relates to a powdery probiotic tabletting device which comprises a fixing frame, the fixing frame is rotationally connected with a rotating plate, a tabletting frame is fixedly connected in each through hole, the upper end face of each tabletting frame is fixedly connected with a plurality of shaping cylinders, and two connecting rods on the left side are connected with a moving plate in an up-down sliding mode. The lower end face of the movable plate is fixedly connected with a plurality of tabletting rods which are aligned with the shaping cylinder up and down, so that the tabletting rods can be driven by the hydraulic pump to move downwards into the shaping cylinder for tabletting of the probiotic powder, and the right side of the fixed plate is fixedly connected with a powder box containing the probiotic powder; the lower end face of the powder box is fixedly connected with a plurality of guide cylinders which are coaxially aligned with the shaping cylinders up and down, and the lower end face of the powder box is fixedly connected with a plurality of powder sprayers which are communicated with the interior of the powder box and are located in the guide cylinders, so that quantitative probiotic powder can be sprayed into the guide cylinders and then downwards flow into the shaping cylinders; and cyclically adding the probiotic powder, and cyclically tabletting.

The invention relates to a doxepin hydrochloride tablet. The doxepin hydrochloride tablet is prepared from doxepin hydrochloride, polyethylene glycol 6000, a filling agent, a disintegrating agent, a flow aid and a lubricating agent. The preparation method comprises the following steps: heating and melting polyethylene glycol 6000, adding a doxepin hydrochloride raw material according to a prescription proportion, and uniformly stirring and mixing; and after complete melting, rapidly cooling and solidifying to form a solid dispersion. And after curing, drying in a drying oven, crushing and sieving. And uniformly mixing the crushed particles with the filler and the lubricant, and directly tabletting. The doxepin hydrochloride has high hygroscopicity, is unstable to damp and heat and easily generates a large amount of impurities under strong oxidation conditions, the doxepin hydrochloride is firstly prepared into a solid dispersion and then is directly compressed, so that the medicine is highly dispersed in a carrier material in the states of molecules, colloids, amorphous forms, microcrystals and the like, and the effect of wrapping the medicine is achieved by controlling the ratio of the medicine to the carrier. Direct contact between the medicine and air is avoided, so that the problems of hygroscopicity and instability of the medicine are solved, and the product stability is improved.

The invention relates to a terahertz spectrum detection technology, in particular to a pericarpium citri reticulatae producing area identification method based on graph regularization sparse principal component analysis and a support vector machine algorithm, and belongs to the field of pericarpium citri reticulatae producing area quality detection. The method comprises the following steps: grinding and tabletting a dried orange peel sample to be detected, firstly detecting the dried orange peel sample in a nitrogen environment by adopting a terahertz time-domain spectroscopy system in a transmission mode to obtain a terahertz time-domain spectroscopy signal of the sample, and performing Fourier transform on the time-domain spectroscopy signal to obtain a frequency-domain spectrum of the sample; and obtaining a corresponding terahertz absorption spectrum according to the frequency domain spectrum. Savitzky-Golay smoothing preprocessing is carried out on the obtained terahertz absorption spectrum, the terahertz absorption spectrum is divided into a training set and a test set, and then feature extraction is carried out on data by utilizing sparse principal component analysis in combination with graph regularization. And taking the processed data as the input of a classification model. And finally, a combined parameter of an optimal regularization coefficient c and a kernel function parameter g of the support vector machine is obtained through a particle swarm optimization algorithm, so that an optimal pericarpium citri reticulatae producing area classification model is established. The method provided by the invention is convenient in sample preparation and simple in operation, can effectively realize rapid and accurate identification of dried orange peel from different producing areas, and provides a new method for identification of dried orange peel in high-value producing areas.

The invention discloses a composite embedded vitamin liposome as well as a preparation method and application thereof, by optimizing a formula and a process, adopting high-purity natural plant source phospholipid, a proper amount of a wall material and a membrane stabilizer and combining an antioxidant, the vitamin retention rate exceeds 95% after the liposome is accelerated at 60 DEG C for 20 days, and the rehydration particle size is between 200 and 800nm; the flowability is good, no bad taste or smell exists, and efficient embedding and stable release of vitamins are realized. The liposome has excellent physical and chemical stability and is suitable for various dosage forms such as tablets and hard-shell capsules, and the bioavailability and market application value of the product are remarkably improved. In addition, a clean solvent ethanol is used in the preparation process and is effectively removed and recycled, so that the method meets the requirements of food processing industry laws and regulations, is environment-friendly and is suitable for large-scale production.

The invention provides a preparation method of metformin empagliflozin tablets, and relates to the technical field of pharmaceutical preparations. The metformin empagliflozin tablet is prepared from the following auxiliary materials in percentage by mass: 8-15% of a diluent, 2-5% of an adhesive and 0.5-2% of a lubricant, and the preparation method comprises the following steps: adding empagliflozin and the adhesive into water, and heating to obtain a clear solution; the preparation method comprises the following steps: crushing metformin hydrochloride, and mixing with a diluent to obtain mixed powder; atomizing and spraying the clarified solution into the mixed powder, performing wet granulation, drying, granulating, adding a lubricant, tabletting and coating to obtain the tablet. Compared with an original product, the tablet prepared from the granules obtained by adopting a wet granulation process and optimizing auxiliary materials and a preparation process has better intra-batch and inter-batch uniformity, is shorter in disintegration time limit and smaller in friability, and has more excellent stability under an acceleration condition.

The invention discloses an aspirin enteric-coated micro-tablet capsule and a preparation method thereof. The micro-tablet core auxiliary materials of the enteric-coated micro-tablet capsule comprise an excipient, a disintegrating agent, a stabilizer, a flow aid and a lubricant. Tartaric acid is adopted as a stabilizer of aspirin, gel silicon dioxide is adopted as a flow aid, a moisture absorption agent and a swelling agent, and a direct powder tabletting method is adopted to prepare a micro-tablet core; the invention provides the aspirin enteric-coated micro-tablet capsule which is good in powder flowability, stable and easy to control in process, good in stability, uniform in dissolution and release characteristics, stable in blood concentration and high in bioavailability.

The invention discloses a method for preparing a powder sample of an X-ray photoelectron spectrometer, and relates to the technical field of X-ray photoelectron spectrometers, which comprises the following steps of: weighing a powder sample to be detected, putting the powder sample into a crucible, and then putting the crucible filled with the powder sample into a drying box for drying treatment; the method comprises the following steps: putting a sample and spectroscopically pure into an agate grinding body, fully grinding and uniformly mixing, sieving for later use after grinding, weighing the sieved powder, and dividing into a plurality of equal parts; preparing a tabletting mold, placing a powder sample in the tabletting mold, and grinding and uniformly mixing the sample again through an upper mold; according to the method disclosed by the invention, the spectral purity is proportionally added into the powder sample, so that the number display intensity of the powder sample during detection can be improved, and the final detection effect is further improved; according to the invention, the sample is sheeted by using the pressing machine, so that the stability of the formed sample can be improved, the loosening phenomenon in the transfer and detection process can be avoided, and meanwhile, the flatness of the surface of the sample can be ensured, so that the accuracy of detection data can be ensured.

The invention provides lead-free piezoelectric ceramic capable of being used for a road vibration energy collecting device and a preparation method and application of the lead-free piezoelectric ceramic, and relates to the technical field of ceramic material preparation. The tabletting ceramic is prepared by the following steps: S1, respectively drying the required raw materials, weighing according to the chemical composition of the piezoelectric ceramic, and mixing to obtain a uniform mixture I; s2, performing primary ball milling, sieving, washing and drying on the mixture I to obtain a mixture II; s3, pre-sintering the mixture II, and then carrying out secondary ball milling to obtain a mixture III; s4, the mixture III is sieved and subjected to centrifugal granulation, then tabletting forming is conducted, and a test piece is obtained; and S5, discharging glue from the test piece, sintering, and carrying out polarization treatment to obtain the lead-free piezoelectric ceramic. The lead-free piezoelectric ceramic material provided by the invention shows excellent piezoelectric property near Curie temperature, and has good dielectric stability and long-term service capability in a road environment.

The invention relates to the technical field of pharmaceutical preparations, and provides an oral solid preparation for treating gout and a preparation method thereof. The preparation method comprises the following steps: sieving a filling agent, a disintegrating agent, an adhesive and dotenorad to obtain a sieved material; and mixing the sieved material and a lubricant, and tabletting to obtain the oral solid preparation for treating gout, the filling agent is lactose, mannitol and microcrystalline cellulose. By optimizing the prescription and the preparation process, the dissolution rate and bioavailability of the medicine are improved, so that the curative effect is improved; by selecting proper auxiliary materials and preparation types, the stimulation to gastrointestinal tracts is reduced, and the tolerance of patients is improved; the oral solid preparation is convenient to take, accurate in dosage, high in patient compliance and beneficial to long-term treatment; moreover, the preparation method provided by the invention is simple to operate, easy for industrial production and relatively low in cost.

The invention discloses a granulation device and a granulation method for tablet candy production, and belongs to the technical field of candy production, the granulation device comprises a bottom plate, a box body and a granulation assembly, a mounting box is fixedly connected above the bottom plate, and the granulation assembly comprises a first motor fixedly mounted in the mounting box; the output end of the first motor is fixedly connected with a first belt wheel, a transmission belt is arranged on the first belt wheel, and a second belt wheel is arranged at the end, away from the first belt wheel, of the transmission belt. A first motor is started to drive a forming plate and a material receiving plate to rotate, a rotating roller rotates under the action of an attaching ring, raw materials of candies can be granulated and formed through the forming plate, the rotating roller and a groove, meanwhile, the granulated candies can be directly sent out through the material receiving plate under the action of centrifugal force, operation is easy and convenient, and the practicability is high. And under the action of the fan, the formed candies can be dried by using heat generated when the first motor works.