1571 results about "Tableting" patented technology

The invention belongs to the field of synthesis of inorganic non-metallic materials, and particularly relates to an equimolar-ratio seven-element high-entropy oxide and a preparation process thereof. The preparation process comprises the following steps: putting seven oxide powder Al2O3, Y2O3, TiO2, ZrO2, NiO, CuO and CeO2 into a ball milling tank according to a molar ratio of 1: 1: 2: 2: 2: 2: 2: 2, adding absolute ethyl alcohol and zirconium oxide grinding balls, performing ball milling in a ball mill, and fully drying and sieving after ball milling to obtain mixed powder; carrying out tabletting treatment on the mixed powder to obtain a to-be-sintered green body; and putting the to-be-sintered green body into an alumina crucible, and putting the alumina crucible into a microwave oven for microwave sintering. According to the method, the equimolar-ratio seven-element high-entropy oxide (AlYTiZrNiCuCe) Ox with good solid solution is obtained, the crystallinity and element uniformity of the seven-element high-entropy oxide are improved, all the raw materials react completely, meanwhile, the process efficiency is high, and energy consumption is low.

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.

The invention discloses an abesilil raw material medicine, a composition, a tablet and a preparation method thereof. The particle size distribution of the abesilil raw material medicine is as follows: D10 is more than or equal to 20 microns, D90 is more than or equal to 60 microns and less than or equal to 300 microns, and the span (D90-D10) / D50 is less than or equal to 2.5. According to the present invention, the large raw material particle size within a certain range is provided, the dissolution rate and the dissolution amount of the abelsilil tablet in the pH 6.8 medium can be easily improved, the sticking phenomenon during the tabletting process can be solved, the production process is simple, the production period is short, the production cost is low, the mixing and the tabletting are smooth, and the dissolution end point is high.

The invention discloses a potassium ferrate composite environmental remediation material as well as a preparation method and application thereof. The material comprises the following components in percentage by weight: 40-70% of potassium ferrate; 20-50% of a porous carrier; and 5-10% of a stabilizer. The preparation method comprises the following steps: S1, potassium ferrate synthesis: synthesizing potassium ferrate under the action of an auxiliary catalyst by adopting a sodium hypochlorite oxidation method; s2, modifying a porous carrier: activating the porous carrier with acid, soaking the porous carrier in a stabilizer solution, and drying for later use; and S3, composite loading: mixing the potassium ferrate powder and the porous carrier in proportion, then adding a binder, carrying out ball milling, then carrying out tabletting molding, and then carrying out calcination in an inert atmosphere to obtain porous composite particles, namely the environmental remediation material. The composite structure delays decomposition of potassium ferrate, and the validity period of the material is prolonged to 6 months or above. The porous carrier provides adsorption sites and cooperates with the oxidation-adsorption effect to improve the pollutant removal rate. The calcining process enhances the mechanical strength of the material, and is suitable for flowing water or deep soil injection.

The application discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptides, wherein the calcium chelate peptide provided by the application has an amino acid sequence as shown in SEQ ID No.1, and the specific sequence is GETGPA (F21-1), and the calcium binding capacity of the calcium chelate peptide is 4.72±1.06 μg / mg. The bone health tablet candy provided by the application has good calcium absorption promoting activity. The results of a mouse experiment show that the bone health tablet candy does not cause adverse effects on the growth of mice, can reverse high bone conversion caused by osteoporosis, improves the bone biomechanical properties of osteoporotic mice, and thus achieves the effect of enhancing bone density.

The invention relates to the technical field of preparation of marine bioactive substances and functional foods, in particular to oyster peptide and application thereof in preparation of products for improving alcoholic liver injury. According to the invention, oyster peptide raw materials rich in natural taurine are adopted, scientific formula design and natural plant alcohol effect dispelling and liver protecting components are adopted, and adverse reactions after drinking, such as hangover, fatigue and alcoholic liver injury, are effectively relieved; according to the oyster peptide tabletted candy formula with the functions of dispelling the effects of alcohol and protecting the liver, provided by the invention, functional components all meet design requirements through detection.

The invention discloses a method for extracting active ingredients of traditional Chinese medicinal materials based on ultralow-temperature crushing and deep eutectic solvent synergy, a tableted candy for dispelling effects of alcohol and protecting liver and a preparation method of the tableted candy. The ultralow-temperature crushing and deep eutectic solvent synergy extraction technology is combined, and the active ingredients of the traditional Chinese medicinal materials with homology of medicine and food are extracted at low temperature; the method comprises the following steps: firstly, quickly freezing a raw material by using liquid nitrogen and mechanically crushing the raw material to improve the cell wall breaking rate, then stirring and mixing a deep eutectic solvent based on choline chloride and glycerol with water to reduce the viscosity of the solvent for extraction, and carrying out ultrasonic extraction, filtration, macroporous adsorption resin recovery and other steps to obtain a high-purity extract. According to the preparation method, the extraction rate of active substances in the traditional Chinese medicinal materials is increased, and extracts of multiple medicinal and edible Chinese herbal medicines such as lucid ganoderma, radix puerariae, hawthorn and olive are compounded into the tablet candy, so that liver injury caused by alcohol is effectively improved, and side effects caused by long-term administration of medicines can be effectively avoided.

According to the preparation method of the high-temperature-resistant durable super-hydrophobic powder coating, integrated powder coating particles are prepared by mixing through a tabletting-crushing-sieving technology, and finally, one end of a solid nano-material in the integrated powder coating particles is embedded into a bottom layer, and the other end of the solid nano-material protrudes out of the surface of the coating, so that a nano-fiber bridging interface strengthening structure is formed. According to the invention, the low surface energy material, the solid nano material and the thermoplastic film-forming resin are effectively combined together to construct firm and stable integrated powder coating particles, so that the overall performance is synergistically enhanced, and the protection capability of a micron-scale structure to a nano-scale structure is greatly improved; the solvent-free durable super-hydrophobic powder coating is directly prepared through electrostatic spraying, so that the technological process is simplified; the solid, solvent-free and environment-friendly super-hydrophobic powder coating is prepared, has excellent high-temperature resistance and super-hydrophobic performance, and has potential advantages in the aspect of anti-corrosion and anti-drag application of a heat distribution pipeline.

The invention relates to a doxepin hydrochloride tablet. The doxepin hydrochloride tablet is prepared from doxepin hydrochloride, polyethylene glycol 6000, a filling agent, a disintegrating agent, a flow aid and a lubricating agent. The preparation method comprises the following steps: heating and melting polyethylene glycol 6000, adding a doxepin hydrochloride raw material according to a prescription proportion, and uniformly stirring and mixing; and after complete melting, rapidly cooling and solidifying to form a solid dispersion. And after curing, drying in a drying oven, crushing and sieving. And uniformly mixing the crushed particles with the filler and the lubricant, and directly tabletting. The doxepin hydrochloride has high hygroscopicity, is unstable to damp and heat and easily generates a large amount of impurities under strong oxidation conditions, the doxepin hydrochloride is firstly prepared into a solid dispersion and then is directly compressed, so that the medicine is highly dispersed in a carrier material in the states of molecules, colloids, amorphous forms, microcrystals and the like, and the effect of wrapping the medicine is achieved by controlling the ratio of the medicine to the carrier. Direct contact between the medicine and air is avoided, so that the problems of hygroscopicity and instability of the medicine are solved, and the product stability is improved.

The invention relates to a terahertz spectrum detection technology, in particular to a pericarpium citri reticulatae producing area identification method based on graph regularization sparse principal component analysis and a support vector machine algorithm, and belongs to the field of pericarpium citri reticulatae producing area quality detection. The method comprises the following steps: grinding and tabletting a dried orange peel sample to be detected, firstly detecting the dried orange peel sample in a nitrogen environment by adopting a terahertz time-domain spectroscopy system in a transmission mode to obtain a terahertz time-domain spectroscopy signal of the sample, and performing Fourier transform on the time-domain spectroscopy signal to obtain a frequency-domain spectrum of the sample; and obtaining a corresponding terahertz absorption spectrum according to the frequency domain spectrum. Savitzky-Golay smoothing preprocessing is carried out on the obtained terahertz absorption spectrum, the terahertz absorption spectrum is divided into a training set and a test set, and then feature extraction is carried out on data by utilizing sparse principal component analysis in combination with graph regularization. And taking the processed data as the input of a classification model. And finally, a combined parameter of an optimal regularization coefficient c and a kernel function parameter g of the support vector machine is obtained through a particle swarm optimization algorithm, so that an optimal pericarpium citri reticulatae producing area classification model is established. The method provided by the invention is convenient in sample preparation and simple in operation, can effectively realize rapid and accurate identification of dried orange peel from different producing areas, and provides a new method for identification of dried orange peel in high-value producing areas.

The invention discloses a composite embedded vitamin liposome as well as a preparation method and application thereof, by optimizing a formula and a process, adopting high-purity natural plant source phospholipid, a proper amount of a wall material and a membrane stabilizer and combining an antioxidant, the vitamin retention rate exceeds 95% after the liposome is accelerated at 60 DEG C for 20 days, and the rehydration particle size is between 200 and 800nm; the flowability is good, no bad taste or smell exists, and efficient embedding and stable release of vitamins are realized. The liposome has excellent physical and chemical stability and is suitable for various dosage forms such as tablets and hard-shell capsules, and the bioavailability and market application value of the product are remarkably improved. In addition, a clean solvent ethanol is used in the preparation process and is effectively removed and recycled, so that the method meets the requirements of food processing industry laws and regulations, is environment-friendly and is suitable for large-scale production.

The invention discloses an aspirin enteric-coated micro-tablet capsule and a preparation method thereof. The micro-tablet core auxiliary materials of the enteric-coated micro-tablet capsule comprise an excipient, a disintegrating agent, a stabilizer, a flow aid and a lubricant. Tartaric acid is adopted as a stabilizer of aspirin, gel silicon dioxide is adopted as a flow aid, a moisture absorption agent and a swelling agent, and a direct powder tabletting method is adopted to prepare a micro-tablet core; the invention provides the aspirin enteric-coated micro-tablet capsule which is good in powder flowability, stable and easy to control in process, good in stability, uniform in dissolution and release characteristics, stable in blood concentration and high in bioavailability.

The invention discloses a method for preparing a powder sample of an X-ray photoelectron spectrometer, and relates to the technical field of X-ray photoelectron spectrometers, which comprises the following steps of: weighing a powder sample to be detected, putting the powder sample into a crucible, and then putting the crucible filled with the powder sample into a drying box for drying treatment; the method comprises the following steps: putting a sample and spectroscopically pure into an agate grinding body, fully grinding and uniformly mixing, sieving for later use after grinding, weighing the sieved powder, and dividing into a plurality of equal parts; preparing a tabletting mold, placing a powder sample in the tabletting mold, and grinding and uniformly mixing the sample again through an upper mold; according to the method disclosed by the invention, the spectral purity is proportionally added into the powder sample, so that the number display intensity of the powder sample during detection can be improved, and the final detection effect is further improved; according to the invention, the sample is sheeted by using the pressing machine, so that the stability of the formed sample can be improved, the loosening phenomenon in the transfer and detection process can be avoided, and meanwhile, the flatness of the surface of the sample can be ensured, so that the accuracy of detection data can be ensured.

The invention provides lead-free piezoelectric ceramic capable of being used for a road vibration energy collecting device and a preparation method and application of the lead-free piezoelectric ceramic, and relates to the technical field of ceramic material preparation. The tabletting ceramic is prepared by the following steps: S1, respectively drying the required raw materials, weighing according to the chemical composition of the piezoelectric ceramic, and mixing to obtain a uniform mixture I; s2, performing primary ball milling, sieving, washing and drying on the mixture I to obtain a mixture II; s3, pre-sintering the mixture II, and then carrying out secondary ball milling to obtain a mixture III; s4, the mixture III is sieved and subjected to centrifugal granulation, then tabletting forming is conducted, and a test piece is obtained; and S5, discharging glue from the test piece, sintering, and carrying out polarization treatment to obtain the lead-free piezoelectric ceramic. The lead-free piezoelectric ceramic material provided by the invention shows excellent piezoelectric property near Curie temperature, and has good dielectric stability and long-term service capability in a road environment.

The invention relates to the technical field of pharmaceutical preparations, and provides an oral solid preparation for treating gout and a preparation method thereof. The preparation method comprises the following steps: sieving a filling agent, a disintegrating agent, an adhesive and dotenorad to obtain a sieved material; and mixing the sieved material and a lubricant, and tabletting to obtain the oral solid preparation for treating gout, the filling agent is lactose, mannitol and microcrystalline cellulose. By optimizing the prescription and the preparation process, the dissolution rate and bioavailability of the medicine are improved, so that the curative effect is improved; by selecting proper auxiliary materials and preparation types, the stimulation to gastrointestinal tracts is reduced, and the tolerance of patients is improved; the oral solid preparation is convenient to take, accurate in dosage, high in patient compliance and beneficial to long-term treatment; moreover, the preparation method provided by the invention is simple to operate, easy for industrial production and relatively low in cost.

The invention discloses a granulation device and a granulation method for tablet candy production, and belongs to the technical field of candy production, the granulation device comprises a bottom plate, a box body and a granulation assembly, a mounting box is fixedly connected above the bottom plate, and the granulation assembly comprises a first motor fixedly mounted in the mounting box; the output end of the first motor is fixedly connected with a first belt wheel, a transmission belt is arranged on the first belt wheel, and a second belt wheel is arranged at the end, away from the first belt wheel, of the transmission belt. A first motor is started to drive a forming plate and a material receiving plate to rotate, a rotating roller rotates under the action of an attaching ring, raw materials of candies can be granulated and formed through the forming plate, the rotating roller and a groove, meanwhile, the granulated candies can be directly sent out through the material receiving plate under the action of centrifugal force, operation is easy and convenient, and the practicability is high. And under the action of the fan, the formed candies can be dried by using heat generated when the first motor works.

A bottle includes a vessel, a grate, and a lid. The vessel includes an opening. The grate is positioned at the opening. The lid is lid configured to seal the opening. The lid comprises a shaft and a first threaded portion. The bottle also includes a second threaded portion. The first threaded portion and second threaded portion are configured such that threadedly advancing the first threaded portion into the second threaded portion moves the shaft toward the grate.

The invention belongs to the technical field of X-ray fluorescence spectrum analysis, and provides a WDXRF testing method based on polyester film pretreatment and application thereof.The method comprises the steps that a sample to be tested is placed in a sample cup, covered with a polyester film and pressed into a tablet through a hydraulic machine, the tablet is placed in a mold, and a WDXRF test is conducted; the parameters of the hydraulic machine comprise that the target pressure is 300-400 kn, and the pressure maintaining time is 5-20 s; the pressing time is 3-5 s; the sampling time is 5-7 s; the sample adding depth is 7-9 s. The method disclosed by the invention is simple, convenient and feasible, is low in cost, can be widely applied to WDXRF tests of various special samples, and has extremely high practical value. According to the method, the polyester film is used for treating the special sample, so that the test of the special sample which cannot be tested originally is realized, the change of sample components is avoided, the side effect is small, the accuracy is high, and the test method has an important application prospect.

The utility model discloses a tablet pressing device for lercanidipine hydrochloride tablet production. The tablet pressing device comprises a rack; the working table is connected to the machine frame, and a template is arranged on the working table; the upper die set is connected to the upper portion of the workbench; the upper die set is connected to the lower portion of the workbench; and the material pushing assembly is connected to the working table. By controlling an electric telescopic rod to work, a loading frame can be driven to move, a forming groove is filled with medicine powder in the loading frame, the loading frame is returned, then an upper die set is controlled to work, the medicine powder in the forming groove is pressed into tablets, a lower die set works to eject extruded tablets out, the electric telescopic rod is controlled to work, and the loading frame and a pushing plate are driven to move. And tablets can be automatically pushed into the material collecting assembly through the material pushing plate to be collected, meanwhile, medicine powder is automatically fed in the material loading frame, the automation degree is high, and the working efficiency is improved.

The invention discloses a melatonin rapidly disintegrating oral tablet and a preparation method thereof, and the melatonin rapidly disintegrating oral tablet is prepared from the following raw materials in parts by weight: 40 to 55 parts of mannitol, 3 to 6 parts of cross-linked povidone, 0.5 to 2.0 parts of povidone, 2 to 6 parts of melatonin, 30 to 45 parts of filler and 0.3 to 1.5 parts of lubricant. Wherein the mannitol is beta-crystal form mannitol. According to the invention, mannitol of a limited type is matched with raw materials such as polyvinylpolypyrrolidone, and meanwhile, a specific mixing and tabletting process is adopted, so that the tablet can be rapidly disintegrated in an oral cavity while the hardness of the tablet is maintained, the bioavailability is high, and the requirements of the health food field on taking convenience, effectiveness and industrial production can be met.

The utility model relates to a nutrition tablet press which comprises a tablet pressing box, a pressure bearing plate is arranged in the tablet pressing box, a powder suction assembly is arranged on the tablet pressing box and comprises an air suction pump, the air suction end of the air suction pump is communicated with a powder collecting box, the powder collecting box is communicated with a corrugated pipe, and a powder suction plate is slidably connected to the surface of the pressure bearing plate. A cavity is formed in the powder suction plate, one end of the corrugated pipe extends into the tabletting box and communicates with the cavity, a plurality of powder suction holes are formed in the bottom of the powder suction plate and communicate with the interior of the cavity, and a driving assembly is arranged in the tabletting area and drives the powder suction plate to reciprocate along the surface of the pressure bearing plate. And during moving, the powder suction plate sucks residual medicine powder on the surface of the pressure bearing plate into the powder collection box, and the phenomenon that the residual powder is mixed into new materials to pollute new medicines is avoided. The tablet press has the effect of improving the quality of tablets pressed by the tablet press every time.

The utility model discloses a sheet food tabletting and filling device which comprises a tabletting mechanism, a conveying mechanism, a transmission mechanism and a counting mechanism, and the tabletting mechanism is used for forming powder food into sheet food and conveying the sheet food; the conveying mechanism is provided with a filling position and used for conveying food cans with openings in the tops to pass through the filling position. The conveying mechanism is used for conveying the flaky food formed by the tabletting mechanism into a food can at a filling position of the conveying mechanism; the counting mechanism is arranged at the conveying tail end of the conveying mechanism so as to count the flaky food filled into the food cans, after a preset number of flaky food is filled, conveying of the conveying mechanism is stopped, and the conveying mechanism conveys new empty food cans into the filling position. According to the flaky food tabletting and filling device in the embodiment, the filling efficiency of flaky food can be improved, and then the production efficiency is improved. The utility model is applied to the field of food processing.

The invention relates to the technical field of dry powder conveying, and discloses a dry powder closed conveying online high-precision intelligent sampling analysis system and method.The system comprises an air sealing device used for preventing dry powder from escaping in the non-sampling time period, forming a barrier through airflow, isolating a sampling pipeline and maintaining system pressure balance; the stirring device is used for homogenizing the sample; the tabletting device is used for tabletting the loose powder into a compact sample wafer; when the dry powder enters the dry powder inlet and the sampling pipeline, the sampling control valve is used for controlling; wherein the air seal device comprises an external air source, an air seal branch pipe and a corresponding air seal control valve; the stirring device comprises a vertical dry powder stirrer and a corresponding blanking valve; the pressure relief opening is formed in the upper right part of the vertical dry powder stirrer; the tabletting device comprises a tabletting machine and a push-out rod. The whole sampling detection process can be automatically realized, the labor cost is saved to a great extent, and the working efficiency is improved.

The invention relates to the technical field, and discloses a tablet weight automatic control system based on tablet candy production, comprising: a pressure detection module for detecting the actual pressure value of a candy tablet in real time in the tabletting process; the signal conversion module is used for converting the analog quantity signal output by the pressure detection module into a VME digital signal; the control processing module is used for executing a discretization PID control algorithm, comparing the actual pressure value with a set pressure value and outputting a control instruction; the filling adjusting module is used for adjusting the material filling amount according to the control instruction; the metering guide rail module is used for accurately controlling the material feeding position; vME bus high-speed data transmission (40MB / s) and a PID real-time control algorithm are adopted, the system response time is shortened to be within 100 ms, and compared with 3-5 min response time of a traditional method, the response time is improved by 1800-3000 times. Adjustment can be completed within three tabletting periods after deviation is detected, and generation of unqualified products is greatly reduced.

The invention provides an anti-fouling self-cleaning powder coating and a preparation method thereof, and belongs to the technical field of powder coatings. The preparation method comprises the following steps: mixing the modified resin, the modified filler, the curing agent, the antioxidant, the flatting agent and the dispersing agent, and sequentially performing melt extrusion, tabletting, crushing and screening to obtain the anti-fouling self-cleaning powder coating. Structures such as a silane group, tert-butylphenyl and adamantane provide low surface energy to form a hydrophobic substrate, a multistage micro-nano coarse structure of the pretreated pollen provides a morphology basis for a super-hydrophobic surface, and after grafting treatment of hydrophobic groups of 1-adamantanol and hexamethylene diisocyanate, the hydrophobicity of the pretreated pollen is enhanced, so that the super-hydrophobic surface is formed. All the materials cooperate with one another to construct a'micro-nano binary structure 'similar to a lotus leaf, a super-hydrophobic surface is formed, pollutant attachment is reduced, and therefore the efficient anti-pollution self-cleaning effect is achieved.

The present invention discloses a fluorocarbon powder coating and a preparation method thereof, belonging to the technical field of powder coatings, which comprises the following steps: premixing methyl methacrylate, 2-hydroxyethyl methacrylate, 1H,1H,2H,2H-hexafluorobutyl methacrylate and methyl p-coumarate to obtain a premixed solution; transferring the premixed solution to a reaction kettle, heating up, adding an initiator, carrying out a reaction, filtering, and drying to obtain a modified acrylic resin, then carrying out melt mixing and extrusion to obtain material A; putting PVDF fluorocarbon resin and a filler into a reaction kettle, heating up and stirring to obtain material B, adding material A and modified PMMA, stirring, cooling and pressing into tablets to obtain the powder coating. The fluorocarbon powder coating of the present invention can maintain the advantage of high weather resistance, while also improving the internal compatibility and anti-ultraviolet performance, and enhancing the internal bonding effect of the double-layer powder body.

The present invention provides an oxyhalide, a preparation method therefor, and an all-solid-state lithium battery. The preparation method comprises: (1) grinding a mixture of a lithium source and a boron source, which are weighed in a stoichiometric ratio, tableting the mixture, then putting the tableted mixture into a reaction tube, evacuating the reaction tube to establish a vacuum, sealing the reaction tube, and then performing primary calcination, wherein the primary calcination temperature is 300-450ºC, and the primary calcination time is 4-20 h; and (2) after the primary calcination, cooling to room temperature, taking out the intermediate product from the reaction tube, grinding and tableting the intermediate product, then putting the tableted product into a reaction tube, evacuating the reaction tube to establish a vacuum, sealing the reaction tube, performing secondary calcination, and then cooling to room temperature. The preparation method of the present invention is simple and has high raw material utilization rate and no byproducts, thereby facilitating industrial production. The prepared oxyhalide has relatively high ionic conductivity and stability, and relatively good interface stability with metal lithium. The prepared all-solid-state lithium battery has excellent electrochemical performance.

The utility model discloses a pharmaceutical tableting device which comprises a tableting body, a medicine pushing telescopic rod fixedly connected to one side of the tableting body, a loading frame fixedly connected to one end of the medicine pushing telescopic rod, a scraping strip fixedly connected to the bottom of the loading frame, a tableting frame fixedly connected to the top of the tableting body, and a hydraulic telescopic rod installed at the top of the tableting frame. A tablet pressing groove is formed in the center of the top of the tablet pressing body, a lower mold is embedded into the inner side of the tablet pressing groove, a mold groove is formed in the top of the lower mold, a medicine pushing lifting rod is fixedly connected into the lower mold, and a medicine pushing plate is fixedly connected to the top end of the medicine pushing lifting rod. The medicine powder can be continuously laid without manual auxiliary operation of working personnel, so that the working intensity of the working personnel is reduced, the medicine preparation tabletting device can automatically push tablets out of a medicine preparation position, meanwhile, the medicine powder can be filled, and the medicine preparation efficiency is improved.

The invention relates to the technical field of medicine preparation, and particularly discloses a preparation method of a trazodone hydrochloride tablet, which comprises the following steps: mixing trazodone hydrochloride, a filler, a disintegrating agent and an adhesive, melting and granulating under the conditions that the feeding speed is 1kg / h-5 kg / h, the screw speed is 30rpm / min-80rpm / min and the temperature is 60-90 DEG C, mixing with a lubricant after melting and granulating to obtain total mixed granules, and granulating to obtain the trazodone hydrochloride tablet. And tabletting to obtain the trazodone hydrochloride tablet. The adhesive is melted in the heating section to initiate agglomeration to establish a liquid bridge between particles, and forms a firm bridge to consolidate agglomerates when the temperature is reduced, and the adhesive is retained in the prescription as a component, so that the particle density is higher, the porosity is lower, and the flowability and compressibility of the particles are improved.

The utility model belongs to the technical field of forming mechanisms, and particularly relates to a biscuit tabletting and forming mechanism which comprises a processing seat. A discharging opening is formed in the top of the machining base. Through the arrangement of the tabletting mechanism, feeding, tabletting and discharging of biscuits can be conducted synchronously, the steps are simplified, and the production efficiency is improved, that is, the biscuits are far away from one another, guided into a guide groove through a discharging opening and filled into a plurality of tabletting grooves distributed at equal intervals, meanwhile, an air cylinder is started, the tabletting grooves filled with biscuit raw materials rotate, and the biscuit raw materials are fed into the tabletting mechanism. Then the air cylinder is started again to drive the transmission plate to move in the direction of the tabletting roller, the multiple tabletting blocks are pressed into the tabletting grooves to conduct tabletting on the biscuit raw materials in the tabletting grooves, in the process, the tabletting grooves which conduct tabletting firstly and then rotate, openings of the tabletting grooves face downwards gradually, then the biscuits can fall off under the gravity of the biscuits, the steps are repeated, and the biscuit raw materials are obtained. Therefore, the feeding, the tabletting and the blanking of the biscuit tabletting are synchronously carried out.