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1446 results about "Tableting" patented technology

Tableting is a method of pressing medicine or candy into tablets. Confectionery manufacture shares many similarities with pharmaceutical production. A powder or granule mixture is prepared, a dye mold is filled, and then the mixture is compressed and ejected. While drug tablets are constrained to shapes that can be swallowed easily, candy tablets are chewable.

Equal-molar-ratio seven-element high-entropy oxide and preparation process thereof

The invention belongs to the field of synthesis of inorganic non-metallic materials, and particularly relates to an equimolar-ratio seven-element high-entropy oxide and a preparation process thereof. The preparation process comprises the following steps: putting seven oxide powder Al2O3, Y2O3, TiO2, ZrO2, NiO, CuO and CeO2 into a ball milling tank according to a molar ratio of 1: 1: 2: 2: 2: 2: 2: 2, adding absolute ethyl alcohol and zirconium oxide grinding balls, performing ball milling in a ball mill, and fully drying and sieving after ball milling to obtain mixed powder; carrying out tabletting treatment on the mixed powder to obtain a to-be-sintered green body; and putting the to-be-sintered green body into an alumina crucible, and putting the alumina crucible into a microwave oven for microwave sintering. According to the method, the equimolar-ratio seven-element high-entropy oxide (AlYTiZrNiCuCe) Ox with good solid solution is obtained, the crystallinity and element uniformity of the seven-element high-entropy oxide are improved, all the raw materials react completely, meanwhile, the process efficiency is high, and energy consumption is low.
Owner:LUOYANG INST OF SCI & TECH +1

Preparation method of perindopril amlodipine tablet

The invention discloses a preparation method of perindopril amlodipine tablets, and belongs to the field of pharmacy. The perindopril amlodipine tablet is prepared from the following raw material medicines: arginine perindopril and amlodipine besylate and auxiliary materials: lactose, microcrystalline cellulose, hydrophobic colloidal silicon dioxide and magnesium stearate. The preparation method of the perindopril amlodipine tablet comprises the following steps: weighing according to the prescription amount, crushing and sieving the raw materials for pretreatment, sieving the whole particles of the auxiliary materials for pretreatment, premixing, feeding and total mixing, tabletting and the like. The prepared perindopril amlodipine tablet is relatively good in quality, high in stability and relatively few in waste products.
Owner:HAINAN HUALON PHARM

Abesilib raw material medicine, composition, tablet and preparation method of abesilib raw material medicine, composition and tablet

The invention discloses an abesilil raw material medicine, a composition, a tablet and a preparation method thereof. The particle size distribution of the abesilil raw material medicine is as follows: D10 is more than or equal to 20 microns, D90 is more than or equal to 60 microns and less than or equal to 300 microns, and the span (D90-D10) / D50 is less than or equal to 2.5. According to the present invention, the large raw material particle size within a certain range is provided, the dissolution rate and the dissolution amount of the abelsilil tablet in the pH 6.8 medium can be easily improved, the sticking phenomenon during the tabletting process can be solved, the production process is simple, the production period is short, the production cost is low, the mixing and the tabletting are smooth, and the dissolution end point is high.
Owner:JIANGSU WANBANG BIOPHARMLS

A bone health pressed tablet candy enriched with a marine peptide calcium chelate and a method of making the same

The application discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptides, wherein the calcium chelate peptide provided by the application has an amino acid sequence as shown in SEQ ID No.1, and the specific sequence is GETGPA (F21-1), and the calcium binding capacity of the calcium chelate peptide is 4.72±1.06 Όg / mg. The bone health tablet candy provided by the application has good calcium absorption promoting activity. The results of a mouse experiment show that the bone health tablet candy does not cause adverse effects on the growth of mice, can reverse high bone conversion caused by osteoporosis, improves the bone biomechanical properties of osteoporotic mice, and thus achieves the effect of enhancing bone density.
Owner:OCEAN UNIV OF CHINA

Oyster peptide and application thereof in preparation of product for improving alcoholic liver injury

The invention relates to the technical field of preparation of marine bioactive substances and functional foods, in particular to oyster peptide and application thereof in preparation of products for improving alcoholic liver injury. According to the invention, oyster peptide raw materials rich in natural taurine are adopted, scientific formula design and natural plant alcohol effect dispelling and liver protecting components are adopted, and adverse reactions after drinking, such as hangover, fatigue and alcoholic liver injury, are effectively relieved; according to the oyster peptide tabletted candy formula with the functions of dispelling the effects of alcohol and protecting the liver, provided by the invention, functional components all meet design requirements through detection.
Owner:QUANZHOU MARINE BIOTECHNOLOGY IND RES INST

Preparation method of high-temperature-resistant durable super-hydrophobic powder coating and application of coating to heat distribution pipeline

According to the preparation method of the high-temperature-resistant durable super-hydrophobic powder coating, integrated powder coating particles are prepared by mixing through a tabletting-crushing-sieving technology, and finally, one end of a solid nano-material in the integrated powder coating particles is embedded into a bottom layer, and the other end of the solid nano-material protrudes out of the surface of the coating, so that a nano-fiber bridging interface strengthening structure is formed. According to the invention, the low surface energy material, the solid nano material and the thermoplastic film-forming resin are effectively combined together to construct firm and stable integrated powder coating particles, so that the overall performance is synergistically enhanced, and the protection capability of a micron-scale structure to a nano-scale structure is greatly improved; the solvent-free durable super-hydrophobic powder coating is directly prepared through electrostatic spraying, so that the technological process is simplified; the solid, solvent-free and environment-friendly super-hydrophobic powder coating is prepared, has excellent high-temperature resistance and super-hydrophobic performance, and has potential advantages in the aspect of anti-corrosion and anti-drag application of a heat distribution pipeline.
Owner:TIANJIN UNIV +2

Doxepin hydrochloride tablet and preparation method thereof

The invention relates to a doxepin hydrochloride tablet. The doxepin hydrochloride tablet is prepared from doxepin hydrochloride, polyethylene glycol 6000, a filling agent, a disintegrating agent, a flow aid and a lubricating agent. The preparation method comprises the following steps: heating and melting polyethylene glycol 6000, adding a doxepin hydrochloride raw material according to a prescription proportion, and uniformly stirring and mixing; and after complete melting, rapidly cooling and solidifying to form a solid dispersion. And after curing, drying in a drying oven, crushing and sieving. And uniformly mixing the crushed particles with the filler and the lubricant, and directly tabletting. The doxepin hydrochloride has high hygroscopicity, is unstable to damp and heat and easily generates a large amount of impurities under strong oxidation conditions, the doxepin hydrochloride is firstly prepared into a solid dispersion and then is directly compressed, so that the medicine is highly dispersed in a carrier material in the states of molecules, colloids, amorphous forms, microcrystals and the like, and the effect of wrapping the medicine is achieved by controlling the ratio of the medicine to the carrier. Direct contact between the medicine and air is avoided, so that the problems of hygroscopicity and instability of the medicine are solved, and the product stability is improved.
Owner:NANJING ZEHENG PHARM TECH DEV CO LTD

Pericarpium citri reticulatae production place identification method based on graph regularization sparse principal component analysis and support vector machine

The invention relates to a terahertz spectrum detection technology, in particular to a pericarpium citri reticulatae producing area identification method based on graph regularization sparse principal component analysis and a support vector machine algorithm, and belongs to the field of pericarpium citri reticulatae producing area quality detection. The method comprises the following steps: grinding and tabletting a dried orange peel sample to be detected, firstly detecting the dried orange peel sample in a nitrogen environment by adopting a terahertz time-domain spectroscopy system in a transmission mode to obtain a terahertz time-domain spectroscopy signal of the sample, and performing Fourier transform on the time-domain spectroscopy signal to obtain a frequency-domain spectrum of the sample; and obtaining a corresponding terahertz absorption spectrum according to the frequency domain spectrum. Savitzky-Golay smoothing preprocessing is carried out on the obtained terahertz absorption spectrum, the terahertz absorption spectrum is divided into a training set and a test set, and then feature extraction is carried out on data by utilizing sparse principal component analysis in combination with graph regularization. And taking the processed data as the input of a classification model. And finally, a combined parameter of an optimal regularization coefficient c and a kernel function parameter g of the support vector machine is obtained through a particle swarm optimization algorithm, so that an optimal pericarpium citri reticulatae producing area classification model is established. The method provided by the invention is convenient in sample preparation and simple in operation, can effectively realize rapid and accurate identification of dried orange peel from different producing areas, and provides a new method for identification of dried orange peel in high-value producing areas.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Composite embedded vitamin liposome as well as preparation method and application thereof

The invention discloses a composite embedded vitamin liposome as well as a preparation method and application thereof, by optimizing a formula and a process, adopting high-purity natural plant source phospholipid, a proper amount of a wall material and a membrane stabilizer and combining an antioxidant, the vitamin retention rate exceeds 95% after the liposome is accelerated at 60 DEG C for 20 days, and the rehydration particle size is between 200 and 800nm; the flowability is good, no bad taste or smell exists, and efficient embedding and stable release of vitamins are realized. The liposome has excellent physical and chemical stability and is suitable for various dosage forms such as tablets and hard-shell capsules, and the bioavailability and market application value of the product are remarkably improved. In addition, a clean solvent ethanol is used in the preparation process and is effectively removed and recycled, so that the method meets the requirements of food processing industry laws and regulations, is environment-friendly and is suitable for large-scale production.
Owner:INNOBIO CORP LTD

Aspirin enteric-coated micro-tablet capsule and preparation method thereof

The invention discloses an aspirin enteric-coated micro-tablet capsule and a preparation method thereof. The micro-tablet core auxiliary materials of the enteric-coated micro-tablet capsule comprise an excipient, a disintegrating agent, a stabilizer, a flow aid and a lubricant. Tartaric acid is adopted as a stabilizer of aspirin, gel silicon dioxide is adopted as a flow aid, a moisture absorption agent and a swelling agent, and a direct powder tabletting method is adopted to prepare a micro-tablet core; the invention provides the aspirin enteric-coated micro-tablet capsule which is good in powder flowability, stable and easy to control in process, good in stability, uniform in dissolution and release characteristics, stable in blood concentration and high in bioavailability.
Owner:JILIN TIANHENG PHARM CO LTD

Preparation method of powder sample of X-ray photoelectron spectrometer

The invention discloses a method for preparing a powder sample of an X-ray photoelectron spectrometer, and relates to the technical field of X-ray photoelectron spectrometers, which comprises the following steps of: weighing a powder sample to be detected, putting the powder sample into a crucible, and then putting the crucible filled with the powder sample into a drying box for drying treatment; the method comprises the following steps: putting a sample and spectroscopically pure into an agate grinding body, fully grinding and uniformly mixing, sieving for later use after grinding, weighing the sieved powder, and dividing into a plurality of equal parts; preparing a tabletting mold, placing a powder sample in the tabletting mold, and grinding and uniformly mixing the sample again through an upper mold; according to the method disclosed by the invention, the spectral purity is proportionally added into the powder sample, so that the number display intensity of the powder sample during detection can be improved, and the final detection effect is further improved; according to the invention, the sample is sheeted by using the pressing machine, so that the stability of the formed sample can be improved, the loosening phenomenon in the transfer and detection process can be avoided, and meanwhile, the flatness of the surface of the sample can be ensured, so that the accuracy of detection data can be ensured.
Owner:XINJIANG UNIVERSITY

Lead-free piezoelectric ceramic capable of being used for road vibration energy collecting device and preparation method and application of lead-free piezoelectric ceramic

The invention provides lead-free piezoelectric ceramic capable of being used for a road vibration energy collecting device and a preparation method and application of the lead-free piezoelectric ceramic, and relates to the technical field of ceramic material preparation. The tabletting ceramic is prepared by the following steps: S1, respectively drying the required raw materials, weighing according to the chemical composition of the piezoelectric ceramic, and mixing to obtain a uniform mixture I; s2, performing primary ball milling, sieving, washing and drying on the mixture I to obtain a mixture II; s3, pre-sintering the mixture II, and then carrying out secondary ball milling to obtain a mixture III; s4, the mixture III is sieved and subjected to centrifugal granulation, then tabletting forming is conducted, and a test piece is obtained; and S5, discharging glue from the test piece, sintering, and carrying out polarization treatment to obtain the lead-free piezoelectric ceramic. The lead-free piezoelectric ceramic material provided by the invention shows excellent piezoelectric property near Curie temperature, and has good dielectric stability and long-term service capability in a road environment.
Owner:GEZHOUBA HUBEI XIANGJING FREEWAY CO LTD +1

Oral solid preparation for treating gout and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, and provides an oral solid preparation for treating gout and a preparation method thereof. The preparation method comprises the following steps: sieving a filling agent, a disintegrating agent, an adhesive and dotenorad to obtain a sieved material; and mixing the sieved material and a lubricant, and tabletting to obtain the oral solid preparation for treating gout, the filling agent is lactose, mannitol and microcrystalline cellulose. By optimizing the prescription and the preparation process, the dissolution rate and bioavailability of the medicine are improved, so that the curative effect is improved; by selecting proper auxiliary materials and preparation types, the stimulation to gastrointestinal tracts is reduced, and the tolerance of patients is improved; the oral solid preparation is convenient to take, accurate in dosage, high in patient compliance and beneficial to long-term treatment; moreover, the preparation method provided by the invention is simple to operate, easy for industrial production and relatively low in cost.
Owner:SHANDONG INOMIC INST OF PHARM RES CO LTD

WDXRF testing method based on polyester film pretreatment and application of WDXRF testing method

The invention belongs to the technical field of X-ray fluorescence spectrum analysis, and provides a WDXRF testing method based on polyester film pretreatment and application thereof.The method comprises the steps that a sample to be tested is placed in a sample cup, covered with a polyester film and pressed into a tablet through a hydraulic machine, the tablet is placed in a mold, and a WDXRF test is conducted; the parameters of the hydraulic machine comprise that the target pressure is 300-400 kn, and the pressure maintaining time is 5-20 s; the pressing time is 3-5 s; the sampling time is 5-7 s; the sample adding depth is 7-9 s. The method disclosed by the invention is simple, convenient and feasible, is low in cost, can be widely applied to WDXRF tests of various special samples, and has extremely high practical value. According to the method, the polyester film is used for treating the special sample, so that the test of the special sample which cannot be tested originally is realized, the change of sample components is avoided, the side effect is small, the accuracy is high, and the test method has an important application prospect.
Owner:HANGZHOU YANQU INFORMATION TECH CO LTD

Tabletting device for lercanidipine hydrochloride tablet production

The utility model discloses a tablet pressing device for lercanidipine hydrochloride tablet production. The tablet pressing device comprises a rack; the working table is connected to the machine frame, and a template is arranged on the working table; the upper die set is connected to the upper portion of the workbench; the upper die set is connected to the lower portion of the workbench; and the material pushing assembly is connected to the working table. By controlling an electric telescopic rod to work, a loading frame can be driven to move, a forming groove is filled with medicine powder in the loading frame, the loading frame is returned, then an upper die set is controlled to work, the medicine powder in the forming groove is pressed into tablets, a lower die set works to eject extruded tablets out, the electric telescopic rod is controlled to work, and the loading frame and a pushing plate are driven to move. And tablets can be automatically pushed into the material collecting assembly through the material pushing plate to be collected, meanwhile, medicine powder is automatically fed in the material loading frame, the automation degree is high, and the working efficiency is improved.
Owner:ANHUI HONGYE PHARMA

Melatonin rapidly disintegrating tablet and preparation method thereof

The invention discloses a melatonin rapidly disintegrating oral tablet and a preparation method thereof, and the melatonin rapidly disintegrating oral tablet is prepared from the following raw materials in parts by weight: 40 to 55 parts of mannitol, 3 to 6 parts of cross-linked povidone, 0.5 to 2.0 parts of povidone, 2 to 6 parts of melatonin, 30 to 45 parts of filler and 0.3 to 1.5 parts of lubricant. Wherein the mannitol is beta-crystal form mannitol. According to the invention, mannitol of a limited type is matched with raw materials such as polyvinylpolypyrrolidone, and meanwhile, a specific mixing and tabletting process is adopted, so that the tablet can be rapidly disintegrated in an oral cavity while the hardness of the tablet is maintained, the bioavailability is high, and the requirements of the health food field on taking convenience, effectiveness and industrial production can be met.
Owner:WEIHAI BAIHE BIOTECH

Flaky food tabletting and filling device

The utility model discloses a sheet food tabletting and filling device which comprises a tabletting mechanism, a conveying mechanism, a transmission mechanism and a counting mechanism, and the tabletting mechanism is used for forming powder food into sheet food and conveying the sheet food; the conveying mechanism is provided with a filling position and used for conveying food cans with openings in the tops to pass through the filling position. The conveying mechanism is used for conveying the flaky food formed by the tabletting mechanism into a food can at a filling position of the conveying mechanism; the counting mechanism is arranged at the conveying tail end of the conveying mechanism so as to count the flaky food filled into the food cans, after a preset number of flaky food is filled, conveying of the conveying mechanism is stopped, and the conveying mechanism conveys new empty food cans into the filling position. According to the flaky food tabletting and filling device in the embodiment, the filling efficiency of flaky food can be improved, and then the production efficiency is improved. The utility model is applied to the field of food processing.
Owner:HUNAN DEYANG NUTRITION BIOTECHNOLOGY CO LTD

Dry powder closed conveying online high-precision intelligent sampling analysis system and method

The invention relates to the technical field of dry powder conveying, and discloses a dry powder closed conveying online high-precision intelligent sampling analysis system and method.The system comprises an air sealing device used for preventing dry powder from escaping in the non-sampling time period, forming a barrier through airflow, isolating a sampling pipeline and maintaining system pressure balance; the stirring device is used for homogenizing the sample; the tabletting device is used for tabletting the loose powder into a compact sample wafer; when the dry powder enters the dry powder inlet and the sampling pipeline, the sampling control valve is used for controlling; wherein the air seal device comprises an external air source, an air seal branch pipe and a corresponding air seal control valve; the stirring device comprises a vertical dry powder stirrer and a corresponding blanking valve; the pressure relief opening is formed in the upper right part of the vertical dry powder stirrer; the tabletting device comprises a tabletting machine and a push-out rod. The whole sampling detection process can be automatically realized, the labor cost is saved to a great extent, and the working efficiency is improved.
Owner:KUNMING UNIV OF SCI & TECH

Tablet weight automatic control system based on tablet candy production

The invention relates to the technical field, and discloses a tablet weight automatic control system based on tablet candy production, comprising: a pressure detection module for detecting the actual pressure value of a candy tablet in real time in the tabletting process; the signal conversion module is used for converting the analog quantity signal output by the pressure detection module into a VME digital signal; the control processing module is used for executing a discretization PID control algorithm, comparing the actual pressure value with a set pressure value and outputting a control instruction; the filling adjusting module is used for adjusting the material filling amount according to the control instruction; the metering guide rail module is used for accurately controlling the material feeding position; vME bus high-speed data transmission (40MB / s) and a PID real-time control algorithm are adopted, the system response time is shortened to be within 100 ms, and compared with 3-5 min response time of a traditional method, the response time is improved by 1800-3000 times. Adjustment can be completed within three tabletting periods after deviation is detected, and generation of unqualified products is greatly reduced.
Owner:GUANGDONG SHANTAI FOODSTUFF CO LTD

Oxyhalide, preparation method therefor and all-solid-state lithium battery

The present invention provides an oxyhalide, a preparation method therefor, and an all-solid-state lithium battery. The preparation method comprises: (1) grinding a mixture of a lithium source and a boron source, which are weighed in a stoichiometric ratio, tableting the mixture, then putting the tableted mixture into a reaction tube, evacuating the reaction tube to establish a vacuum, sealing the reaction tube, and then performing primary calcination, wherein the primary calcination temperature is 300-450ÂșC, and the primary calcination time is 4-20 h; and (2) after the primary calcination, cooling to room temperature, taking out the intermediate product from the reaction tube, grinding and tableting the intermediate product, then putting the tableted product into a reaction tube, evacuating the reaction tube to establish a vacuum, sealing the reaction tube, performing secondary calcination, and then cooling to room temperature. The preparation method of the present invention is simple and has high raw material utilization rate and no byproducts, thereby facilitating industrial production. The prepared oxyhalide has relatively high ionic conductivity and stability, and relatively good interface stability with metal lithium. The prepared all-solid-state lithium battery has excellent electrochemical performance.
Owner:SHANGHAI JIAOTONG UNIV

Pharmaceutical tabletting device

The utility model discloses a pharmaceutical tableting device which comprises a tableting body, a medicine pushing telescopic rod fixedly connected to one side of the tableting body, a loading frame fixedly connected to one end of the medicine pushing telescopic rod, a scraping strip fixedly connected to the bottom of the loading frame, a tableting frame fixedly connected to the top of the tableting body, and a hydraulic telescopic rod installed at the top of the tableting frame. A tablet pressing groove is formed in the center of the top of the tablet pressing body, a lower mold is embedded into the inner side of the tablet pressing groove, a mold groove is formed in the top of the lower mold, a medicine pushing lifting rod is fixedly connected into the lower mold, and a medicine pushing plate is fixedly connected to the top end of the medicine pushing lifting rod. The medicine powder can be continuously laid without manual auxiliary operation of working personnel, so that the working intensity of the working personnel is reduced, the medicine preparation tabletting device can automatically push tablets out of a medicine preparation position, meanwhile, the medicine powder can be filled, and the medicine preparation efficiency is improved.
Owner:HENAN JIEDENG PHARMACEUTICAL RESEARCH & DEVELOPMENT CO LTD

Preparation method of trazodone hydrochloride tablets

The invention relates to the technical field of medicine preparation, and particularly discloses a preparation method of a trazodone hydrochloride tablet, which comprises the following steps: mixing trazodone hydrochloride, a filler, a disintegrating agent and an adhesive, melting and granulating under the conditions that the feeding speed is 1kg / h-5 kg / h, the screw speed is 30rpm / min-80rpm / min and the temperature is 60-90 DEG C, mixing with a lubricant after melting and granulating to obtain total mixed granules, and granulating to obtain the trazodone hydrochloride tablet. And tabletting to obtain the trazodone hydrochloride tablet. The adhesive is melted in the heating section to initiate agglomeration to establish a liquid bridge between particles, and forms a firm bridge to consolidate agglomerates when the temperature is reduced, and the adhesive is retained in the prescription as a component, so that the particle density is higher, the porosity is lower, and the flowability and compressibility of the particles are improved.
Owner:JINING UNIV

Method for determining gamma-aminobutyric acid in tableted candy

The invention provides a method for measuring gamma-aminobutyric acid in tableted candies, which comprises the following steps: measuring gamma-aminobutyric acid in tableted candies by using HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector) according to a volume ratio of acetonitrile to water of (50-70): (30-50) as a mobile phase; a chromatographic column is an amino column; a detector is ELSD, the temperature of a drift tube is 80-85 DEG C, and carrier gas is air. The detection method disclosed by the invention is strong in specificity, high in accuracy, strong in stability, good in repeatability and high in sensitivity, and compared with an existing derivation method, the method disclosed by the invention is simple, green and efficient, and can be used for effectively detecting the content of gamma-aminobutyric acid in the tabletted candies.
Owner:SICHUAN CREED FOOD CO LTD

Terahertz time-domain spectroscopy-based wheat stripe rust uredospore optical parameter extraction method

The invention discloses a terahertz time-domain spectroscopy-based wheat stripe rust uredospore optical parameter extraction method. The method comprises the following steps: mixing wheat stripe rust uredospore powder and polyethylene powder, and tabletting; a transmission module of the terahertz time-domain spectrometer is used for collecting time-domain spectral data of the mixed tablets in a nitrogen environment; carrying out filtering processing on the collected time-domain spectral data to eliminate high-frequency noise; main waves of the time domain signals are reserved, the echo position is estimated, sampling points are randomly generated through normal distribution to dynamically correct the echo signals, and time domain interference is reduced; and performing fast Fourier transform on the corrected time domain signal, and calculating the refractive index, the absorption coefficient and the dielectric constant of the wheat stripe rust uredospores through frequency domain amplitude and phase information on the basis of an improved Dorne-Duvillaret model. Through sample preparation optimization, echo correction and model improvement, the measurement precision can be remarkably improved.
Owner:NORTHWEST A & F UNIV

Tiopronin-containing composition as well as preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a tiopronin-containing composition as well as a preparation method and application thereof. The preparation method comprises the following steps: granulating by adopting isopropanol as a granulating solution, drying and tabletting to obtain a tablet core with extremely low water content, and meanwhile, dissolving a mixture of an amine alkyl methacrylate copolymer and hydroxypropylcellulose in isopropanol as an isolating layer solution to coat the tablet core, so that the stability of the tablet core is improved; and finally, calcium carbonate, cane sugar and the like are adopted for sugar coating, so that unpleasant odor is effectively covered, the compliance of a patient is improved, the preparation is suitable for large-scale production, the medicine taking convenience and the medicine administration safety of the patient are improved, and therefore, the preparation has a good practical application value.
Owner:BEIJING YUANFANG TONGDA PHARM TECH CO LTD

Veterinary GS-441524 tablet and preparation method thereof

The invention relates to the field of veterinary drugs, in particular to a veterinary GS-441524 tablet and a preparation method thereof. In the application, the GS-441524 raw material medicine, the filling agent, the disintegrating agent, the lubricating agent and the stabilizing agent are used as raw materials, the combination of mannitol and microcrystalline cellulose is selected as the filling agent, and coating is performed, so that the novel veterinary GS-441524 tablet is prepared, the medicine loss caused by thermal decomposition of API in the tabletting process is reduced, and the uniformity and the stability of the medicine in the tablet are improved.
Owner:HUNAN SHANGCHENG BIOTECHNOLOGY CO LTD

A tabletting device for powder coating production

The present invention discloses a tableting device for powder coating production, and relates to a tableting device comprising an equipment frame, a panel fixedly connected to the equipment frame, a driving roller and a driven roller rotatably connected to the panel, the driving roller and the driven roller being connected via a gear transmission, the driving roller and the driving motor being connected via a gear transmission, the driving roller and the driven roller both comprising a rotating extrusion roller body, the outer edges of the extrusion roller bodies being provided with cooling channels for supplying cool air, and a cooling fan being further provided on the equipment frame for supplying air to the cooling channels. By providing cooling channels on the driving roller and the driven roller, the cooling airflow provided by the cooling fan can be injected into the cooling channels in real time. Based on the structural arrangement of the air distribution mechanism, the cooling airflow can be directly injected into the extrusion surface between the driving roller and the driven roller, thereby avoiding insufficient cooling and providing a guarantee for the continuous tableting of the powder coating.
Owner:HAIYANG ELECTROSTATIC EQUIP CO LTD

A lead-carbon composite material, a preparation method and application thereof

The application belongs to the technical field of ion batteries, and particularly relates to a lead-carbon composite material and a preparation method and application thereof. The preparation method comprises the following steps: grinding and tabletting a lead source and a carbon source, and roasting the tabletted tablet to obtain the lead-carbon composite material; the lead source comprises at least one of lead citrate, lead acetate, lead chloride and lead oxalate; and the carbon source comprises at least one of polyvinylpyrrolidone, carboxymethyl cellulose, glucose and sucrose. The lead-carbon composite material has a three-dimensional porous structure formed by metal lead particles embedded in a carbon skeleton, and the carbon skeleton can effectively alleviate the volume expansion generated in the alloying process of metal lead and metal sodium in the charging and discharging process, so as to improve the conductivity and electrochemical performance of the material.
Owner:SHANDONG UNIV

Anhydrous crystal form ch of resmetirom and preparation method therefor

Provided in the present invention is an anhydrous crystal form CH of resmetirom. The preparation process of the crystal form is simple, and is easy and convenient to operate. The new crystal form has good stability, is easy to store during the production and circulation process, has a stable quality when used for preparing a tablet formulation, and has a certain advantage in dissolution rate compared with the original crystal form, thereby providing a good selection for the preparation of a pharmaceutical formulation thereof, and having a very important significance on drug development.
Owner:HANGZHOU CHEMINSPIRE TECH CO LTD

Method for monitoring baicalein-betaine eutectic process based on terahertz spectrum

The invention relates to the technical field of pharmaceutical analysis, and discloses a method for monitoring a baicalein-betaine eutectic process based on terahertz spectroscopy, and the method comprises the following steps: mixing and ball-milling baicalein and betaine to obtain powder samples, collecting the powder samples with different ball-milling times, drying, mixing with a dispersing agent, tabletting, and drying to obtain the baicalein-betaine eutectic crystal. The method comprises the following steps: measuring spectral data by using terahertz time-domain spectroscopy equipment, selecting a characteristic peak and tracking intensity change to obtain a curve, carrying out nonlinear fitting on the curve, obtaining a molecular vibration mode through a density functional theory, and analyzing the eutectic process by combining the two modes. The terahertz spectrum technology is combined with theoretical calculation, complete analysis of the baicalein-betaine eutectic process from macrodynamics monitoring to microcosmic molecular action mechanism analysis is achieved, and an effective means is provided for eutectic formation research and process optimization.
Owner:ZHENGZHOU UNIV