The invention discloses a weeding composition for a wheat field. The active ingredients of the weeding composition comprise (A): any one of carfentrazone and clodinafop-propargyl, and (B): any one or two of tribenuion methyl, bensulfuron methyl, fluroxypyr, florasulam, pyrazosulfuron, isoproturon and MCPA-Na (2-methyl-4-chloro-phenoxyacetic acid-sodium); or comprise two ingredients of A and any one of B. The ratio of two ingredients is 1-70:1-70, and the ratio of three ingredients is 1-50:1-50:1-50. The composition of the invention can be prepared into missible oil, oil suspension agent, wettable powder, water dispersible granules and the like, and has the advantages of good weeding effect, wide weeding spectrum, small use amount, low residue, safety to crops and low cost. Moreover, the composition has good prevention and control effect in removing broadleaf weeds and partial grass family weeds, the prevention and control rate is over 90%, and the harm of weeds in the wheat field can be essentially controlled throughout the season by once application.