185 results about "Cyclohexenone" patented technology

The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorate, in particular to 4-hydroxy-2,3 -dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in tumor growth inhibition. The compound of the invention, which has never been discovered in Antrodia camphorate, can be applied in inhibiting the growth of cancer cells, such as breast cancer, hepatic cancer and prostate cancer; and be used as a pharmaceutical composition to inhibit the tumor growth; or further be applied in prevention of heart and blood vessel disease or dietary supplements for health needs through its antioxidant activity.

A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase, a 4-acetylbutyrate dehydratase, a 3-hydroxycyclohexanone dehydrogenase, a 2-cyclohexenone hydratase, a cyclohexanone dehydrogenase and an enzyme selected from a 3-oxopimeloyl-CoA synthetase, a 3-oxopimeloyl-CoA hydrolase (acting on thioester), and a 3-oxopimeloyl-coA transferase. Each these pathways can include a PEP carboxykinase. A method for producing cyclohexanone includes culturing these non-naturally occurring microbial organisms.

A method for reducing the concentration of cyclohexenone in a cyclohexenone containing organic mixture is disclosed. The method includes contacting an organic mixture comprising cyclohexenone with an effective amount of at least one of sulfurous acid, a salt of sulfurous acid, an alkali hydroxide, or a mixture of two or more of these compounds.

The present invention relates to a compound of Antrodia camphorata used to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata, and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.

The invention provides a herbicide combination, containing Trifloxysulfuron, Pyrithiobac-sodium, APP and / or Cyclohexenone, and the ratio of parts by weights of Trifloxysulfuron: Pyrithiobac-sodium:APP and / or Cyclohexenone is 0.1:1:20-20:1:0.1. The combination can be used to prepare emulsifiable solution, liquor, thick emulsion, microemulsion, wettable powder, water suspending agent, oil suspending agent, water-dispersible granules or soluble powder (granules). The herbicide combination can be used to prevent and control Gramineae and broad-leaved weeds which have grown for one year or more than one year in the cotton field.

The present invention provides methods and compositions for treating lung cancer by cyclohexenone compounds.

The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.

The invention discloses a new compound and the usage, in particular to a 4-hydroxy-2, 3- dimethoxy -6-methyl-5 (3, 7, 11- trimethyl-2, 6, 10-dodecatrien) -2- cyclohexenone (4-hydroxy- 2, 3-dimethoxy -6- methy-5 (3, 7, 11-trimethyl -dodeca-2, 6, 10- trienyl) -cyclohex-2-enone) separated from antrodia camphorate extract and the application in inhibiting the growth of tumor cell. The new compound is firstly seen in antrodia camphorate. The 4-hydroxy-2, 3- dimethoxy -6-methyl-5 (3, 7, 11- trimethyl-2, 6, 10-dodecatrien) -2- cyclohexenone (4-hydroxy- 2, 3-dimethoxy -6- methy-5 (3, 7, 11-trimethyl -dodeca-2, 6, 10- trienyl) -cyclohex-2-enone) separated from antrodia camphorate extract and the application in inhibiting the growth of tumor cell has the advantages of inhibiting the growth of breast cancer, liver cancer and prostate cancer tumor cell, being a component of drug combination inhibiting the growth of the tumor cell at the same time or further being applied in preventing cardiovascular disease or being added into healthy food by right of antioxidant activity.

The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.

The invention provides a microemulsion liquid herbicide composition, which includes: (i) water; (ii) water-soluble herbicide; (iii) oil-soluble cyclohexenone or aryloxyphenoxy propionate Graminous herbicides, the weight ratio of which is about 1:50 to about 1:1 with water-soluble herbicides; (iv) an organic solvent that is substantially immiscible with water, which is selected from those organic solvents in which the grass herbicides have A solvent with a partition coefficient of / water, expressed in a logarithm of about 4 or higher, which has a weight ratio to the grass herbicide of about 3:1 to about 30:1; (v) an emulsion system, which contains one or more A surfactant having tertiary amine functional groups in an amount not exceeding about 10% by weight but sufficient to provide acceptable physical stability of the microemulsion; (vi) 0 to a stabilizing amount of one or more water-soluble chlorides , which is selected from the group consisting of hydrogen chloride, alkali metal chlorides, ammonium chloride, low molecular weight organic ammonium chlorides and quaternary ammonium chloride surfactants; and (vii) a dispersion system containing one or more nonionic surfactants , the total amount used does not exceed about 5% by weight but is sufficient to provide acceptable dispersion of the microemulsion diluted with an appropriate amount of water for application to plants, but is not sufficient to destabilize the microemulsion. The compositions of the invention wherein the water-soluble herbicide is a glyphosate salt are particularly useful for controlling undesirable glyphosate-tolerant grasses in glyphosate-tolerant broadleaf crops.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of ovarian cancer cells and be used as a pharmaceutical composition to inhibit the ovarian tumor growth.

The invention discloses a hierarchical-pore titanium silicon molecular sieve catalyst synthesized with the assistance of an aerosol and a preparation method of titanium silicon molecular sieve catalyst, and the titanium silicon molecular sieve catalyst is applied to the catalytic oxidation reaction of cyclohexene. The silicon molecular sieve catalyst is a hierarchical-pore titanium silicon molecular sieve synthesized through an aerosol method, is spherical, contains TS-1 nanometer crystals with MFI micropore structures, and is covered with a porous titanium silicon material. The catalyst can adopt hydrogen peroxide as an oxidant to perform catalytic oxidation on the cyclohexene to synthesize cyclohexene oxide, cyclohexanediol, cyclohexenone and cyclohexanol. The titanium silicon molecular sieve catalyst has the advantages that the preparation process is simple and continuous, the synthesis period is short, the atom utilization ratio is high, the titanium distribution is uniform, and the reaction can be magnified according to a certain ratio. The titanium silicon molecular sieve catalyst provided by the invention has the characteristics of mild reaction conditions, high activity and selectivity, small using amount, and easy recycling.

The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.

The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6-10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80% VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of pancreatic cancer cells and be used as a pharmaceutical composition to inhibit the pancreatic tumor growth.

Described is a cyclohexenone long-chain alcohol represented by the formula (1):wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexanone long-chain alcohol according to the present invention has excellent neurite growth stimulating effects and is therefore useful as a preventive and / or therapeutic agent for Alzheimer's disease.

The invention provides a method for preparing a cyclohexanedione herbicide microcapsule, which comprises the following steps: mixing oil-in-water emulsions with first water-soluble high polymer materials; and then drying the obtained mixture so as to obtain the cyclohexanedione herbicide microcapsule, wherein the oil-in-water emulsion contains particles in which cyclohexanediones herbicide is packaged, and the first water-soluble high polymer material comprises at least one material selected from sodium polyacrylate, polyving akohol, polyethylene glycol, Arabic gum, Chinese gelatin, sodium alginate and chitosan which can be used as the wall materials of the microcapsule. The invention also provides a cyclohexanedione herbicide microcapsule prepared by using the method. For the microcapsule prepared by using the method of the invention, the storage stability is improved, and environmental pollution can be avoided.

A composition for dyeing material of synthetic aromatic polyamide fibers, said composition containing a mixture of (a) a cationic dye and (b) a cyclohexenone as a dye assistant. Preferably, 2-cyclohexen-1-one,3,5,5-trimethyl is the dye assistant.

A method for reducing the concentration of cyclohexenone in a cyclohexenone containing organic mixture is disclosed. The method includes contacting an organic mixture comprising cyclohexenone with an effective amount of at least one of sulfurous acid, a salt of sulfurous acid, an alkali hydroxide, or a mixture of two or more of these compounds.

The invention discloses a method for synthesizing cyclohexenone through the catalytic oxidation of cyclohexene. The method comprises the following steps: adding reactants including cyclohexene, a solvent and a solid catalyst into a reactor to mix, and carrying out ultrasonic processing on the obtained mixture so as to form suspension liquid, wherein the solid catalyst is a carbon material, the carbon material is a carbon nanotube, a nitrogen-doped carbon nanotube, diamond, graphite or activated carbon, and the solvent is an organic solvent mutually soluble in cyclohexene and oxidation products thereof; heating the suspension liquid to 40-150 DEG C, feeding oxygen or air as an oxidant, and reacting 0.1-20 h at a pressure of 0.1-5 MPa; separating the obtained reaction mixture so as to obtain the solid catalyst and a liquid mixture containing a reaction product, unreacted reactants and the solvent; carrying out separation and purification to obtain a product cyclohexenone, mixing residual mother liquor with reaction raw materials and then returning the mixture to the reactor. According to the invention, the used nonmetal catalyst is non-corrosive, environment-friendly, cheap, reusable, high in reaction selectivity, and good in activity.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of lymphoma cells and be used as a pharmaceutical composition to inhibit the lymphoma tumor growth.

The invention discloses a benzyl cyclohexenone derivative and a preparation method and medical application thereof. The benzyl cyclohexenone derivative is a compound in a general formula I. The compound can be individually prepared into a preparation or can be combined with one or more pharmaceutically acceptable carriers to prepare the preparation for administration. The compound can be combined with other antitumor drugs for application, and can also be combined with radiotherapies for application. These antitumor drugs or radiotherapies and the compound disclosed by the invention can be given at the same time or different times. These combination therapies can generate a synergistic effect to improve the treatment effect.

The invention discloses a novel fried wheat essence, comprising 2-acetylthiophene, furanone, 2,3-pentanedione, 3-methyl-2-cyclohexenyl-1-one, 2,3,5,6-tetramethylpyrazine, 5-methyl-6,7-dihydrocyclopentylpyrazine, 2-acetylpyrazine, tricin, furfuryl thioacetate, biradical disulfide and propylene glycol. The invention not only has fried wheat fragrance and but also can be used in the coarse grain beverage after baking, in particular to wheat smell milk beverage. Meanwhile, the invention can better enhance the mouthfeel and cover the bilgy odour and musty taste of legume coarse grain in base materials.

The invention relates to a preparation method and application of a double-photon fluorine ion fluorescent probe compound. The formula of the double-photon fluorine ion fluorescent probe compound is as shown in formula I. The preparation method includes: allowing 2, 4-dihydroxy benzaldehyde and cyclohexenone to react under nitrogen protection by using imidazole as the catalyst; allowing the product obtained by separation to react with tert-butyldimethylsilyl chloride to obtain the pure fluorine ion fluorescent probe compound. The fluorine ion fluorescent probe compound has the advantages that the probe compound has good selectivity and sensitivity to fluorine ions and is nontoxic to cells; probe molecules can be stimulated by double photons to avoid an ultraviolet region, so that the probe molecules are applicable to detection of the fluorine ions in water and detection and imaging of the fluorine ions in cells.

The invention provides a method for preparing cyclohexenone through oxidizing cyclohexene with molecular oxygen. According to the method, the cyclohexenone is prepared by taking reaction at 0.1 to 1.0MPa and 80 to 160 DEG C through using easy-to-obtain cyclohexene as raw materials and using oxygen or air as oxygen sources under the existence of copper compound catalysts such as copper acetate, copper trifluoroacetate, copper sulfate, copper oxide, copper chloride, copper bromide and the like. According to the method, low-price clean oxidizing agents are adopted, the addition of solvents is not needed, the catalysts are simple and are easy to obtain, the conversion rate and the selectivity are high, the production cost is low, and the method is suitable for large-scale industrial production.

The invention provides a method for preparing 3,3,5-trimethyl-cyclohexanone by selectively hydrogenating isophorone (namely 3,3,5-trimethyl-2- cyclohexenone). The method comprises the step of selectively hydrogenating to reduce isophorone into 3,3,5-trimethyl-cyclohexanone through combined use of supported Pd or Pt catalyst and co-catalyst under the condition that the reaction temperature is 20-100 DEG C. The method is remarkably characterized in that the byproduct 3,3,5-trimethyl-cyclohexanol is inhibited by adding the preferred cocatalyst, so that the product 3,3,5-trimethyl-cyclohexanone has relatively high selectivity and yield on the premise of realizing the high conversion rate of the isophorone under a relatively mild condition.

The invention relates to a preparation method of trienes liquid crystal monomers. The method comprises the following steps: using alkyl 2,3-difluorobenzene, alkoxy 2,3-difluorobenzene, 1-bromine-4-alkyl 2,3-difluorobenzene or 1-bromine-4-alkoxy 2, 3-difluorobenzene as raw materials, performing a metallization reaction or a Grignard reaction and a reaction with a cyclohexanone compound, performing hydroxyl protection, a Wittig reaction, alkene-ether hydrolysis, hydroxyl deprotection and alcohol dehydration so as to obtain an intermediate of which the formula is shown in the specification, performing the Wittig reaction once again, and performing a double-bond isomerization reaction so as to obtain the finished product, wherein three steps of the reactions of the alkene-ether hydrolysis, the hydroxyl deprotection and the alcohol dehydration can be combined to be performed in one step. The preparation method disclosed by the invention overcomes the disadvantage that the yield of cyclohexenone in the Wittig reaction is extremely low in the conventional preparation method of the compound, the yield of products is increased, the production cost is reduced, the large-scale production is facilitated, and the preparation method has very good application prospects.

The present invention relates to a novel application of a compound. The compound 4-hydroxy-2,3-dimethoxy-6-methyl-5-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone of the invention is isolated and purified from the extracts of Antrodia camphorata, which can be applied for inhibiting the survival of lymphoma cells and be used as a pharmaceutical composition to inhibit the lymphoma tumor growth.