101 results about "Propargyl" patented technology

A composition of a compound represented by FIGS. 1A-1E for use in treating a medical disorder. A method of changing neurotransmission, by administering a pharmaceutically effective amount of composition to a mammal of a compound represented by FIGS. 1A-1E and inducing psychoactive effects in the mammal. A method of treating a patient having adverse reactions to psychedelics or entactogens, by administering a pharmaceutically effective amount of composition to the patient of a compound represented by FIGS. 1A-1E and avoiding adverse effects present with psychedelics or entactogens.

The invention relates to a radionuclide-labeled glucose derivative molecular probe and application thereof, and belongs to the technical field of nuclear medicine. According to the present invention, propargyl glycine is used to synthesize an amino acid skeleton, and the amino acid skeleton reacts with glucose azide to prepare a series of radionuclide-labeled glucose derivative molecular probes, such as [68Ga] Ga-NOTA-SDG, [68Ga] Ga-NOTA-DDG, [68Ga] Ga-NOTA-TDG, [68Ga] Ga-DOTA-SDG, [68Ga] Ga-DOTA-DDG and the like; the glucose derivative molecular probe labeled by the series of radionuclides has the advantages of being simple and rapid in labeling, high in radiolabeling yield and good in stability, can accurately position tumors, has good tumor uptake and lower non-target tissue uptake, and has great application prospects in preparation of broad-spectrum tumor imaging agents.

The invention belongs to the technical field of nanofiltration, and provides a preparation method of a recrystallized silicon carbide-silicon carbonitride ceramic membrane. The preparation method comprises the following steps: applying a polysilazane solution to a porous substrate for the first time, and then performing first pyrolysis to obtain a pyrolysis material; and applying a polysilazane solution on the pyrolysis material for the second time, and then carrying out second pyrolysis to obtain the recrystallized silicon carbide-silicon carbonitride ceramic membrane. According to the invention, a solution containing propargyl polysilazane or organic polysilazane Durazane 1500 quick-drying resin is used as a precursor to prepare the ceramic membrane, and the ceramic membrane has the advantages of high ceramic yield, excellent high-temperature stability, high retention rate and controllable microstructure, and is suitable for separation and protection application in extreme environments.

The invention belongs to the field of medicinal chemistry, and relates to an indole allylamine amide derivative as well as a preparation method and application thereof. Functional activity screening of G protein dependent signaling pathways is carried out on all the synthesized compounds, and it is found that the new derivatives can be used for preparing beta2-adrenergic receptor allosteric antagonism regulator drugs. Trans-indole allylamine is used as a raw material, amide coupling is performed to obtain the novel indole allylamine amide derivative, and R1 is any one of phenyl, m-methylbenzene, m-methoxyphenyl, m-bromophenyl, m-chlorphenyl, m-fluorophenyl, o-methoxyphenyl, p-methoxyphenyl, naphthalene ring, oxazole, cyclohexyl, cyclopentyl, methyl, ethyl and isopropyl. A biological activity test result shows that the indole allylamine amide derivative disclosed by the invention has relatively good antagonistic activity on beta2AR and can be used for carrying out negative allosteric regulation on the functional activity of isoproterenol.

The invention provides an application of combination of SPRC and a PD-1 or PD-L1 inhibitor in preparation of a lung cancer immunotherapy sensitizing drug, and relates to the technical field of biomedicine.In the application, through in-vitro cell experiments, cell co-culture experiments and in-vivo animal experiments, S-propargyl-L-cysteine (SPRC) can play a sensitizing role in the anti-lung cancer curative effect of the PD-1 inhibitor, and can be used for preparing a sensitizing drug for lung cancer immunotherapy. The core mechanism is as follows: 30 [mu] M SPRC is in a non-cytotoxic dose window and can specifically inhibit IFN-gamma induced STAT1 phosphorylation and PD-L1 up-regulation by depending on a CSE / H2S pathway, while IFN-gamma-STAT1-PD-L1 is a core signal axis of PD-L1 adaptive up-regulation in lung cancer cells, and the induction effect of TNF-alpha on PD-L1 is relatively weak; meanwhile, SPRC can inhibit activation of NF-kB induced by TNF-alpha and expression of inflammatory factors such as IL-6 and IL-8 through the pathway so as to exert the anti-inflammatory effect, the CD8 + T cell depletion proportion can be remarkably reduced by combining SPRC with anti-PD-1, the synergistic tumor inhibition effect is formed, the effect is verified in in-vivo and in-vitro experiments, and a closed loop of an in-vitro mechanism and an in-vivo curative effect is achieved.

To provide a method, a perfuming composition and a perfumed consumer product for imparting long-lasting properties for standard perfumery raw materials which are too volatile or have a poor substantivity by themselves or which are only deposited in a small amount on the surface of the final application.SOLUTION: The present invention relates to compounds of formula (I) as properfume compounds. In particular, the present invention relates to a method of releasing a compound, namely, a carbonyl, a formate ester and / or an alcohol represented by specific formulas, by exposing the compound of formula (I) to an environment in which it is oxidized. Moreover, the present invention relates to a perfuming composition and a perfumed consumer product comprising at least one compound of formula (I).SELECTED DRAWING: None

The invention relates to a method for synthesizing an iodo-pyridine compound from N-propargyl enaminone, which comprises the following steps: by taking N-propargyl enaminone as a raw material, DMF (Dimethyl Formamide) as a reaction solvent and copper acetate and N-iodosuccinimide as accelerators, carrying out intramolecular coupling reaction at 60 DEG C to synthesize the iodo-pyridine compound. The method for directly synthesizing the pyridine heterocyclic compound through the intramolecular coupling reaction of the N-propargyl enaminone under the non-alkaline condition is disclosed for the first time, reaction substrates are not limited to benzene rings on alkynyl, the application range of the reaction is greatly expanded, and the method has the advantages of being wide in substrate range, strong in functional group application range, mild in reaction condition, easy to operate, safe, high in yield and the like. And raw materials are cheap.

The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing propargyl silane derivatives through nickel catalytic reduction coupling. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, and reacting a halogen-containing butyne compound with chlorosilane under the action of a catalyst, a ligand and a reducing agent to obtain the propargyl silane derivative. The structural formula of the propargyl silane derivative is I, the catalyst is a nickel catalyst, and the ligand is a nitrogen or phosphine ligand. The method disclosed by the invention is simple, low in cost, efficient in reaction, few in byproducts, easy to separate and purify and high in yield.

The application belongs to the technical field of nanofiltration, and provides a preparation method of recrystallized silicon carbide-silicon carbon nitride ceramic membrane. The application obtains a pyrolytic material by first applying a polysilazane solution on a porous base and then performing first pyrolysis; and obtains the recrystallized silicon carbide-silicon carbon nitride ceramic membrane by second applying the polysilazane solution on the pyrolytic material and then performing second pyrolysis. The application uses a solution containing propargyl polysilazane or an organic polysilazane Durazane 1500 rapid cure fast-drying resin as a precursor to prepare the ceramic membrane, and the ceramic membrane has high ceramic yield, excellent high-temperature stability, high rejection rate and controllable microstructure, and is suitable for separation and protection applications in extreme environments.

The application discloses a propargyl polysiloxane modified cyanate ester resin and a preparation method and application thereof, and comprises the following steps: S1, a propargyl compound shown in formula I and polysiloxane shown in formula II are subjected to a heating reaction in the presence of a platinum catalyst and a solvent to obtain a propargyl polysiloxane; S2, the propargyl polysiloxane is mixed with a cyanate ester monomer, heated and stirred until a transparent solution is obtained, and subjected to a heat curing treatment to obtain the propargyl polysiloxane modified cyanate ester resin. The propargyl polysiloxane modified cyanate ester resin can be cured and formed at a lower curing temperature, and the prepared modified resin has lower dielectric loss, water absorption, higher impact strength and thermal stability, and has a good application prospect in high-end electronic materials.

This invention relates to a novel use of propargylcysteine ​​in the preparation of anti-mastopathy drugs. The invention discovers that S-propargylcysteine ​​can improve E2 / P imbalance by regulating HPO axis function and inhibiting abnormal activation of the GnRH-sex hormone axis; it also reduces the inflammatory microenvironment by inhibiting the release of inflammatory factors; ultimately, it downregulates ER / PR-mediated proliferation signals and inhibits PCNA expression locally in the breast. Through multi-target regulation of neuroendocrine, inflammatory responses, and proliferation-related signaling pathways, it effectively alleviates breast hyperplasia and its associated chronic stress-induced depressive-like behaviors, thus exerting anti-mastopathy and therapeutic effects on breast hyperplasia complicated with depression.

The invention discloses a continuous flow preparation method of polysubstituted propargyl alcohol, which uses a microtube continuous flow reaction device and comprises the following specific steps: simultaneously conveying acetylene gas or terminal alkyne compound and an organic alkali solution into a mixer for premixing; simultaneously conveying the keto-carbonyl substrate and the flowing-out reaction liquid to a reactor to carry out an alkyne hydrogenation reaction; and carrying out gas-liquid separation on the outflowing reaction liquid, and rectifying in a rectifying tower to obtain a target propargyl alcohol product. According to the method for continuously preparing the polysubstituted propargyl alcohol by using the continuous flow reaction system, full mixing of reaction materials of each reaction unit and accurate control of the reaction can be realized by regulating and controlling pipeline parameters, the automation degree is greatly improved, the manual operation is reduced, the energy consumption cost is reduced, and the method is suitable for industrial production.

This disclosure relates to a process for the synthesis of a compound of formula (I): (I) wherein w, x, y, and z are as defined in the description. The process includes the reaction of a compound of formula (II): (II) with carbonyldiimidazole, and the reaction of the resulting compound with propargylamine.

The invention relates to the technical field of pesticide preparations, in particular to a preparation method of a propionate and oligosaccharin compounded soluble concentrate, which is realized by the following steps: firstly, preparing a mixed solvent; performing ultrasonic and nanometer grinding treatment on the propionate raw medicine, and dissolving the propionate raw medicine in the mixed solvent to obtain a propionate solution; then adding an oligosaccharin combination, and carrying out gradient stirring to obtain a compound stock solution; then, lentinan, a surfactant, a compound stabilizer and other assistants are sequentially added, secondary filtration is performed, and finally the volume is fixed to obtain a finished product. The problems that an existing compound preparation is poor in lipid-water compatibility, insufficient in extreme environment stability and weak in crop stress resistance adaptation are solved, synergism of antifungal, antiviral, cold-resistant, lodging-resistant and quality-improving and yield-increasing is achieved, the compound preparation is particularly suitable for crops such as rice and tobacco in cold regions, the process is compatible with an existing production line, and the compound preparation has wide application prospects.

The present invention provides an organic film-forming composition, a pattern-forming method, and an organic film-forming compound and polymer. The solution provided by the present invention is an organic film-forming composition characterized by containing an organic film-forming material represented by the following general formula and an organic solvent. In the general formula, R1 is a hydrogen atom, an allyl group, or a propargyl group; R2 is a nitro group, a halogen atom, a hydroxyl group, an alkyloxy group having 1 to 4 carbon atoms, an alkynyloxy group having 2 to 4 carbon atoms, an alkenyloxy group having 2 to 4 carbon atoms, a linear, branched, or cyclic alkyl group having 1 to 6 carbon atoms, a trifluoromethyl group, or a trifluoromethyloxy group; m = 0, 1, n = 1, 2, l = 0, 1, k is an integer from 0 to 2, W is a divalent organic group having 1 to 40 carbon atoms; and V each independently represents a hydrogen atom or a linking moiety.

The present disclosure relates, in one aspect, to propargyl amino-ionizable lipid compounds of formula (I), and methods of preparing the same. In another aspect, the disclosure relates to lipid nanoparticles (LNPs) comprising at least one ionizable lipid of formula (I) or (III). In another aspect, the LNPs of the disclosure are useful for gene editing applications. In another aspect, the LNPs of the disclosure are useful for splenic delivery of therapeutic cargo.

The invention relates to a nano nickel electroplating process used after secondary zinc deposition of an aluminum alloy. The nano nickel electroplating process comprises two steps of preparing a plating solution and electroplating. A nano nickel agent A and a nano nickel agent B are added into the plating solution, and the nano nickel agent A comprises, by mass, 5%-9% of nickel sulfate, 6%-10% of sodium propargyl sulfonate, 5%-9% of sodium hypophosphite monohydrate and 72%-84% of deionized water; and the nano nickel B agent comprises the following components in percentage by mass: 5-9% of butynol alcohol ether sodium propane sulfonate, 6-10% of sodium propargyl sulfonate, 5-9% of sodium hypophosphite monohydrate and 72-84% of deionized water. Sodium propargyl sulfonate is coordinated with Ni < 2 + > in a high-activity area of a workpiece through electrostatic adsorption and coordination so as to inhibit deposition of Ni < 2 + >; the surface energy of a low-activity area of the workpiece is low, Ni < 2 + > deposition is basically not affected, negatively-charged propargyl sulfonate radicals can be attracted by weak positive charges in the area, and continuous generation of new crystal nucleuses is promoted. The sodium hypophosphite monohydrate can prevent Ni < 2 + > from being oxidized through reaction with oxygen. Butynol alcohol ether sodium propane sulfonate inhibits overgrowth of crystal grains and refines the crystal grain structure through adsorption and steric hindrance effect.

The present invention discloses a polysubstituted alkylaryl azo compound, its synthesis method, and application. The present invention provides polysubstituted alkylaryl azo compounds as shown in Formula I and Formula II. Using propargyl reagents and hydrazones as substrates and various nitrogen heterocyclic carbene (NHC) ligands, allene products or propargyl-substituted products can be prepared with high selectivity, all of which contain azo functional groups. The polysubstituted alkylaryl azo compounds prepared by the present invention provide a technical solution that is completely different from the prior art for preparing polysubstituted α-quaternary carbon amine compounds, achieving good yield and selectivity. #imgabs0#

The application relates to the technical field of acoustic materials, in particular to a sound matching material, a preparation method thereof, an ultrasonic transducer, an ultrasonic probe and an ultrasonic imaging device. The sound matching material comprises a polystyrene telechelic polymer with a chemical structure as shown in formula I: wherein n1 and n2 are positive integers; X comprises at least one of halogen atoms, hydroxyl groups, carboxyl groups, amino groups, propargyl groups, methoxyl groups, azido groups, pyrimidyl groups and malonate groups. The sound matching material has not only good low sound attenuation characteristics, but also good bonding performance, can improve the stable reliability of sound transmission, and has a good application prospect in medical ultrasonic probes.

The invention relates to the technical field of detection, in particular to a method for determining the content of propargyl and / or isopropargyl by using nuclear magnetic resonance. The method comprises the following steps: preparing a detection solution by taking dimethyl terephthalate as an internal standard substance and propargyl or isopropargyl as a detection sample, then carrying out nuclear magnetic resonance measurement, respectively establishing linear regression equations, and determining that the isopropargyl is Y1 = 0.2214 X1-0.0236 and R12 = 0.99082; the Y2 is equal to 0.6524, the X < 2 > is equal to 0.0104, and the R22 is equal to 0.99981. Then performing NMR measurement on a to-be-measured solution to obtain a quantitative peak area, and substituting the quantitative peak area into the equation to obtain the content. According to the method, a standard substance is not needed, a specific quantitative peak is selected to avoid interference, the detection linear range is 0.05 mg / mL-20 mg / mL, the detection limit is 0.02 mg / mL, operation is easy and convenient, cost is low, accuracy and reliability are achieved, and the method is suitable for content detection of propargyl and / or isopropargyl.

This invention discloses a method for synthesizing chiral quinoxalones. Using a copper salt, a chiral ligand, and a base as a catalytic system, the target chiral quinoxalone compound is obtained by reaction in an organic solvent. This invention utilizes an economical and readily available copper catalyst, constructing C-N bonds through propargyl substitution and aminolysis of the ester group to synthesize chiral quinoxalones. This method has advantages such as good substrate universality, high yield, good enantioselectivity, and ease of industrial production. The synthesis method of this invention does not require the use of special and expensive catalysts, and the reaction conditions are simple, requiring no special reaction environment such as high-pressure hydrogen, with low requirements for reaction equipment, making it easy to scale up for industrial production.

The application discloses a self-curable propargyl polysiloxane monomer and a preparation method and application thereof, the propargyl polysiloxane is obtained by reacting a propargyl compound shown in formula I with a polysiloxane shown in formula II, is liquid at room temperature, and can be self-cured to form a resin at high temperature. The resin formed by self-curing the propargyl polysiloxane as a monomer has an initial thermal decomposition temperature of up to 503.3 DEG C under a nitrogen atmosphere, a carbon residue rate of up to 83.1% at 800 DEG C, and a total heat release amount of only 4.8 kJ˙g ‑1 , a heat release capacity of only 33.6 J˙g ‑1 , ‑1 , and a peak temperature of 518.8 DEG C, and exhibits outstanding thermal stability and flame retardancy, can effectively inhibit the chemical combustion reaction of a flame, and has a good application prospect in the fields of aerospace, insulating electricity, building materials and the like.

The invention discloses a carbon dot corrosion inhibitor with excellent corrosion inhibition and tracing performance, a preparation method and application, and relates to the technical field of corrosion inhibition of metal materials. The technical problems that in the prior art, a carbon dot corrosion inhibitor is prone to aggregation and instability in a high-temperature and strong-acid environment, and application is single are solved. The method comprises the following steps: firstly, taking citric acid and propargyl-PEG2-amine as raw materials, and dissolving the raw materials in deionized water to obtain a mixed solution; the mixed solution is placed in a high-pressure reaction kettle to be subjected to a hydrothermal reaction, and citric acid carbon dots modified by propargyl-PEG2-amine are prepared; sequentially carrying out centrifugation, dialysis and freeze drying treatment on the citric acid carbon dots modified by the propargyl-PEG2-amine, so as to obtain the citric acid carbon dots modified by the propargyl-PEG2-amine. The prepared carbon dot corrosion inhibitor can be used as a corrosion inhibition material in a high-temperature-resistant strong-acid environment, and can also be used for in-situ monitoring of dichromate ions in industrial wastewater and in-situ monitoring of iron ions and ferrous ions in underground water, surface water and drinking water so as to judge whether the content of the iron ions and the ferrous ions exceeds the standard or not.

The invention relates to the technical field of fluorescence detection and molecular probes, in particular to a fluorescent probe for detecting bivalent palladium as well as a preparation method and application of the fluorescent probe. The fluorescent probe for detecting bivalent palladium is a compound with a structure shown in a formula (I). The fluorescent probe provided by the invention takes benzopyran as a fluorescent parent nucleus and propynyl as a recognition site, and is novel in structure. When the fluorescent probe is used for divalent palladium detection, the fluorescent probe has the characteristics of single selective recognition, high sensitivity and low detection limit (0.18 mu M) on divalent palladium, and the fluorescence intensity of the fluorescent probe and the concentration of divalent palladium are in a good linear relationship within the range of 0-40 mu M. Meanwhile, an application experiment verifies that when the fluorescent probe is used for detecting the divalent palladium in the traditional Chinese medicinal materials, the adding standard recovery rate ranges from 90.8% to 106.4%. Therefore, the fluorescent probe disclosed by the invention has a wide application prospect in the fields of bivalent palladium detection reagents and rapid detection of heavy metals in traditional Chinese medicinal materials.

The invention discloses a method for preparing a polyfluoroalkyl coumarin derivative, and belongs to the field of organic synthesis. According to the method, cheap and easily available polyfluorocarboxylic acid anhydride is used as a polyfluoroalkylating reagent, and in-situ activation of NHPI is combined to prepare the C3-site polyfluoroalkyl substituted coumarin derivative. Under the condition of visible light catalysis, polyfluoroalkyl carboxylic acid anhydride is used as a polyfluoroalkylating reagent, polyfluoroalkyl free radicals are generated through in-situ activation of NHPI, the free radicals and aromatic propiolate are subjected to a free radical cyclization rearrangement reaction, and finally preparation of the C3-site polyfluoroalkyl substituted coumarin derivative is achieved. The polyfluoroalkyl carboxylic acid anhydride used in the method is stable in property, low in price and easy to obtain, and the synthesis cost is reduced. The method is wide in applicable substrate range and applicable to various polyfluoroalkyl carboxylic acid anhydrides, and the tolerance of reaction functional groups is good.

The invention discloses synthesis of triazene reversible termination nucleotide and application of the triazene reversible termination nucleotide in DNA (deoxyribonucleic acid) sequencing. According to a fluorescence labeled nucleotide structure # imgabs0 #, Base is four different basic groups, namely U, C, A and G; r1 and R2 are independently selected from allyl, aryl methyl, heteroaryl methyl, propargyl, alkyl or acyl; and R3 is # imgabs1 # Dye which is a fluorescent dye. When participating in a DNA chain extension reaction, the reversible termination nucleotide can rapidly and completely extend, and then fluorescein can be rapidly and completely removed. After the sequencing cycle is completed, the residual groups on the basic group of the DNA chain are small, so that the continuous and smooth proceeding of the subsequent DNA sequencing cycle is facilitated. In the observed DNA synthesis sequencing cycle, the reaction is clean and thorough no matter the extension reaction or the rapid fracture of the connecting unit, and almost no side reaction is observed; the compounds are simple and convenient to synthesize and can be synthesized in a large scale, the sequencing efficiency can be greatly improved, the error rate is reduced, and the sequencing cost is reduced.

In one aspect, the disclosure relates to axially chiral cannabinoid analogs and methods of making the same. In one aspect, several tetracyclic scaffolds can be prepared from O-propargyl vinyl coumarins in good yields. In a further aspect, these tetracyclic scaffolds can be treated with a reductant to form the axially chiral cannabinoid analogs. In another aspect, the axially chiral cannabinoid analogs are shelf stable and maintain a three-dimensional structure during storage, enabling superior recognition of biological targets such as cannabinoid receptors. Also disclosed herein are prochiral cannabinoid analogs that can be synthesized from axially chiral cannabinoid analogs.

The present invention relates to a poly(arylpiperidinium) copolymer ionomer that does not contain an aryl ether bond in the polymer backbone but has propargyl groups grafted thereto and piperidinium groups introduced therein, an anion exchange membrane crosslinked therefrom, and a method for manufacturing the same. The propargyl group-grafted poly(arylpiperidinium) copolymer ionomer exhibits excellent chemical and thermal stability, ionic conductivity, mechanical properties, dimensional stability, and durability. Furthermore, the crosslinked anion exchange membrane manufactured therefrom exhibits significantly improved catalyst layer peel strength and promotes interaction between the ionomer and the membrane, stabilizing the catalyst layer and thereby dramatically improving fuel cell durability.

The application discloses a method for preparing aromatic benzyl propargyl ketone by light induction and biological application, belongs to the technical field of organic synthesis and biological medicine, and converts aromatic benzyl propargyl alcohol into aromatic benzyl propargyl ketone under the condition of light induction; the change of the functional group before and after light induction is that the hydroxyl alkyne without reaction activity is converted into the carbonyl alkyne with click reaction activity, fluorescence enhancement can be realized, and the method can be used for imaging and tracing; and the aromatic benzyl propargyl ketone can react with a compound containing an amino group or a biological macromolecule to realize the killing of tumor cells. The method uses light as a starting switch, the reaction condition is simple, controllability is good, no additional catalyst is needed, and the method is easy to mass-produce, so the method has wide application prospects in polypeptide or protein labeling, anti-tumor and the like.

The invention discloses a method for preparing propargyl ester through 1, 3-enyne 1, 2-carbon esterification reaction based on a polarity matching strategy and application, and the method comprises the following steps: in the presence of a copper catalyst, a ligand and tert-butyl peroxybenzoate and under the heating condition, reacting a compound in a formula (1) with a compound in a formula (2) in an organic solvent to generate the propargyl ester in a formula (3). The preparation method provided by the invention can be suitable for alkyl-substituted 1, 3-enyne, aryl-substituted 1, 3-enyne, silicon-substituted 1, 3-enyne, an electron-rich C-H substrate, an electron-deficient C-H substrate, a Si-H substrate and a Ge-H substrate, and has the advantages that the substrates are simple and easy to obtain, and the universality is wide. The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, simple reaction operation, wide application range of reaction substrates, easy amplification of reaction, mild reaction conditions and the like, and can realize industrial production and application.