133 results about "Propargyl" patented technology

A composition of a compound represented by FIGS. 1A-1E for use in treating a medical disorder. A method of changing neurotransmission, by administering a pharmaceutically effective amount of composition to a mammal of a compound represented by FIGS. 1A-1E and inducing psychoactive effects in the mammal. A method of treating a patient having adverse reactions to psychedelics or entactogens, by administering a pharmaceutically effective amount of composition to the patient of a compound represented by FIGS. 1A-1E and avoiding adverse effects present with psychedelics or entactogens.

The invention relates to a radionuclide-labeled glucose derivative molecular probe and application thereof, and belongs to the technical field of nuclear medicine. According to the present invention, propargyl glycine is used to synthesize an amino acid skeleton, and the amino acid skeleton reacts with glucose azide to prepare a series of radionuclide-labeled glucose derivative molecular probes, such as [68Ga] Ga-NOTA-SDG, [68Ga] Ga-NOTA-DDG, [68Ga] Ga-NOTA-TDG, [68Ga] Ga-DOTA-SDG, [68Ga] Ga-DOTA-DDG and the like; the glucose derivative molecular probe labeled by the series of radionuclides has the advantages of being simple and rapid in labeling, high in radiolabeling yield and good in stability, can accurately position tumors, has good tumor uptake and lower non-target tissue uptake, and has great application prospects in preparation of broad-spectrum tumor imaging agents.

The invention belongs to the technical field of nanofiltration, and provides a preparation method of a recrystallized silicon carbide-silicon carbonitride ceramic membrane. The preparation method comprises the following steps: applying a polysilazane solution to a porous substrate for the first time, and then performing first pyrolysis to obtain a pyrolysis material; and applying a polysilazane solution on the pyrolysis material for the second time, and then carrying out second pyrolysis to obtain the recrystallized silicon carbide-silicon carbonitride ceramic membrane. According to the invention, a solution containing propargyl polysilazane or organic polysilazane Durazane 1500 quick-drying resin is used as a precursor to prepare the ceramic membrane, and the ceramic membrane has the advantages of high ceramic yield, excellent high-temperature stability, high retention rate and controllable microstructure, and is suitable for separation and protection application in extreme environments.

The invention belongs to the technical field of pesticide weeding, and discloses a weeding composition and application thereof.The weeding composition comprises an active component A and an active component B. The active component A is isoxafop-butyl, the active component B is any one of metamifop, cyhalofop-butyl, clodinafop-propargyl and pinoxaden, and the active component B is one of isoxafop-butyl, cyhalofop-butyl, clodinafop-propargyl and pinoxaden. The mass ratio of the active component A to the active component B is (1: 12)-(24: 1). The weeding composition disclosed by the invention is wide in weed control spectrum and can be used for comprehensively preventing and controlling various weeds in rice fields and wheat fields.

The invention discloses a dual stimuli-responsive polymer micelle as well as a preparation method and application thereof. The micelle is jointly formed by a phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer and a catechol modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer, wherein the phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer is used for modifying the phenylboronic acid; when the micelle is formed, pH and ROS can be formed in a hydrophobic core to stimulate corresponding boric acid ester bonds; the micelle is used for loading hydrophobic antitumor drugs. The polymer micelle prepared by the invention can be stable in an in-vivo circulating physiological environment, and makes stimulation response to a tumor microenvironment to cause structure loosening or dissociation, so that effective delivery of hydrophobic antitumor drugs is realized, the problems of instability of the micelle in vivo and drug pre-leakage are effectively solved, and the drug delivery efficiency is improved. Theoretical and practical basis is provided for promoting cancer treatment of a polymer micelle drug delivery system.

The invention discloses silver-copper alloy nanoparticles with a core-shell structure as well as a preparation method and application of the silver-copper alloy nanoparticles. The core of the core-shell structure silver-copper alloy nanoparticle is a silver-copper alloy nanoparticle, and the shell of the core-shell structure silver-copper alloy nanoparticle is a ZIF-8 coating layer. The preparation method of the silver-copper alloy nanoparticles with the core-shell structure comprises the following steps: 1) preparing the silver-copper alloy nanoparticles; (2) preparing surface modified silver-copper alloy nanoparticles; and 3) dispersing the surface-modified silver-copper alloy nanoparticles, zinc salt and 2-methylimidazole in methanol for reaction. The silver-copper alloy nano-particles with the core-shell structure have the advantages of rich active sites, good catalytic effect, high cycling stability, mild reaction conditions, simple preparation method and the like, can be used for carboxylation of terminal alkyne and CO2 to generate propiolic acid compounds and carboxylation of propargyl amine and CO2 to generate 2-oxazolidinone compounds; and the method has a very wide application prospect.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of polysubstituted 1, 3-conjugated diene. The synthesis method of the polysubstituted 1, 3-conjugated diene comprises the following steps: in a protective atmosphere, with an organic solvent as a reaction medium, carrying out a reaction on a carboxylic acid compound, isonitrile and propargyl ester under the action of a weakly alkaline salt, a catalyst and a ligand to obtain the polysubstituted 1, 3-conjugated diene. The structure of the polysubstituted 1, 3-conjugated diene is shown in the specification. The method is simple, the raw materials are cheap and easy to obtain, the polysubstituted 1, 3-conjugated diene compound with rich and diversified structures can be constructed in one step, the yield is high, the substrate applicability is wide, and the atom economy is high. # imgabs0 #

The invention belongs to the field of medicinal chemistry, and relates to an indole allylamine amide derivative as well as a preparation method and application thereof. Functional activity screening of G protein dependent signaling pathways is carried out on all the synthesized compounds, and it is found that the new derivatives can be used for preparing beta2-adrenergic receptor allosteric antagonism regulator drugs. Trans-indole allylamine is used as a raw material, amide coupling is performed to obtain the novel indole allylamine amide derivative, and R1 is any one of phenyl, m-methylbenzene, m-methoxyphenyl, m-bromophenyl, m-chlorphenyl, m-fluorophenyl, o-methoxyphenyl, p-methoxyphenyl, naphthalene ring, oxazole, cyclohexyl, cyclopentyl, methyl, ethyl and isopropyl. A biological activity test result shows that the indole allylamine amide derivative disclosed by the invention has relatively good antagonistic activity on beta2AR and can be used for carrying out negative allosteric regulation on the functional activity of isoproterenol.

The invention provides an application of combination of SPRC and a PD-1 or PD-L1 inhibitor in preparation of a lung cancer immunotherapy sensitizing drug, and relates to the technical field of biomedicine.In the application, through in-vitro cell experiments, cell co-culture experiments and in-vivo animal experiments, S-propargyl-L-cysteine (SPRC) can play a sensitizing role in the anti-lung cancer curative effect of the PD-1 inhibitor, and can be used for preparing a sensitizing drug for lung cancer immunotherapy. The core mechanism is as follows: 30 [mu] M SPRC is in a non-cytotoxic dose window and can specifically inhibit IFN-gamma induced STAT1 phosphorylation and PD-L1 up-regulation by depending on a CSE / H2S pathway, while IFN-gamma-STAT1-PD-L1 is a core signal axis of PD-L1 adaptive up-regulation in lung cancer cells, and the induction effect of TNF-alpha on PD-L1 is relatively weak; meanwhile, SPRC can inhibit activation of NF-kB induced by TNF-alpha and expression of inflammatory factors such as IL-6 and IL-8 through the pathway so as to exert the anti-inflammatory effect, the CD8 + T cell depletion proportion can be remarkably reduced by combining SPRC with anti-PD-1, the synergistic tumor inhibition effect is formed, the effect is verified in in-vivo and in-vitro experiments, and a closed loop of an in-vitro mechanism and an in-vivo curative effect is achieved.

To provide a method, a perfuming composition and a perfumed consumer product for imparting long-lasting properties for standard perfumery raw materials which are too volatile or have a poor substantivity by themselves or which are only deposited in a small amount on the surface of the final application.SOLUTION: The present invention relates to compounds of formula (I) as properfume compounds. In particular, the present invention relates to a method of releasing a compound, namely, a carbonyl, a formate ester and / or an alcohol represented by specific formulas, by exposing the compound of formula (I) to an environment in which it is oxidized. Moreover, the present invention relates to a perfuming composition and a perfumed consumer product comprising at least one compound of formula (I).SELECTED DRAWING: None

The invention relates to a method for synthesizing an iodo-pyridine compound from N-propargyl enaminone, which comprises the following steps: by taking N-propargyl enaminone as a raw material, DMF (Dimethyl Formamide) as a reaction solvent and copper acetate and N-iodosuccinimide as accelerators, carrying out intramolecular coupling reaction at 60 DEG C to synthesize the iodo-pyridine compound. The method for directly synthesizing the pyridine heterocyclic compound through the intramolecular coupling reaction of the N-propargyl enaminone under the non-alkaline condition is disclosed for the first time, reaction substrates are not limited to benzene rings on alkynyl, the application range of the reaction is greatly expanded, and the method has the advantages of being wide in substrate range, strong in functional group application range, mild in reaction condition, easy to operate, safe, high in yield and the like. And raw materials are cheap.

Methods of labeling, processing and analyzing protein samples. Surface-accessible residues in a protein sample (such as a proteome) can be labeled using a carbodiimide coupling agent an amine comprising a click chemistry handle, such as glycine propargyl amide. The click chemistry handle can then be derivatized using high-yield "click" chemistry to form a stable linkage with an enrichable label. The proteome can then be digested, peptides that have been modified can be enriched, and the enriched peptides can be analyzed, for example, by mass spectrometry. The analyzed peptides can constitute a highly enriched subset of the original peptides while still representing many sites of modification on many proteins (~95%) originally present in the proteome. The methods can be used to identify solvent-accessible regions of proteins, conformational changes, and drug targets across a whole proteome.

The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing propargyl silane derivatives through nickel catalytic reduction coupling. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, and reacting a halogen-containing butyne compound with chlorosilane under the action of a catalyst, a ligand and a reducing agent to obtain the propargyl silane derivative. The structural formula of the propargyl silane derivative is I, the catalyst is a nickel catalyst, and the ligand is a nitrogen or phosphine ligand. The method disclosed by the invention is simple, low in cost, efficient in reaction, few in byproducts, easy to separate and purify and high in yield.

The application belongs to the technical field of nanofiltration, and provides a preparation method of recrystallized silicon carbide-silicon carbon nitride ceramic membrane. The application obtains a pyrolytic material by first applying a polysilazane solution on a porous base and then performing first pyrolysis; and obtains the recrystallized silicon carbide-silicon carbon nitride ceramic membrane by second applying the polysilazane solution on the pyrolytic material and then performing second pyrolysis. The application uses a solution containing propargyl polysilazane or an organic polysilazane Durazane 1500 rapid cure fast-drying resin as a precursor to prepare the ceramic membrane, and the ceramic membrane has high ceramic yield, excellent high-temperature stability, high rejection rate and controllable microstructure, and is suitable for separation and protection applications in extreme environments.

The invention relates to tryptanthrin derivatives with thiosemicarbazone substitution of the general formulae I and II, where R1-R8 are independently H, OH, alkyl with 1 to 6 carbon atoms, C(CH3)3, allyl, propargyl, ben-zyl, phenyl, F, Cl, Br, I, CH2OH, O (alkyl), CF3, OCF3, CN, COOH, COO(alkyl), CONH2, CONH(alkyl), NO2, N(alkyl)2, NH(alkyl), NHCO(alkyl), where the alkyl has 1 to 6 carbon atoms, or R1-R2 or R2-R3 or R3-R4 or R5-R6 or R6-R7 or R7-R8 is —CH═CH—CH═CH—, i.e., a fused benzene ring, X and Z are independently H, alkyl of 1 to 6 carbon atoms, benzyl or phenyl. The compounds combine a structural motif suitable for PLpro targeting, have strong affinity and selectivity for RNA over DNA, and at the same time effectively chelate ferric and ferrous ions. Thus, these compounds have the desired properties for potential use as inhibitors of the production of SARS-COV-2 viral particles and can thus be used for the preparation drugs for the treatment of coronavirus diseases, especially COVID-19.

The application discloses a propargyl polysiloxane modified cyanate ester resin and a preparation method and application thereof, and comprises the following steps: S1, a propargyl compound shown in formula I and polysiloxane shown in formula II are subjected to a heating reaction in the presence of a platinum catalyst and a solvent to obtain a propargyl polysiloxane; S2, the propargyl polysiloxane is mixed with a cyanate ester monomer, heated and stirred until a transparent solution is obtained, and subjected to a heat curing treatment to obtain the propargyl polysiloxane modified cyanate ester resin. The propargyl polysiloxane modified cyanate ester resin can be cured and formed at a lower curing temperature, and the prepared modified resin has lower dielectric loss, water absorption, higher impact strength and thermal stability, and has a good application prospect in high-end electronic materials.

This invention relates to a novel use of propargylcysteine ​​in the preparation of anti-mastopathy drugs. The invention discovers that S-propargylcysteine ​​can improve E2 / P imbalance by regulating HPO axis function and inhibiting abnormal activation of the GnRH-sex hormone axis; it also reduces the inflammatory microenvironment by inhibiting the release of inflammatory factors; ultimately, it downregulates ER / PR-mediated proliferation signals and inhibits PCNA expression locally in the breast. Through multi-target regulation of neuroendocrine, inflammatory responses, and proliferation-related signaling pathways, it effectively alleviates breast hyperplasia and its associated chronic stress-induced depressive-like behaviors, thus exerting anti-mastopathy and therapeutic effects on breast hyperplasia complicated with depression.

The invention discloses a continuous flow preparation method of polysubstituted propargyl alcohol, which uses a microtube continuous flow reaction device and comprises the following specific steps: simultaneously conveying acetylene gas or terminal alkyne compound and an organic alkali solution into a mixer for premixing; simultaneously conveying the keto-carbonyl substrate and the flowing-out reaction liquid to a reactor to carry out an alkyne hydrogenation reaction; and carrying out gas-liquid separation on the outflowing reaction liquid, and rectifying in a rectifying tower to obtain a target propargyl alcohol product. According to the method for continuously preparing the polysubstituted propargyl alcohol by using the continuous flow reaction system, full mixing of reaction materials of each reaction unit and accurate control of the reaction can be realized by regulating and controlling pipeline parameters, the automation degree is greatly improved, the manual operation is reduced, the energy consumption cost is reduced, and the method is suitable for industrial production.

The invention discloses a nickel pre-plating additive suitable for a high area and an electroplating method. The invention discloses a cleaning agent, which comprises the following five main functional additives: 10-20 wt% of a surfactant, 10-20 wt% of a brightening agent, 4-8 wt% of a leveling agent, 10-15 wt% of a softening agent, 8-12 wt% of a surface cleaning agent, 1-3 wt% of a wetting agent and the balance of five main functional additives. Wherein the brightener mainly comprises one or a mixture of more of pyridinium propyl sulfobetaine (PPS), a sodium allysulfonate aqueous solution (ALS), trichloroacetaldehyde hydrate (TCA), 1, 4-butynediol (BOZ), pyridinium hydroxy propyl sulfobetaine (PPS-OH) and butynediol ethyl oxide (BEO). The leveling machine mainly comprises one or a mixture of more of pyridinium sulfobetaine (PPS), propargyl alcohol ethyl oxide (PME), propargyl alcohol propoxy compound (PAP), butynediol propoxy compound (BMP), N, N-diethyl propargyl amine formate (PABS) and pyridinium hydroxy propyl sulfobetaine (PPS-OH). The softening agent mainly comprises one or a mixture of more of a sodium allysulfonate aqueous solution (ALS), sodium allysulfonate (SAS), N, N-diethyl propynylamine (DEP) and propinyl-3-sulfopropyl ether sodium salt (POPS). The surface cleaning agent mainly comprises one or a mixture of more of sodium gluconate, sodium benzoate, sodium salicylate, sodium acetate, sodium hypophosphite and 2, 5-dimethyl-3-hexyne-2, 5-diol (HD-M). The wetting agent mainly comprises one or a mixture of more of 2-ethylhexyl sodium sulfate (TC-EHS), sodium dihexyl sulfosuccinate and sodium mono (2-ethylhexyl) sulfate. The corresponding substances are classified according to the characteristics of the additive, and the dispersing capacity of the plating solution is remarkably enhanced by utilizing mutual synergism and combined action of different substances and matching with the formula of the Watt plating solution. Meanwhile, matching is carried out according to the characteristics of the nickel pre-plated steel strip, and the nickel pre-plated steel strip has the advantages of being suitable for a high-current-density interval, adjustable in coating glossiness, good in coating ductility, good in compactness, few in pinhole, few in blue point and the like.

This disclosure relates to a process for the synthesis of a compound of formula (I): (I) wherein w, x, y, and z are as defined in the description. The process includes the reaction of a compound of formula (II): (II) with carbonyldiimidazole, and the reaction of the resulting compound with propargylamine.

The invention relates to the technical field of pesticide preparations, in particular to a preparation method of a propionate and oligosaccharin compounded soluble concentrate, which is realized by the following steps: firstly, preparing a mixed solvent; performing ultrasonic and nanometer grinding treatment on the propionate raw medicine, and dissolving the propionate raw medicine in the mixed solvent to obtain a propionate solution; then adding an oligosaccharin combination, and carrying out gradient stirring to obtain a compound stock solution; then, lentinan, a surfactant, a compound stabilizer and other assistants are sequentially added, secondary filtration is performed, and finally the volume is fixed to obtain a finished product. The problems that an existing compound preparation is poor in lipid-water compatibility, insufficient in extreme environment stability and weak in crop stress resistance adaptation are solved, synergism of antifungal, antiviral, cold-resistant, lodging-resistant and quality-improving and yield-increasing is achieved, the compound preparation is particularly suitable for crops such as rice and tobacco in cold regions, the process is compatible with an existing production line, and the compound preparation has wide application prospects.

The present invention provides a method for preparing propargyl sulfones by a multi-component coupling reaction with SO2 insertion. Using propargyl acetate, aryl iodide, and solid sulfur dioxide (SO2) reagent as raw materials, in the presence of a palladium catalyst, a ligand, a base, a reducing agent, and an additive are simultaneously added, and a multi-component coupling reaction with SO2 insertion is carried out in an organic solvent to obtain propargyl sulfones as shown in formula (III). This preparation method quickly obtains propargyl sulfones through a multi-component one-pot method, with good atom and step economy. This method avoids the use of extremely foul-smelling thioethers and toxic sulfur dioxide gas, and has good environmental friendliness. In addition, the reaction has good yields, good functional group tolerance, strong substrate generality, and strong versatility and practicability.

The present invention provides an organic film-forming composition, a pattern-forming method, and an organic film-forming compound and polymer. The solution provided by the present invention is an organic film-forming composition characterized by containing an organic film-forming material represented by the following general formula and an organic solvent. In the general formula, R1 is a hydrogen atom, an allyl group, or a propargyl group; R2 is a nitro group, a halogen atom, a hydroxyl group, an alkyloxy group having 1 to 4 carbon atoms, an alkynyloxy group having 2 to 4 carbon atoms, an alkenyloxy group having 2 to 4 carbon atoms, a linear, branched, or cyclic alkyl group having 1 to 6 carbon atoms, a trifluoromethyl group, or a trifluoromethyloxy group; m = 0, 1, n = 1, 2, l = 0, 1, k is an integer from 0 to 2, W is a divalent organic group having 1 to 40 carbon atoms; and V each independently represents a hydrogen atom or a linking moiety.

This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

The present disclosure relates, in one aspect, to propargyl amino-ionizable lipid compounds of formula (I), and methods of preparing the same. In another aspect, the disclosure relates to lipid nanoparticles (LNPs) comprising at least one ionizable lipid of formula (I) or (III). In another aspect, the LNPs of the disclosure are useful for gene editing applications. In another aspect, the LNPs of the disclosure are useful for splenic delivery of therapeutic cargo.

The invention relates to a nano nickel electroplating process used after secondary zinc deposition of an aluminum alloy. The nano nickel electroplating process comprises two steps of preparing a plating solution and electroplating. A nano nickel agent A and a nano nickel agent B are added into the plating solution, and the nano nickel agent A comprises, by mass, 5%-9% of nickel sulfate, 6%-10% of sodium propargyl sulfonate, 5%-9% of sodium hypophosphite monohydrate and 72%-84% of deionized water; and the nano nickel B agent comprises the following components in percentage by mass: 5-9% of butynol alcohol ether sodium propane sulfonate, 6-10% of sodium propargyl sulfonate, 5-9% of sodium hypophosphite monohydrate and 72-84% of deionized water. Sodium propargyl sulfonate is coordinated with Ni < 2 + > in a high-activity area of a workpiece through electrostatic adsorption and coordination so as to inhibit deposition of Ni < 2 + >; the surface energy of a low-activity area of the workpiece is low, Ni < 2 + > deposition is basically not affected, negatively-charged propargyl sulfonate radicals can be attracted by weak positive charges in the area, and continuous generation of new crystal nucleuses is promoted. The sodium hypophosphite monohydrate can prevent Ni < 2 + > from being oxidized through reaction with oxygen. Butynol alcohol ether sodium propane sulfonate inhibits overgrowth of crystal grains and refines the crystal grain structure through adsorption and steric hindrance effect.

Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

The present invention relates to the field of chemical engineering technology, and particularly to a method for synthesizing propargyl esters based on N-benzylideneaziridine. The propargyl esters are obtained by an esterification reaction of propargylic acid compounds and alcohol reagents in the presence of N-benzylideneaziridine. In a reactor, N-benzylideneaziridine, propargylic acid compounds, and alcohol reagents are added, and the reaction is carried out at room temperature for 24-48 hours. After the reaction is completed, the remaining alcohol reagents participating in the reaction are evaporated to dryness, and the propargyl esters are obtained after purification. This method has cheap and easily available raw materials, simple operation, mild conditions, and does not require the addition of a catalyst.

The present invention discloses a polysubstituted alkylaryl azo compound, its synthesis method, and application. The present invention provides polysubstituted alkylaryl azo compounds as shown in Formula I and Formula II. Using propargyl reagents and hydrazones as substrates and various nitrogen heterocyclic carbene (NHC) ligands, allene products or propargyl-substituted products can be prepared with high selectivity, all of which contain azo functional groups. The polysubstituted alkylaryl azo compounds prepared by the present invention provide a technical solution that is completely different from the prior art for preparing polysubstituted α-quaternary carbon amine compounds, achieving good yield and selectivity. #imgabs0#

The application relates to the technical field of acoustic materials, in particular to a sound matching material, a preparation method thereof, an ultrasonic transducer, an ultrasonic probe and an ultrasonic imaging device. The sound matching material comprises a polystyrene telechelic polymer with a chemical structure as shown in formula I: wherein n1 and n2 are positive integers; X comprises at least one of halogen atoms, hydroxyl groups, carboxyl groups, amino groups, propargyl groups, methoxyl groups, azido groups, pyrimidyl groups and malonate groups. The sound matching material has not only good low sound attenuation characteristics, but also good bonding performance, can improve the stable reliability of sound transmission, and has a good application prospect in medical ultrasonic probes.