2522results about How to "Growth inhibition" patented technology

A preparation method of a ferment Chinese Traditional Herbs for feeding belongs to the production field of the feed additives. The technical proposal provided by the present invention is that one or various intestinal probiotics is inoculated on a cultivation matrix containing extracts of Chinese Traditional Herbs, and undergoes ferment cultivation in a proper condition. The probiotics include Lactobacillus acidophilus, Bacillus subtilis, and candida utilis, etc, and the selected Chinese Traditional Herbs include astragalus, atractlylis lancea formalyrata, codonopsis pilosula, pericarpium citri reticulatae, and atractylis atractylis ovata, etc. The ferment Chinese Traditional Herbs for feeding provided by the present invention used to breed the livestock and the poultry is capable of preventing and treating epidemic diseases and improving the growth of the animal. The biological ferment of the water extract of Chinese Traditional Herbs by the probiotics is utilized to produce the elements with higher activities, thereby improving the absorption, transportation, metabolism, activation and medical efficacy of the Chinese Traditional Herbs in human body.

The invention relates to a medicine of a bispecific monoclonal antibody, and especially to a medicine of a bispecific monoclonal antibody to human vascular endothelial growth factor (VEGF/VEGF-A) and platelet-derived growth factor receptor (PDGFR) for resistance to angiogenesis of tumor. The bispecific antibody to VEGF/PDGFR beta provided in the invention is characterized in that: a monoclonal antibody to VEGF is used as the base for the antibody and a single chain antibody to PDGFR beta is connected with the terminal of FC segment of the monoclonal antibody to VEGF to form the bispecific antibody to VEGF/PDGFR beta. The bispecific antibody related to in the invention is obtained by employing technical means like gene engineering and constructing antibody segments which identify VEGF and PDGFR beta in a same antibody molecule that can be specifically bound with the two antibody segments; the effect of the bispecific antibody on inhibiting angiogenesis of tumor issue is obviously superior to that of a single antibody to VEGF; and the bispecific antibody has good activity in resisting tumors.

Methods and compositions relating to recombinant anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells.

The invention provides methods for the selection of transgenic cells. The invention relates to the unexpected finding that cells expressing a gene conferring tolerance to auxin-like herbicides such as dicamba may be directly selected from non-transgenic cells using auxin-like herbicides as a selective agent. In this manner, plants exhibiting tolerance to auxin-like herbicides can be directly produced without the need for separate selectable markers.

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., a B-cell cancer such as Hodgkin's lymphoma or acute lymphoblastic leukemia). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to programmed death 1 (PD-1) receptor in combination with a therapeutically effective amount of a bispecific antibody that specifically binds to CD20 and CD3.

The invention provides recombinant immunotoxins that have been modified from a parental immunotoxin to lower liver toxicity. The immunotoxins are created by specifically mutating charged residues in the framework regions of the heavy chain, the light chain, or both, of the antibody portion or antigen-binding fragment thereof of the parental immunotoxin to reduce the pI of the antibody or fragment. In preferred forms, the antibody portion of the parental is an anti-Tac, anti-mesothelin, or anti-LewisY antigen antibody or antigen-binding fragment, and in particularly preferred forms the antibody portion is an M16 dsFv, a St6 dsFv or a Mt9 dsFv, or a sequence that has at least 90% sequence identity to one of these molecules but retain the particular mutations that lower pI without affecting antibody activity. The invention further provides nucleic acids encoding the recombinant immunotoxins of the invention, expression cassettes comprising the nucleic acids, and host cells comprising the expression cassettes. The invention also provides a method for killing a cell comprising an antigen on the surface of the cell, the method comprising contacting the cell with a recombinant immunotoxin of the invention that has an antibody or antigen-binding fragment thereof that binds specifically to the antigen on the surface of the cell, and uses of immunotoxins of the invention for the manufacture of medicaments.

An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual, anti-microbial “invisible glove” on the skin. The composition provides an immediate reduction in bacterial microbes. The polymer system creates an invisible film on the skin following solvent evaporation. This invisible film provides a lasting anti-microbial barrier on the skin which acts to prevent microbial growth.

The present invention relates to materials and methods for the in vivo transport and deliver of nucleic acids. More particularly, it concerns the use of lipoproteins, including but not limited to, low density lipoproteins ("LDL"), and/or apolipoproteins for the binding and in vivo transport of nucleic acids. In addition, the present invention relates to the use of lipoproteins in the early detection of cancer and/or metastatic cancer and/or arteriosclerosis.

A display device in which interconnection—electrode comprising a Cu alloy film having a lower electrical resistivity than Al alloy and a transparent conductive film are directly connected not by way of a refractory metal thin film, wherein the Cu alloy film contains Zn and/or Mg in a total amount from 0.1 to 3.0 at %, or Ni and/or Mn in a total amount from 0.1 to 5 at %, thereby enabling the direct connection at low resistivity between the Cu alloy film and the transparent electrode without using a barrier metal, and giving high display quality in a case of application, for example, to a liquid crystal display.

An object of the present invention is to provide nickel cobalt manganese composite hydroxide particles having a small particle diameter and a uniform particle size distribution, and a method for producing the same.

[Solution]

A method for producing a nickel cobalt manganese composite hydroxide by a crystallization reaction is provided. The method includes: a nucleation step of performing nucleation by controlling a pH of an aqueous solution for nucleation including metal compounds containing nickel, cobalt and manganese, and an ammonium ion donor to 12.0 to 14.0 in terms of the pH as measured at a liquid temperature of 25° C. as a standard; and a particle growth step of growing nuclei by controlling a pH of an aqueous solution for particle growth containing nuclei formed in the nucleation step to 10.5 to 12.0 in terms of the pH as measured at a liquid temperature of 25° C. as a standard.

The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules.

Compositions comprising a Labiatae herb extract and a hop extract containing beta acids and methods of using them to extend the color life and retard the growth of microorganisms in fresh meat, fish and poultry stored in an atmosphere that contains 20% or more oxygen.

The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of preventing or treating persistent chronic gastritis, ulcers and/or stomach cancer in subjects at risk for, or in need of treatment thereof.

A contaminant-removal filter for removing basic contaminants from a gas stream, such as air. The filter has a porous or fibrous body that includes a plurality of passages extending from a first, inlet face to a second, outlet face, the passages providing flow paths. The body has an acidic material, such as citric acid, and at least one of a preservative and a stabilizer impregnated throughout the substrate. The filter is free of any humectants.

The invention provides a method for continuously synthesizing a precursor of a lithium ion battery positive material, relating to an improvement of a synthesis method of a nickle cobalt manganese termary positive material nickle cobalt lithium manganate of the lithium ion battery positive material. The method is characterized in that the synthesis process is as follows: merging a complexing agent ammonia, an aqueous solution of metal nickle cobalt manganese ions and a precipitator sodium hydroxide solution and then continuously adding the substances into a reaction kettle for a synthesis reaction under the strong stirring condition in the presence of protective gas; and aging, filtering and washing the effluent from the reaction kettle, and then drying to obtain the lithium ion battery positive material precursor spherical nickle cobalt manganese termary hydroxide. The method has the advantages that the preparation process is continuous, the particle size of the prepared nickle cobalt manganese compound hydroxide powder is controlled in a range of 5-20 microns, and the prepared nickle cobalt manganese compound hydroxide powder is even in distribution and excellent in electrochemistry property. The method has the advantages of high production efficiency, low production cost and significant economic and social benefits, and the energy is saved.

The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Th1 response, leading to an enhanced antitumor cytotoxic T-cell response.

The invention relates to sterilized type organic fertilizer. The sterilized type organic fertilizer consists of the following raw materials in percentage by weight: 55 to 70 percent of chicken manure leavening, 6 to 25 percent of plant crushing materials, 5 to 10 percent of organic additive and 6 to 15 percent of inorganic additive. The sterilized type organic fertilizer has high sterilization effect, provides various nutritive elements for crops, has a simple process, and is convenient to use and to be popularized and applied in large scale.

Feedback systems and methods enhance obstructive and other obesity treatments by presenting feedback regarding patients' actual eating and/or exercise habits. An ingestion restricting implant body can be deployed along the gastrointestinal tract. In some embodiments, ingestion alters the implant body, which, in turn, generates signals. The generated signals can be used to inhibit unhealthy ingestion by the patient. In other embodiments, the implant body can be altered by signals so as to selectable change the restriction imposed on the gastrointestinal tract, optionally in response to ingestion events, an eating schedule, or the like. The implant body may comprise a gastric band or an intragastric balloon. Sensor signals may be processed to identify ingestion and/or characterize ingestion of a solid or a liquid, and the results may be displayed on a screen for a patient or coach to view.

The invention relates to an innocent treatment method for animal carcasses died of illness and organic wastes. The innocent treatment method comprises the following steps: collecting to-be-treated materials of animal carcasses died of illness and organic wastes, then, mixing the to-be-treated materials and auxiliary materials as organic matters including wood flour and rice husk, and next, supplementing water until the water content is up to 50-60%; adding a compound microorganism preparation into a treatment tank; carrying out micro-biological degradation so as to ensure that main components such as the animal carcasses died of illness, various organic wastes and the like can be completely degraded within 24 hours and can be processed into an available organic fertilizer. The innocent treatment method is reasonable in process, simple and convenient in operation, energy-saving, environment-friendly, pollution-free and capable of utilizing the animal carcasses died of illness and the organic wastes as fertilizers.

The present invention is process of twice fermenting garbage-sludge mixture to produce microbial fertilizer. The production process can eliminate environment pollution caused garbage and sludge while providing environment friendly efficient microbial fertilizer. The produced microbial fertilizer has high fertility, beneficial bacteria content up to 10<8>-10<10>/g and various bioactive matters. The produced microbial fertilizer can promote the growth of crop, strengthen the disease resistance of crop and raise yield of crop.

The present invention discloses an inorganic-organic nano composite solid electrolyte membrane and a preparation method and application thereof. The composite solid electrolyte is a novel inorganic-organic nanocomposite combining the respective advantages of inorganic ceramic solid electrolyte and organic polymer electrolyte and is composed of a negative electrode protective layer, a support layerand a positive electrode interface layer. The support layer plays a supporting role, and the main component of the negative electrode protective layer is the inorganic solid electrolyte with good mechanical properties, which can effectively inhibit the growth of lithium dendrite; and the positive electrode interface layer is mainly composed of organic polymer electrolyte with good flexibility, ensures good contact with active materials and provides a continuous ion transport channel. In the present invention, the composite solid electrolyte with good interface compatibility is prepared by coating on both sides of the support layer, and the process is simple and efficient. The composite solid electrolyte can effectively inhibit dendritic crystal and reduces interface resistance so that a solid lithium metal battery has higher energy density and longer cycle life.

The invention discloses freshwater fish feed and a preparation method thereof. The feed comprises the following materials in percentage by weight: 5%-17% of import fish powder, 8%-22% of flour, 3%-16% of potato starch, 3%-18% of beer yeast, 5%-15% of bean pulps, 5%-15% of peanut pulps, 5%-10% of rape seed cakes, 2%-8% of corn powder, 3%-9% of cooked egg protein, 5%-8% of dried meat floss powder, 1%-2% of liquid phytase, 1%-3% of non-starch polysaccharase, 0.5%-1.9% of glutamine, 1%-2% of microecological preparation and 1%-3% of immune polysaccharides. The preparation process comprises a crushing step, a mixing step, a pelletizing step and a spraying step. The freshwater fish feed has the beneficial effects of being capable of well satisfying the nutrition needs of freshwater fish, improving the immunity of the freshwater fish, prompting intestinal absorption and improving the production performance of the freshwater fish.

The present disclosure provides a lithium-ion battery positive electrode material and a preparation method thereof. In the lithium-ion battery positive electrode material, a secondary particle comprises lithium-containing multi-element transition metal oxide primary particles and a second phase material, a second phase material forms a second phase material layer distributed on a surface of the primary particle and forms a diffusion layer together with the lithium-containing multi-element transition metal oxide by means of atoms mutual diffusion to make the second phase material layer combined with the primary particle during formation of the secondary particle from the primary particles, thereby effectively suppressing chalking of the secondary particle along boundary among the primary particles, and effectively controlling size of the primary particles and the secondary particles, and improving specific capacity, cycling performance and safety performance of a lithium-ion battery to which the lithium-ion battery positive electrode material is applied.

The present invention provides non-coding regulatory element molecules isolated from the adenylate translocator protein gene and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the polynucleotide molecules useful for expressing transgenes in plants.

The invention relates to a preparation method of a soil conditioner, belonging to the technical field of fertilizer preparation. The soil conditioner is mainly prepared from the following raw materials in parts by weight: 50-70 parts of plant straw carbon, 20-35 parts of fowl/livestock dung, 10-15 parts of bone meal, 1-8 parts of potassium sulfate, 2-8 parts of wood vinegar liquid, 3-9 parts of plant growth regulator and 0.5-1 part of active agent. The preparation method comprises the following steps: preparing carbon powder, pretreating the fowl/livestock dung, preparing a mixture, assaying and detecting, granulating and packaging. The soil conditioner is prepared by mixing the crop straw/bamboo/wood/grass carbon, which is used as the main component, with certain amounts of trace elements, plant growth regulator and bamboo/wood/grass vinegar liquid; since the soil conditioner not only is rich in the three main nutrient elements (nitrogen, phosphorus and potassium) which are essential for crops, but also contains secondary and trace elements, such as calcium, magnesium, sulfur, iron, boron, molybdenum, copper, cobalt and the like, the nutrient proportion of the soil conditioner is reasonable; and when being used as a conditioner, the soil conditioner can increase the organic content of soil and provide more comprehensive nutrients for crops, so that the crops have the advantages of good growth vigor, plump grains and much higher yield.

A multi-layer moisture management fabric composite includes a three-dimensional fabric spacer. The spacer forms a first layer of the fabric composite. The spacer has a first facing adapted for residing nearest the skin, a second facing, and an intermediate spacer yarn interconnecting the first and second facings. A plurality of overlying moisture-absorbent layers reside outside of the spacer, and are adapted for receiving and dispersing moisture entering the fabric composite and passing through the first layer. A liquid impermeable jacket resides outside of the absorbent layers and defines an outermost layer of the fabric composite adapted for trapping liquid moisture within the absorbent layers.

The present invention provides methods of coating or impregnating medical devices with an antiseptic composition that will inhibit or prevent the nosocomial infections typically associated with the use of such medical devices. The present invention further provides methods of coating or impregnating medical devices that produce devices with effective activity against infection, while avoiding destroying the devices or causing the devices to become toxic. In addition, the invention provides medical devices coated or impregnated with antiseptic compositions by the aforementioned novel methods.

The invention discloses a method and a system for preparing restaurant-kitchen wastes into a livestock and poultry feed, wherein the method comprises the following steps: carrying out sorting preprocessing on restaurant-kitchen wastes so as to obtain biodegradable restaurant-kitchen wastes; carrying out solid-liquid separation on the obtained biodegradable restaurant-kitchen wastes; adding bran, corn flour and coarse meal into the obtained product so as to obtain a mixed material; adding composite fungicides into the mixed material according to the inoculum concentration (8-20 wt%) so as to ferment the mixed material; and finally, drying and cooling the fermented mixture, then packing the obtained object so as to obtain a livestock and poultry feed product. The system comprises a feed device, a wet sorting machine, a pressafiner, an agitated mixer, a fermentation tank, a low-temperature drying machine, a crusher and a finished product material storage tank which are sequentially connected; and the system has the advantages that the growth of putrefying bacterias and the reproduction of pathogenic microorganisms in restaurant-kitchen wastes can be inhibited, and the freshness retaining effect and organoleptic quality of the livestock and poultry feed are good; meanwhile, the protein content of the livestock and poultry feed can be improved; in addition, the system is low in used equipment cost, small in energy consumption, high in production efficiency and beneficial to environmental protection.

The invention relates to the field of deodorization, and especially relates to a plant extract and microbe composite deodorant. According to the invention, a plant extract and a microbial fermentation broth are mixed according to a ratio of 1:3; the mixture is placed in plastic buckets; and sealed anaerobic fermentation is carried out for 5-9 days, such that the composite deodorant is obtained. The microbial fermentation broth is obtained through the following steps: saccharomycetes, lactobacillus, bacillus subtilis, acetobacter pasteurianus and photosynthetic bacteria are inoculated according to the ratio of 1-4:2-6:5-25:1-4:1-2, and mixed fermentation is carried out; and after 60-84h of aerobic fermentation, the microbial fermentation broth is obtained. The invention aims at providing the plant extract and microbe composite deodorant. Deodorizing is realized with the combination of the plant extract and microbes. With the deodorant, fast and continuous deodorization can be realized; production cost is reduced; and a deodorization effect is good. With the deodorant, deodorization can be achieved fundamentally.