195results about How to "Effective approach" patented technology

This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.

Breed-specific dog food formulations that comprise chicken meat as the major ingredient, rice as the predominant (or sole) grain source, fruit and / or vegetable fiber as the primary or sole fiber source, unique fat and antioxidant blend, vitamins, herbs and spices, carotenoids, and no corn or artificial colors, preservatives, flavors or sugars are provided.

The electrical vehicle energy storage system permits the electric refueling of the electric vehicle just like an automobile would be refueled with gasoline at a gas station. Circuitry on board the vehicle accessible by the electric refueling station enables the determination of the energy content of the battery module or modules returned to the electric refueling station and the owner of the vehicle is given credit for the energy remaining in the battery module or modules which have been exchanged. Selective refueling may take place for given battery modules by removing them from the battery system and charging them at home, office or factory. A process for operating an electric vehicle is also disclosed and claimed.

A system and method are provided to alert two mobile communications users in the event they come in close proximity to one another. The present system uses a distributed algorithm denoted as the Strips algorithm, in which a pair of moving friends with mobile telecommunications devices makes an agreement about a static buffering region between them. After the agreement is made, the users do not need to follow each other's location until one of them enters the buffering region for the first time. By doing so, they invalidate the agreement. Consequently, they replace a location update message between them, determine if they got within the vicinity of each other, and otherwise make a new agreement on a new buffering region. When one of them enters the buffering region for the first time, a message is sent to both friends alerting them of the proximity of the other.

Microbial ecology of a specimen is evaluated using an approach (Level I) that utilizes nucleic acid amplification with specific gene primers that will identify panels of microorganisms and antibiotic-resistance factors generating a diagnostic report (optionally with quantification of each microorganism or antibiotic-resistance factor) and an approach (Level II) that utilizes universal or semi-universal primers to amplify conserved genes at a general or specific taxonomic level that are tagged specimen specifically using a genetic or chemical marker that is specific to the specimen from which it was derived, then sequencing the amplified products with highly-parallel, high-throughput technology to provide comprehensive sequences of the microbial population in the specimen followed by analysis of this sequence information and specific targeted information from Level I and / or Level II to generate a comprehensive analysis, interpretation, and / or diagnostic report.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

A method for maintaining a cache of dynamically generated objects. The method includes storing in the cache dynamically generated objects previously served from an originating server to a client. A communication between the client and server is intercepted by the cache. The cache parses the communication to identify an object determinant and to determine whether the object determinant indicates whether a change has occurred or will occur in an object at the originating server. The cache marks the object stored in the cache as invalid if the object determinant so indicates. If the object has been marked as invalid, the cache retrieves the object from the originating server.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of LAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

Systems and methods to generate business recommendations for specific business actions based on weather element forecasts and known relationships between a business activity and weather elements are provided. The system includes a confidence level filter, an opportunity matrix filter, a weather decision point generator, a business rule recommendation engine and a business rule knowledge database. Methods to generate a business recommendation for a business activity are also provided. The methods include receiving weather driven demand data, assigning opportunity measures to each of the data points, identifying weather decision points based on opportunity measures, and applying business weather rules to the weather decision points to generate business recommendations. In a further feature, a weather element relationship and / or a weather element forecast confidence level is assigned to each data point within the weather driven demand data. These confidence levels are then factored in to determine weather decision points.

A system and method is disclosed for formal verification of software programs that advantageously translates the software, which can have bounded recursion, into a Boolean representation comprised of basic blocks and which applies SAT-based model checking to the Boolean representation.

An ink container includes an ink accommodation chamber for directly accommodating ink; a sensor portion for detecting a remaining amount of the ink in said ink accommodation chamber, wherein ambient air is introduced from an outside of said ink accommodation chamber into the ink in accordance with supplying the ink into an ink jet recording head; a division wall extended from an inner bottom portion of said ink accommodation chamber substantially upwardly, said division wall divides a space between an ambient air introducing portion which introduces the air into the ink in said ink accommodation chamber and said sensor portion to permit passage of the ink therethrough and to prevent passage, therethrough, of bubbles which are produced with introduction of the air.

A method and a system for image haze removal are provided. The method includes the following steps: receiving an input hazy image including input pixels; determining a hybrid dark channel for each of the input pixels according to a first minimum dark channel of a corresponding large local patch and a second minimum dark channel of a corresponding small local patch; determining a transmission map for each of the input pixels according to the hybrid dark channel prior, the corresponding hybrid dark channel, and atmospheric light associated with the input hazy image in each color channel; determining a color spectrum adjustment parameter corresponding to each of the color channels; recovering scene radiance for each of the input pixels in each of the color channels according to the corresponding color spectrum adjustment parameter, the transmission map, and the corresponding atmospheric light to produce and output a de-hazed image.

Embodiments of the invention present an approach to conversion rate estimation which relies on using past performance observations along user, publisher, and advertiser data hierarchies. More specifically, embodiments of the invention model the conversion event at different select hierarchical levels with separate binomial distributions and estimate the distribution parameters individually. It is shown how to combine these individual estimators using logistic regression to identify conversion events accurately. Embodiments of the invention can also handle many practical issues, such as data imbalance, missing data, and output probability calibration, which render this estimation problem more difficult for a real-world implementation of the approach.

Method for evaluating cement integrity in a cased well environment using a logging tool that has a neutron source and one or more neutron or gamma ray detectors. Neutron porosity logs are obtained from the well before (42) and after (41) casing. This log data along with well dimensions and material composition parameters are the input quantities to a multi-parameter database (43) that is constructed by computer modeling or laboratory experiments to relate volume fraction for fluid filled channels in the cement sheath to the input quantities. The channel volume fraction (45) corresponding to the input quantities is identified or interpolated (44) from the multi-parameter database.

An apparatus that allows a glove wearer or the wearer of a prosthetic limb to operate a device having a capacitive touchscreen is disclosed. The first embodiment of the disclosed invention is a conductive finger sock that can be applied to the tip or all of a digit of a non-conductive artificial limb. The second embodiment is an adhesive element having a conductive material such as conductive thread or a conductive sponge material. The adhesive element can be attached to a glove or to a prosthetic limb or may be used as an actual bandage. The third embodiment is directed to a factory integrated conductive tip that is part of a digit of a non-conductive artificial limb. The conductive element may be attached to the wearer's skin by a conductive line or may be used without the conductive line and thus may function in isolation.

An abstraction layer is provided between databases of back office systems and a markup language based interface, which may allow Web access to data in the databases of the back office systems. Schemas, metadata and validation files are generated from an intermediary representation of the database, which may be flat, non-hierarchical files. Markup language based templates may be generated based on the schemas, metadata and validation files. Markup documents or “markup” may be generated using the templates and the schemas, metadata and validation files. Workflow may be defined and imposed on the generation of the markup.

This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates generally to bioparticle separation, bioparticle enrichment, and electric field-mediated immunochemical detection on active electronic matrix devices utilizing AC and DC electric fields. More specifically, the invention relates to devices and methods for sample preparation / manipulation, immunoimmobilization, and immunoassays, all of which can be conducted on one or more active electronic chip devices within a single system. These manipulations are useful in a variety of applications, including, for example, detection of pathogenic bacteria and biological warfare agents, point-of-care diagnostics, food or medical product quality control assays, and other biological assays.

The present invention relates to a stable solid-state Raman laser (1), the solid-state Raman laser including: (a) a resonator cavity defined by at least two reflectors (M1 and M2), (b) a laser material (2A) located in the resonator cavity and capable of generating a cavity laser beam which propagates within the resonator cavity, (c) a solid Raman medium (7) located in the resonator cavity for shifting the frequency of the cavity laser beam to produce a Raman laser beam which propagates within the resonator cavity; and (d) an output coupler (M2) for coupling and outputting the Raman laser beam from the resonator cavity, wherein at least one parameter selected from the group consisting of (i) the position of the laser material (2A) relative to the position of the Raman medium (7) in the cavity, (ii) the length of the cavity and (iii) the curvature of at least one of the reflectors (M1 or M2), is selected such that changes in the focal lengths of both the laser material (2A) and the Raman medium (7) as a result of thermal effects in the laser material (2A) and the Raman medium (7) during operation of the laser do not substantially cause instability in the power of the output Raman laser beam. A method of maintaining stable operation of a solid state Raman laser is also described.

A direction-recognizing apparatus has a photographing unit, an image database, an image-recognizing unit, and a direction-recognizing unit. The database stores registered images and direction-data items associated with the registered images. The image-recognizing unit receives an input image and compares the input image with the registered images stored in the database. The image-recognizing unit selects one registered image that is identical or similar to the input image. The direction-recognizing unit recognizes a direction from the direction data associated with the registered image selected by the image-recognizing unit. The database may store N direction-data items associated with N surface segments SN of the circumferential surface of a pole 100. If so, the images registered in the database represent direction-recognition regions ASN that are larger than the N surface segments SN.

An efficient approach to exploit hyperspectral imagery and detect target of interest is disclosed. This approach uses proximity pixels as reference signatures to detect potential discontinuity that represents material of unknown existing on the terrain. By incorporating signature of a chosen material of interest, this approach provides an effective way for target detection and identification. An evolutionary algorithm is employed to estimate the abundance of material of interest.

Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural variable heavy chain III (“VH3”) Ig-Fab binding region (“binding region”) of SpA, wherein the polypeptide exhibits a different binding specificity for Ig-Fab than does SpA or exhibits a different binding specificity for a non-Ig target molecule than does SpA. Further provided are methods of making the variants and methods of using the variants, as well as native SpA, for in purification of Ig as well as diagnostic and therapeutic intervention.

Sheet metal forming is a manufacturing process in which flat sheet metal is drawn into a die cavity to form a product shape. Draw-in amount is the single most important stamping index that controls all forming characteristics (strains and stresses), formability failures (splits, wrinkles) and surface quality (distortions) on a panel. Adaptation of a new die set for repetitively stamping sheet metal parts to a part design specification is simplified by using a math-based simulation of the stamping operation under specified engineering stamping conditions for the specified part. The stamping simulations are used to create an engineered draw-in map comparing selected locations on the peripheral edge of the stamped part with corresponding locations on the peripheral edge of its original sheet metal blank. The resulting map of sheet metal draw-in dimensions reflect suitable displacements of the metal sheet between the binder ring and binder surface of the female die member at all such locations as the punch member of the die set executes its stamping operation. The engineered draw-in dimensions for a simulated part identify specific locations for adjustment of the binder ring / binder surface system in adapting the die set for production of parts.

An ion source(s) is configured to generate ions from one or more elements including a plurality of different isotopes or unique molecular combinations of two or more different isotopes from at least one of the selected elements. A selection filter(s) directs a subset of the ions onto a catalytic transmembrane to grow nanotubes of a specific isotope composition on the opposite side of the transmembrane. The nanotubes may be uniformly or selectively doped with dopant atoms. A controller can configure the selection filter(s) to sequentially pass different subsets of ions to form isotope, molecular or element junctions in the growing nanotubes.

A UPS includes an AC output, power factor control circuitry; and a DC bus coupled to the power factor control circuitry where the power factor control circuitry is configured to determine a difference in instantaneous power supplied to the AC output and to adjust a voltage of the DC bus based, at least partly, on the difference. In one embodiment, the UPS includes a single phase AC input. In another embodiment, the power factor control circuitry is configured to determine a cumulative difference in instantaneous power supplied to the AC output.

A computer-assisted educational system. Educational courses are provided, comprising individual lessons. The lessons are stored at one, or more, servers, and are transmitted to remote computers over a network, such as an internet. Students utilize the remote computers to participate in the lessons. At any given time, the remote computer displays the lessons available to a student, so that, for a given course, the student is not held in lock-step with the other students, but may study the lesson's of the student's own choice. This freedom is subject to any requirements of certain lessons which require prerequisite lessons be completed. The prerequisites must be completed first.

Systems and methods to generate business recommendations for specific business actions based on weather element forecasts and known relationships between a business activity and weather elements are provided. The system includes a confidence level filter, an opportunity matrix filter, a weather decision point generator, a business rule recommendation engine and a business rule knowledge database. Methods to generate a business recommendation for a business activity are also provided. The methods include receiving weather driven demand data, assigning opportunity measures to each of the data points, identifying weather decision points based on opportunity measures, and applying business weather rules to the weather decision points to generate business recommendations. In a further feature, a weather element relationship and / or a weather element forecast confidence level is assigned to each data point within the weather driven demand data. These confidence levels are then factored in to determine weather decision points.

A system and method are disclosed for capturing the full dynamic and multi-dimensional nature of the asset allocation problem through applications of stochastic dynamic programming and stochastic programming techniques. The system and method provide a novel approach to asset allocation and based on stochastic dynamic programming and Monte Carlo sampling that permit one to consider many rebalancing periods, many asset classes, dynamic cash flows, and a general representation of investor risk preference. The system and method further provide a novel approach of representing utility by directly modeling risk aversion as a function of wealth, and thus provide a general framework for representing investor preference. The system and method demonstrate how the optimal asset allocation depends on the investment horizon, wealth, and the investors risk preference and how optimal asset allocation therefore changes over time depending on cash flow and the returns achieved and how dynamic asset allocation leads to superior results compared to static or myopic techniques. Examples of dynamic strategies for various typical risk preferences and multiple asset classes are described.