This invention provides novel formulations for promoting cell recycling and methods for increasing the responses of various genes related to cell recycling. It also includes degradation system promoters for promoting recycling, containing water-soluble nucleoproteins, particularly low molecular weight compounds (250 to 15000) obtained through enzymatic treatment of fish sclerotium; health foods containing these degradation system promoters; and methods for increasing the responses of various degradation system-related genes and promoting cell recycling through oral intake of these degradation system promoters.