The invention provides miRNA miR-148b-3p for targeted regulation of the action of SLC7A11 in
ferroptosis as well as an action mechanism and application of the miRNA miR-148b-3p, and finds and proves that miR-148b-3p can promote the
ferroptosis process of
breast cancer cells and inhibit proliferation and migration of the
breast cancer cells through targeted regulation of the SLC7A11 for the first time. Related action mechanisms are disclosed by researches such as construction of a ceRNA network, and potential targets and strategies are provided for
breast cancer treatment. Meanwhile, it is found that the compound also has a regulation effect in other cancers, but the effect is weaker than that of the breast
cancer, the specific regulation effect on the breast
cancer is highlighted, and a
solid theoretical foundation is laid for accurate treatment of the breast
cancer, so that breast
cancer treatment and research are more effectively carried out. Meanwhile, regulation and control of the miR-148b-3p on
ferroptosis are researched through various analyses, and it is shown that the miR-148b-3p can regulate ferroptosis related genes, and then
cell survival and death are regulated and controlled. A new perspective is provided for breast
cancer treatment, a basis is also provided for research on tumor
cell biological behaviors, and the application prospect is important.