13 results about "Chitosan coating" patented technology

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.

The application provides a kind of image positioning sticker marking method based on iodine-gallium complex chelate, through chelation reaction to prepare excellent stability iodine-gallium complex developer, non-woven fabric substrate is modified by chitosan coating, combined with screen printing process to prepare high-precision positioning sticker, and establish standardized clinical marking process. The method uses iodine-gallium double element synergistic development mechanism, so that the CT value of the marking area is 350-400HU, the contrast of the surrounding tissue is improved by 40%, the development clarity retention rate is more than 92% after 48 hours of sticking, the positioning error is stable within 0.3mm, solves the pain points of traditional marking easy diffusion and poor adhesion. The application has excellent biocompatibility, the skin allergy rate is only 0.8%, the single patient positioning operation time is shortened to 5-10 minutes, the production cost is reduced by 40%, can be widely used in precise medical positioning scenes such as tumor radiotherapy and interventional surgery, has significant clinical popularization value.

This application relates to the field of water pollution control technology and discloses a method for preparing a sediment microecological reconstruction and pollutant-targeted immobilization conditioner. The method includes: modifying mesoporous silica with amino- and thiolated compounds and mixing it with biochar to obtain an adsorbent material; dispersing ferrous sulfate, sodium thiosulfate, and hydroxyapatite with the adsorbent material in a sodium alginate solution and adding it dropwise to a calcium chloride solution for cross-linking and chitosan coating to obtain microcapsules; compounding riboflavin, humic acid, carbon source nutrients, and adding signaling molecules to obtain a metabolic enhancer; compounding metalloenzyme inhibitors and activating them with microorganisms to obtain an activator; granulating and coating calcium carbonate, magnesium hydroxide, ferrous sulfate, sulfur powder, calcium peroxide, and sodium lactate to obtain buffer particles; mixing the adsorbent material, microcapsules, and buffer particles, spraying, adding the metabolic enhancer and activator, adding binders and pore-forming agents, granulating, drying, sieving, and spraying a protective film to obtain the conditioner. This application solves the technical problems of existing sediment conditioners, such as single function, uncontrolled release, and microecological imbalance.

The present application relates to the technical field of animal feed nutrition, and discloses a coated lavender essential oil microcapsule as well as a preparation method and application thereof.The microcapsule has a double-layer structure and comprises, from inside to outside, a core and a chitosan coating layer wrapped outside the core; the core is an essential oil-beta-cyclodextrin complex; the essential oil-beta-cyclodextrin complex is formed by vacuum adsorption inclusion of lavender ester essential oil obtained by short path distillation of lavender essential oil at 6-8 kPa and 45-55 DEG C and beta-cyclodextrin.The coated lavender essential oil microcapsule prepared by the double-layer coating technology realizes efficient utilization of lavender essential oil in livestock and poultry, significantly improves the growth performance of animals, effectively reduces the incidence of diarrhea, and shows the comprehensive effects of selective bacteriostasis and immune enhancement, thereby providing a feasible solution for green feed additives to replace antibiotics.

This invention discloses a microsphere-filled lysozyme-chitosan / casein composite antibacterial hydrogel and its preparation method. The technical solution involves using casein as a substrate, with lysozyme adsorbed onto the surface of casein micelles via electrostatic forces, and chitosan coating the outer layer of the lysozyme. The casein micelle solution, lysozyme solution, and chitosan solution are uniformly mixed through physical blending. Electrostatic forces physically cross-link the carboxyl groups on the casein micelle surface with the cations of lysozyme and chitosan amino groups, forming a microsphere-filled lysozyme-chitosan / casein composite hydrogel. This material exhibits excellent sustained-release performance, is environmentally friendly, has good biocompatibility, stable performance, and good antibacterial function.

This invention relates to the field of fluoride-containing wastewater treatment technology, specifically to a method for preparing a high-efficiency composite defluoridating agent and its application. The composite defluoridating agent provided by this invention comprises a composite defluoridating core, a chitosan coating layer, and an F-imprinted outer layer. The composite defluoridating core is formed by in-situ co-precipitation of Mg-Al-La layered double hydroxides by chitosan complexing with Mg, Al, and La metal sources, and the introduction of TiO2 and MnO2 functional oxides. The chitosan coating layer coats the surface of the composite defluoridating core. The F-imprinted outer layer... ‑ The outer layer of the imprint is formed by pre-assembly, cross-linking, and template elution of fluoride ion template, quaternized chitosan, and chitosan. This invention also provides a composite defluorinating agent working solution obtained by mixing a double aluminum salt solution and a composite defluorinating agent dispersion, used for deep defluorination treatment of fluoride-containing wastewater containing competing anions of phosphate, silicate, bicarbonate, and / or carbonate, with advantages such as high defluorination efficiency, good selectivity, and strong anti-interference ability.

This invention discloses a multilayer microsphere for the prevention and / or treatment of bacterial diarrhea, its preparation method, and its applications, relating to the field of biomedical technology. The multilayer microsphere has a three-layer core-shell structure: the core layer is loaded with *Lactobacillus plantarum* and sodium butyrate, the middle layer is a chitosan coating layer, and the outer layer is a sodium alginate coating layer. This invention has found that *Lactobacillus plantarum* and sodium butyrate have a significant synergistic antibacterial effect, effectively inhibiting the proliferation of pathogenic *Escherichia coli* and *Salmonella*. In vivo experiments have confirmed that the multilayer microsphere can effectively restore the body weight of diarrhea-prone animals, repair pathological damage to the jejunum and colon, and alleviate intestinal inflammation at the molecular level by inhibiting the activation of NF-κB and MAPK inflammatory pathways, downregulating the expression of pro-inflammatory factors IL-1β, IL-6, and TNF-α, and upregulating the level of the anti-inflammatory factor IL-10. The multilayer microsphere provided by this invention can serve as a novel, green, and safe formulation suitable for the prevention and control of bacterial diarrhea in livestock and poultry farming.

The application provides a postharvest preservation method of mango, which comprises the following steps: S1. picking and pretreatment, S2. short-wave ultraviolet mild irradiation treatment, S3. preservative solution immersion and storage. The preservative solution is composed of phyllium extract solution, mango leaf extract solution, arginine grafted modified chitosan, glacial acetic acid and sterile water. Through the synergistic process of the short-wave ultraviolet mild irradiation and the preservative solution immersion, combined with the multiple effects of the modified chitosan coating and the plant extract, the mango can be stored for 30 days under the condition of 13-15 DEG C and 85-90% relative humidity, the good fruit rate is still kept to be more than 90%, and the weight loss rate is less than 5%, so that the industry problems that the mango is prone to rot and fast water loss after harvesting are effectively solved. The components of the preservative solution used in the application are all safe natural sources, no chemical synthetic fungicides are used in the whole process, there is no pesticide residue risk, and the green preservation and food safety requirements are met.

This invention relates to the interdisciplinary fields of agricultural ecological environment materials science, polymer material modification, and in-situ remediation technology for heavy metal contaminated soil, specifically to a slow-release calcium peroxide soil conditioner and its preparation method. It aims to solve the problems of uncontrollable oxygen release rate, drastic local pH fluctuations, and limited functionality in existing soil conditioners. The conditioner of this invention comprises, from the inside out: a functional core, an inner responsive layer, and an outer buffer layer. The functional core is a mixture of anhydrous calcium peroxide, citric acid, and calcium dihydrogen phosphate, granulated using sodium alginate binder, achieving pH self-buffering through the acid-base neutralization reaction between citric acid and the decomposition products of calcium peroxide. The inner responsive layer is a chitosan coating for intelligent oxygen release. The outer buffer layer is biochar-supported nano-hydroxyapatite.

This invention discloses a compound microbial inoculant and a microbial fertilizer. The compound microbial inoculant is composed of Bacillus subtilis, Bacillus amyloliquefaciens, Bacillus mucilaginosus, Aspergillus niger, Saccharomyces cerevisiae, and Bacillus sicca in specific weight proportions. The microbial fertilizer contains the compound inoculant, mogroside V, sodium iron ethylenediamine di-o-hydroxyphenylacetate, potassium dihydrogen phosphate, alkaline hydrolyzed modified tobacco dust, expanded perlite, and potassium humate. The preparation method includes: mixing alkaline hydrolyzed and enzymatically hydrolyzed tobacco dust with a carrier, inoculating with the compound inoculant for staged temperature-controlled fermentation; mixing the fermentation product with functional factors, followed by sodium alginate-calcium chloride gelation and chitosan coating to form microcapsule particles. This invention achieves multifunctional integration of growth promotion, disease resistance, and stress resistance induction through synergistic functional microbial community development, waste resource utilization, and slow-release encapsulation technology, resulting in a product with good stability and long-lasting fertilizer effect.

The application discloses a preparation method of a honeycomb filter rod for cigarettes, the filter rod and application, and comprises the following steps: mixing a composite adsorption carrier material with essence, and adsorbing the essence on the composite adsorption carrier material; wherein the composite adsorption carrier material comprises at least two of mesoporous silica, gamma-cyclodextrin, porous starch and sodium carboxymethyl cellulose; the adsorption amount of the essence accounts for 20%-50% of the mass of the composite adsorption carrier material; the composite adsorption carrier material with the adsorbed essence is extruded into a honeycomb filter rod blank through a honeycomb mold under the conditions of room temperature to 80 DEG C and a pressure of 0.5-5 MPa, so that a filter rod blank body with a honeycomb structure is formed; the filter rod blank body is dried under the condition of a microwave power of 500-3000 W for 1-10 minutes, so that a honeycomb filter rod base body is obtained; a chitosan coating is formed on the surface of the honeycomb filter rod base body, and the honeycomb filter rod for cigarettes is obtained; the method and the filter rod can realize slow-release, flavor enhancement, moisture retention, tar reduction and harm reduction simultaneously.