861 results about "Tumor site" patented technology

The present application relates to a real-time three-dimensional (3D) tumor tracking method and apparatus, and a computer device and a storage medium. The method comprises: acquiring a moving image and a reference image of a tumor site; performing hybrid data enhancement on the moving image and the reference image, so as to obtain a 3D CT image that represents each respiratory phase, and a segmented moving image; projecting the 3D CT image by using a ray casting algorithm, so as to generate a 2D DRR at a corresponding moment; and inputting the 2D DRR into a trained tumor tracking network, outputting a 3D deformation field of the 2D DRR by means of the tumor tracking network, and making the 3D deformation field act on the reference image, so as to generate a predicted segmented tumor image of the 2D DRR at the corresponding moment. In the embodiments of the present application, tumor tracking is performed on the basis of a single-angle X-ray image, such that the radiation dose is greatly reduced, high-precision tumor tracking performed at a low dose is realized, and the tumor tracking speed is significantly increased.

The invention discloses a method and equipment for predicting a tumor position under respiratory movement based on LSTM (Long Short Term Memory), and the method comprises the steps: collecting a 4DCT (4 Discrete Cosine Transform) image sequence of a tumor part of a plurality of patients under free respiration; based on the acquired 4DCT image sequence, extracting a movement track of a tumor centroid point position along with time change; sequentially inputting all tumor motion data points in each fixed time window on the motion trail into a CNN-Attention-LSTM model for offline training, wherein the CNN-Attention-LSTM model is used for predicting the tumor position at the next time; and in a radiotherapy stage, performing online real-time updating on the trained CNN-Attention-LSTM model by using the latest respiratory movement data of the current patient, and predicting the tumor position at the next time. The real-time position of the tumor is provided for the radiotherapy robot, the time delay of the whole system is compensated, and the tumor position tracking is accurately realized in real time.

The invention discloses a tumor cholesterol metabolism regulation microneedle patch and a preparation method, the microneedle patch comprises a needle tip and a backing which are connected, the needle tip comprises a needle tip body and nanoparticles loaded on the needle tip body, the nanoparticle is a manganese ion-doped organic metal framework, the outer layer of the manganese ion-doped organic metal framework is modified with a targeting agent, cholesterol oxidase and superoxide dismutase are carried on the manganese ion-doped organic metal framework, the targeting agent can target a CD44 receptor, and the organic metal framework can carry drugs. The targeted drug can enter tumor cells in a targeted mode, superoxide dismutase catalyzes superoxide anions overexpressed in the tumor cells to generate H2O2 and O2, O2 needed by catalysis is provided for cholesterol oxidase, cholesterol at the tumor site is consumed by the cholesterol oxidase, accumulation of 7-DHC is reduced, meanwhile H2O2 can be generated, and the cholesterol oxidase can be used for catalyzing the tumor site. H2O2 is catalyzed by manganese ions through a Fenton-like reaction to generate OH to induce tumor cells to generate ferroptosis, so that ferroptosis-immune synergistic treatment is realized.

The invention provides an aggregation-induced emission molecule, a nano motor and a preparation method and application of the aggregation-induced emission molecule, the aggregation-induced emission molecule is used for near-infrared emission, has photo-thermal properties, and has the characteristics of near-infrared II region luminescence, heat production and good light stability; the nano motor is prepared by taking an asymmetric double-mesoporous nano material with different pore diameters as a support material and selectively loading aggregation-induced emission molecules on one side of the support material with a larger pore diameter; under the irradiation of near-infrared light, the aggregation-induced emission molecules with the photothermal effect can form a non-uniform thermal gradient to push the self-thermophoresis movement of the nano motor; tumor sites can be diagnosed and reported under the mediation of near-infrared II region imaging; through the photo-thermal effect, the motor can destroy tumor interstitial cells and degrade tumor matrix components; and in combination with autothermophoresis, blood vessels can be penetrated, so that penetration to the deep layer of the tumor can be realized.

The invention belongs to the technical field of genetic engineering and biological medicine, and particularly discloses a cascade response type nano-particle with a microenvironment remodeling function and a preparation method and application of the cascade response type nano-particle. The nanoparticle provided by the invention adopts a bionic hybrid membrane engineering strategy: an inner core is formed by loading an exosome inhibitor on a nano material, and the surface is covalently coupled with M2 type macrophage specific targeting peptide; the outer layer coats a macrophage membrane and active oxygen response type liposome composite membrane layer through a co-extrusion technology, and is loaded with a TLR agonist. Animal experiments show that after being injected through caudal vein, the nano-particles are enriched at a tumor site in a targeted manner through homing receptors such as membrane surface integrin alpha4beta1 and the like, and outer membrane cracking is triggered in a high-ROS tumor microenvironment, so that space-time controlled release of a TLR agonist and targeted phagocytosis of an exosome inhibitor by macrophages guided by a targeted peptide are realized. The anti-tumor synergistic effect is achieved through multiple regulation and control mechanisms, and an effective treatment strategy is provided for tumor immunotherapy.

Provided herein are novel anti-CD20 x anti-CD28 antibodies and methods of using such antibodies for the treatment of B-cell malignancies. Subject anti-CD20 x anti-CD28 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and CD20 on tumor cells. Thus, such antibodies enhance anti-tumor activity at tumor sites. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-CD20 x anti-CD79b antibodies) for the treatment of B-cell malignancies.

The invention belongs to the technical field of biological medicine, and particularly relates to a manganese-doped zeolite imidazole framework and application thereof in tumor radiotherapy. According to the present invention, the new use of the manganese-doped zeolite imidazole framework as the tumor radiosensitizer is found, Mn-ZIF-8 has ray responsiveness, can continuously release Mn < 2 + > ions under X-ray irradiation, and can enhance the activation of a cGAS-STING signal channel so as to promote DCs maturation and antigen presentation, and enhance the T cell mediated immune response, such that the tumor treatment effect is enhanced. Furthermore, the invention provides the Mn-ZIF-8 microneedle, the microneedle has the characteristics of rapid dissolution and controlled release, ensures accurate delivery and continuous action of drugs at tumor sites, reduces systemic toxicity, and can significantly amplify local and systemic immune effects caused by radiotherapy and improve the therapeutic effect when used in combination with an immune checkpoint inhibitor.

The invention relates to the field of biological medicine, in particular to IMSFs hydrogel, a ferroptosis induction system, a preparation method and application. The IMSFs hydrogel comprises a hydrogel body, and ferroferric oxide nanoparticles and sorafenib are loaded in the hydrogel body in a wrapping manner. The IMSFs hydrogel can be used as an injectable cascade ferroptosis anti-cancer drug. The preparation method of the IMSFs hydrogel comprises the following steps: firstly, preparing a silk fibroin-hyaluronic acid hydrogel body: dissolving silk hydrogel and hyaluronic acid in a lithium bromide solution; bDDE is added into the dissolved solution, and incubation is carried out; then dialyzing and washing with deionized water to obtain a silk fibroin-hyaluronic acid hydrogel body; and then loading the sorafenib nanoparticles and the ferroferric oxide nanoparticles into the silk fibroin-hyaluronic acid hydrogel body. The IMSFs hydrogel disclosed by the invention integrates magnetic thermal response and drug controlled release, and can be injected to a tumor site, so that the treatment effect on TNBC is remarkably improved.

The invention belongs to the technical field of engineered probiotics, and particularly relates to engineered probiotics for radiosensitization and tumor metabolism regulation as well as a preparation method and application of the engineered probiotics. The engineering probiotics comprise probiotics and core-shell type metal nanoparticles which are loaded on the probiotics and are synthesized through a biological directional mineralization effect; the core of the core-shell type metal nanoparticle is a palladium element, and the outer layer of the core-shell type metal nanoparticle is a palladium element and a gold element. The engineering probiotics provided by the invention have excellent enzyme catalysis performance and can target and retain in tumor sites, and through the synergistic effect of all components in the engineering probiotics, adenosine metabolism is effectively inhibited, secretion of pro-inflammatory cytokines is enhanced, tumor microenvironment is promoted to be converted into an inflammatory state, up-regulation of immune checkpoints is inhibited, and the immune checkpoints are inhibited. And T cells are inhibited from being transformed into depletion phenotype and transformed into effect type from depletion type. After the SBRT and the immune checkpoint inhibitor are combined for use, the growth of tumors can be effectively inhibited, and the effect of enhancing immune radiotherapy is achieved.

The invention discloses organic nano composite hydrogel as well as a preparation method and application of the organic nano composite hydrogel, and belongs to the technical field of biological medicine delivery. The polysaccharide-based nano prodrug in the composite hydrogel can be subjected to surface protonation under the stimulation of a tumor extracellular slightly acidic environment, so that cellular uptake is promoted, low-pH / high-concentration glutathione in tumor cells is responded, intracellular aggregation and controllable release of the nano drug are realized, the retention time of the drug in the cells is prolonged, and the bioavailability of the drug is improved. The technical effect of killing tumor cells through combined chemotherapy is achieved. According to the preparation method disclosed by the invention, the release of the polysaccharide-based nano prodrug from the hydrogel and the tissue infiltration capacity are accelerated by adopting fluorinated orthoester, the infiltration of the polysaccharide-based nano prodrug to cells is increased, and then the drug-loaded compound is encapsulated by using gellan gum, so that the slow-release effect of the polysaccharide-based nano prodrug is enhanced; therefore, the efficient enrichment of the medicine at the tumor part is realized.

The invention relates to the technical field of medical image processing, and discloses a neurovascular tumor recognition method and system based on multi-modal image fusion, and the system comprises a multi-dimensional collection module and an intelligent recognition module. According to the neural vascular tumor identification method and system based on multi-modal image fusion, PET / CT images and MRI images of a tumor part are obtained through a multi-dimensional acquisition module and are classified to form an image set, and an intelligent identification module carries out gray scale range standardization processing on the images of different modalities according to the same time point; according to the method, the difference between images collected by different devices or time points is eliminated, the images are registered and aligned to a unified three-dimensional coordinate system, the visual fusion registration capacity is high, and an intelligent recognition module analyzes the horizontal diameter and the vertical diameter of tumor tissue and the growth state of the tumor tissue according to the three-dimensional coordinate system, generates a tumor data set and a compression index and displays the tumor data set and the compression index. The compression degree of the tumor tissue on the blood vessel wall is evaluated, corresponding treatment suggestions are output, and the intelligent recognition and diagnosis effect is good.

The invention provides a near-infrared fluorescent probe for actively targeting a fibroblast growth factor receptor as well as a preparation method and application of the near-infrared fluorescent probe, and relates to the technical field of specific molecular targeting diagnostic reagents. The near-infrared fluorescent probe for actively targeting the fibroblast growth factor receptor can be quickly cleared in normal tissues and detained in tumor parts for a long time, so that the effect of in-vivo diagnosis can be achieved, and the near-infrared fluorescent probe has a certain clinical application prospect and is applied to clinical intraoperative navigation.

Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.

The present invention relates to: a temperature-sensitive hydrogel for cancer treatment; a photothermal composition comprising the hydrogel as an active ingredient; and a preparation method for the temperature-sensitive hydrogel for cancer treatment. The temperature-sensitive hydrogel of the present invention includes gold nanostars as active ingredients, and thus can generate heat by light irradiation, thereby exhibiting a photothermal therapy effect. In addition, the hydrogel temperature increases so that the release of nitric oxide (NO) from S-nitrosocysteine can be induced. In addition, the temperature-sensitive hydrogel of the present invention includes S-nitrosocysteine as an active ingredient so that, upon a temperature rise due to a photothermal reaction, the penetration of drugs into a tumor site can be improved by the release of NO, and at the same time, apoptosis of cancer cells can be directly caused; and includes an immunotherapy agent as an active ingredient so that tumor size can be effectively suppressed even with the passage of time. Therefore, as a material that enables complex treatment combined with photothermal therapy and immunotherapy, the temperature-sensitive hydrogel of the present invention having the aforementioned effect can be usefully utilized in the field of medicine for cancer treatment.

The invention belongs to the technical field of nano biological medicines, and particularly relates to injectable organic composite hydrogel combined with photo-thermal chemotherapy as well as a preparation method and application thereof. The injectable organic composite hydrogel combined with photo-thermal chemotherapy is composed of an orthoester compound and a water-phase hydrogel, the orthoester compound is emulsified and then uniformly dispersed in the hydrogel, and the hydrogel is formed by crosslinking carboxymethyl chitosan and glutaraldehyde. In the injectable organic composite hydrogel combined with photo-thermal chemotherapy provided by the invention, firstly, oily orthoester is utilized to dissolve a cis-platinum prodrug and indocyanine green to obtain an orthoester compound, then the orthoester compound is uniformly emulsified and loaded in the hydrogel, dynamic imine bonds of the hydrogel respond to tumor slightly acidic environment breakage, and then the dynamic imine bonds of the hydrogel are separated from the dynamic imine bonds of the hydrogel, so that the injectable organic composite hydrogel combined with photo-thermal chemotherapy can be used for preparing the injectable organic composite hydrogel combined with photo-thermal chemotherapy. The orthoester compound successfully escapes, along with degradation of the oily orthoester, the cis-platinum prodrug and the indocyanine green are self-assembled through hydrogen bonds to form nanoparticles, the enrichment and retention capacities of the two drugs at the tumor site are enhanced, and the overall curative effect is improved.

The invention relates to a multifunctional silica plastid integrating chemotherapy, immunotherapy and gas therapy, and relates to a preparation method of the multifunctional silica plastid and application of the multifunctional silica plastid in tumor diagnosis and treatment. The schematic diagram is as shown in the figure, the membrane components comprise conventional phospholipid and complex lipid, a chemotherapeutic drug doxorubicin (DOX) entrapped on a hydrophilic core and Fe3 (CO) 12 entrapped on a hydrophobic core, and the chemotherapeutic drug can be adjusted according to needs and is suitable for broad-spectrum tumor treatment. The drug-loaded silica plastid can generate part of carbon monoxide in a tumor high-concentration hydrogen peroxide (H2O2) environment and release internally-loaded chemotherapeutic drugs. Under the action of ultrasound (US), the multifunctional silicon plastid can realize fixed-point release of chemotherapeutic drugs DOX and carbon monoxide at a tumor site, the enrichment and uptake of the drugs at the tumor site are greatly improved, in addition, the system is combined with the alphaPD-L1 antibody, the immunosuppressive PD-L1 / PD-1 axis can be blocked, T cells are recruited to attack tumors, meanwhile, the immunosuppressive regulatory T cells (Tregs) are reduced, and the tumor treatment effect is improved. The tumor inhibition can be enhanced; the pulmonary metastasis can be obviously reduced.

The invention belongs to the technical field of biological medicines, and particularly discloses a nano-engineering T cell membrane coated nano-particle as well as a preparation method and application of the nano-engineering T cell membrane coated nano-particle. Nanoparticles of a specific structure are constructed based on a phospholipid bilayer bionic nanometer platform through a membrane fusion technology, immune clearance caused by phagocytosis of the nanoparticles by macrophages can be avoided through disguise of a T cell membrane, and the blood circulation time is prolonged; the functions of T cells are recovered through specific blocking of immune checkpoint molecules loaded on the immune checkpoint molecules on corresponding immune checkpoint ligands on tumor cells; under ultrasonic radiation, the nano-particles are gradually decomposed and release the sound-sensitive agent to generate a large amount of active oxygen, so that immunogenic death of tumor cells is promoted, more cytotoxic T lymphocytes are recruited to infiltrate into tumor parts, and the recovery of T cell mediated immune response function is facilitated. The synergistic effect of the sound-sensitive agent and the immune checkpoint protein can effectively inhibit tumor growth, induce a long-term immune memory effect and prevent tumor metastasis and recurrence.

The invention discloses a GSH response type cell membrane bionic nano-drug, a preparation method and application, the cell membrane bionic nano-drug comprises cell membrane vesicles serving as a carrier, the cell membrane vesicles are prepared by performing cell membrane extraction and membrane extrusion on immune cells of which the membrane surfaces overexpress azide, and the cell membrane vesicles serve as a carrier. The azide on the cell membrane vesicles and the bio-coupling compound are bonded through a click chemical reaction to form-SH groups, and the-SH groups and the small-molecule inhibitor are combined together in a disulfide bond mode through the cross-linking agent. The drug is connected with a small-molecule inhibitor through a disulfide bond, so that the drug loading rate is relatively higher, the stability is better, and drug leakage in the blood circulation process is relatively less; the small-molecule inhibitor can be completely released only in a tumor site microenvironment, so that the tumor m6A methylation level is reduced, the EMT state is reversed, the tumor drug resistance is overcome, and a better tumor treatment effect is displayed in cooperation with chemotherapy drugs for tumor treatment.

The invention belongs to the field of tumor drugs, and discloses a radioactive hydrogel based on crosslinking of sodium alginate and metal ions and a preparation method and application thereof.The preparation method of the radioactive hydrogel comprises the following steps that lutetium chloride and metal ions are mixed, and a metal ion mixed solution is obtained; doping 177Lu radioactive isotope into the obtained metal ion mixed solution to obtain a metal ion cross-linking agent; and injecting a metal ion cross-linking agent into the sodium alginate solution under a vortex condition, centrifuging, and discarding the supernatant to obtain the radioactive hydrogel. The radioactive hydrogel (177Lu-RH) provided by the invention has good in-tumor colonization capability, can be directly injected into a tumor to realize local radiotherapy, has good radioactive stability, and can be stably retained at a tumor part for more than 120 hours, so that the stability of radioactive labeling in a treatment process is ensured.

The invention discloses a multifunctional nano delivery system based on targeted ferritin as well as a preparation method and application of the multifunctional nano delivery system. According to the system, traditional Chinese medicine active ingredients, namely neogambogic acid GNA, a photosensitizer Ce6 and ferritin targeting peptide HKN15 are integrated through a self-assembly technology, a synergistic treatment system integrating photodynamic therapy PDT and ferroptosis induction is constructed, and the treatment effect on non-small cell lung cancer NSCLC can be remarkably enhanced. According to the nano delivery system, precise targeting of a tumor site is achieved through the ferritin targeting peptide HKN15, and a double anti-tumor mechanism is formed by utilizing the photodynamic effect of the photosensitizer Ce6 and the ferroptosis induction effect of GNA. The preparation process is based on a molecular self-assembly principle, and has the advantages of high tumor accumulation efficiency, low system toxicity, remarkable tumor inhibition effect and the like, and an innovative solution is provided for precise treatment of the non-small cell lung cancer.

The invention relates to a combined traditional Chinese medicine composition for treating tumors by improving a tumor immune microenvironment and application thereof. The combined traditional Chinese medicine composition comprises rhein and hesperidin. Rheinic acid and hesperidin have stronger antitumor activity than single components in combined application, and the combined pharmaceutical composition can significantly inhibit the growth of cancer-related fibroblasts, reduce CCL2 secreted by cancer-related adipocytes and increase infiltration of CD8 + T cells at tumor sites, so that the growth of tumors is significantly inhibited, and the antitumor effect is improved. And a new method and thought are provided for combined treatment of cancers.

The invention discloses a multifunctional nano-enzyme as well as a preparation method and application thereof, and belongs to the technical field of nano-enzyme synthesis. Aiming at the problems that a traditional nano-enzyme is single in activity, limited in treatment effect, poor in tumor active targeting specificity and the like, the multifunctional nano-enzyme provided by the invention is simple and efficient in preparation method, and is prepared by taking N and P double-doped hollow carbon nanospheres as a carrier, loading L-arginine and glucose oxidase and taking an aptamer as a targeting molecule. The multifunctional nano-enzyme is small in particle size, high in dispersion degree and good in biological safety. The multifunctional nano-enzyme not only has the activities of peroxidase, nitric oxide synthase and glucose oxidase, but also has excellent photo-thermal conversion capacity in tumor targeted therapy. The multifunctional nano-enzyme provided by the invention has a tumor focus specific recognition capability, can be highly enriched at a tumor part, finally realizes the purpose of photothermal / catalytic treatment combined tumor treatment, and provides a new thought and platform for tumor treatment.

The invention relates to the technical field of preparation of biological materials and pharmaceutical preparations, in particular to organic composite hydrogel as well as a preparation method and application thereof. The specific preparation method comprises the following steps: dissolving a targeted drug in orthoester to obtain a targeted drug-orthoester solution; the preparation method comprises the following steps: mixing an oxidized dextran solution, a targeted drug-orthoester solution and a carboxymethyl chitosan solution, carrying out vortex treatment, and standing to prepare the organic composite hydrogel. The solubility of the targeted drug in the hydrogel is improved by utilizing orthoester, the orthoester can carry the targeted drug to efficiently escape from the hydrogel, and the targeted drug can be self-assembled to form nanoparticles along with degradation of the orthoester in the escape process, so that the retention capacity of the targeted drug at a tumor site is enhanced, and the targeting drug can be used for treating tumor tumors. The drug enrichment capacity is improved, meanwhile, the toxic and side effects of the whole body are reduced, and the problems that nano-drugs are poor in solubility, still prone to being removed after intravenous administration and poor in enrichment effect at tumor sites are solved.

The invention discloses an EGFR (epidermal growth factor receptor) targeted nano-drug carrier and a preparation method thereof, the EGFR targeted nano-drug carrier comprises drug-loading nanoparticles, an erythrocyte membrane coating the drug-loading nanoparticles and GE11 peptide connected to the erythrocyte membrane, and the drug-loading nanoparticles are formed by connecting tannic acid, ellagic acid and 1, 4-phenyldiboronic acid through boric acid ester bonds. The EGFR targeted nano-drug carrier disclosed by the invention can be enriched at an EGFR overexpressed tumor site in a targeted manner, and can be effectively prevented from being cleared by an immune system, and the drug loaded by the drug-loaded nanoparticles is released in a high-active oxygen environment, so that the treatment effect on tumors can be improved, and the toxic and side effects on normal tissues can be reduced; and photothermal therapy and chemotherapy effects can be simultaneously generated under NIR illumination, and the anticancer efficiency can be remarkably improved through the synergistic effect of the photothermal therapy and the chemotherapy.

The invention provides a boron drug with tumor targeted release capability for boron neutron capture therapy and a preparation method thereof, relates to the technical field of tumor therapy, and provides a boron drug which can be activated through high-concentration NAD (P) H at a tumor site and can release a B-10 drug in a targeted manner for boron neutron capture therapy. A boron-10-containing compound in the boron medicine is connected with 3-aldehyde quinoline salt through a self-elimination reactive group, the 3-aldehyde quinoline salt can be specifically reduced by NAD (P) H rich in tumor cells to trigger chain reaction, and the effective boron-10 compound is released for boron neutron capture therapy. The damage to normal cells in the BNCT process can be effectively reduced by a method for targeted aggregation of the boron drug in the tumor cells. The boron drug synthesis method is simple, mild in condition and high in yield, has the advantages of stable chemical property, good light stability, small toxicity and the like, and provides a good application prospect for the field of boron neutron capture therapy.

The invention provides a photodynamic combined active oxygen response type tripterine polymer micelle as well as a preparation method and application thereof, and belongs to the technical field of medicines. According to the present invention, the photodynamic therapy is combined, the photosensitizer Ce6 and the antitumor drug Cela are co-entrapped in the reactive oxygen species (ROS)-responsive liver targeting polymer micelle, and the prepared drug-loaded micelle has characteristics of small particle size and high stability. When the photosensitizer absorbs exogenous visible-near infrared light energy, ROS free radicals can be generated, the ROS concentration of a tumor site is improved, the breaking speed of ketal thiol bonds in the micelle is accelerated, and drug release is accelerated. The polymer micelle drug-loading system is good in biological safety, has the ROS response type drug release characteristic, gives full play to the synergistic effect in combination with the photodynamic therapy, prolongs the residence time in the body, enhances the targeting to liver tumors, improves the bioavailability and the anti-tumor effect of Cela, reduces the toxic and side effects on healthy tissues and visceral organs, and has a good application prospect. And a better anti-tumor synergistic treatment effect is exerted.

The invention relates to a nano drug delivery system for delivering at least one drug and a preparation method of the nano drug delivery system. The nano drug delivery system is formed by assembling a recombinant fusion protein and hydrophobic degradable polyester or a derivative thereof with an albumin hydrophobic structural domain in the recombinant fusion protein through weak acting force and loading at least one drug, the medicine is a small molecule medicine used clinically. The hydrophobic degradable polyester or the derivative thereof is selected, different drug molecules and specific recombinant fusion protein are prepared into the nano drug delivery system for targeted delivery of at least one drug, the stability is excellent, the efficiency of targeted delivery of the drug to a tumor site can be improved, the anti-tumor curative effect is enhanced, and toxic and side effects are reduced. The preparation method of the nano drug delivery system is mild and controllable, and has high clinical application potential. The nano drug delivery system delivers at least one drug to different types of tumors in a targeted manner, and can be applied to tumor treatment.

The invention belongs to the technical field of tumor treatment, and relates to a nanometer material for treating tumors based on near-infrared light response in combination with photo-thermal, photodynamic and nitric oxide as well as preparation and application of the nanometer material. The invention relates to a near-infrared light response-based nano material for combined treatment of tumors, which is of a sphere-like structure, takes hollow mesoporous copper sulphide with photo-thermal performance as a carrier, loads a nitric oxide donor, and wraps a phase change material containing a photosensitizer. According to the nano material, photo-thermal conversion of the hollow mesoporous copper sulfide nano particles is triggered through near-infrared light, high temperature is generated, the phase change material is molten, and release of the photosensitizer IR780 and L-Arg is promoted; under irradiation of near-infrared light, IR780 generates active oxygen, and L-Arg is further triggered to release nitric oxide. The linkage mechanism of thermal controllable drug release closely combines photo-thermal, photodynamic and nitric oxide treatment, and the construction of the obtained nano material solves the problem that < 1 > O2 and NO cannot be effectively supplied to tumor sites.

The invention discloses a tumor experiment medicine preparation device, and relates to the technical field of biomedicine, the tumor experiment medicine preparation device comprises an inhaler used for preparing and feeding a dry powdery tumor medicine, the inhaler comprises a shell, a partition plate is fixed in the shell, and the interior of the shell is divided by the partition plate to form a preparation cavity and a treatment cavity; and the configuration cavity is located above the treatment cavity, a suction pipe is fixed to the shell, and one end of the suction pipe is fixedly installed on the bottom of the partition plate. Aiming at lung tumor experiments, quantitative anti-tumor medicine is directly delivered to the lung tumor part of the human body through the configuration effect of the inhaler, and in the using process of the inhaler, through mutual cooperation of the cutting release assembly, the anti-overflow communicating assembly and the air inlet control assembly, the anti-tumor medicine can be directly delivered to the lung tumor part of the human body. The cut tumor experiment medicine is fully separated, partial overflow is inhibited, deviation of the actual suction volume of the anti-tumor medicine is avoided, and accurate preparation and use of the tumor experiment medicine are guaranteed.

A method for preparing nanoparticles of triterpenoid small molecules co-assembled with Ce6 and copper ions wrapped in cancer cell membranes and its application. The present invention prepares a pure natural co-assembled nanotransmission system with new morphological characteristics and multiple biological activities - terpenoid compound and photosensitizer co-assembled nanoparticles. In the composite nanoassembly, triterpenoid compounds and photosensitizer Ce6 are assembled into nanoparticles, providing effective and safe chemotherapy and photodynamic therapy. Subsequently, Cu is complexed on the surface of the nanoparticles. 2+ , when Cu is introduced 2+ When activated, the reduced PDT effect caused by excessive glutathione in the tumor consuming reactive oxygen species can be counteracted. Furthermore, it can enhance CDT therapy through a Fenton-like catalytic reaction with overexpressed H₂O₂ at the tumor site. Finally, these molecules are encapsulated by the tumor cell membrane. By constructing CM@OABACe6 / CuNPs with homologous targeting, a triple synergistic platform for cancer treatment using PDT, chemotherapy, and CDT has been created.