7results about How to "React Safe" patented technology

This invention relates to the field of new energy and discloses a highly selective photocatalytic method for producing acetone from methane. The method includes: placing a transparent substrate coated with a photocatalyst in a photocatalytic reactor, adding liquid water, introducing methane gas to purge air, sealing the photocatalytic reactor, and conducting a gas-solid two-phase photocatalytic reaction under light irradiation and heating at 50-100°C to generate a liquid oxygen-containing organic compound, primarily acetone. The photocatalyst is BiVO4, ZnO, or a modified photocatalyst based on morphology control, surface modification, semiconductor composite, or elemental doping of BiVO4 or ZnO. This invention uses methane and water as raw materials, reacting with a photocatalyst in a gas-solid two-phase reaction to produce a liquid oxygen-containing organic compound, primarily acetone, with high acetone yield and selectivity. This invention has advantages such as low requirements for the reaction environment, simple and environmentally friendly process, and low cost.

The application discloses a preparation method of zolmitriptan, relates to the technical field of drug synthesis, and comprises the following steps: adding compound 1 and reagent 1 into solvent 1 to perform a first reaction to obtain compound 2; adding the compound 2, reagent 2 and reagent 3 into solvent 2 to perform a second reaction to obtain compound 3 and the like. Compared with the prior art, the application provides a novel synthetic route for preparing zolmitriptan, the route uses L-4-bromophenylalanine as a starting material, and new synthetic steps are adopted, such as using reagent 5, such as a t-butyl alcohol metal salt and sodium hydride, to construct the oxazolidinone structure in zolmitriptan and using a coupling reaction to construct the indole ring in zolmitriptan, so that the yield of the obtained target product is significantly improved, the use of high-toxicity and high-risk reagents in the existing synthetic route is effectively avoided, and a mild, efficient, green and environmentally-friendly synthetic route for preparing zolmitriptan is provided.

The application discloses a preparation method of a bistrifluoromethyl sulfide. The disclosed preparation method comprises the following steps: reacting a cracking gas and a trifluoromethylthio salt in an organic solvent under the conditions of 0-50 DEG C and in the presence of a composite catalyst and a protonic acid, and cooling and recovering a product generated in the reaction process through a condenser; the cracking gas is a gas generated by reacting tetrafluoroethylene and sulfur at a reaction temperature of 400-600 DEG C. The application provides a safe and non-toxic preparation method of the bistrifluoromethyl sulfide.

The invention relates to a naphthalimide photoinitiator as well as a synthesis method and application thereof. The method takes 4-bromo-1, 8-naphthenic anhydride as a starting raw material, and is efficiently synthesized through three steps of reaction: 1, under the catalysis of cuprous iodide and bis (triphenylphosphine) palladium dichloride, carrying out Sonogashira coupling on the compound and 1-octyne in tetrahydrofuran, and introducing an eight-carbon alkyne long chain to obtain a compound 3; secondly, the compound 3 and ethanolamine (0.37 g, 6 mmol) are subjected to aminolysis in ethyl alcohol, an intermediate compound 4 containing hydroxyl is generated, and the yield is as high as 92%; and 3, reacting the compound 4 with 2-chloroethyl isocyanate under the catalysis of dibutyltin dilaurate to generate a final product compound 1, and the yield reaches 95%. The process route is simple, the condition is mild, the total yield is high, and the obtained photoinitiator has excellent solubility, reaction activity and compatibility with high polymer materials and is suitable for a photocuring system.

The invention belongs to the technical field of organosilicon chemistry, and particularly discloses a method for preparing p-chloromethyl phenethyl triethoxy silane through continuous alcoholysis of a silane mixture. The method specifically comprises the following steps: preheating a mixed raw material consisting of p-chloromethyl phenethyl trichlorosilane and chloropropyl trichlorosilane, and continuously and reversely flowing the preheated mixed raw material and overheated ethanol steam into an effective-height packed tower reactor, so that a mixed silane liquid film and the ethanol steam are in full contact on the surface of packing to generate alcoholysis reaction; hydrogen chloride generated by the reaction is immediately entrained and moved out by ethanol steam, and a product is continuously extracted from the tower bottom and is rectified and purified. The non-catalytic continuous alcoholysis process has multiple remarkable advantages, the greenization and simplification of the production process are realized by thoroughly abandoning the catalyst and the acid-binding agent, and the generation amount of three wastes is extremely small.

The utility model relates to the technical field of chemical production equipment, and discloses a reaction device for imazethapyr production, which comprises a horizontal solid-liquid reactor provided with a temperature control jacket, the upper part of the side surface of one end of the solid-liquid reactor is provided with a liquid material inlet, the top of the end is provided with a solid material inlet, and the end is communicated with a variable frequency motor through a stirring shaft; a discharge hole is formed in the bottom of the other end of the solid-liquid reactor; a spiral conveyor is arranged below the discharge hole; a plurality of connecting rods are uniformly arranged on the stirring shaft in the solid-liquid reactor, and scrapers are arranged at the tops of the connecting rods; and the variable frequency motor and the temperature control jacket are electrically connected to the DCS automatic control system. According to the utility model, continuous production can be realized, the solid-liquid reaction is uniform, the product quality is stable, and the production safety is high.

The invention relates to the technical field of synthesis of organic chemicals, in particular to methionine and a preparation method thereof. The preparation method of methionine provided by the invention comprises the following steps: (1) dissolving isonitrile acetate in an aprotic solvent to form a first solution, adding a non-nucleophilic strong base into the first solution for reaction, and then adding 2-halogenated ethyl methyl sulfide for reaction to obtain a reaction solution containing 2-isocyan-4-(methylthio) butyrate; (2) adding an ammonium salt of an acid and an alcohol solvent into the reaction solution of the 2-isocyanato-4-(methylthio) butyrate obtained in the step (1), and reacting to obtain a 2-amino-4-(methylthio) butyrate solution; and (3) adding alkali into the 2-amino-4-(methylthio) butyrate solution obtained in the step (2) to carry out saponification reaction, and then adjusting the pH value to 5-7 to obtain methionine. The preparation method provided by the invention avoids the use of high-toxicity reagents, and the reaction is safer.