The invention relates to a manufacturing method of an implant denture individualized positioning guide plate in the technical field of tooth repair technologies, which comprises the steps of: firstly, establishing a three-dimensional model of anatomical structures of teeth, jaws, maxillary antrums, mandibular nerve conduits and the like according to oral cavity CT data of patients; secondly, carrying out virtual implanting on a solid modeled implant model, matching an implanted model with a patient oral cavity structural data model established after scanning a dental model by using an opticalscanner, determining the position of a guide hole of the positioning guide plate and the shape of a contact surface of gums, inserting a guide pipe in the guide hole; and thirdly, manufacturing a solid positioning guide plate. The solid positioning guide plate can provide optimal implanting position and direction to ensure the safety of an implanting technology and the long-term stability of an implant. The positioning guide plate can maximally utilize the bone quantity of the alveolar bone when in application. The invention can improve the efficiency and the accuracy of the implanting technology, ensure that the implanted implant accords with the biomechanical principle, and guarantee the repair aesthetic effect.