The invention discloses a geometrical parameter calibration method of an X-ray cone beam computed tomography system and belongs to the field of the X-ray cone beam computed tomography systems (a cone beam CT for short). By means of a camera calibration technique, a geometrical position relationship among an X-ray source, a panel detector and a rotary shaft in a cone beam CT system is reproduced, thereby geometrical parameters and errors of the cone beam CT can be directly solved, the geometrical parameter calibration method is a systematized measurement solving method, the cone beam CT can beabstracted to be a basic camera system model, and then a plurality of correlative geometrical parameters in the system can be simultaneously solved. Compared with prior calibration methods, the geometrical parameter calibration method has the advantages that the geometrical parameters are not required to be measured one by one, repeated adjustment for the parameters one by one is not required, thereby the complexity level of calibration measurement of the whole system is greatly simplified, and simultaneously the stability of the cone beam CT geometrical calibration is improved.