16results about How to "Increase dose" patented technology

The invention discloses a compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands is prepared from an iron-based metal organic framework composite drug carrying system, dopamine hydrochloride, a blank gel matrix, ethyl oleate, menthol, a solubilizer, a wetting agent and water, the iron-based metal organic framework composite drug loading system is composed of traditional Chinese medicine dihydric alcohol plastid, iron-based metal organic framework nanoparticles and cinnamomum camphora essential oil. The traditional Chinese medicine dihydric alcohol plastid and the cinnamomum camphora essential oil are loaded in the iron-based metal organic framework nano particles, so that the transdermal absorption of the medicine is improved, the pH response release property is realized, the dosage of active ingredients permeating into a focus part and the lasting action time are effectively increased, and then a coating layer is formed by polydopamine, so that the anti-inflammatory effect is improved. The dispersibility and compatibility of the drug loading system in vivo are further enhanced, the drug effect can be fully exerted, and the treatment effect on the hyperplasia of mammary glands is remarkably improved.

The invention discloses a sewage treatment device with a multi-stage filtering function, and relates to the technical field of sewage treatment. The sewage treatment device comprises a filtering cabin, a regulating cabin, a sedimentation cabin, a dosing tank, a detection mechanism and a conveying mechanism. The filtering cabin, the regulating cabin and the sedimentation cabin are arranged in sequence along the conveying direction of the water flow. The dosing tank is tightly connected to the outer wall of the filtering cabin, the dosing tank is communicated with the conveying mechanism, the conveying mechanism is tightly connected to the filtering cabin, the conveying mechanism is used to transport sewage, the detection mechanism is communicated with the conveying mechanism, and the detection mechanism is used to detect the metal ion content in the sewage. The sewage to be treated is first filtered through the filtering cabin to remove solid impurities in the sewage, and then the conveying mechanism conveys the treated sewage to the regulating cabin for chemical precipitation treatment, so that the metal ions in the sewage are converted into insoluble precipitates, and the treated sewage finally flows into the sedimentation cabin for natural sedimentation, thereby removing the metal ions in the sewage.

The invention provides a camptothecin prodrug. The camptothecin prodrug provided by the invention has higher drug retention in the liposome and better stability, and the prodrug liposome can maintain long-time plasma concentration in plasma. In-vitro characterization of the camptothecin prodrug liposome shows that the camptothecin prodrug liposome has higher encapsulation efficiency, drug loading capacity and stability, and can achieve a slow release effect in plasma; the experimental result on the cellular level shows that the compound has higher cellular uptake rate; in-vivo experiments prove that the compound has a better tumor accumulation effect and antitumor activity, can tolerate a higher dosage, and has higher biological safety.

This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally encoded amino acid. Disclosed herein are αCD70 antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αCD70 antibodies of the invention are conjugated to one or more toxins. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.

This invention discloses a high-crack-resistant cement-fly ash stabilized base course material, belonging to the field of road engineering technology. The material comprises the following components by mass percentage: 2.0-3.0% cement, 16-20% fly ash, and the balance being stabilized aggregate. The cement is an external admixture, the fly ash is an internal admixture, and the gradation of the stabilized aggregate conforms to the specifications of CF-A-2L or CF-A-2S in JTG / T F20-2015. This invention, by adopting a "low cement, high fly ash" mix design, controls the 7-day unconfined compressive strength within a reasonable range of 3.5-4.5 MPa, effectively avoiding the problem of regular transverse cracks in the base course caused by excessively high early strength. Simultaneously, the high fly ash content ensures the continuous growth of the material's later strength, with its 21-day unconfined compressive strength remaining stable above 6 MPa. Its overall performance is superior to the mix ratios recommended by current standards. This invention is particularly suitable for highway base course construction in arid regions with large temperature differences, such as Xinjiang.

The present invention discloses a composition for synergistically inhibiting pancreatic lipase and its application, belonging to the technical field of natural medicines. The composition of the present invention is composed of isorhamnetin and compound A; wherein compound A is selected from EGCG or luteolin. The composition of the present invention can inhibit the activity of pancreatic lipase, thereby achieving the effect of preventing or treating obesity. There is a synergistic effect between the components in the composition. The combined use of the components can greatly reduce the dosage of each component when used alone, and improve the inhibitory activity of pancreatic lipase. Therefore, when achieving the corresponding effect of preventing or treating obesity, low-dose combined use can effectively reduce the occurrence of drug resistance in the body.

This invention provides a recombinant acetyl-CoA carboxylase encoding gene and its applications. Mutations at positions 5374, 5229, 5335, 5336, and 5493 in the recombinant acetyl-CoA carboxylase encoding gene provided by this invention can induce more significant resistance in rice expressing this recombinant acetyl-CoA carboxylase. In particular, it shows a significant increase in resistance to seven ACCase inhibitors from three major chemically distinct classes: arbutin (APP), quizalofop-P-ethyl, quizalofop-P-ethyl, and flupyrflupyr; cyclohexenone (CHD), clethodim and clodinafop-P-ethyl; and neophenylpyrazoline (DEN), clodinafop-P-ethyl.

The present invention relates to a preparation method and application of an albumin-bound sorafenib nanoformulation chemically modified by MHI-148, comprising the following steps: S1, synthesizing albumin chemically modified by MHI-148 (BSA-MHI148); S2, synthesizing BSA-MHI148@SRF nanoparticles; the albumin-bound sorafenib nanoformulation (BSA-MHI148@SRF) is used for anti-tumor treatment. The albumin-bound sorafenib nanoformulation (BSA-MHI148@SRF) of the present invention can simultaneously solve the problems of tumor hypoxia and high expression of PD-L1.

The invention discloses a composition for promoting aquatic animal body surface tissue repair and a preparation method and application thereof.The composition is prepared from active ingredients, a biological adhesive and a protein stabilizer, the active ingredients are trachinotus ovatus recombinant IGF1 protein and trachinotus ovatus recombinant IGF2 protein, and the biological adhesive is a biological adhesive. The trachinotus ovatus recombinant IGF1 protein is a fusion protein containing an amino acid sequence as shown in SEQ ID NO: 2, and the N end of the trachinotus ovatus recombinant IGF1 protein is connected with an SUMO tag protein; the invention further discloses a preparation method of the composition for promoting aquatic animal body surface tissue repair and application of the composition in preparation of aquatic animal body surface tissue repair drugs. The composition has the advantages of fusion expression, stability, high efficiency, synergistic repair, low dosage, high efficiency, biological adhesion, long-acting slow release and the like.

The invention relates to a pharmaceutical composition capable of improving the bioavailable rate of oral statins and application of the pharmaceutical composition, and the pharmaceutical composition comprises statins, a pH value regulator, a metabolic enzyme safety inhibitor and a modified release coating or coating, the pH value regulator can regulate the pH value of the gastrointestinal tract absorbing the medicine, so that the living body availability of the medicine composition is improved, the variation of the concentration in blood in the body caused by individual difference is small, the variation range of the increase of the medicine absorption amount is reduced, the serious side effects of the medicine, such as the serious side effects of rhabdomyolysis and even the lethal side effects, are reduced, and the curative effect of the medicine is improved. The medicine safety is improved; the design of the special dosage form not only reduces the serious side effects which may cause death, but also prolongs the action time, reduces the administration frequency, and can greatly reduce the treatment failure caused by the fact that a patient forgets to take the medicine.

The invention discloses sewage treatment equipment with a multi-stage filtering function, and relates to the technical field of sewage treatment.The sewage treatment equipment comprises a filtering cabin, an adjusting cabin, a precipitation cabin, a dosing tank, a detection mechanism and a conveying mechanism, the filtering cabin, the adjusting cabin and the precipitation cabin are sequentially arranged in the water flow conveying direction, and the dosing tank is fixedly connected with the outer wall of the filtering cabin; the dosing tank is communicated with the conveying mechanism, the conveying mechanism is fixedly connected with the filtering cabin and is used for transferring sewage, and the detection mechanism is communicated with the conveying mechanism and is used for detecting the content of metal ions in the sewage; to-be-treated sewage firstly passes through the filtering cabin to be filtered to remove solid impurities in the sewage, then the conveying mechanism conveys the treated sewage into the adjusting cabin to be subjected to chemical precipitation treatment, metal ions in the sewage are converted into insoluble precipitates, and the treated sewage finally flows into the precipitation cabin to be naturally settled. Therefore, metal ions in the sewage are removed.

The present invention relates to a composition for caring for keratin materials and a mask comprising the same. The invention also relates to a non-therapeutic method for caring for keratin materials using said composition or mask.

This invention discloses a drug-coated balloon catheter with retrievable drugs, comprising a catheter and a balloon unit. The balloon unit includes first to fifth balloons. The first balloon is fitted at the distal end of the catheter to carry the drug. The second and third balloons are fitted at the proximal and distal ends of the first balloon, respectively. The fourth and fifth balloons are fitted at the proximal and distal ends of the second and third balloons, respectively. When the drug-coated balloon catheter is in the closed state, all five balloons are in a contracted state. When in the drug release state, the second and third balloons expand and adhere to the blood vessel wall to form a working area, so that the drug released by the expanded first balloon is blocked in the working area and will not be lost to other places with the blood flow. In the drug retrieval state, the first to third balloons are in a closed state, and the fourth and fifth balloons are in an expanded state to adhere to drugs, thrombi, or plaques floating in the blood vessel, ensuring the quality of vascular interventional treatment and reducing the risk of blockage.

The invention relates to the technical field of 4D-CT images, in particular to a 4D-CT image reconstruction method. The respiratory curve is obtained by utilizing the three-dimensional image body surface data of the 3D scanning equipment, so that additional equipment is not needed to collect respiratory movement information, the operation is simpler, a patient does not feel uncomfortable due to wearing of additional respiratory equipment, the experience of the patient is improved, the operation process of a doctor is simplified, and the working efficiency of the doctor is improved. The operation error is reduced to a certain extent; moreover, for thoracic and abdominal radiotherapy, in the process of collecting respiration data, collection can be carried out according to the position of the patient needing radiotherapy, and the selected ROI is directly selected in the radiotherapy area, so that the obtained respiration phase information can better fit the fluctuating motion of the area to be subjected to radiotherapy, the setting of the target area can be more accurate, and the radiotherapy accuracy is improved. The external boundary of a target region is reduced, the exposure dose of the target region is improved, and the toxic and side effects on normal tissues are reduced, so that the radiotherapy precision is improved.

The invention discloses an application of a snow white water lily extract. The invention relates to the field of medicines, in particular to the preparation of medicines for treating, preventing or improving depression and anxiety disorder, medicines for protecting brain neurons or repairing brain neuron injury, medicines for protecting tissues and organs induced by LPS, medicines for reducing expression of inflammatory factors 1L-1beta and / or TNF-alpha, medicines for treating, preventing or improving depression and anxiety disorder, medicines for protecting brain neurons or repairing brain neuron injury, medicines for protecting tissues and organs induced by LPS, medicines for reducing expression of inflammatory factors The invention also relates to an application in medicines for reducing the level of a hippocampus microglial cell marker Iba-1 and / or medicines for up-regulating the expression of brain-derived neurotrophic factors in hippocampus. The snow-white water lily extract is an ethyl acetate extract of a snow-white water lily ethanol water solution extract. The preparation method is green and safe, the raw materials are sustainable, the preparation process is simple, the activity is remarkable, and a foundation is provided for using the ethyl acetate extract of the water lily ethanol aqueous solution extract as an antidepressant and an antianxiety drug or as a main component or a characteristic component of the antidepressant and the antianxiety drug for clinically treating depression and the like.

The invention discloses ACE (angiotensin converting enzyme) inhibitory peptide VR8 as well as application and a preparation method thereof, and relates to the technical field of biology, and the key point of the technical scheme is that the amino acid sequence of the ACE inhibitory peptide VR8 is VPNSAEER. The invention also discloses application of the ACE inhibitory peptide VR8 in functional food for assisting in lowering blood pressure. The ACE inhibitory peptide VR8 obtained by the invention is extracted from bovine cheese protein, controls blood pressure while effectively inhibiting in-vitro ACE activity, and has the advantages of high specificity, small toxic and side effects and good curative effect, so that daily use and health care requirements are met in a mode of increasing the dosage.