111 results about "Tumor ablation" patented technology

The invention discloses a puncture robot tumor ablation method and system based on magnetic resonance. The method comprises the following steps: scanning a focus through medical imaging examination to obtain a preoperative magnetic resonance image; reconstructing to obtain a three-dimensional model of the focus and surrounding tissues, and planning to obtain an optimal puncture path; updating the position relation between the needle point of the puncture needle and the focus center in real time, feeding back deviation information of the needle point position, and guiding the puncture needle to a tumor ablation area in real time; two-way ablation is adopted, real-time temperature monitoring and whole blood circulation dynamic monitoring are conducted, and ablation power and time are correspondingly adjusted; the ablation effect is consolidated by adopting a postoperative wound management and closing technology; the ablation effect is evaluated through magnetic resonance imaging examination and postoperative biopsy. According to the puncture robot tumor ablation method based on magnetic resonance, tumor ablation can be achieved, temperature and blood flow monitoring is effectively carried out, and the ablation effect and the residual focus condition are reflected in real time through a comprehensive postoperative evaluation method.

The invention discloses a real-time monitoring puncture robot tumor ablation method and system, and the method comprises the steps: obtaining a tumor molecular level image, combining the tumor molecular level image with medical image data, carrying out the multi-level reconstruction, and obtaining a three-dimensional model of an organ and a tumor; extracting feature points of a tumor and a surrounding anatomical structure, and performing precision registration on a tumor position in the three-dimensional model and an ablation needle; adopting a self-adaptive path planning algorithm to formulate an optimal insertion path of the puncture needle; a sensor network is integrated on the ultrasonic probe and the puncture needle, information of a needle tip and surrounding tissue is monitored, thermal field distribution and the real-time position of the needle are updated in combination with the three-dimensional model, and the power and time of the ablation needle are adjusted; after ablation is finished, ultrasonic and CT image combined examination is carried out, and the tumor coverage condition of an ablation area is detected. According to the system, more accurate real-time guidance can be provided in the puncture process, the system cost is remarkably reduced, and the operation convenience is improved.

The invention discloses a tumor irreversible electroporation ablation simulation prediction system, which comprises the following modules: a simulation model geometric structure establishment module, which is used for determining related parameters of a tumor irreversible electroporation ablation operation and a catheter electrode structure, and establishing a geometric structure of a simulation model; the geometric model and numerical model setting module is used for setting a geometric model and a numerical model; respectively constructing a two-electrode plate type three-dimensional finite element multi-physical field simulation model and a three-electrode plate type three-dimensional finite element multi-physical field simulation model for irreversible electroporation ablation of tumors; the data set establishment module is used for respectively performing simulation calculation on the two numerical models constructed by the geometric model and the numerical model setting module; the model training module is used for training the respective data sets of the two numerical models obtained by the data set establishing module by using a random forest regression algorithm; and the simulation prediction module is used for predicting the tumor ablation condition and the damage condition of surrounding normal tissues. The system provided by the invention can accurately predict the tumor ablation condition and the damage condition of surrounding normal tissues.

The invention discloses a tumor ablation puncture operation planning method and system, and relates to the technical field of medical image processing, and the method comprises the steps: obtaining multi-modal image data of a tumor region, carrying out the preprocessing, carrying out the fusion processing of the preprocessed multi-modal image data through an image fusion algorithm, generating a fusion image, and carrying out the planning of a tumor ablation puncture operation based on the fusion image. A tumor area is automatically marked by using an image segmentation technology, a doctor manually corrects a segmentation result, an optimal puncture path is selected through design and simulation according to a fusion image with a tumor mark, a model and a tumor entity position are accurately aligned by using a space positioning technology based on the fusion image and augmented reality equipment, and an AR view is generated. And under the guidance of the AR view, the puncture needle carries out ablation operation according to the optimal puncture path. Through high-quality images and three-dimensional guidance, high precision and visualization of the whole process from image acquisition to operation implementation are achieved, and the safety and success rate of the operation are remarkably improved.

The invention relates to an ablation monitoring system based on real-time temperature and image feedback data, and the system comprises a temperature collection device which collects first temperature change information in a tumor internal ablation process in real time; the ablation device is configured to provide energy required by tumor ablation and is provided with a model of a color and temperature corresponding relation of a tumor surface image, and the model is called a first relation model for short; the image acquisition device acquires tumor surface ablation process image information in real time, which is called a first image for short; the temperature identification device is used for matching the color of each pixel of the first image with the first relation model to obtain the second temperature change information; the three-dimensional model simulation device is used for establishing a tumor three-dimensional model; and displaying the first temperature change information and the second temperature change information on the three-dimensional model in real time. By monitoring the temperature change in the tumor and the temperature change of the surface in the ablation process, the tumor ablation boundary is accurately controlled, and transition ablation is prevented.

The invention relates to a planning method, device and equipment for treating brain glioma through multi-fiber laser ablation. The method comprises the following steps: according to pre-acquired image information of a target patient and a segmentation result of a tumor region, sequentially performing segmentation sampling processing on the image information to obtain a candidate optical fiber path set; screening the candidate optical fiber path set according to an optical fiber planning objective function and an optical fiber planning constraint condition to obtain an intermediate optical fiber path set, and determining the number of optical fibers required by tumor ablation according to the intermediate optical fiber path set; determining a target optical fiber path set from the intermediate optical fiber path set according to the number of optical fibers required by tumor ablation and a predetermined path evaluation score; the target optical fiber path set at least comprises position information corresponding to each target optical fiber path. The method can improve the tumor ablation rate and reduce the use of optical fibers.

The present invention relates to a CT-guided tumor ablation scanning positioning and a device for an external fixator for an ablation needle, which is characterized by comprising a transparent adhesive tape and a fixator, wherein the transparent adhesive tape is rectangular and is provided with nine evenly arranged X-ray development positioning lines parallel to the long side direction thereof; a fixator is provided on at least one of the long sides of the transparent adhesive tape, and the fixator comprises a fixing seat and a support rod, wherein the fixing seat is long and fixedly connected to the long side of the transparent adhesive tape, a slide groove is provided in the fixing seat, a slider is installed in the slide groove, and there is friction resistance between the slider and the slide groove; the lower end of the support rod is connected to the slider, and a caliper for holding and fixing the ablation needle is installed at the upper end of the support rod. The present invention has an ingenious structure, a reasonable design, and is easy to use. It can free the doctor's hands during microwave ablation, and can prevent the displacement of the ablation needle to avoid causing serious complications.

The invention provides an electric tungsten fire needle tumor ablation system, and the system comprises an image navigation module which is used for integrating CT / MRI / ultrasonic images, constructing a three-dimensional tumor model in real time, tracking a target region through electromagnetic positioning, and dynamically calibrating a needle insertion path; the insulating tungsten fire needle execution module is used for adopting a high-density tungsten alloy needle body and a multi-axis mechanical arm to control multi-angle puncture; the energy output module is used for intelligently adjusting radio frequency / microwave power and releasing energy in a pulse mode; and the temperature control feedback module is used for monitoring the temperature in real time and automatically terminating overheating energy. According to the technical scheme, accurate, safe and effective ablation of tumors is achieved.

The invention belongs to the technical field of cancer drugs, and particularly relates to a pancreatin-responsive bioactive peptide, nanofiber hydrogel prepared from the pancreatin-responsive bioactive peptide and application of the pancreatin-responsive bioactive peptide. The trypsin response-based bioactive peptide 1-Pept (the sequence of the trypsin response-based bioactive peptide 1-Pept is naphthylacetic acid-phenylalanine-glycine-tyrosine-lysine-cysteine-aspartic acid) and an anti-cancer drug adriamycin can be jointly assembled into 1-Pept / Dox nanofiber hydrogel, and a cytoskeleton can be destroyed by combining nanofibers with Dox; a series of cascade events resulting in cellular dysfunction are initiated, including mitochondrial damage, activation of apoptosis-associated proteins, and nuclear damage, thereby cooperatively causing tumor ablation. Compared with the existing single anti-cancer drug adriamycin, the in-vivo and in-vitro anti-cancer effect of the compound is obviously superior to that of the adriamycin pure drug, and the compound has obvious advantages in the aspect of resisting colon cancer.

The invention relates to a bone tumor ablation target region identification and real-time updating method. The method comprises the following steps: processing a multi-modal medical image acquired before an operation, performing information trust empowerment on a bone tumor area according to an image source type, structural definition, bone tissue shielding degree and spatial distribution complexity, and dividing the bone tumor area into a core target area, a semi-trusted marginal area and a dispute area; in the intraoperative ablation process, an ablation temperature change path, power response distribution and navigation position information are continuously monitored, and when it is detected that temperature response is sparse, a needle tip is static and energy motivates discontinuous feature combination in a semi-credible marginal area or a dispute area, target area offset warning logic is triggered; according to the bone tumor target region identification mechanism based on the multi-modal medical image trust empowerment, multi-dimensional information factors such as the image source type, the structure definition, the bone tissue shielding degree and the spatial distribution complexity can be considered at the same time.

The invention discloses a tumor ablation decision-making method and system driven by CT big data. The method comprises the following steps: acquiring CT image data of a patient, preprocessing, and extracting to obtain an anatomical structure feature identifier set; calculating possible puncture path connecting lines to obtain a candidate path space set; adopting a discrete optimization algorithm to obtain an optimal solution of the puncture path; managing a needle point and a needle entry point of the ablation needle, and controlling an intraoperative needle passage to accord with a planned path; calculating through a heat conduction equation, generating and updating an ablation thermal field model, and dynamically displaying ablation thermal field distribution; and calculating an ablation index, and adjusting an ablation parameter or a puncture path. The system comprises a data set extraction module, a puncture path connecting line calculation module, an optimal space set module, a puncture path optimal solution calculation module, a needle passage control module, a thermal field distribution display module and an adjustment module. The precision and safety of tumor ablation can be greatly improved, excessive ablation or incomplete ablation is avoided, and damage to normal tissue is reduced.

The invention relates to an integrated optical fiber diagnosis and treatment integrated minimally invasive probe based on a rare earth nano material, and belongs to the technical field of medical minimally invasive machinery. The probe is composed of a flexible silica fiber, a rare earth doped nano core transfer material and a graphene composite photo-thermal layer. The temperature of the focus is monitored in real time through the fluorescence intensity ratio technology. In order to achieve the purpose of photo-thermal treatment, the graphene composite material is added, by means of the high thermal conductivity of the graphene composite material and the non-radiative relaxation effect of rare earth ions, the photo-thermal conversion efficiency is improved, and the thermal conductivity is further enhanced. The device has the advantages of miniaturization, high sensitivity, electromagnetic interference resistance and the like, and can be applied to scenes such as tumor ablation and vascular intervention.

The invention discloses a difunctional nano preparation for tumor starvation and photothermal therapy as well as a preparation method and application of the difunctional nano preparation. The difunctional nano preparation is prepared from PDA (at) MXene and glucose oxidase loaded on the PDA (at) MXene, wherein the glucose oxidase is loaded on the PDA (at) MXene; the PDA (at) MXene comprises an MXene nanosheet and polydopamine, and the MXene nanosheet is modified by the polydopamine. According to the invention, polydopamine (PDA) is modified on an MXene nanosheet so as to improve the photothermal conversion efficiency, and glucose oxidase (GOX) is loaded on PDA-coated MXene with a large surface area so as to catalyze glucose in situ. The bifunctional nano preparation shows higher photo-thermal response efficiency than that of a single MXene nanosheet, promotes the pharmacokinetic effect of glucose oxidase, and realizes '1 + 1gt, multipurpose 'deep tumor ablation.

1. Name of the design product: Electrode ablation needle. 2. Use of the design product: For performing tumor ablation surgery. 3. Design key points of the design product: Lies in the shape. 4. Picture or photograph that best shows the design key points: Perspective view.

A method and a system for thermally or hyperthermally treating an object. A precipitating hydrophobic injectable liquid (PHIL) embolic agent is prepared and enhanced with a magnetic nanoparticle (NP). A delivery device is advanced to a target area and the PHIL−IONP embolic agent is injected directly at the target area. The PHIL and IONPS are observed in-situ using complementary imaging and an impulse is applied to the target area to generate heat sufficient to thermally ablate or induce hyperthymia at the target area. Additional impulses applied to the target areas at later times generate heat sufficient to ablate or induce hyperthymia at the target.

The invention discloses a nano-knife for clinical tumor ablation treatment. The nano-knife comprises a nano-knife electrode needle, and a puncture needle outer sleeve, a puncture sharp needle, a puncture blunt needle, a power supply containing and holding cylinder, a Luer taper and a round block which are matched with the nano-knife electrode needle for use. The puncture needle has the advantages that the puncture needle outer sleeve made of the matched insulation material is adopted, the gravity of the insulation puncture needle is small, and the influence of the gravity and the traction effect in the needle moving process is reduced; the puncture needle core is taken out, the puncture needle outer sleeve is reserved, the nanometer knife electrode needle can enter the tumor position through the puncture needle outer sleeve conveniently, and after the nanometer knife electrode needle is in place, the size of an electrode axial discharge area is controlled through cooperation of the nanometer knife electrode needle and the puncture needle outer sleeve; the puncture needle comprises a coaxial sharp puncture needle and a coaxial blunt puncture needle, and the coaxial sharp puncture needle is adopted when the puncture percutaneously passes through the tissue; the needle passes through the cavity and can be penetrated by a puncture blunt needle, so that the injury to a patient can be reduced.

The utility model relates to the technical field of medical equipment, and particularly discloses a bipolar nanosecond pulse synchronous output circuit and ablation equipment, which comprise a positive pulse output circuit and a negative pulse output circuit, the positive pulse output circuit comprises a positive pulse charging unit, a positive pulse output control unit, a positive pulse transmission unit and a positive pulse output electrode wire which are electrically connected in sequence; the negative pulse output circuit comprises a negative pulse charging unit, a negative pulse output control unit, a negative pulse transmission unit and a negative pulse output electrode wire which are electrically connected in sequence; the positive pulse transmission unit at least comprises a forward multiplication transmission unit which is used for performing forward voltage multiplication or forward current multiplication on the forward output pulse signal; the negative pulse transmission unit at least comprises a negative multiplication transmission unit which is used for carrying out negative voltage multiplication or negative current multiplication on the negative output pulse signal. The bipolar nanosecond pulse synchronous output circuit provided by the utility model can improve instant pulse energy of nanosecond pulse tumor ablation equipment.

The invention discloses a precise positioning system for efficient tumor interventional ablation. The precise positioning system comprises the following steps: step 1, a CT image processing module; step 2, weak attribute pixel point processing; 3, a machine learning module; 4, a tumor ablation navigation module; and step 5, a visualization module. More comprehensive tumor information is provided by fusing CT, MRI and PET images, the advantages of each modal image are combined, the recognition of a tumor area is more accurate and comprehensive, the fused image is automatically segmented by using a U-Net deep learning model, the accurate boundary of a tumor can be effectively recognized, the deep learning model has strong image recognition capability, and the recognition efficiency of the tumor area is improved. The tumor segmentation precision can be greatly improved, a multi-probe strategy is introduced, the positions and insertion paths of a plurality of thermal ablation needles are planned, through the synergistic effect of the plurality of probes, it is ensured that the ablation range covers the whole tumor area, the ablation coverage range is widened, the problem of incomplete ablation can be effectively avoided, and the postoperative recurrence risk is reduced.

The invention relates to the technical field of medical robots, in particular to a super-resolution optical-photoacoustic bimodal imaging guided tumor ablation treatment robot system which comprises a super-resolution optical imaging module, a photoacoustic imaging module, a multi-degree-of-freedom mechanical arm, an ablation energy generating device, a main control system and a real-time navigation module. According to the system, high resolution and deep tissue information fusion is realized through bimodal imaging, and the problems of tumor boundary positioning and deep information acquisition in a complex anatomical environment can be effectively solved in combination with the precise positioning and ablation treatment functions of the mechanical arm. The system supports 5G remote operation, augmented reality navigation and self-inspection functions, has high precision, real-time performance and safety, and can significantly improve the efficiency and accuracy of tumor ablation treatment.

The invention discloses a tumor ablation image fusion modeling method based on deep learning, and relates to the technical field of intelligent medicine, and the method comprises the steps: obtaining a plurality of preoperative tumor images of a tumor patient before an ablation treatment puncture operation is carried out on a tumor; performing image fusion on the first ultrasonic tumor image, the first CT tumor image and the first MRI tumor image to obtain a preoperative fusion tumor image; the method comprises the following steps of: acquiring a plurality of intraoperative tumor images of a tumor patient in the process of performing ablation therapy puncture operation on the tumor; obtaining an intraoperative fusion tumor image for the second ultrasonic tumor image, the second CT tumor image and the second MR I tumor image; and according to the extracted spatial mode data and deep learning training data, constructing a deep learning model, and carrying out training optimization on the constructed deep learning model to obtain a tumor ablation image fusion model. According to the invention, the treatment effect of the ablation treatment puncture operation can be accurately evaluated based on the tumor ablation image.

The invention discloses a high-voltage steep pulse tumor ablation needle with a gas-liquid channel, and relates to the field of ablation needles, the high-voltage steep pulse tumor ablation needle comprises a fixed cylinder, a second needle body with a gas channel is fixedly connected in the fixed cylinder, a third needle body with a gas-liquid channel is coaxially arranged in the second needle body, and the high-voltage steep pulse tumor ablation needle further comprises a sliding cylinder, the sliding cylinder is fixedly connected with a first needle body with a gas channel, the first needle body is sleeved outside a second needle body in a sliding manner, the sliding cylinder is connected to the end part of the fixed cylinder in a sliding manner, the first electrode column is arranged at the end part of the first needle body, the end part of the second needle body is fixedly connected with a second electrode column, and the second electrode column is arranged at the end part of the first needle body. And through holes are uniformly formed in the side walls of the first electrode column and the second electrode column. The single needle is used for achieving triple treatment of freezing, steep pulse and PD-1 inhibitor of tumor ablation, the tumor ablation effect is effectively improved, and meanwhile the surgical operation difficulty is lowered.

A system and method for navigation of a luminal network including receiving a computed tomography (CT) image data set, generating a three-dimensional (3D) model, displaying the 3D model in a user-interface on a display operatively connected to the computing device, and receiving an indication of a location of a tumor in the CT image data set. The system and method further including displaying the location of the tumor in the 3D model, receiving an indication of a margin around the tumor to achieve a desired therapy, generating a pathway to the tumor for navigation of a catheter, receiving a location of a sensor associated with a navigation catheter and registering the CT image data set with a luminal network of a patient, displaying the location of the sensor within the 3D model that substantially corresponds to the location of the sensor within the luminal network of the patient.

Spinal tumor ablation devices and related systems and methods are disclosed. Some spinal tumor ablation devices include electrodes that are fixedly offset from one another. Some spinal tumor ablation devices include a thermal energy delivery probe that has at least one temperature sensor coupled thereto. The position of the at least one temperature sensor relative to other components of the spinal tumor ablation device may be controlled by adjusting the position of the thermal energy delivery probe in some spinal tumor ablation devices. Some spinal tumor ablation devices are configured to facilitate the delivery of a cement through a utility channel of the device.

Disclosed are systems and methods for biopsy, drainage, drug administration, electrode implantation and / or tumor ablation employing percutaneous procedures for diagnostic or therapeutic purposes, performed by inserting a needle or probe through the skin of patient towards target anatomy using a patient mounted robot.

The invention relates to the technical field of medical instrument auxiliary equipment, and discloses an auxiliary device for tumor ablation therapy, which comprises a plurality of groups of brackets, the locking mechanism is connected between the adjacent brackets and is used for folding, adjusting and locking the adjacent brackets; the clamping mechanism is arranged at one end of a whole formed by the multiple sets of supports, a universal sleeve is fixedly installed at the other end of the whole, a rigid guide channel is formed by the auxiliary device for tumor ablation treatment and the puncture hole, and an ablation needle is restrained by the hole wall when penetrating through the hole, so that transverse shaking is avoided; the angle can be flexibly adjusted during unlocking, the movement range of the ablation needle is effectively limited through the design, the problem that puncture fails due to shaking of a tumor with the small size or the deep position is solved, the probability of repositioning or operation termination is reduced, and the working efficiency is improved. The treatment risk and pain of a patient are reduced, positioning deviation caused by slight vibration or operation touch of the device is avoided, and it is ensured that the ablation needle accurately reaches the tumor core area.

The application discloses a percutaneous needle type ultrasonic probe, which comprises a handle (1), an outer sleeve (2), a puncture tip (21) formed at the front end of the outer sleeve (2), an ultrasonic window (22) arranged at the side of the outer sleeve (2) close to the puncture tip (21), the outer sleeve (2) being provided with a first cavity (23) arranged along the axial direction, a rotating shaft (3) arranged in the first cavity (23), an ultrasonic assembly (4) arranged at the front end of the rotating shaft (3) and corresponding to the position of the ultrasonic window (22) when arranged in the first cavity (23), and a rotating mechanism (5) for driving the rotating shaft (3) to rotate and thus driving the ultrasonic assembly (4) to rotate, wherein the rotating mechanism (5) is arranged in the handle (1). The percutaneous needle type ultrasonic probe can directly penetrate into tissues through skin, obtain high-resolution ultrasonic images, and generate two-dimensional and real-time three-dimensional stereoscopic images through multi-angle rotation, thereby providing accurate ultrasonic guidance for diagnosis and interventional treatment, and being suitable for precise treatment operations such as tumor ablation, drug delivery and energy delivery.

The utility model relates to a tumor ablation needle for a nanometer knife. The tumor ablation needle comprises a puncture needle head, an anode conductor and a cathode conductor, the puncture needle head is cylindrical, the front end of the puncture needle head is in a closed tip shape, the rear end of the puncture needle head is open, and a small hole penetrating in the radial direction is formed in the middle of the puncture needle head. The periphery and the inner wall of the middle part of the puncture needle head are respectively coated with a conductive coating I and a conductive coating II; the inner wall of the small hole is coated with a conductive coating III; the conductive coating III is respectively connected with the conductive coating I and the conductive coating II; the positive electrode conductor is cylindrical, and the periphery of the positive electrode conductor except two ends is coated with a positive electrode insulating sleeve; the cathode conductor is a cylinder with two open ends, and the periphery of the cathode conductor is wrapped with cathode insulating sleeves except the two ends; the front end of the negative conductor is connected with the rear end of the puncture needle head, and the negative conductor is electrically connected with a negative wire; the front end of the positive conductor is tightly attached to the conductive coating II, and the rear end of the positive conductor is connected with a positive wire. According to the utility model, the operation difficulty can be reduced.

Devices, systems, and methods to generate a plan for an interstitial laser ablation procedure are disclosed. The systems may be configured as an interstitial optical mapping system including a catheter, an emitter optical fiber, an imaging optical fiber, a light source, and a processing unit. The emitter optical fiber and the imaging optical fiber are used to interstitially image a fluorescent dye associated with a tumor, including the tumor margin, at discrete imaging positions along a length of the catheter. The processor calculates a location of the fluorescent dye at each discrete position and creates an optical map representing the tumor. The optical map is used to generate an interstitial laser ablation plan that includes laser fiber pull-back positions.

The present invention discloses a puncture robot tumor ablation method and system based on magnetic resonance imaging. The method includes: scanning the lesion through medical imaging examination to obtain a preoperative magnetic resonance image; reconstructing a three-dimensional model of the lesion and surrounding tissues, and planning the optimal puncture path; updating the positional relationship between the needle tip and the center of the lesion in real time, feeding back the deviation information of the needle tip position, and guiding the puncture needle to the tumor ablation area in real time; using dual-path ablation to perform real-time temperature monitoring and whole blood circulation dynamics monitoring, and adjusting the ablation power and time accordingly; using postoperative wound management and closure technology to consolidate the ablation effect; and evaluating the ablation effect through magnetic resonance imaging examination and postoperative biopsy. The present invention can realize a puncture robot tumor ablation method based on magnetic resonance for tumor ablation, effectively perform temperature and blood flow monitoring, and reflect the ablation effect and residual lesion status in real time through a comprehensive postoperative evaluation method.

The invention relates to the technical field of medical image processing and tumor treatment planning, and discloses a tumor ablation assessment method based on clustering and dynamic weight Monte Carlo sampling, and the method comprises the steps: dividing a tumor, i.e., a healthy region, through spatial clustering, optimizing sample distribution in combination with an error feedback mechanism related to a region density compensation factor, and obtaining a tumor ablation result; introducing a momentum enhanced weight updating strategy, correcting sparse region sampling deviation, adaptively balancing historical errors, rapidly judging a sample membership relationship through an ablation ellipsoid model, and synchronously calculating a tumor ablation coverage rate and a healthy tissue damage rate; the tumor ablation coverage rate and the healthy tissue damage rate can be rapidly, stably and accurately calculated synchronously, and a reliable quantitative basis is provided for real-time planning in an operation and accurate evaluation after the operation.