494results about "Surgical instruments for cooling" patented technology

Embodiments of the invention provide devices and methods for at least one disease by delivering an effective amount of energy and / or a formulation to tissue on or near a body lumen. The formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, a suspension, or a combination thereof of one or more ingredients. The delivered amount of formulation and / or energy may be effective to damage or damage tissue, nerves, and / or nerve endings to relieve disease symptoms.

A current supply arrangement (22) is used for electrical supply of two electrodes (18, 19), as well as for mechanical force transmission in a thermofusion instrument. Due to the configuration of the two electrical conductors (23, 28) as upright arranged flat parts and the force concerned coupling thereof in an interlocking section (32), the electrical conductors (23, 28) can be used as mechanical stiffening elements, whereby a filigree, gap-free, easily and reliably sterilizable configuration is achieved. The current supply of the instrument (10) is provided via one single cable (20) only, which is provided only on one of the two jaws (11, 12).

A cryoprobe includes a needle defining an internal cavity, a cryogen conduit positioned in the internal cavity, an adjustable insulating sleeve positioned in the inner cavity radially outward of the cryogen conduit, and a heater configured to heat the needle to predetermined temperature.

The invention discloses an adjustable targeting area type cryoablation needle with a heating function and a novel refrigerant hole structure, and belongs to the technical field of interventional medical instruments, the adjustable targeting area type cryoablation needle comprises a needle rod, a vacuum wall, a J-T groove, a J-T groove sleeve and an adjusting device; the vacuum wall is sleeved with the needle rod, the area from the far end of the needle rod to the far end of the vacuum wall is a target area, the area of the vacuum wall is a vacuum heat insulation area, and the vacuum wall comprises a vacuum wall outer pipe and a vacuum wall inner pipe; the J-T groove is formed in the vacuum wall inner tube, the far end of the J-T groove is located in the far end of the needle rod, and a side hole is formed in the side wall of the J-T groove; the J-T groove is sleeved with the J-T groove sleeve; the J-T groove sleeve and the vacuum wall are fixed together through a connecting piece and can move synchronously and axially. And the adjusting device is used for adjusting the length of the target area. By innovatively designing the arrangement of the cooling ablation air holes and the heat conduction isolation layer, more accurate control over the cryoablation range is achieved, and the safety and effectiveness of cryoablation interventional therapy are improved.

Methods and devices for treating nasal airways are provided. Such devices and methods may improve airflow through an internal and / or external nasal valve, and comprise the use of mechanical re-shaping, energy application and other treatments to modify the shape, structure, and / or air flow characteristics of an internal nasal valve, an external nasal valve or other nasal airways.

A probe for performing a cryoablation treatment that includes a handle with a heater configured to heat a fluid and a needle connected to the handle and extending therefrom to a distal end. The needle includes a pathway configured to move the fluid from the handle toward the distal end to heat the needle.

A method of positioning a cryoprobe includes receiving a cryoprobe repositioning selector indicating a desire to reposition a cryoprobe relative to a target tissue; obtaining cryoprobe operating information from one or more sensors positioned in the cryoprobe, wherein the cryoprobe operating information characterizes one or more operating parameters of the cryoprobe; energizing a heater in the cryoprobe to heat a tip of the cryoprobe to a predetermined cautery temperature threshold; and displaying a cautery indicator when the tip of the cryoprobe is greater than or equal to the cautery temperature threshold.

The invention discloses an efficient freezing radiofrequency ablation catheter and ablation system, and belongs to the technical field of freezing ablation, the efficient freezing radiofrequency ablation catheter comprises a needle head part, a catheter part, a handle part, a water injection connector part, a catheter extension tube part and a plug assembly; the needle head part is of a metal head structure, and the near end of the needle head part is connected with the inner and outer multilayer structures of the catheter part; the catheter part is of a multi-layer flexible tube structure and is used for connecting the handle part and the needle head part; the handle part is held by a user, the near end of the handle part is connected with the catheter extension tube part and the water injection joint part, and the far end of the handle part is connected with the catheter part; the water injection joint part is used as a water quantity control water inlet; the catheter extension tube part expands the use range; the plug assembly realizes plugging and fixation of a product. The flexible ablation catheter can be widely applied to natural orifice ablation operations and has the advantages of integration of cold and hot ablation design, diversity of ablation application range, high ablation efficiency and the like.

The invention discloses a cryoablation needle, and relates to the field of medical equipment, the cryoablation needle comprises a handle, a needle rod, a first air inlet pipe assembly, an air return pipe, a connecting sleeve, a sealing head, a clamping sleeve type compression joint and a second air inlet pipe assembly, the interior of the needle rod is arranged to be of a cavity structure with one end open, and one end of the connecting sleeve is fixedly connected with the handle; the sealing head is arranged on the needle rod in a sleeving mode and is in threaded sealing connection with the inserting end of the connecting sleeve, the air inlet end of the air return pipe is arranged in an air return channel of the connecting sleeve, and the cavity of the needle rod, the air return channel of the connecting sleeve and the air return pipe jointly form an air return channel. The air outlet end of the second air inlet pipe assembly is fixedly connected to the open end of the air return channel of the connecting sleeve and used for being in butt joint with the air inlet end of the first air inlet pipe assembly, and the clamping sleeve type compression connector is fixedly connected to the end of the telescopic structure of the connecting sleeve. The length of the needle rod exposed out of the body of a patient can be adjusted according to actual needs, and meanwhile the connection sealing performance of the needle rod is improved.

Embodiments herein relate to cryoablation systems. In an embodiment, a cryosurgery system includes a closed-loop working fluid circuit configured to contain a working fluid. The system can include a compressor configured to increase the pressure of the working fluid. The system can include a heat exchanger configured to lower the temperature of the working fluid. The system can include a cryoablation probe having a shaft having a supply tube and a return tube surrounding the supply tube. The system is configured so that, after exiting the first heat exchanger, the working fluid will enter the cryoablation probe, travel to the expansion chamber, expand in the expansion chamber at a Joule-Thomson orifice, travel to the cryoablation probe interface via the return tube, exit the cryoablation probe via the working fluid outlet, enter the compressor, and enter the first heat exchanger.

A transperineal biopsy guide for use with an access needle and a transrectal imaging probe. The transperineal biopsy guide includes a mount, a guide member, and an access needle support structure. The mount is attachable to the probe. The guide member includes: a first side comprising a first distal member and a first surface extending proximally from the first distal member; a second side comprising a second distal member and a second surface extending proximally from the second distal member; and a gap between the first distal member and the second distal member. The access needle support structure is securable to the guide member in a distal position that inhibits vertical and distal displacement of the access needle support structure relative to the guide member while permitting disengagement from the distal position via proximal movement of the access needle support structure relative to the guide member.

Disclosed herein is a composition comprising an amount of water; hyaluronic acid; and a first excipient, wherein the composition is configured to form into a flowable cold slum when the composition is exposed to a temperature below 0° C.

A cryogenic device with a cartridge holder for a cryogen cartridge, cryogen cartridge is coupleable to a cryogen pathway; a probe receptacle for receiving a needle probe, wherein the probe receptacle is configured to couple the needle probe to the cryogen cartridge via the cryogen pathway, and wherein the needle probe comprises: one or more needles having needle lumens disposed therein; a probe extension extending proximally, the probe extension having a probe lumen disposed therein, the probe lumen including an elongate element that extends from a proximal end to a distal end, wherein the probe lumen is coupled to the needle lumens at the distal end, and the cryogen pathway at a first location in between the proximal end and the distal end. Various connection mechanisms for securing needle probes to a handpiece portion are disclosed.

A system (12), comprising: a display device (24); a memory (20) comprising instructions (32); and one or more processors (16) configured by the instructions to: receive an ablation plan comprising plural ablation zones corresponding to plural applicators, the plural ablation zones comprising one or more single ablation zones and one or more composite ablation zones; and provide on the display device a representation of the ablation plan (58) and a visual distinction between sequentially activated applicators and simultaneously activated applicators, the plural applicators comprising the sequentially activated and simultaneously activated applicators.

Elongate medical devices with an expandable structure including elongated splines and a distal hub. An elongate medical device includes a handle including a control mechanism, a catheter shaft, and an expandable structure including elongated splines and a distal hub. Each of the elongated splines includes a shape memory material and an interactive element. Each of the elongated splines includes a respective spline proximal end and a spline distal end. Each of the spline proximal ends is connected to the catheter shaft distal end. Each of the spline distal ends is connected to the distal hub. A deflection control member is connected to the distal hub. The control mechanism is drivingly coupled to the distal hub via the deflection control member and operable to selectively vary a position of the distal hub relative to the catheter shaft distal end to selectively vary an amount of expansion of the expandable structure.

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The present application belongs to the field of medical devices, and relates to an ablation needle positioning support, comprising a support body, a limiting component and a support leg component. The limiting component is fixed to the support body and is used for limiting the movement of the ablation needle in a preset direction; the support leg component comprises a plurality of support legs mounted on the support body, and at least part of the support legs are movably connected with the support body so as to be able to adjust the relative position and / or angle with the support body. The support body of the present application establishes support on the surface of the human body, and at least part of the support legs are movably connected with the support body, so that the adaptation of the skin curve at different positions of the human body can be realized. The limiting component can establish the limitation on the ablation needle, limit the movable direction of the ablation needle, and significantly reduce the difficulty of keeping the ablation needle stable after puncture.

The present invention relates to a cosmetic composition for application to the epidermis for the treatment of cutaneous hyperpigmentation by means of a cryogenic fluid and a device configured to ensure the ejection and spraying of a controlled quantity of said fluid, characterized in that it comprises a dose of cryogenic fluid obtained by a sequence of at least one spray (N) of said fluid onto the epidermis at a flow rate of 0.61 ml / s, within a range of negative skin temperatures between 0°C and -5°C, creating oscillations in the temperature of said epidermis with a total duration of between 1.5 seconds and 25 seconds, each oscillation consisting of a rapid cooling phase at a temperature decrease rate between 50°C / s and 170°C / s followed by a slower temperature increase phase to a temperature between 20°C and 34°C. Abstract figure: Fig. 1

A method performed by a surgical system. The method determines a resonance frequency of an end effector of an ultrasonic instrument, and determines whether the end effector of the ultrasonic instrument is in a heating state or a cooling state. Responsive to determining that the end effector is in the heating state, the method estimates a temperature of the end effector based on output of a first temperature model that has input based on the resonance frequency. Responsive, however, to determining that the end effector is in the cooling state, the method estimates the temperature of the end effector based on output of a second temperature model that has input based on the resonance frequency. The method presents a notification based on the estimated temperature.

Methods and devices for reducing visceral fat within the mesenteric structure of the body by cooling visceral fat within the mesentery while leaving arteries, veins, nerves and lymph nodes within the mesentery, and the mesentery membrane, undamaged, and thereafter allowing natural processes of the body to eliminate the cooled visceral fat from the body. The system comprises a pair of flat-faced cooling probes configured for insertion into the abdomen and placement on opposite sides of a section of mesentery for application of cooling power to the mesentery, at temperatures in a range which kills visceral fat cells but does not harm other tissue.

The present disclosure provides a method for treating cancer, which includes, inter alia, a) an intratumoral cell lysis step mediated by cryolysis, and b) an intratumoral administration step of a combination of immunotherapeutic agents including: 1) i) a TLR9 agonist CpG oligodeoxynucleotide, ii) an agonistic anti-CD40 monoclonal antibody, iii) an agonistic anti-OX40 monoclonal antibody, and iv) an anti-CTLA4 monoclonal antibody, or 2) i) a TLR9 agonist CpG oligodeoxynucleotide, ii) an agonistic anti-CD40 monoclonal antibody, iii) an anti-PD1 monoclonal antibody, and iv) an anti-CTLA4 monoclonal antibody.

Apparatus, including an enclosure having a base and a cover with respective conductive layers. The conductive layers connect to form a shield attenuating electromagnetic radiation originating outside the enclosure in a range of 10 kHz - 100 kHz by at least 20 dB within the enclosure. An adapter circuit within the enclosure processes electrophysiological signals to generate an output signal. A first connector passing through the enclosure connects to a probe to receive the electrophysiological signals and convey them to the adapter circuit. A second connector passing through the enclosure receives the output signal from the adapter circuit and conveys it to a console. A control input receives a control signal indicative of a frequency within the range, and a sensing circuit senses a magnetic field within the enclosure and outputs a warning signal when the magnetic field at the frequency indicated by the control signal exceeds a preset threshold.

The invention pertains to an electrically operated cryocabin arrangement (100) comprising an open-top cabin (10) with a number of thermal sensor arrays (13) arranged at different heights along an internal perimeter of the cabin, a number of cooling units (20), and a data processing unit (30), wherein the data processing unit is configured to receive user-specific data comprising at least temperature indications (t1) measureable at skin surface of a user by the thermal sensor arrays throughout an operation cycle, during which cycle a cooling fluid (201) is delivered into the cabin and distributed inside the cabin via the cooling units (20), and, based on said user-specific data, to selectively adjust variables related to distribution of the cooling fluid inside the cabin to a predetermined level, said variables being at least a flow velocity (V) of a cooling fluid stream and / or a temperature (t2) of the cooling fluid, wherein the cooling fluid distribution variables are adjusted to reach the values, at which temperature indications (t1) measureable at the user skin surface are within a range of 0 to +20 degree Celsius, and wherein adjustment is performed in real time, continuously throughout the operation cycle. A computer implemented method to operate the cryocabin arrangement and a computer program product adapted to perform the method are further provided.

The present invention provides tissue processing systems, apparatus, and methods. [Solution] Provided herein is a system for treating patient tissue. The system comprises an energy delivery console and at least one energy delivery device. The energy delivery console can deliver a first dose of energy and a second dose of energy. The energy delivery device comprises a first delivery element configured to deliver a first dose of energy to target tissue and a second delivery element configured to deliver a second dose of energy to target tissue. The first dose of energy may include the delivery of energy that reversibly alters the target tissue, and the second dose of energy may include the delivery of energy that irreversibly alters the target tissue. The first dose of energy is delivered to enhance the therapy provided by the second dose of energy.

A portable cryogenic applicator includes a vessel for liquid nitrogen to deliver liquid nitrogen for treatment of skin surfaces using the rotating roller from porous biocompatible material. The cryogenic applicator includes a capillary U-bend to prevent spontaneous discharge of liquid nitrogen through the capillary system to the roller during filling or refilling the cryogenic applicator with liquid nitrogen. The cryogenic applicator also includes a vacuum valve that produce an insulating vacuum environment in a vacuum cavity to prevent heat transfer between the vessel for liquid nitrogen and a vacuum casing, which allows the external surface of the cryogenic applicator to be maintained at ambient temperature. The cryogenic applicator may include a control valve for regulating and maintaining the working pressure in the vessel for liquid nitrogen sufficient to deliver liquid nitrogen through the capillary system and the porous roller body to the surface skin of a patient.

Embodiments herein relate to cryoablation systems. In an embodiment, a cryosurgery system includes a closed-loop working fluid circuit configured to contain a working fluid. The system can include a compressor configured to increase the pressure of the working fluid. The system can include a heat exchanger configured to lower the temperature of the working fluid. The system can include a cryoablation probe having a shaft having a supply tube and a return tube surrounding the supply tube. The system is configured so that, after exiting the first heat exchanger, the working fluid will enter the cryoablation probe, travel to the expansion chamber, expand in the expansion chamber at a Joule-Thomson orifice, travel to the cryoablation probe interface via the return tube, exit the cryoablation probe via the working fluid outlet, enter the compressor, and enter the first heat exchanger.

Methods and devices for treating nasal airways are provided. Such devices and methods may improve airflow through an internal and / or external nasal valve, and comprise the use of mechanical re-shaping, energy application and other treatments to modify the shape, structure, and / or air flow characteristics of an internal nasal valve, an external nasal valve or other nasal airways.

A freezing probe comprising (a) a handle, (b) a shaft located distal to the handle and having a generally rigid proximal portion and a generally flexible distal portion, and (c) an active tip located distal to the shaft, wherein the shaft includes a supply conduit configured to supply freezing fluid to the active tip, a discharge conduit configured to discharge used freezing fluid from the active tip, and a vacuum insulation layer disposed around the supply conduit and the discharge conduit.

A surgical kit for providing a cryoprotective composition configured to be applied during cryotreatment of a patient includes: a first container containing a predetermined amount or volume of a biodegradable and / or bioerodible fluid agent; and a second container containing a predetermined amount or volume of a non-toxic cryoprotectant agent. The predetermined amount or volume of the of biodegradable and / or bioerodible fluid agent and the predetermined amount or volume of a non-toxic cryoprotectant agent are configured to be mixed together to form the cryoprotective composition in which a therapeutically effective amount of the cryoprotective composition deposited in a body space of the patient in proximity to the cryotreatment remains within at least a portion of the body space for a duration of the cryotreatment and at least a portion of a body tissue proximate to the body space is viable after the cryotreatment.

The invention provides a device for treating at least one of rhinitis, congestion, and / or rhinorrhea to thereby reduce or eliminate symptoms associated therewith, including, but not limited to, coughing, sneezing, nasal or throat irritation and itching, and difficulty sleeping. The device includes a shaft, a retractable and expandable end effector, and handle, that, as a whole, provide a high level of precise control and feedback to an operator during a procedure. The shaft includes an electrode array provided along a length thereof configured to deliver energy to specific target sites within the nasal passage and nasal cavity in conjunction with neuromodulation provided by the end effector.