273 results about "Alimentary tract" patented technology

The invention relates to the technical field of medical robots, in particular to an alimentary canal catheterization robot navigation method and system based on multi-modal information fusion. The method comprises the following steps: carrying out real-time data acquisition on a human body cavity by utilizing a multi-mode sensor; the collected multi-modal data is preprocessed; synthesizing multi-modal data, extracting cavity environment characteristics, and establishing a three-dimensional model of a human body cavity in real time; human body cavity environment characteristics are analyzed, and local and global paths are generated; outputting the path to a catheterization robot controller, driving a catheterization robot, monitoring a navigation abnormal state in real time, and collecting and storing the path, the sensor state and operation data in the navigation process; the system comprises a data acquisition module, a data processing module, a three-dimensional model establishment module, a path generation module and a data monitoring module. Through the mode, the environment is comprehensively perceived, the navigation precision and the real-time performance are improved, and the high-precision operation requirement in a clinical complex environment is met.

The invention relates to the technical field of medical robot control, in particular to a teleoperation control method and system for an alimentary canal catheterization robot. The control method comprises the following steps: acquiring digestive tract three-dimensional structure data of a patient by utilizing imaging equipment; based on the three-dimensional structure data, establishing a patient individualized three-dimensional operation model through a teleoperation system; planning a catheterization path and an operation strategy according to the three-dimensional operation model; collecting motion state data of the alimentary canal catheterization robot in real time through a sensor of the teleoperation system; dynamically matching the motion state data acquired in real time with the three-dimensional operation model of the patient; deviation information fed back by a sensor in the operation process is obtained, an angle error signal is generated, and the catheter arranging robot is corrected in real time by adjusting a control strategy; the control system comprises a target sensor, a teleoperation part, a control module and an upper computer. By means of the mode, delay is reduced, high-precision control is provided, the force sensing technology is introduced, the feedback experience of an operator is enhanced, and therefore the precision and safety of surgical operation are improved.

The invention discloses application of a gene marker in early screening of esophagus, stomach and intestine multiple cancer species, an early screening model construction method and a detection device, and belongs to the technical field of early noninvasive detection of digestive tract tumors. By analyzing the whole genome characteristics of circulating free DNA in peripheral blood, a novel multi-cancer-species screening system is established. On the basis of low-depth whole genome sequencing data, molecular markers in three dimensions, namely a genome copy number variation mode, a DNA fragment distribution characteristic with a specific length and an epigenetics signal of a transcription initiation region, are emphatically detected. An advanced converter neural network architecture is adopted, and the model can efficiently capture complex feature association in a whole genome range through a specific self-attention mechanism. The model design particularly considers the particularity of genome data, introduces an adaptive position coding system, and accurately reflects the spatial distribution relationship of DNA fragments on chromosomes. Therefore, the system can still maintain excellent detection performance under extremely low sequencing depth.

The invention relates to the technical field of artificial intelligence, and provides a gastric cancer risk quantitative scoring method, system and equipment based on artificial intelligence, and the method comprises the steps: recognizing the image type of each image frame in alimentary canal endoscope image data; for the electronic dyeing image frame, identifying a part contour region and an intestinal contour region of the feature part in the image frame, determining an intestinal epithelial metaplasia grading category of the feature part according to an area proportion of the intestinal contour region in the part contour region, and performing electronic dyeing intestinal scoring on the image data; for the white light image frame, gastroscope part types included in the image frame and focus area types of all gastroscope parts are recognized; performing atrophy scoring on the image data according to the position distribution of the focus area of the atrophy type; performing table state scoring on the image data according to whether the plica enlargement, nodular gastritis and diffuse redness focus areas exist or not; and realizing gastric cancer risk quantitative scoring according to the electronic staining intestinal scoring, the atrophy scoring and the epistatic state scoring.

The invention provides a capsule endoscopy path prediction method and device based on multi-modal data fusion, and belongs to the technical field of medical equipment.The method comprises the steps that body position time sequence data of a patient are collected in the current time period through a plurality of inertial measurement units (IMUs), collecting time sequence image data of the digestive tract of the patient in the current time period through a capsule endoscopy; preprocessing the body position time sequence data and the time sequence image data to obtain preprocessed body position time sequence data and preprocessed time sequence image data; and inputting the preprocessed body position time sequence data and the preprocessed time sequence image data into a pre-trained prediction model to obtain a capsule endoscopy path prediction result output by the prediction model and a body position adjustment prompt of the patient. According to the method, the accuracy of capsule endoscopy path prediction is improved, and missing detection can be effectively avoided.

The invention discloses a non-invasive intestinal flora fixed-point sampling and drug release device, and belongs to the technical field of micro-ecological diagnosis and treatment. The device comprises a shell, an internal storage bin, a medicine loading cavity and a channel switching mechanism. The shell adopts a capsule-shaped design, and an enteric coating is arranged on the surface of the shell, so that the function is started after the shell reaches a specified position of an intestinal tract. Through the internal ingenious mechanism linkage design, the device can firstly complete non-invasive fixed-point sampling of intestinal contents, and after the sampling action is completed, a drug release mechanism is automatically triggered, so that accurate drug delivery of the same part is realized. Cooperative operation of sampling and drug release in time sequence and space is achieved, and the problems of pain, disjunction of the diagnosis and treatment process, poor drug targeting and the like caused by traditional invasive operation are effectively solved. The device is flexible in structural design, has the advantages of being noninvasive, efficient, accurate in time sequence control and the like, and is suitable for integrated application of diagnosis and treatment of various digestive tract diseases such as inflammatory bowel disease management, micro-ecological regulation and the like.

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The invention relates to an electric field ablation device for digestive tracts, an ablation system and application, the electric field ablation device comprises a slender carrier and an expandable part carried by the slender carrier, the expandable part comprises a balloon and an electrode assembly, and a plurality of electrodes of the electrode assembly are arranged on the surface of the balloon. The balloon cavity of the balloon is filled with liquid, so that the balloon can be expanded, the expandable assembly has a first state with the large transverse size, the electrodes on the periphery of the outer side of the balloon can be tightly attached to tissue of the alimentary canal, and ablation treatment on the alimentary canal is achieved; when the liquid in the balloon cavity is discharged, the balloon can be shrunk, so that the expandable assembly has a second state with a smaller transverse size and can conveniently enter a human body or retreat from the human body, thereby facilitating the surgical operation of a doctor and relieving the pain of a patient; the sacculus is soft in texture and can be more tightly attached to the tissue of the digestive tract of the human body, and the accurate ablation treatment effect is achieved.

The invention discloses polysaccharide fluid hydrogel for digestive tract submucous injection and a preparation method of the polysaccharide fluid hydrogel, and belongs to the field of medical biological materials. According to the invention, carboxylated chitin or a carboxylated chitosan derivative with a mass percentage of 0.1-6%, or hydroxyalkylated chitin or a hydroxyalkylated chitosan derivative and collagen or gelatin are subjected to micro-crosslinking to form a low-crosslinking-degree supramolecular derivative as a solute; the polysaccharide fluid hydrogel is formed by taking water, normal saline, a physiological equilibrium solution, a phosphate buffer solution or a Green's solution as a solvent. By controlling the molar ratio of the raw materials to the cross-linking agent and performing micro-crosslinking with a small amount of the cross-linking agent, the prepared low-crosslinking-degree supramolecular derivative can form hydrogel in an aqueous solvent, has shear thinning and self-repairing characteristics, has certain viscosity, is easy to push and inject, and can be applied to the field of water treatment. The lifting height of the mucous membrane can be effectively kept, the height keeping time can be effectively prolonged, the mucous membrane is not prone to overflowing under the condition that the mucous membrane is damaged, an endoscope injection device is not blocked, and the material is an ideal material for forming a safe liquid pad through digestive tract submucous injection.

The invention discloses an esophageal cancer local chemotherapy device, and belongs to the technical field of chemotherapy auxiliary equipment, the esophageal cancer local chemotherapy device comprises a sealing device, the sealing device comprises a drug delivery tube, the lower end of the drug delivery tube is fixedly connected with a zigzag mounting tube, and the side wall of the zigzag mounting tube is rotatably connected with a plurality of hinge connecting rods; the lower end of the zigzag mounting tube is fixedly connected with a closed collecting film fixedly connected with the upper ends of the hinge connecting rods, the interior of the zigzag mounting tube is slidably connected with a movable block, and the device can be tightly attached to the inner wall of the esophagus through unfolding of the closed collecting film to form an effective closed structure, so that the position of medicine at the focus is locked, and the medicine is prevented from being damaged. Therefore, the local treatment effect of the medicine can be improved, meanwhile, the medicine is prevented from flowing to the stomach along with natural physiological movement of the esophagus, stimulation to the digestive tract of a patient is reduced, meanwhile, the influence on normal tissue of the patient is reduced, precise treatment is achieved, and the health of the patient is protected to the maximum extent.

The invention belongs to the technical field of medical instruments, and particularly relates to an adjustable endoscope probe for pediatric digestive tract examination, which comprises a main body assembly, the main body assembly comprises a holding assembly, and a hose is arranged below the holding assembly; the probe assembly comprises a long pipe assembly, a shooting assembly is arranged at the bottom end of the long pipe assembly, and a positioning assembly is arranged in an inner cavity of the shooting assembly; and the regulation and control assembly comprises an energy supply assembly, and a driving assembly is arranged below the energy supply assembly. Before digestive tract examination, the endoscope probe part can be preheated and can enter the body of a patient at a comfortable temperature, discomfort is reduced, the orientation of the camera shooting part on the side face of the probe is adjusted according to requirements during examination, states of different positions in different digestive tracts can be observed at a short distance, and the examination efficiency is improved. And the camera shooting part can be wiped, so that body fluid and residues in the digestive tract are prevented from covering the camera shooting part to influence examination.

A magnetic drive soft capsule robot and system comprises a miniature camera, a flexible foldable skin and an internal drive permanent magnet, the miniature camera is installed on a capsule formed by the flexible foldable skin, the flexible foldable skin is provided with a flexible fold type structure which can be folded or stretched in the length direction of the capsule and can be bent, and the internal drive permanent magnet is installed on the flexible fold type structure. The soft capsule robot comprises a capsule, a miniature camera and an internal driving permanent magnet, the internal driving permanent magnet is arranged in the capsule, the miniature camera is used for collecting images, and the internal driving permanent magnet is used for driving the flexible foldable skin to deform and move under the action of an external magnetic field, so that the posture and the movement track of the soft capsule robot are controlled. The magnetically-driven soft capsule robot is suitable for narrow and multi-curve digestive tracts, and can overcome the limitations that the posture of a current wireless capsule for endoscopic disease diagnosis cannot be actively controlled in real time, and discomfort or jamming is caused by a rigid shell.

The invention discloses a digestible quality analysis system for chicken feed, relates to the technical field of chicken feed analysis, and aims to solve the problem of poor simulation effect of digestion of the chicken feed. According to the method, low-temperature and high-temperature staged drying treatment is adopted, the characteristics of components such as moisture and fat in the residues are fully considered, the secretion rules of different alimentary canal parts of animals are simulated, sufficient and reasonable contact of digestive juice and feed is ensured, the simulation process is closer to the real physiological condition, and the situation that the digestion analysis result is affected by liquid amount errors is avoided; animal digestive tracts are scientifically segmented into stomach, small intestine and large intestine stages, corresponding external buffer solution and internal digestive juice are injected respectively, and a real digestion scene is comprehensively simulated from a physical structure to a chemical environment.

The invention relates to the technical field of artificial intelligence, and provides a digestive tract tumor non-invasive evaluation system and method based on an artificial intelligence technology, and the method comprises the steps: carrying out the recognition of a lesion position and a digestive tract part of a digestive endoscopy image; guiding a confocal laser microendoscope to perform targeted biopsy on the central position and / or the edge position of the focus; lesion classification identification is carried out on the confocal endoscope image; when it is determined that the lesion exists, an ultrasonic endoscope is guided to conduct ultrasonic scanning on the lesion position; performing focus size and focus infiltration depth identification on the ultrasonic endoscope image; generating a question text based on multi-modal data according to the lesion position, the alimentary canal part, the lesion category, the lesion size and the lesion infiltration depth, retrieving an answer from a preset vector database according to the question text, filling a prompt template with a retrieval result and the question text, and inputting the retrieval result and the question text into an intelligent question and answer language model to generate an alimentary canal tumor assessment result, and non-traumatic evaluation and auxiliary diagnosis of digestive tract tumors are realized.

The protective sleeve comprises a fixing sleeve, a mounting surface is formed at the front end of the fixing sleeve and used for covering a water outlet, a limiting block is arranged on the portion, corresponding to the mounting surface, of the fixing sleeve, and after the fixing sleeve is connected with an endoscope in a sleeved mode, a gap is formed between the mounting surface and the front end of the endoscope through the limiting block; the soft sleeve is trumpet-shaped, one end of the soft sleeve is connected with the mounting surface, a protection space is formed in the soft sleeve, the soft sleeve is provided with a supporting channel corresponding to the mounting surface, the supporting channel extends in the length direction of the soft sleeve, an opening is formed in one end of the supporting channel corresponding to the mounting surface, and the opening is used for water flow to enter so as to keep the supporting channel in an open state; the flexible sleeve can be automatically deformed to the tail end of the endoscope when the endoscope enters so as to reduce interference to the endoscope entering, and meanwhile, the flexible sleeve can be naturally deformed to the front end of the endoscope when the flexible sleeve is clamped and withdrawn so as to complete wrapping of sharp foreign matters, so that damage possibly caused when the sharp foreign matters are moved out is avoided.

The invention discloses anti-inflammatory polypeptide nanoparticles and a preparation method thereof, and belongs to the technical field of bioactive peptides. The anti-inflammatory polypeptide nano-particles are nano-particles obtained by coating polypeptide with an anti-inflammatory effect with chitosan and sodium tripolyphosphate, the polypeptide with the anti-inflammatory effect contains bioactive peptides of which the amino acid sequences are YAADQ, FPYTT and YVTYA. The phycocyanin anti-inflammatory peptide is natural in source, the performance of the phycocyanin anti-inflammatory peptide can be remarkably improved through the nanometer embedding technology, and compared with traditional drugs, the phycocyanin anti-inflammatory peptide has lower toxic and side effects and potential cost advantages. The polypeptide nanoparticles prepared by the invention can effectively prevent the phycocyanin anti-inflammatory peptide from being degraded in the digestive tract, have a remarkable treatment effect on mice with ulcerative colitis, and have an important application prospect in preparation of ulcerative colitis prevention and treatment products.

The utility model discloses a jejunum catheterization human body model teaching aid, comprising a human body model which is internally provided with a catheterization channel which simulates an implantation path of a bionic human body nasointestinal tube; the human body model and the catheter placing channel are made of transparent materials. Therefore, the complete digestive tract structure from the oral cavity to the jejunum of the human body can be simulated, the whole process of nasointestinal tube placement can be visually and dynamically displayed, and the effect of jejunum tube placement teaching and practice training is improved.

The invention discloses freeze-dried powder for promoting alimentary canal hair discharge of pet cats and a preparation method thereof.The freeze-dried powder is prepared from, by mass, 80%-85% of chicken breast, 8%-10% of cellulose, 4%-6% of whole goat milk powder, 2.5%-3.5% of barley seedlings, 0.25%-0.35% of keratinase, 0.08%-0.12% of vitamin E and 0.08%-0.12% of rosemary extract.The freeze-dried powder not only has good palatability but also is good in hair discharge effect; in addition, diarrhea or constipation cannot be caused.

The invention discloses an anti-helicobacter pylori pharmaceutical composition containing lactobacillus reuteri as well as a preparation method and application of the anti-helicobacter pylori pharmaceutical composition, and relates to the technical field of medicines. The anti-helicobacter pylori pharmaceutical composition comprises a traditional Chinese medicine composition and a lactobacillus reuteri liquid, the traditional Chinese medicine composition comprises the following components: uncinata spikemoss herb, dianthus chinensis root, airpotato yam rhizome, rabdosia rubescens and rabdosia amethystoides. The mass volume ratio of the traditional Chinese medicine composition to the lactobacillus reuteri liquid is (30-50) g: (7-15) mL. The traditional Chinese medicine composition and the lactobacillus reuteri liquid are combined for use, helicobacter pylori in the oral cavity and digestive tract of the human body is efficiently removed, and other side effects are not generated.

Provided is an overtube with improved insertability of a distal end side of the overtube into a digestive tract. An overtube includes a supply and discharge port for supplying and discharging a fluid, a first region that is located on a distal end side with respect to the supply and discharge port and includes an outer tube, an inner tube, and a shape-deformable body, and a second region that is located on the distal end side with respect to the first region and includes the outer tube and the inner tube. The first region is switchable between a first state in which the fluid is supplied to a tube inner space between the outer tube and the inner tube via the supply and discharge port and a second state that is stiffer than the first state and in which the fluid is discharged, and the second region is softer than the second state of the first region.

The invention relates to the field of medicines, and discloses slow-release composite powder for removing nitrite and a preparation method thereof, and the slow-release composite powder comprises the following raw materials: bovine bone collagen peptide, sorbitol, L-sodium ascorbate, L-alanine composite powder, vitamin E, earthworm protein, natto powder, cranberry powder and magnesium stearate. Wherein the L-alanine composite powder is prepared from L-alanine, y-aminobutyric acid and L-glutamic acid; according to the present invention, the L-alanine composite powder and the active substance can chemically react with the nitrite in the body so as to convert the nitrite into the safe substance to be discharged out of the body, such that the absorption and the adsorption of the nitrite can be easily reduced, and the formation of the nitrite in the digestive tract can be reduced so as to reduce the concentration of the nitrite in the body; and nitrite is directly prevented from being accumulated to the level of potential health hazards.

The invention relates to the technical field of biological medicines, and discloses a preparation method of ganoderma lucidum wall-broken superfine powder for female insomnia, which is characterized in that thick ganoderma lucidum slices are subjected to spray moistening, hot-pressing steam heating, ultrasonic treatment, microwave drying and other process treatments, so that the contents of polysaccharides, triterpenes and sterols are increased; and the release rate of the active ingredients is also obviously improved. According to the technology, the structure of the cell wall of the ganoderma lucidum mycelium is destroyed, so that active ingredients such as polysaccharide, triterpenes and sterol originally existing in ganoderma lucidum can be easily extracted and released. Ganoderma lucidum cells are loosened and broken, polysaccharide in a combined state can be changed into a free state, and the content of ganoderma lucidum polysaccharide can be greatly increased. The cell-broken ganoderma lucidum wall-broken superfine powder can be directly taken in digestive tracts to quickly release active ingredients in ganoderma lucidum to the maximum extent, and the effect of improving female insomnia by the superfine powder is improved.

The invention belongs to the technical field of biology, and particularly relates to a colipase inhibitory peptide and application thereof. The colipase inhibitory peptide has colipase inhibitory activity, can significantly reduce fat absorption by inhibiting the activity of colipase, achieves the effects of losing weight and reducing blood fat, is safe and free of toxic and side effects, has good stability and low blood absorptivity, and is beneficial for polypeptide to better inhibit the colipase to play a role in digestive tracts.

The application provides a multifunctional catheter, comprising a catheter main body and a distal tube with a multi-cavity tube structure. The distal tube comprises a soft end at the proximal end and a functional end at the distal end. The catheter main body and the soft end are provided with a working cavity and a lens cavity. The functional end is further provided with a through hole communicating with the lens cavity. The lens cavity is a circular tube cavity structure extending along the catheter main body and the soft end. The inner wall of the lens cavity is provided with a plurality of accommodation grooves for accommodating photosensitive chips in a lens assembly. The catheter provided by the application can form a space for accommodating photosensitive chips through the plurality of accommodation grooves in the lens cavity, and the lens assembly can be installed without increasing the diameter of the lens cavity, thereby reducing the overall diameter of the catheter to adapt to the more complex bile duct environment relative to the digestive tract.

The present invention relates to the technical field of probiotics, in particular to a Lactiplantibacillus plantarum GOLDGUT-LP618 having a function of resisting Salmonella infection and application thereof. The Lactiplantibacillus plantarum GOLDGUT-LP618 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28399. The strain has high resistance to acid and bile salt and can adapt to the digestive tract environment. The strain can inhibit Salmonella infection, relieve diarrhea, inflammation and intestinal damage caused by Salmonella infection, and promote intestinal health. The strain can be used for preparing functional foods, dietary supplements or drugs that can resist Salmonella infection and improve diarrhea and inflammation caused by Salmonella infection, and has good application prospects.

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.

Relates to a magnesium phosphate substance, a pharmaceutical composition containing the magnesium phosphate substance and application of the magnesium phosphate substance. And a method for manufacturing the same. The present invention relates to the use of a magnesium phosphate substance in a medicament for preventing and / or treating a disease or disorder associated with an increase in the level of ammonia and / or ammonium ions in the blood and / or digestive tract of a subject, and a pharmaceutical composition for such use, kits and related methods of prevention and / or treatment of diseases or conditions as well as methods of reducing the levels of ammonia and / or ammonium ions in a biological sample.

The invention relates to the field of medicines, discloses a composition as well as a preparation method and application thereof, and particularly relates to a solid composition containing rutin and amino acid compounds, which can be used for preparing a rutin supersaturated solution which is high in concentration, is kept stable for a long time and cannot separate out crystals on the premise of not changing the chemical structure of rutin. The rutin supersaturated solution can keep a high-concentration solution state in a digestive tract without separating out crystals, so that the bioavailability of rutin is improved.

The invention discloses a linear cutting and closing device for polyp resection under an endoscope, relates to the technical field of medical closing devices, and aims to solve the technical problems that perforation is easily generated in linear cutting and closing cutting, and repeated cutting is needed. Magnetic attraction linkage is taken as a core, the clamping force of the closed clamp is accurately controlled through the first magnetic attraction block, and a fine adjustment structure and a clamping limiting design are matched, so that sufficient clamping and one-time complete excision of a polyp are realized, and multiple times of cutting are avoided; the flexible lead body and the miniaturized structure are matched with an endoscope channel, so that the operation flexibility of a complex digestive tract is improved; the automatic conveying and clamping structure can immediately close the wound surface, and the bleeding and perforation risks are reduced; the whole-course button control simplifies operation, the elastic reset assembly reduces manual steps, and the operation time is shortened. The operation safety, the operation convenience and the adaptability are considered on the whole, the complication occurrence rate is effectively reduced, and the clinical treatment effect and efficiency of the endoscopic polyp resection operation are remarkably improved.

The chyme-adapted saline electrolyte solution for administering enteral infusions includes sodium chloride, potassium chloride, sodium acetate, sodium phosphate, calcium chloride, magnesium sulfate, water at the following ions ratio, wt. %: sodium 12.4-35.4—potassium 2.5-15.6—calcium 0.65-7.785—magnesium 0.45-4.671—chlorine 20.4-48.65—phosphate 3.1-34.4—sulphate 0.28-13.27—acetate to 23.27—water the rest.