201 results about "Alimentary tract" patented technology

The invention discloses application of a gene marker in early screening of esophagus, stomach and intestine multiple cancer species, an early screening model construction method and a detection device, and belongs to the technical field of early noninvasive detection of digestive tract tumors. By analyzing the whole genome characteristics of circulating free DNA in peripheral blood, a novel multi-cancer-species screening system is established. On the basis of low-depth whole genome sequencing data, molecular markers in three dimensions, namely a genome copy number variation mode, a DNA fragment distribution characteristic with a specific length and an epigenetics signal of a transcription initiation region, are emphatically detected. An advanced converter neural network architecture is adopted, and the model can efficiently capture complex feature association in a whole genome range through a specific self-attention mechanism. The model design particularly considers the particularity of genome data, introduces an adaptive position coding system, and accurately reflects the spatial distribution relationship of DNA fragments on chromosomes. Therefore, the system can still maintain excellent detection performance under extremely low sequencing depth.

The invention relates to the technical field of artificial intelligence, and provides a gastric cancer risk quantitative scoring method, system and equipment based on artificial intelligence, and the method comprises the steps: recognizing the image type of each image frame in alimentary canal endoscope image data; for the electronic dyeing image frame, identifying a part contour region and an intestinal contour region of the feature part in the image frame, determining an intestinal epithelial metaplasia grading category of the feature part according to an area proportion of the intestinal contour region in the part contour region, and performing electronic dyeing intestinal scoring on the image data; for the white light image frame, gastroscope part types included in the image frame and focus area types of all gastroscope parts are recognized; performing atrophy scoring on the image data according to the position distribution of the focus area of the atrophy type; performing table state scoring on the image data according to whether the plica enlargement, nodular gastritis and diffuse redness focus areas exist or not; and realizing gastric cancer risk quantitative scoring according to the electronic staining intestinal scoring, the atrophy scoring and the epistatic state scoring.

The invention discloses a non-invasive intestinal flora fixed-point sampling and drug release device, and belongs to the technical field of micro-ecological diagnosis and treatment. The device comprises a shell, an internal storage bin, a medicine loading cavity and a channel switching mechanism. The shell adopts a capsule-shaped design, and an enteric coating is arranged on the surface of the shell, so that the function is started after the shell reaches a specified position of an intestinal tract. Through the internal ingenious mechanism linkage design, the device can firstly complete non-invasive fixed-point sampling of intestinal contents, and after the sampling action is completed, a drug release mechanism is automatically triggered, so that accurate drug delivery of the same part is realized. Cooperative operation of sampling and drug release in time sequence and space is achieved, and the problems of pain, disjunction of the diagnosis and treatment process, poor drug targeting and the like caused by traditional invasive operation are effectively solved. The device is flexible in structural design, has the advantages of being noninvasive, efficient, accurate in time sequence control and the like, and is suitable for integrated application of diagnosis and treatment of various digestive tract diseases such as inflammatory bowel disease management, micro-ecological regulation and the like.

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The invention relates to an electric field ablation device for digestive tracts, an ablation system and application, the electric field ablation device comprises a slender carrier and an expandable part carried by the slender carrier, the expandable part comprises a balloon and an electrode assembly, and a plurality of electrodes of the electrode assembly are arranged on the surface of the balloon. The balloon cavity of the balloon is filled with liquid, so that the balloon can be expanded, the expandable assembly has a first state with the large transverse size, the electrodes on the periphery of the outer side of the balloon can be tightly attached to tissue of the alimentary canal, and ablation treatment on the alimentary canal is achieved; when the liquid in the balloon cavity is discharged, the balloon can be shrunk, so that the expandable assembly has a second state with a smaller transverse size and can conveniently enter a human body or retreat from the human body, thereby facilitating the surgical operation of a doctor and relieving the pain of a patient; the sacculus is soft in texture and can be more tightly attached to the tissue of the digestive tract of the human body, and the accurate ablation treatment effect is achieved.

The invention discloses polysaccharide fluid hydrogel for digestive tract submucous injection and a preparation method of the polysaccharide fluid hydrogel, and belongs to the field of medical biological materials. According to the invention, carboxylated chitin or a carboxylated chitosan derivative with a mass percentage of 0.1-6%, or hydroxyalkylated chitin or a hydroxyalkylated chitosan derivative and collagen or gelatin are subjected to micro-crosslinking to form a low-crosslinking-degree supramolecular derivative as a solute; the polysaccharide fluid hydrogel is formed by taking water, normal saline, a physiological equilibrium solution, a phosphate buffer solution or a Green's solution as a solvent. By controlling the molar ratio of the raw materials to the cross-linking agent and performing micro-crosslinking with a small amount of the cross-linking agent, the prepared low-crosslinking-degree supramolecular derivative can form hydrogel in an aqueous solvent, has shear thinning and self-repairing characteristics, has certain viscosity, is easy to push and inject, and can be applied to the field of water treatment. The lifting height of the mucous membrane can be effectively kept, the height keeping time can be effectively prolonged, the mucous membrane is not prone to overflowing under the condition that the mucous membrane is damaged, an endoscope injection device is not blocked, and the material is an ideal material for forming a safe liquid pad through digestive tract submucous injection.

A magnetic drive soft capsule robot and system comprises a miniature camera, a flexible foldable skin and an internal drive permanent magnet, the miniature camera is installed on a capsule formed by the flexible foldable skin, the flexible foldable skin is provided with a flexible fold type structure which can be folded or stretched in the length direction of the capsule and can be bent, and the internal drive permanent magnet is installed on the flexible fold type structure. The soft capsule robot comprises a capsule, a miniature camera and an internal driving permanent magnet, the internal driving permanent magnet is arranged in the capsule, the miniature camera is used for collecting images, and the internal driving permanent magnet is used for driving the flexible foldable skin to deform and move under the action of an external magnetic field, so that the posture and the movement track of the soft capsule robot are controlled. The magnetically-driven soft capsule robot is suitable for narrow and multi-curve digestive tracts, and can overcome the limitations that the posture of a current wireless capsule for endoscopic disease diagnosis cannot be actively controlled in real time, and discomfort or jamming is caused by a rigid shell.

The invention discloses a digestible quality analysis system for chicken feed, relates to the technical field of chicken feed analysis, and aims to solve the problem of poor simulation effect of digestion of the chicken feed. According to the method, low-temperature and high-temperature staged drying treatment is adopted, the characteristics of components such as moisture and fat in the residues are fully considered, the secretion rules of different alimentary canal parts of animals are simulated, sufficient and reasonable contact of digestive juice and feed is ensured, the simulation process is closer to the real physiological condition, and the situation that the digestion analysis result is affected by liquid amount errors is avoided; animal digestive tracts are scientifically segmented into stomach, small intestine and large intestine stages, corresponding external buffer solution and internal digestive juice are injected respectively, and a real digestion scene is comprehensively simulated from a physical structure to a chemical environment.

The invention relates to the technical field of artificial intelligence, and provides a digestive tract tumor non-invasive evaluation system and method based on an artificial intelligence technology, and the method comprises the steps: carrying out the recognition of a lesion position and a digestive tract part of a digestive endoscopy image; guiding a confocal laser microendoscope to perform targeted biopsy on the central position and / or the edge position of the focus; lesion classification identification is carried out on the confocal endoscope image; when it is determined that the lesion exists, an ultrasonic endoscope is guided to conduct ultrasonic scanning on the lesion position; performing focus size and focus infiltration depth identification on the ultrasonic endoscope image; generating a question text based on multi-modal data according to the lesion position, the alimentary canal part, the lesion category, the lesion size and the lesion infiltration depth, retrieving an answer from a preset vector database according to the question text, filling a prompt template with a retrieval result and the question text, and inputting the retrieval result and the question text into an intelligent question and answer language model to generate an alimentary canal tumor assessment result, and non-traumatic evaluation and auxiliary diagnosis of digestive tract tumors are realized.

The invention discloses anti-inflammatory polypeptide nanoparticles and a preparation method thereof, and belongs to the technical field of bioactive peptides. The anti-inflammatory polypeptide nano-particles are nano-particles obtained by coating polypeptide with an anti-inflammatory effect with chitosan and sodium tripolyphosphate, the polypeptide with the anti-inflammatory effect contains bioactive peptides of which the amino acid sequences are YAADQ, FPYTT and YVTYA. The phycocyanin anti-inflammatory peptide is natural in source, the performance of the phycocyanin anti-inflammatory peptide can be remarkably improved through the nanometer embedding technology, and compared with traditional drugs, the phycocyanin anti-inflammatory peptide has lower toxic and side effects and potential cost advantages. The polypeptide nanoparticles prepared by the invention can effectively prevent the phycocyanin anti-inflammatory peptide from being degraded in the digestive tract, have a remarkable treatment effect on mice with ulcerative colitis, and have an important application prospect in preparation of ulcerative colitis prevention and treatment products.

The utility model discloses a jejunum catheterization human body model teaching aid, comprising a human body model which is internally provided with a catheterization channel which simulates an implantation path of a bionic human body nasointestinal tube; the human body model and the catheter placing channel are made of transparent materials. Therefore, the complete digestive tract structure from the oral cavity to the jejunum of the human body can be simulated, the whole process of nasointestinal tube placement can be visually and dynamically displayed, and the effect of jejunum tube placement teaching and practice training is improved.

The invention discloses an anti-helicobacter pylori pharmaceutical composition containing lactobacillus reuteri as well as a preparation method and application of the anti-helicobacter pylori pharmaceutical composition, and relates to the technical field of medicines. The anti-helicobacter pylori pharmaceutical composition comprises a traditional Chinese medicine composition and a lactobacillus reuteri liquid, the traditional Chinese medicine composition comprises the following components: uncinata spikemoss herb, dianthus chinensis root, airpotato yam rhizome, rabdosia rubescens and rabdosia amethystoides. The mass volume ratio of the traditional Chinese medicine composition to the lactobacillus reuteri liquid is (30-50) g: (7-15) mL. The traditional Chinese medicine composition and the lactobacillus reuteri liquid are combined for use, helicobacter pylori in the oral cavity and digestive tract of the human body is efficiently removed, and other side effects are not generated.

The invention belongs to the technical field of biology, and particularly relates to a colipase inhibitory peptide and application thereof. The colipase inhibitory peptide has colipase inhibitory activity, can significantly reduce fat absorption by inhibiting the activity of colipase, achieves the effects of losing weight and reducing blood fat, is safe and free of toxic and side effects, has good stability and low blood absorptivity, and is beneficial for polypeptide to better inhibit the colipase to play a role in digestive tracts.

The application provides a multifunctional catheter, comprising a catheter main body and a distal tube with a multi-cavity tube structure. The distal tube comprises a soft end at the proximal end and a functional end at the distal end. The catheter main body and the soft end are provided with a working cavity and a lens cavity. The functional end is further provided with a through hole communicating with the lens cavity. The lens cavity is a circular tube cavity structure extending along the catheter main body and the soft end. The inner wall of the lens cavity is provided with a plurality of accommodation grooves for accommodating photosensitive chips in a lens assembly. The catheter provided by the application can form a space for accommodating photosensitive chips through the plurality of accommodation grooves in the lens cavity, and the lens assembly can be installed without increasing the diameter of the lens cavity, thereby reducing the overall diameter of the catheter to adapt to the more complex bile duct environment relative to the digestive tract.

Relates to a magnesium phosphate substance, a pharmaceutical composition containing the magnesium phosphate substance and application of the magnesium phosphate substance. And a method for manufacturing the same. The present invention relates to the use of a magnesium phosphate substance in a medicament for preventing and / or treating a disease or disorder associated with an increase in the level of ammonia and / or ammonium ions in the blood and / or digestive tract of a subject, and a pharmaceutical composition for such use, kits and related methods of prevention and / or treatment of diseases or conditions as well as methods of reducing the levels of ammonia and / or ammonium ions in a biological sample.

The invention discloses a linear cutting and closing device for polyp resection under an endoscope, relates to the technical field of medical closing devices, and aims to solve the technical problems that perforation is easily generated in linear cutting and closing cutting, and repeated cutting is needed. Magnetic attraction linkage is taken as a core, the clamping force of the closed clamp is accurately controlled through the first magnetic attraction block, and a fine adjustment structure and a clamping limiting design are matched, so that sufficient clamping and one-time complete excision of a polyp are realized, and multiple times of cutting are avoided; the flexible lead body and the miniaturized structure are matched with an endoscope channel, so that the operation flexibility of a complex digestive tract is improved; the automatic conveying and clamping structure can immediately close the wound surface, and the bleeding and perforation risks are reduced; the whole-course button control simplifies operation, the elastic reset assembly reduces manual steps, and the operation time is shortened. The operation safety, the operation convenience and the adaptability are considered on the whole, the complication occurrence rate is effectively reduced, and the clinical treatment effect and efficiency of the endoscopic polyp resection operation are remarkably improved.

The present invention relates to an equipment for magnetic recanalization of benign biliary strictures. The equipment (100) includes a wire-guided magnet pusher tube (102a), atleast one magnet (110), and a magnet retrieval tube (102b). The equipment (100) works in conjunction with a visualization system to guide placement of the magnet (110) at the target site for recanalization of the biliary stricture. The magnet (110), may be deployed at opposing ends of a biliary stricture to create a controlled recanalization channel via magnetic attraction. The deployment process can be performed using endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), or a combination of both. Magnets may be retrieved following recanalization using biopsy forceps or allowed to pass naturally through the digestive tract, avoiding permanent implantation.

The present invention relates to a chair-based capsule endoscope control device and system for controlling a capsule endoscope that is inserted into the human digestive system and acquires images of organs. The present invention provides a capsule endoscope control device that is inserted into the digestive tract of a subject and controls the position or posture of a capsule endoscope equipped with a magnet. The device comprises: a chair for the subject to sit on, comprising a seat portion and a backrest connected to the seat portion; and a magnet controller disposed on the backrest. The magnet controller includes a control magnetic force generator for adjusting the position or posture of the capsule endoscope, wherein the control magnetic force generator is movable in at least one direction.

The invention relates to the technical field of medical instrument simulation and testing, in particular to a high-precision 3D printing personalized alimentary canal entity model method which comprises the steps that alimentary canal CT image data covering the range from the nasal cavity to the jejunum of a target individual and biomechanical property reference data of different sections of the alimentary canal are obtained; generating a stiffness distribution diagram; transparent flexible photosensitive resin is used as a base material, and various transparent flexible photosensitive resin materials with different elastic moduli are prepared by adding a modifier; generating a printing instruction; a digital light processing 3D printer is adopted, a solid model is printed layer by layer according to a printing instruction, the distributed transparent flexible photosensitive resin material is automatically switched and used in the printing process, and exposure parameters of ultraviolet light are dynamically adjusted based on the characteristics of the currently used transparent flexible photosensitive resin material so as to control the post-curing elastic modulus of different sections. Through accurate elastic modulus control and dynamic exposure adjustment, the mechanical properties of different sections of the digestive tract are highly consistent with the actual situation.

The invention discloses a traditional Chinese medicine compound for preventing or treating digestive tract mucositis caused by targeted drugs, which is prepared from the following components in parts by weight: 2-4 parts of fructus evodiae, 5-7 parts of marmor serpentinatum, 5-7 parts of geranium wilfordii, 5-7 parts of persimmon frost and 2-4 parts of rhizoma kaempferiae, preferably 3: 6: 6: 6: 3. The preparation method is water decoction and concentration. The compound has the effects of eliminating cold to stop pain, supporting yang to stop diarrhea, dispersing blood stasis, stopping bleeding and the like, obviously reduces the index of diarrhea caused by TKI and the score of oral mucositis, and is suitable for complication management of targeted therapy of NSCLC patients in the stage IV. An orthogonal test verifies scientificity of the formula, and the formula has safety and effectiveness.

This invention belongs to the field of medical device technology, specifically a surgical treatment device for digestive tract malformations. It includes a support plate and casters, all fixedly connected to the bottom of the support plate. An adjustment mechanism is located on the top of the support plate, and a replacement mechanism is located on the top of the adjustment mechanism. The adjustment mechanism includes a cylindrical body fixedly connected to the top of the support plate. A vertical rod is inserted into the cylindrical body, and limit grooves are formed on both sides of the cylindrical body. Limit plates are inserted into the limit grooves, and support rings are fixedly connected to the surface of the limit plates. Fixing plates are fixedly connected to both sides of the cylindrical body. This surgical treatment device for digestive tract malformations allows for height adjustment by threading a fixing bolt into a threaded hole inside the fixing plate when the vertical rod is moved to a suitable height, ensuring the stability of the device during surgery.

A method of treating a subject having a metabolic disorder, caused or promoted by pathogen-associated molecular patterns (PAMPs) derived from intestinal sources, including: administering to the subject a specially formulated drug that is targeted to deliver a sequestrant into the distal region of small intestine for sequestration of PAMPs including endotoxins or CpG-DNA derived from gut microbes. The sequestrant binds to the PAMPs to form a sequestrant-PAMP complex; and the sequestrant-PAMP complex is eliminated from the digestive tract along with the rest of digestive contents.

This invention discloses a capsule system for electro-adhesion in the digestive tract and its operating method, relating to the field of medical devices. The system includes a transparent outer shell forming a sealed cavity within it; multiple electrode adhesion units are axially arranged on the outer wall of the shell; an image acquisition device is fixed inside the shell, with its acquisition end adjacent to the transparent end of the shell; a wireless transmission device is used for bidirectional wireless data transmission with an external workstation; when the drug storage device's release port is open, the drug within the storage device can be released to the outside; a control module can control the opening and closing of the release port, and can control the power supply to the electrode adhesion units, as well as the direction of current flow after power is applied; a power supply is electrically connected to the image acquisition device, the wireless transmission device, the drug storage device, and the control module. The system and its operating method of this invention can save internal capsule space, avoid mechanical damage to intestinal wall tissue, and the anchoring and release process is rapid, controllable, and reversible.

The invention relates to a chewing gum containing a digestive tract defoaming agent and a preparation method thereof in the technical field of endoscopy, and is characterized in that the chewing gum comprises the following components in percentage by weight: 40 to 60 percent of gum base, 0.5 to 1.0 percent of dimeticone, 0 to 30 percent of sugar or sweetening agent, 0.1 to 0.5 percent of spice, 0.15 to 0.45 percent of softening agent, 0.1 to 0.5 percent of lubricating agent and 8 to 15 percent of water. The chewing gum disclosed by the invention is convenient to carry and use, and is particularly suitable for preparation before endoscopy; in the form of chewing gum, the chewing gum can be used when waiting for examination, so that intestinal movement is improved, and intestinal bubbles are improved; components which do not increase the gas production rate are adopted, and the problem of bubble aggravation is avoided; the taste is mainly fruity, such as mint, so that the acceptability of patients is improved.

Disclosed are bolus compositions for ruminants comprising potassium phosphate dibasic and water configured to rapidly dissolve in the rumen for use in the prevention or treatment of hypokalemia and hypophosphatemia. These conditions occur in ruminants at around the time of calving or during periods when ruminants do not eat (anorexia). The bolus compositions may comprise a coating that is compatible with a ruminant digestive tract. Additionally, the bolus compositions may comprise a wick which may be used during the manufacturing process to facilitate the bulk handling and transfer of the bolus compositions.

The balloon structure comprises a main catheter and a one-way valve arranged on one side of the main catheter, an auxiliary catheter is arranged on one side of the main catheter, the auxiliary catheter is detachably connected with the main catheter through a connecting mechanism, a hollow gooseneck pipe is arranged on one side of the auxiliary catheter, and the hollow gooseneck pipe is detachably connected with the main catheter through a connecting mechanism. A bag body structure is arranged on one side of the auxiliary catheter; the bag body structure comprises a hollow bag body, the bottom face of the hollow bag body is arranged on the outer surface of the auxiliary catheter, multiple sets of water inlet pipes are further arranged on one side of the auxiliary catheter and communicated with the hollow bag body, and an adjusting ring is further arranged on one side of the hollow bag body and slidably arranged on the auxiliary catheter. The angle of the hollow bag body can be adjusted according to the bending angle of the digestive tract, the hollow bag body can be conveniently guided in, meanwhile, expansion of the hollow bag body is guided, the sealing performance of the hollow bag body on plugging of the digestive tract is improved, overall installation and operation are convenient, and medical staff can conveniently use the hollow bag body.

The alimentary canal liquid biopsy sampling device comprises an inner detection part and an outer equipment part, the inner detection part comprises a detection sphere and a spherical shell, the diameter of the detection sphere is smaller than that of the spherical shell, the detection sphere is arranged in an inner cavity of the spherical shell, the spherical shell is hollow, and a magnet part is arranged at one end in the detection sphere; the external equipment part comprises a main body frame, an annular moving part capable of sliding back and forth is arranged on the main body frame, and an electromagnet capable of moving along the inner side wall of the annular moving part is arranged on the inner side of the annular moving part. According to the invention, the internal detection part adopts the detection sphere with the built-in magnetic control and is sleeved with the hollow sphere shell, the detection sphere is isotropic and flexible in steering, the hollow sphere shell rolls during movement, so that the friction force is reduced, the hollow sphere shell is easy to roll in intestinal wrinkles, the rolling speed can be effectively improved, and the magnetic field driving efficiency is effectively improved.

The present invention provides a digestive tract expander, comprising a traction rope, a bracket with an open state and a closed state, the distal end of which is fixedly arranged with the distal end of the traction rope, a push tube slidably sleeved on the traction rope and the distal end of which is fixedly connected to the proximal end of the bracket, a sheath tube slidably sleeved on the push tube, and an operating handle fixedly connected to the proximal end of the sheath tube, the operating handle comprising a shell fixedly connected to the sheath tube, a slider slidably connected to the shell, and a control button connected to the slider and capable of driving the slider to slide, and the push tube is fixedly connected to the slider. The present invention has a simple structure, convenient operation, and obvious effect. It can expand the digestive tract radially and help loosen trapped foreign matter from the mucosal layer.

The protective cover is of a multi-section structure, the multi-section structure comprises a protective section located at the front end, a visual expansion section located in the middle and a gastroscope fixing section located at the rear end, and when a gastroscope is fixed to the gastroscope fixing section, the protective section reversely wraps the gastroscope; and the protection section is made of a medical elastomer material. According to the technical scheme, when foreign bodies in the digestive tract are taken out, mucous membranes of the whole esophagus, the junction of the esophagus and the stomach and the esophagus inlet can be protected, long foreign bodies and sharp foreign bodies can be conveniently taken out under an endoscope, the occurrence rate of complications of the upper digestive tract foreign body taking-out operation is reduced, and the safety and effectiveness of treatment are improved.

The invention belongs to the technical field of biological medicine, and relates to a brain-targeted delivery system of semeglutide as well as a preparation method and application of the brain-targeted delivery system of semeglutide, the delivery system comprises yeast microcapsules and a semeglutide-cationic polymer; the delivery system takes a yeast microcapsule as a delivery carrier, and a semeglutide-cationic polymer is encapsulated in the yeast microcapsule. By simulating a natural way that microorganisms are recognized by macrophages through digestive tracts, active uptake is realized by utilizing specific binding of yeast microcapsules and Dectin-1 receptors on the surfaces of the macrophages, the semeglutide is accurately delivered to the brain by virtue of the cross-blood-brain-barrier migration ability of the macrophages, a central GLP-1 receptor pathway is activated to regulate metabolism, and meanwhile, the semeglutide can be used for preparing a medicine for treating liver cancer. According to the system, the oral bioavailability of the semeglutide can be improved, and non-specific distribution of the whole body is reduced.