457 results about "Alimentary tract" patented technology

Methods of ablating tissue in an alimentary tract are provided. The methods include advancing an ablation structure into an alimentary tract while supporting the ablation structure with an endoscope. The methods further include a step of moving at least part of the ablation structure with respect to the endoscope and toward a tissue surface, before activating the ablation structure to ablate a tissue surface.

The invention provides a hydrogel-type sustained-release preparation comprising (1) at least one drug, (2) an additive which insures a penetration of water into the core of the preparation and (3) a hydrogel-forming polymer, wherein said preparation is capable of undergoing substantially complete gelation during its stay in the upper digestive tract such as stomach and small intestine and is capable of releasing the drug in the lower digestive tract including colon.By the preparation of the invention, the drug is efficiently released and absorbed even in the colon so that a steady and sustained release effect can be achieved.

Apparatus for treating abnormal mucosa in an alimentary tract are provided. The apparatus include an ablation structure configured to be removably coupled to an endoscope and a deflection mechanism adapted to move the ablation structure with respect to the endoscope and toward a tissue surface.

Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting a vacuum source comprising one or more suction ports into an alimentary canal; (ii) inserting an operative element comprising a conduit for a tissue ablation source into the alimentary canal; (iii) positioning the vacuum source and the operative element proximate a portion of the alimentary canal having a site of abnormal tissue to be ablated; (iv) applying a vacuum to at least one of each suction port to draw the tissue against the operative element; and (v) applying the tissue ablation source to the tissue through the conduit to effect tissue ablation.

The present invention is directed to a mucoadhesive delivery system for the local or systemic administration of a pharmaceutical agent. The delivery system of the invention effectively and facilely enables transport of the pharmaceutical agent through mucosal membranes and into the vasculattire of the mucosa. The delivery system includes an at least partially water soluble bioadhesive layer and an at least partially water soluble backing layer. Incorporated within either or both of these layers are the pharmaceutical agent and a mucosal penetration enhancing agent. The mucosal penetration enhancing agent displays localized tissue irritation properties. The mucoadhesive delivery system may be in the form of a gel, film, disc or patch. It may be applied to any mucosal membrane of a patient including but not limited to those of the buccal and nasal cavities, throat, eye, vagina, alimentary tract and peritoneum.

The invention provides a hydrogel-type sustained-release preparation comprising (1) at least one drug, (2) an additive which insures a penetration of water into the core of the preparation and (3) a hydrogel-forming polymer, wherein said preparation is capable of undergoing substantially complete gelation during its stay in the upper digestive tract such as stomach and small intestine and is capable of releasing the drug in the lower digestive tract including colon. By the preparation of the invention, the drug is efficiently released and absorbed even in the colon so that a steady and sustained release effect can be achieved.

The present invention was completed based on these discoveries and relates to in a hydrogel-forming compression-coated solid pharmaceutical preparation comprising a core tablet containing drug and outer layer made from hydrogel-forming polymer substance and hydrophilic base, the improvement, a timed-release compression-coated solid composition for oral administration, said composition comprising (1) drug and freely erodible filler are mixed with the core tablet, (2) the percentage erosion of the core tablet is approximately 40 to approximately 90%, and (3) the outer layer essentially does not contain the same drug as the above-mentioned drug. By releasing a drug after a specific lag time, it becomes possible to effectively deliver a drug to a specific site in the digestive tract. It is therefore useful as presented as a timed-release solid composition for oral administration of a drug that is to be effectively delivered in high concentrations to the afflicted site in the lower digestive tract, a drug that is to be effectively absorbed in the lower digestive tract, a drug that is effective for chronopharmacotherapy, etc.

The present invention relates to the field of medical devices. Specifically, the invention relates to an enteral feeding device comprising expandable means which prevents or significantly reduces aspirations from the alimentary tract to the respiratory system. In further aspects, the invention relates to systems comprising said enteral feeding device, methods and uses thereof.

The invention relates to the field of feed, in particular to a compound premix feed of 1% green laying hens in laying period. The compound premix feed of 1% green laying hens in laying period is formed by uniformly mixing micronutrient substances of trace elements, vitamins, synthetic amino acids and the like, feed additives and powdered grain feed as a carrier, and is characterized by comprising active dry yeast, lactic acid bacteria, bacillus and digestive ferment. In the compound premix feed of 1% green laying hens in laying period, active dry yeast, growing element for poultry containing lactic acid bacteria and bacillus can inhibit propagation of pathogen; in wet mixed feed, active dry yeast and the like can be propagated and fermented, and partial pathogen can be inhibited and killed; and the palatability and digestibility of the feed can be improved in a certain time range. Microzyme, lactic acid bacteria and bacillus enter an alimentary tract for quick propagation, and can inhibit the growth of pathogen such as colon bacillus, salmonella and the like, thereby reducing diseases caused by pathogen, generating the effect similar to antibiotics, eliminating the damage of antibiotics to enteric microorganisms, better balancing intestinal flora, improving the immunizing power of laying hens, and improving the health level of laying hens.

The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.

The invention discloses an alimentary canal anatomical position identification method and device. The method comprises the steps that a training set and a test set are acquired; a deep network model based on a deep learning framework is selected to act as the current deep network model, the current deep network model is trained by using the training set, the trained current deep network model is tested by using the test set and the identification accuracy data of the current deep network model are obtained, whether the identification accuracy data meet the preset accuracy requirements is judged, training is completed if the judgment result is yes, or the deep network model obtained by adjustment of the trained current deep network model is determined as the current deep network model, andthe process returns to the step of performing training on the current deep network model by using the training set; and the alimentary canal anatomical image acquired by the capsule endoscopy is inputted to the completely trained deep network model so that the corresponding alimentary canal anatomical position of the alimentary canal anatomical image outputted by the deep network model is obtained. Accurate locating of the capsule in the body can be realized.

The invention relates to a massage device of strengthen enteron based on microprocessor, wherein it comprises magnetic base and plastic capsule above. The invention is characterized in that: two ends of plastic capsule both have one coin vibration motor; each motor has one button battery beside; two batteries have control plate between them; the control plate uses two-face printing plate, while one face has microprocessor and quartz-oscillator, while another face has current amplifier and closed dry reed; the motors, batteries and control plate are connected via wire; the capsule will move forwards in enteron, as well as operate via preset program, to vibrate via different working modes, to improve the blood circulation, etc. The invention has simple structure and low cost.

Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion.

The invention relates to pannage and a preparation method thereof, in particular to pannage containing Chinese herbal medicines and a preparation method thereof, belonging to the feed processing field. The pannage is prepared by crushing and addition of purslane, dandelion, gentiana scabra bge and plantain; the purslane and the dandelion among the Chinese herbal medicines not only can be ate when fresh but also can be fed when dry, has the efficacies of clearing away heat and toxic materials, helping digestion, strengthening the spleen and stomach, stopping bleeding and relieving dysentery, and not only can get up the appetite of pigs and promotes the growth but also can prevent and treat respiratory and alimentary tract diseases; the gentiana scabra bge contains gentiopicrin, can promote the gastric acid secretion of the pigs and increase the number of free acids, and has good functions of invigorating the stomach and promoting the digestion; and the plantain contains a great deal of lymphatic temperament, amber acid, choline and so on, and can prevent and treat diseases of the pigs such as pyrexia, diarrhea and so on. The pigs fed by the pannage containing the Chinese herbal medicines have the advantages of stable temperament, ruddy skin, glossy dorsal seta, accelerated weight-increasing speed and obviously reduction of the disease rate.

The invention discloses a disposable intelligent alimentary canal anastomat. A nail bin assembly comprises a nail pushing sheet, an annular knife and a nail bin, the nail pushing sheet and the annular knife are integrally arranged, the nail bin is arranged at the front end of the nail pushing sheet, and at least three pressure sensors are uniformly distributed in the nail bin. The application method includes the steps that a nail abutting base assembly is disconnected from the nail bin assembly; the nail abutting base assembly is inserted into tissue to be sutured and with a packet, the packet is tightened, and the nail abutting base assembly and a guide shaft are in butt joint; after butt joint is completed, the distance between the end face of the nail bin and the lower end face of a nail abutting base is between K and S, a pointer in an indication window is displayed in a safe green area; when data, displayed by an observation window, of all the pressure sensors are within the range of P+ / -P1, a green light of an indicator light is turned on, and the tissue can be anastomosed. In this way, the risk of anastomotic leakage caused by improper and blind operation of the anastomat can be thoroughly eliminated, and a surgery digitization revolution is achieved.

The invention provides a weissella cibaria XHR1 and applications thereof and a weissella cibaria XHR1 containing pickled vegetable. The preparation of the pickled vegetable is implemented through the steps of adding a culture solution of weissella cibaria XHR1 and bacterial powder of lactobacillus plantarum CICC 20764 into a pickled vegetable fermentation starting solution for pickling vegetables, so that the final concentration of weissella cibaria XHR1 is 10<6>-10<7> cfu / mL eventually, and then the final concentration of lactobacillus plantarum CICC 2076 is 10<5>-10<6> CFU / mL; and then, adding vegetables into the pickled vegetable fermentation starting solution, and carrying out vegetable pickling according to a traditional vegetable fermentation process, so that the pickled vegetable disclosed by the invention is obtained finally. According to the invention, prebiotic lactobacillus for inhibiting the growth of Candida albicans is applied to the fermentation of Sichuan pickled vegetables, so that the consumer group is wider, and the micro ecological level of alimentary canals of wide consumers can be improved, thereby inhibiting Candida albicans diseases from the perspective of public health.

The invention discloses a strain of rhamnose lactobacillus M8 and a strain of rhamnose lactobacillus SLP prepared from the same. The preparation method of the rhamnose lactobacillus SLP comprises thefollowing steps: taking the rhamnose lactobacillus M8 as a host, guiding lactobacillus surface protein genes into the host by an electrotransformation method, and incubating to successively express the lactobacillus surface protein genes in the host. The adhesive capability of the rhamnose lactobacillus SLP is greatly strengthened in the intestinal canal of a human body so as to efficiently strengthen the positive effect of the rhamnose lactobacillus in the alimentary canal of the human body.

The invention discloses a preparation method of a novel pine pollen preparation, which comprises the following steps of: using pine pollen as a raw material without using any additive, simulating the environment suffered by a medicament in the transportation process of the digestive tract of a human body after ultramicro wall breaking, keeping a lower temperature, carrying out effective component extraction for 60 percent of the gross of the wall-broken pine pollen for many times under the conditions of pH 2, pH 7.6 and pH 8.4, and then mixing an extract with the rest 40 percent of the wall-broken pine pollen to prepare a super-concentrated pine pollen capsule or tablet. Because concentration extraction is carried out for most of the raw material through a biomimetic process at the low temperature by the method, the utilization ratio of natural resources is greatly improved, so that a product has high and abundant nutrient contents and simultaneously is more easily digested and absorbed by the human body, and meanwhile, the preparation formulation is greatly shrunk, so the novel pine pollen preparation is easy to take and convenient to carry.

The invention relates to a health product, in particular to a soft capsule and a method for producing the same. The soft capsule is characterized in that: the soft capsule contains water soluble pearl powder, selenium-enriched yeast, natural vitamin E, beeswax, glycerol monostearate, span-80 and corn oil. The soft capsule is a powerful antioxidant which can effectively improve the rancidity of fatty acid in food and the alimentary tract, and protect cells from being damaged by harmful matters generated by oxidation of unsaturated fatty acid; the soft capsule is an extremely good free radical scavenger which can protect biological membranes from being attacked by free radicals, effectively resist ageing nutrients, improve immunity of a human body, keep the integrity of red blood cells and promote the biological synthesis of the red blood cells; the soft capsule is an indispensible promoting factor for cellular respiration, which can protect the lung tissue from air pollution; moreover, the soft capsule also can prevent the over-aggregation of blood platelets, avoid the increase of lipid peroxidation in the blood, prevent cardiovascular diseases and supplementing calcium element in the human body.

The invention provides an internal tectorial membrane for duodenum, and relates to a built-in degradable medical instrument in a digestive tract. The internal tectorial membrane can be made of biocompatible materials by electrospinning. The internal tectorial membrane is placed in the duodenum of a patient, not only can stop food from contacting with the intestinal mucosae of the patient during dissection, but also avoids affecting functions of cells of the intestinal mucosae physiologically, can be obtained by hybrid electrospinning or / and multi-layered electrospinning or / and core-shell electrospinning or / and dry-method electrospinning, and can be manufactured into a medical instrument which can reduce injury, prevent dropping, avoid being removed and restrain bounce and can be used for treating diabetes mellitus and adiposis.

The invention relates to an enteric material coated chitosan nanoparticle which covers insulin and cell-penetrating peptide Tat and a preparation method of the chitosan nanoparticle. The chitosan nanoparticle is prepared from an enteric material, namely Eudragit S100, insulin, cell-penetrating peptide and chitosan. With the oral administration of the prepared enteric coated insulin chitosan nanoparticle, the amount of loaded contents released from the chitosan nanoparticle in the stomach and the upper part of the small intestine can be greatly reduced due to the protective effect of the enteric material, namely Eudragit S100. As the chitosan nanoparticle arrives at the lower end of the digestive tract, the enteric coating material on the surface of the chitosan nanoparticle begins to dissolve and the chitosan nanoparticle becomes exposed with the increase of pH value; the chitosan nanoparticle is damaged under a weakly alkaline condition, so that the cell-penetrating peptide and the insulin therein are released. The cell-penetrating peptide is capable of prompting the absorption of colonic epithelial cells to the insulin so as to improve the bioavailability of the insulin through oral administration.

The present invention relates to one kind of polycinnamic alcohol injection and its preparation. The polycinnamic alcohol injection is used mainly in treating esophagus varication hemorrhage and esophagus varication cirrhosis under endoscope. The polycinnamic alcohol injection contains in each 100 ml polycinnamic alcohol 1 g and alcohol 5 ml. Alcohol can dissolve polycinnamic alcohol easily and has slight narcosis, so that the polycinnamic alcohol injection has no pain caused, low viscosity for easy injecting, no side effect and less complication.

The objective of the invention is to provide a traditional Chinese medicine granule for treating side effects on an alimentary canal after cancer chemotherapy and a preparation method thereof. The invention is characterized in that the granule is prepared from an active component, a binder and pharmaceutically acceptable adjuvant, and the active component is prepared from the traditional Chinese medicines consisting of 600 to 800 g of milkvetch root, 250 to 350 g of dwarf lilyturf tuber, 150 to 250 g of red ginseng, 150 to 250 g of white atractylodes rhizome fried with bran, 150 to 250 g of Poria cocos, 200 to 300 g of licorice, 200 to 300 g of radix scrophulariae, 200 to 300 g of Chinese angelica, 250 to 350 g of dark plum, 250 to 350 g of prepared pinellia tuber, 200 to 300 g of cablin patchouli herb, 200 to 300 g of dried orange peel and 200 to 300 g of curcuma rhizome. The granule is applicable to cancer patients who vomit or retch because of damage of both qi and yin and rising of stomach qi resulting from damage of the spleen and the stomach by anti-radiogenic cancer and chemotherapy drugs, and the granule can mitigate symptoms like no appetite, tiredness, hypodynamia, a red or light red tongue with little fluid and weak pulse.

Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5′-hydroxyl group of the ribose moiety of α-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.

The invention relates to an effervescent tablet for preparing a mouth rinsing solution, wherein the effervescent tablet exhibits a high release rate of budesonide. A high availability of the active ingredient during use as a mouth rinsing solution on the inflamed mucosa of the upper digestive tract is thereby achieved. The advantage of the formulation according to the invention lies in the bioavailability comparable to oral forms of administration, which allows the formulation to be used safely over an extended period of time.

The invention discloses a two-dimensional plane representation method for the images of the intestinal tract. The realization of the method is based on a wireless sacculus endoscope system in which an attitude motion sensing module and an intestinal cavity identifying module are embedded. The method comprises several following steps: reading images; classifying an image set into turbid images and non-turbid images; dividing a non-turbid image set into a plurality of subsets; calculating the relative position relationship of a camera and the wall of the intestinal tract when shooting each image; carrying out the treatment of rectifying or mapping on the images; carrying out registered splicing or similar matching on the images after being rectified or mapped; and combining the subsets to form a two-dimensional expansion drawing of the wall of the intestinal tract. By adopting the two-dimensional representation method for the images of the intestinal tract, which is provided by the invention, the redundant contents of images collected by a wireless endoscope can be greatly reduced. The two-dimensional plane representation method for the images of the intestinal tract is beneficial for a doctor to comprehend the images, the working difficulty of the doctor can be lowered, and the film reading efficiency is enhanced.

This invention relates to a series of antioxygen peptide stem from collagen protein. It possess one of as follows amino acid sequence: ( 1) Hyl - Cys; ( 2) Gln - Gly - Ala - Arg; ( 3) Leu - Gln - Gly - Met; ( 4)) Leu - Gln - Gly - Met - Hyp. This antioxygen peptide could synthesize through polypeptide instrument chemical process, as well as through hydrolization of collagen protein, and then obtain by separating and purifying acquired hydrolysate. The antioxygenation of this antioxygen peptide is very strong, not only could substitute BHT to use as edible additive, furthermore could as activating functional ingredient. This product could be used in foodstuff, health products, makeup, even animal foodstuff and feedstuff, has abroad field of application and notable social benefit and economic benefit. The antioxygen peptide only has two to five amino acid, molecular weight smallness, more easily directly assimilate by alimentary tract.

A multienzyme high-efficiency concentration forage of the invention plays a part in straws or corncobs through utilizing a complicate enzyme system and microbes to improve the palatability of the forage; the pig house environment is improved through reducing the stink by supplementing insufficient exogenous enzymes in the alimentary canal of an animal via the complicate enzyme system; Chinese herbal medicines are added to obviously reduce the medicine and treatment cost; and effects of fast animal weight gain and culture cost reduction are reached. The high-efficiency multienzyme concentration forage comprises the following raw materials, by weight, 65-70% of soybean meal, 4-6% of powdery stone dust (containing 38.5% of calcium), 2-3% of calcium hydrogen phosphate, 0.12-0.15% of a composite vitamin, 0.8-1.0% of a mineral matter additive, 15-20% of DDGS, 0.1-0.2% of betaine, 6-10% of fermented straws or corncobs, 0.1-0.15% of a glucose oxidase, 0.05-0.1% of a protease, 0.05-0.1% of a phytase, 0.02-0.05% of a cellulase, 0.01-0.02% of a pectase and 0.05-0.1% of an amylase.

Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5′-hydroxyl group of the ribose moiety of α-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptides for conjugation with vitamin B12 include insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.

The invention provides a stichopus japonicus puffing feed added with enteromorpha prolifera, and a preparation method of the feed, belonging to the technology of preparation of the stichopus japonicus puffing feed. The stichopus japonicus puffing feed is prepared by adding enteromorpha prolifera dry powder. The stichopus japonicus puffing feed comprises the following ingredients in percent by mass: 4-8% of defatted fishmeal, 6-10% of cerevisiae fermentum, 15-25% of enteromorpha prolifera powder, 25-35% of seaweed meal, 5-7% of sea mud, 16-20% of strong flour, 5-7% of soybean meal, 3-5% of fish oil, 1% of vitamin complex and 1% of compound microelement; and in addition, 2-4% of zeolite powder and 0.5% of probiotics can be added. The stichopus japonicus puffing feed is prepared by adopting the puffing process, is high in nutrition digestibility and low in feed coefficient, and is reduced in the incidence of digestive tract diseases of intestines and stomach, remarkably enhanced in the survival rate of the stichopus japonicus, promoted in the rapid growth of the stichopus japonicus; and by adopting the enteromorpha prolifera powder to replace sargassum thunbergii powder, gulfweed powder, and the like, the feed has rich raw materials and is low in cost.