95 results about "Alimentary tract" patented technology

The invention relates to the technical field of artificial intelligence, and provides a gastric cancer risk quantitative scoring method, system and equipment based on artificial intelligence, and the method comprises the steps: recognizing the image type of each image frame in alimentary canal endoscope image data; for the electronic dyeing image frame, identifying a part contour region and an intestinal contour region of the feature part in the image frame, determining an intestinal epithelial metaplasia grading category of the feature part according to an area proportion of the intestinal contour region in the part contour region, and performing electronic dyeing intestinal scoring on the image data; for the white light image frame, gastroscope part types included in the image frame and focus area types of all gastroscope parts are recognized; performing atrophy scoring on the image data according to the position distribution of the focus area of the atrophy type; performing table state scoring on the image data according to whether the plica enlargement, nodular gastritis and diffuse redness focus areas exist or not; and realizing gastric cancer risk quantitative scoring according to the electronic staining intestinal scoring, the atrophy scoring and the epistatic state scoring.

The invention discloses a non-invasive intestinal flora fixed-point sampling and drug release device, and belongs to the technical field of micro-ecological diagnosis and treatment. The device comprises a shell, an internal storage bin, a medicine loading cavity and a channel switching mechanism. The shell adopts a capsule-shaped design, and an enteric coating is arranged on the surface of the shell, so that the function is started after the shell reaches a specified position of an intestinal tract. Through the internal ingenious mechanism linkage design, the device can firstly complete non-invasive fixed-point sampling of intestinal contents, and after the sampling action is completed, a drug release mechanism is automatically triggered, so that accurate drug delivery of the same part is realized. Cooperative operation of sampling and drug release in time sequence and space is achieved, and the problems of pain, disjunction of the diagnosis and treatment process, poor drug targeting and the like caused by traditional invasive operation are effectively solved. The device is flexible in structural design, has the advantages of being noninvasive, efficient, accurate in time sequence control and the like, and is suitable for integrated application of diagnosis and treatment of various digestive tract diseases such as inflammatory bowel disease management, micro-ecological regulation and the like.

The invention discloses a linear cutting and closing device for polyp resection under an endoscope, relates to the technical field of medical closing devices, and aims to solve the technical problems that perforation is easily generated in linear cutting and closing cutting, and repeated cutting is needed. Magnetic attraction linkage is taken as a core, the clamping force of the closed clamp is accurately controlled through the first magnetic attraction block, and a fine adjustment structure and a clamping limiting design are matched, so that sufficient clamping and one-time complete excision of a polyp are realized, and multiple times of cutting are avoided; the flexible lead body and the miniaturized structure are matched with an endoscope channel, so that the operation flexibility of a complex digestive tract is improved; the automatic conveying and clamping structure can immediately close the wound surface, and the bleeding and perforation risks are reduced; the whole-course button control simplifies operation, the elastic reset assembly reduces manual steps, and the operation time is shortened. The operation safety, the operation convenience and the adaptability are considered on the whole, the complication occurrence rate is effectively reduced, and the clinical treatment effect and efficiency of the endoscopic polyp resection operation are remarkably improved.

The present invention relates to an equipment for magnetic recanalization of benign biliary strictures. The equipment (100) includes a wire-guided magnet pusher tube (102a), atleast one magnet (110), and a magnet retrieval tube (102b). The equipment (100) works in conjunction with a visualization system to guide placement of the magnet (110) at the target site for recanalization of the biliary stricture. The magnet (110), may be deployed at opposing ends of a biliary stricture to create a controlled recanalization channel via magnetic attraction. The deployment process can be performed using endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), or a combination of both. Magnets may be retrieved following recanalization using biopsy forceps or allowed to pass naturally through the digestive tract, avoiding permanent implantation.

The invention relates to the technical field of medical instrument simulation and testing, in particular to a high-precision 3D printing personalized alimentary canal entity model method which comprises the steps that alimentary canal CT image data covering the range from the nasal cavity to the jejunum of a target individual and biomechanical property reference data of different sections of the alimentary canal are obtained; generating a stiffness distribution diagram; transparent flexible photosensitive resin is used as a base material, and various transparent flexible photosensitive resin materials with different elastic moduli are prepared by adding a modifier; generating a printing instruction; a digital light processing 3D printer is adopted, a solid model is printed layer by layer according to a printing instruction, the distributed transparent flexible photosensitive resin material is automatically switched and used in the printing process, and exposure parameters of ultraviolet light are dynamically adjusted based on the characteristics of the currently used transparent flexible photosensitive resin material so as to control the post-curing elastic modulus of different sections. Through accurate elastic modulus control and dynamic exposure adjustment, the mechanical properties of different sections of the digestive tract are highly consistent with the actual situation.

This invention belongs to the field of medical device technology, specifically a surgical treatment device for digestive tract malformations. It includes a support plate and casters, all fixedly connected to the bottom of the support plate. An adjustment mechanism is located on the top of the support plate, and a replacement mechanism is located on the top of the adjustment mechanism. The adjustment mechanism includes a cylindrical body fixedly connected to the top of the support plate. A vertical rod is inserted into the cylindrical body, and limit grooves are formed on both sides of the cylindrical body. Limit plates are inserted into the limit grooves, and support rings are fixedly connected to the surface of the limit plates. Fixing plates are fixedly connected to both sides of the cylindrical body. This surgical treatment device for digestive tract malformations allows for height adjustment by threading a fixing bolt into a threaded hole inside the fixing plate when the vertical rod is moved to a suitable height, ensuring the stability of the device during surgery.

This invention discloses a capsule system for electro-adhesion in the digestive tract and its operating method, relating to the field of medical devices. The system includes a transparent outer shell forming a sealed cavity within it; multiple electrode adhesion units are axially arranged on the outer wall of the shell; an image acquisition device is fixed inside the shell, with its acquisition end adjacent to the transparent end of the shell; a wireless transmission device is used for bidirectional wireless data transmission with an external workstation; when the drug storage device's release port is open, the drug within the storage device can be released to the outside; a control module can control the opening and closing of the release port, and can control the power supply to the electrode adhesion units, as well as the direction of current flow after power is applied; a power supply is electrically connected to the image acquisition device, the wireless transmission device, the drug storage device, and the control module. The system and its operating method of this invention can save internal capsule space, avoid mechanical damage to intestinal wall tissue, and the anchoring and release process is rapid, controllable, and reversible.

The balloon structure comprises a main catheter and a one-way valve arranged on one side of the main catheter, an auxiliary catheter is arranged on one side of the main catheter, the auxiliary catheter is detachably connected with the main catheter through a connecting mechanism, a hollow gooseneck pipe is arranged on one side of the auxiliary catheter, and the hollow gooseneck pipe is detachably connected with the main catheter through a connecting mechanism. A bag body structure is arranged on one side of the auxiliary catheter; the bag body structure comprises a hollow bag body, the bottom face of the hollow bag body is arranged on the outer surface of the auxiliary catheter, multiple sets of water inlet pipes are further arranged on one side of the auxiliary catheter and communicated with the hollow bag body, and an adjusting ring is further arranged on one side of the hollow bag body and slidably arranged on the auxiliary catheter. The angle of the hollow bag body can be adjusted according to the bending angle of the digestive tract, the hollow bag body can be conveniently guided in, meanwhile, expansion of the hollow bag body is guided, the sealing performance of the hollow bag body on plugging of the digestive tract is improved, overall installation and operation are convenient, and medical staff can conveniently use the hollow bag body.

The invention belongs to the technical field of biological medicine, and relates to a brain-targeted delivery system of semeglutide as well as a preparation method and application of the brain-targeted delivery system of semeglutide, the delivery system comprises yeast microcapsules and a semeglutide-cationic polymer; the delivery system takes a yeast microcapsule as a delivery carrier, and a semeglutide-cationic polymer is encapsulated in the yeast microcapsule. By simulating a natural way that microorganisms are recognized by macrophages through digestive tracts, active uptake is realized by utilizing specific binding of yeast microcapsules and Dectin-1 receptors on the surfaces of the macrophages, the semeglutide is accurately delivered to the brain by virtue of the cross-blood-brain-barrier migration ability of the macrophages, a central GLP-1 receptor pathway is activated to regulate metabolism, and meanwhile, the semeglutide can be used for preparing a medicine for treating liver cancer. According to the system, the oral bioavailability of the semeglutide can be improved, and non-specific distribution of the whole body is reduced.

This invention belongs to the field of medical drainage technology, specifically a drainage device for the care of gastrointestinal tumors. It includes a valve assembly, a valve adjustment assembly, an automatic cleaning assembly, a frame assembly, a liquid storage assembly, and a gas filtration assembly. The valve assembly is mounted on the frame assembly, and the valve adjustment assembly and the automatic cleaning assembly are located within the valve assembly. This invention cleverly utilizes changes in negative pressure within the valve body to trigger a cleaning action. When deposits on the inner wall obstruct the airflow, the reduced air pressure automatically overcomes the spring force, causing the piston to slide. This, in conjunction with a scraper ring, mechanically scrapes away the blockage from the inner wall of the valve body and pushes the obstruction into an independent storage bottle. This process achieves in-situ unblocking without disassembling the tubing, effectively preventing drainage interruption and significantly reducing the probability of cross-infection.

The present invention relates to the technical field of microorganisms, in particular to a Lactobacillus acidophilus GOLDGUT-LA100 having functions of lipid lowering, blood glucose lowering and weight loss and application thereof. The Lactobacillus acidophilus GOLDGUT-LA100 provided by the present invention is preserved in China General Microbiological Culture Collection Center, with the preservation number of CGMCC No. 28398. The strain has strong acid resistance, can adapt to the digestive tract environment, and has high bile salt hydrolase activity. At the same time, in animal experiments, the strain significantly reduces blood glucose and serum cholesterol levels, reduces liver fat deposition, reduces adipose tissue inflammation, effectively reduces the weight, and has broad application prospects in the development of products for improving obesity, lowering lipid and lowering blood glucose.

The invention discloses an ERCP (endoscopic retrograde cholangiopathy) operation simulation method and an ERCP operation simulation system based on a VR (virtual reality) technology. Establishing a space rectangular coordinate system, constructing a human digestive tract model, and importing the human digestive tract model into the space rectangular coordinate system; constructing a simulation insertion tube and a simulation controller, obtaining an operation signal of the simulation controller for controlling the simulation insertion tube, and transmitting the operation signal to VR equipment; acquiring posture data of the simulated insertion tube under the control of the operation signal, and acquiring the advancing direction and position of the simulated insertion tube in the human digestive tract model based on the posture data; determining the spacing distance between the simulated insertion tube and the inner wall of the human alimentary canal model according to the position, and applying operation feedback to the simulated insertion tube according to the spacing distance and the advancing direction so as to complete simulation of the ERCP operation. According to the simulation method provided by the invention, the ERCP operation process can be truly simulated in a safe environment, and the training and learning efficiency is improved.

An access device used with an endoscope includes an access pipe configured to be inserted into a sheath of the endoscope, a piercer disposed on a distal end portion of the access pipe and configured to pierce into a hollow organ through a digestive tract of a patient, and a treatment tool configured to be inserted into the access pipe and to be introduced into the hollow organ by the piercer. The access device is switchable between a first configuration and a second configuration. In the first configuration, a piercing function of the piercer is switched on, so that the piercer pierces the digestive tract and the hollow organ to enter into an interior of the hollow organ, and in the second configuration, the piercing function of the piercer is switched off, the piercer is kept connected to the interior of the hollow organ.

The invention belongs to the technical field of gastroscope sharp foreign body taking-out devices, and particularly discloses a multi-form adjustable gastroscope sharp foreign body taking-out auxiliary device which comprises a gastroscope head tube, one end of the gastroscope head tube is sleeved with a transparent tube cap, and folding rubber bags are evenly and fixedly installed on the outer surface of an auxiliary connecting end. According to the multi-form adjusting sharp foreign matter taking-out auxiliary device for the gastroscope, after the gastroscope lens tube is fed into the body of a patient and a sharp foreign matter is clamped, endoscope foreign matter forceps can be pulled to enable the sharp foreign matter to be close to the auxiliary connecting end, then air can be injected into the folding rubber bag through the ventilation channel, and the sharp foreign matter can be taken out through the ventilation channel. The folding rubber bag can be gradually expanded and expanded through air injection so as to shield the clamped sharp foreign matter, the sharp foreign matter cannot scratch the interior of the digestive tract of a patient in the taking-out process, secondary damage caused by the sharp foreign matter is reduced, and the comfort degree of the patient after the foreign matter is taken out is improved.

Introduced herein is an ingestible device capable of delivering a drug directly to tissues along the digestive tract. Administration of the drug stored in the ingestible device can be achieved through a combination of features. The ingestible device can include a plunging mechanism to which a needle is connected and a dissolvable trigger mechanism that holds the plunging mechanism in a first position. After ingestion, the trigger mechanism can be exposed to bodily fluids to cause dissolution. When the trigger mechanism dissolves, the plunging mechanism can move from the first position to a second position, thereby extending the needle into the tissue in which the ingestible device is housed. Second, the needle can also dissolve upon exposure to bodily fluids to ensure safe passage of the ingestible device through the digestive tract.

The utility model discloses a sampling capsule for in-situ sampling of a digestive tract. The sampling capsule comprises a capsule shell, a sample cabin door is formed in the capsule shell, a sample cabin, a circuit board and a battery are arranged in the capsule shell, the sample cabin corresponds to the sample cabin door in position, the circuit board is electrically connected with a micro motor, the output end of the micro motor is connected with a gear set, and the gear set is used for amplifying the acting force of the micro motor. The gear set is connected with a sample cabin door on the capsule shell through a transmission shaft; the gear set comprises a driving gear connected with the output end of the micro motor, a driven duplicate gear connected with the driving gear in a meshed mode and a driven gear connected with the driven duplicate gear in a meshed mode. The device can prevent proteins, metabolites and the like from being re-absorbed by colon, can effectively reflect the structures of biome, proteome and metabolome at each stage of the digestive tract, and provides a new device for research on space-time structure of microecology of the digestive tract and composition change of the space-time structure during occurrence and development of diseases.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating postoperative digestive tract reaction of malignant tumors, a preparation and application. The traditional Chinese medicine composition comprises the following active ingredient raw materials in parts by weight: 10-20 parts of fried codonopsis pilosula, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of poria cocos, 1-10 parts of liquorice, 10-20 parts of fried endothelium corneum gigeriae galli, 15-25 parts of fried malt, 25-35 parts of adina rubella hance root, 25-35 parts of wild grape root, 15-25 parts of Chinese actinidia root and 15-25 parts of coix seed. The traditional Chinese medicine composition and the preparation can effectively treat patients with malignant tumor postoperative digestive tract reaction, effectively improve symptoms of abdominal distension, stomachache, nausea, vomiting, diarrhea, constipation, anorexia, sour regurgitation, oral cavity / throat dryness and the like of the patients, improve the life quality of the patients and have good safety.

The abdominal cavity drainage fixing device comprises a drainage stabilizing mechanism, an abdominal cavity fixing mechanism and a drainage tube mechanism, the drainage stabilizing mechanism is located on one side of the abdominal cavity fixing mechanism, the drainage tube mechanism is located in the drainage stabilizing mechanism, and the drainage stabilizing mechanism comprises a containing plate; the outer wall of the placing plate is fixedly connected with a hollow column, and one side of the placing plate is fixedly connected with a side plate. By means of the drainage stabilizing mechanism, when a drainage task is conducted after the drainage tube mechanism is connected with a patient, a drainage tube can be fixedly clamped and fixed, the drainage tube can be prevented from falling off accidentally by clamping and fixing the drainage tube, it is ensured that the drainage tube conducts continuous drainage at the correct position, and the position change of the drainage tube can be reduced by fixing the drainage tube; the possibility that bacteria enter a wound is reduced, the risk of infection is reduced, it can be ensured that the drainage tube is not pressed or blocked, smooth drainage is kept, it is ensured that accumulated liquid in the abdominal cavity can be effectively discharged, and meanwhile the stability of the abdomen of a patient is improved through the drainage stabilizing mechanism; and seepage can be reduced and the seepage degree can be reduced.

The present invention relates to a method for reducing lipid binding of brazzein and / or to method for improving digestibility of brazzein in a subject's digestive track as well as to a modified brazzein polypeptide and uses of it and to a nucleic acid encoding the same.

The invention relates to the technical field of medical instruments, in particular to an alimentary canal foreign body taking-out device suitable for children, and aims to solve the problem that secondary injuries such as mucous membrane damage and bleeding are caused by direct friction and scraping between an existing foreign body taking-out device and alimentary canal mucous membranes of children when objects with sharp corners, rough protrusions and the like are taken out. The foreign matter taking-out device comprises a shell, a clamping assembly, a first clamping assembly, a second clamping assembly and a control assembly, a clamping channel is formed in the shell, and the clamping assembly is arranged in the clamping channel and used for clamping foreign matter in the digestive tract of a child; the wrapping assembly is arranged between the shell and the clamping channel and used for wrapping foreign matters in the digestive tract of the child; by arranging the wrapping assembly, the surface of the child can be tightly wrapped after clamping, direct friction and scraping between the foreign matter and the digestive tract mucosa of the child in the pulling and taking-out process are avoided, the mucosa damage and other problems are effectively prevented, and the foreign matter which is irregular in shape, smooth in surface and difficult to clamp can be directly wrapped and taken out.

A system and method for forming an anastomosis between two adjacent walls of the digestive tract is provided. The system includes first and second magnetic implants including first and second magnetic bodies, respectively. Each of the first and second magnetic bodies includes a tissue-facing surface and a lumen-facing surface, and defines a through-hole extending between the tissue-facing surface and the lumen-facing surface. The first and second magnetic implants are configured to be magnetically coupled to each other through two adjacent walls of the digestive tract with the through holes at least partially coincide with each other to compress annular portions of the two adjacent walls therebetween. The first and second magnetic implants may include various features, for example, configured to selectively assume a delivery configuration or an anastomotic configuration, sized to maintain a preliminary pathway between two adjacent walls within its outer periphery, with electrical insulation, etc.

This invention relates to a targeted ileal delivery method for endotoxin chelating agents, their preparation, and applications, belonging to the technical field of pharmaceutical formulations. The drug comprises a specific polymer copolymer containing a three-dimensional framework of organic carbon-carbon chemical bonds and amino groups. The aim is to deliver the polymer chelating agent to the distal small intestine for release, thereby chelating pathogen-associated molecular patterns produced by intestinal microorganisms, including endotoxins and CpG-DNA. The complex formed by the polymer chelating agent and pathogen molecular patterns released in the ileum can be excreted from the digestive tract, thereby reducing inflammation and alleviating various metabolic diseases.

The application discloses a kind of gene markers in esophagus, stomach, intestine multiple cancer early screening application, early screening model construction method and detection device, belong to the early non-invasive detection technical field of digestive tract tumor.It establishes a new type of multiple cancer screening system by analyzing the whole genome characteristics of circulating free DNA in peripheral blood.Based on low-depth whole genome sequencing data, three dimensions of molecular markers are detected: genome copy number variation pattern, DNA fragment distribution characteristics of specific length and epigenetic signals of transcription initiation region.Advanced converter neural network architecture is used, and the model can efficiently capture the complex feature correlation in the whole genome range through its unique self-attention mechanism.The model design specially considers the particularity of genomic data, and introduces an adaptive position coding system to accurately reflect the spatial distribution relationship of DNA fragments on the chromosome.The system can still maintain excellent detection performance at very low sequencing depth.

The invention relates to the technical field of medical instruments, in particular to a double-end linkage type diameter-length synchronous measuring device for interventional operation, which comprises a catheter, a hydraulic driving mechanism and a measuring block arranged at the front end of the catheter. The measuring block is provided with a plurality of extension measuring devices capable of expanding radially along the side wall, and the extension measuring devices are driven by a hydraulic transmission system to act synchronously. According to the device, the surface contact type measurement principle is adopted, the minimum diameter of a lumen can be measured at a time in single operation, multi-point serialization measurement of a lesion area is completed, and synchronous acquisition of the lesion length is achieved in combination with displacement sensing. The device adapts to lumen structures with different tube diameters and forms through modular design, is particularly suitable for accurate morphological data acquisition of narrow or irregular lumens such as bronchus, alimentary canal, blood vessel and urethra, and effectively solves the technical problems that the real narrowest point is easy to omit, the operation is complicated and the data is single in the traditional point contact measurement.

The application discloses a kind of biological hybrid nanoscale enzyme robot pills, with multi-mode regulation intestinal redox homeostasis and dysbiosis in inflammatory bowel disease, steps are as follows: step one, using zinc nitrate, acetylacetone iron and methanol and other drugs synthesis metal organic framework precursor, then calcination obtains iron single atom nanoscale enzyme;Step two, cultivate enrichment long bifidobacterium and human induced pluripotent stem cells, and extract the exosome or outer vesicle membrane of both respectively;Step three, nanoscale enzyme and probiotic vesicle membrane and stem cell exosome are co-extruded, and biological membrane-nanoscale enzyme composite robot is prepared;Step four, the prepared biological membrane-nanoscale enzyme composite particle is encapsulated in magnetic response pill, and engineering biological hybrid nanoscale enzyme robot pill is formed.Engineering biological hybrid nanoscale enzyme robot pill can be targeted to stay in intestinal inflammatory site under the control of rotating magnetic field after entering the intestinal tract of organism, then promote nanoscale enzyme release and enhance enzyme activity under the action of pulse magnetic field, so as to improve the treatment effect.Engineering biological hybrid nanoscale enzyme robot pill has biocompatibility and treatment safety, and has wide application prospect in the field of treating digestive tract inflammation.

[Problem] The purpose of the present invention is to provide a medical simulator for performing a procedure practice of cannulation in ERCP, the medical simulator making it possible to perform a procedure practice that is similar to an actual practice. [Solution] This medical simulator 10 uses an upper gastrointestinal tract model 30 comprising an esophagus model 31, a stomach model 32, and a duodenum model 33 provided with a detachable papilla-of-vater model 60, the upper gastrointestinal tract model 30 being housed in an opaque casing 40.

The invention relates to a preparation method and application of acellular extracellular matrix hydrogel for organoid culture, and the method comprises the following steps: step (1): preparing a small intestine acellular scaffold: sequentially putting pig small intestines without adipose tissues into a first solution, a second solution, a third solution and a fourth solution, stirring, and freezing and freeze-drying to obtain the small intestine acellular scaffold; step (2): preparing small intestine acellular matrix hydrogel, cutting a small intestine acellular scaffold into small pieces or grinding the small intestine acellular scaffold into powder, preparing a small intestine acellular scaffold solution with a hydrochloric acid solution and a pepsase solution, centrifuging, adding a PBS solution to terminate digestion, and adjusting the pH value to 6.0-8.0 to obtain solution state small intestine acellular matrix hydrogel; and gelling the solution-state small intestine extracellular matrix hydrogel at the temperature of 37 DEG C for 20-60 minutes to obtain the gel-state small intestine extracellular matrix hydrogel which is used for culturing alimentary canal organs.

The present application relates to a kind of electric field treatment device for digestive tract, it includes: slender rod, sleeve, expandable component, the expandable component includes: multiple groups of support framework, multiple groups of electrode array film;When the sleeve is slid forward to first position relative to the slender rod, the expandable component is in first expansion working state;When the sleeve is slid forward again to second position relative to the slender rod, the expandable component is in second expansion working state;The present application can accurately carry out electric field treatment to the inner wall of upper digestive tract, especially duodenum.

This invention discloses a deformable capsule endoscope probe and image fusion system based on multimodal imaging, belonging to the field of medical endoscopy technology. This invention solves the problems of existing capsule endoscope technology, which has relatively limited functionality and a fixed shape, making it difficult to adapt to the complex structure of the digestive tract and resulting in poor imaging effects. By using flexible silicone material to make the capsule endoscope probe's shell and deformable structure, it can automatically adjust its shape according to the shape of the digestive tract lumen, ensuring clear and accurate multimodal images are acquired from different locations. A neural network model accurately identifies potential lesion areas and adaptively adjusts the fusion weights based on the importance of the lesion and tissue characteristics to optimize image quality. Furthermore, a deep learning fusion network generates a comprehensive image, which, after contrast optimization and automatic labeling of lesion areas, provides doctors with clearer and more detailed diagnostic prompts, aiding in the early diagnosis and precise treatment of digestive tract diseases.

The application discloses a 1-aryl-5-pyrazolone compound and a pharmaceutical composition and application thereof. The compound has a structure selected from any one of the following structures, and also comprises a tautomer, a pharmaceutically acceptable salt or a mixture thereof: the compound can effectively inhibit COX-2 and effectively scavenge free radicals at a micromolar concentration level, can reduce cardiovascular and digestive tract side effects caused by NSAID-induced free radical production, and can also play a better treatment effect on chronic inflammatory diseases with pain through the synergistic effect of antioxidation stress and anti-inflammatory analgesia.