204 results about "Topical treatment" patented technology

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses a method, a system and equipment for evaluating the treatment effect of PTT on pancreatic cancer. According to the application disclosed by the invention, PTT is found to treat pancreatic cancer by regulating a caspase-1 / GSDMD pathway for the first time, and the expression level of GSDMD is found to be in positive correlation with the drug resistance of pancreatic cancer cells to 5-fluorouracil, irinotecan, paclitaxel and cis-platinum, which prompts that people can adopt a local treatment method of photothermal therapy instead of traditional chemotherapy for patients with high expression of GSDMD. Besides, the invention provides a method, a system and equipment for evaluating the treatment effect of PTT on pancreatic cancer and a method, a system and equipment for predicting the sensitivity of pancreatic cancer patients to chemotherapeutics, thereby assisting doctors in evaluating the treatment effect of pancreatic cancer patients and guiding clinicians to formulate individualized treatment schemes for patients.

The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w / v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

This needle assembly for a laser treatment directly radiates laser into skin by using a needle having an optical fiber inserted therein, and thus may effectively improve various skin problems such as elasticity, wrinkles, inflammation, and acne. In addition, local regional treatment is enabled so that side-effects resulting from the laser irradiation may be minimized and the pain of a subject being treated may be reduced. The needle assembly for a laser treatment comprises: a needle part comprising a hollow needle and a needle support part having one end portion of the needle passing therethrough and fixed therein; an optical fiber positioned inside the needle along the length direction such that one end of the optical fiber is not exposed to the outside of the tip portion of the needle; an optical fiber support part connected to the other end of the one end of the optical fiber; and a guide component positioned between the needle support part and the optical fiber support part so as to guide the insertion of the optical fiber into the hollow of the needle.

The invention discloses a medicine composition for treating atopic dermatitis, a preparation method and application, the medicine composition comprises inactivated malassezia sphaeroides, and the strain preservation number of the malassezia sphaeroides is ATCC 96807. The cream composition disclosed by the invention is externally applied to local treatment of skin lesions of specific dermatitis, supplements skin symbiotic bacteria, assists in recovering skin barriers of patients, remarkably inhibits growth and proliferation of staphylococcus aureus at the skin lesions of dermatitis and exocrine toxins, remarkably relieves inflammatory response, reduces the thickness of cuticles and reduces inflammatory cell infiltration; the traditional Chinese medicine composition assists the treatment of atopic dermatitis through the effects of the proinflammatory factors and the expression and secretion of the proinflammatory factors, has a remarkable treatment effect on the atopic dermatitis, is quick to take effect, small in toxic and side effects and good in safety, and has a good medicinal prospect.

The present: invention relates to a pharmaceutical composition comprising curcumin and ginsenoside, and a formulation comprising same. Using curcumin and ginsenoids according to the present invention in combination with butyric acid and sucralfate restores cell growth, mobility, and endothelial cell tube-forming by ability reduced irradiation, and inhibits an inflammatory response induced in macrophages by LPS treatment. In addition, it was confirmed that, when an irradiated mouse is topically treated with the formulation according to the present invention comprising the compounds, intestinal epithelial tissue damaged by irradiation is restored and the expression of inflammatory cytokines in the intestinal tissue is suppressed. Furthermore, a mixture of a ginseng extract and a turmeric extract also restored the intestinal epithelial tissue damaged by irradiation. Therefore, the pharmaceutical composition comprising curcumin, ginsenoid, butyric acid, and sucralfate, or the pharmaceutical composition comprising a mixture of a ginseng extract and a turmeric extract, and the formulation according to the present invention comprising same can be utilized for treating radiation proctitis.

The utility model discloses a multifunctional biliary tract internal and external drainage tube combination device applied to a patient suffering from hilum cholangiocarcinoma. A drainage catheter is transited from a shaping area and an elastic cabin area to an internal drainage area to form a cylindrical cone; side holes are formed in the inner drainage area and the shaping area; a marker point is arranged between the inner drainage area and the missile cabin area, the missile cabin area is distributed between the inner drainage area and the shaping area, a one-way valve is arranged at the contact position between the shaping area and the missile cabin area, a hole channel is formed in the outer wall, extending into the marker point from the missile cabin area along the one-way valve, of the missile cabin area, and the hole channel forms a missile cabin in the missile cabin area. The magazine is used for placing radioactive particles; the hard support is used in cooperation with the drainage catheter, the hard support penetrates into the outer drainage area and then is pulled to the end of the inner drainage area, and the curled part of the shaping area of the hard support is straightened. The utility model can realize internal and external drainage and achieve the purpose of local tumor treatment, and is simple and convenient to operate and easy for medical staff to use.

The invention discloses a chitosan composite temperature-sensitive gel microsphere for vaginal administration and a preparation method thereof, and relates to the technical field of biological medicines.The preparation method comprises the steps that high-purity chitosan and a temperature-sensitive polymer are mixed, then a cross-linking agent is dropwise added in a gradient mode to form pre-gel, after medicine is ultrasonically embedded, spraying or micro-fluidic forming is conducted, and the chitosan composite temperature-sensitive gel microsphere is obtained; carrying out surface modification and freeze drying by using a stabilizing aid to obtain microspheres; the system is composed of a chitosan matrix, a poly N-isopropylacrylamide temperature-sensitive polymer, a sodium tripolyphosphate cross-linking agent, an antifungal / antiviral / hormone drug and a hydroxypropyl methyl cellulose stabilizing aid, the particle size of microspheres is 50-300 [mu] m, the microspheres are rapidly gelatinized at 37 DEG C, the half-life period of the drug is longer than 8 h, the adhesive force is improved by 30% or above, and the residence time is prolonged to 12 h or above. According to the invention, by constructing a temperature-sensitive interpenetrating network structure and performing surface functional modification, body temperature triggered in-situ gelation, long-acting slow release and strong adhesion synergism are realized, and the local treatment effect and patient compliance are remarkably improved.

The present invention is in the field of ocular disease therapy. In particular, the invention relates to a composition comprising pimecrolimus for use in the topical treatment of moderate to severe blepharitis, in particular in a patient group comprising subjects with a clinical diagnosis of moderate to severe blepharitis, wherein the subjects to be treated have signs and symptoms of moderate to severe blepharitis characterised by swelling of the eyelid margin, ocular debris and ocular discomfort. In particular, the present invention relates to an ophthalmic composition that shows a high patient acceptance and a clinically meaningful improvement in the signs and symptoms of treated patients.

1. The name of the design product: beauty instrument (local care). 2. The use of the design product: for facial skin care. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention discloses a polygala tenuifolia aqueous extract as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) removing impurities from a polygala tenuifolia medicinal material, and crushing to obtain polygala tenuifolia coarse powder for later use; (2) putting the polygala tenuifolia coarse powder obtained in the step (1) and pure water into an extraction device according to a solid-liquid ratio of 1: (10-15) (g / mL), and extracting for 2-3 times while keeping a slight boiling state; (3) after each time of extraction in the step (2) is finished, filtering, and collecting filtrate of each time to obtain a polygala tenuifolia water extract; and (4) concentrating and drying the polygala tenuifolia water extract in the step (3) to obtain polygala tenuifolia water extract dry powder. The polygala tenuifolia aqueous extract is used as an effective component to prepare the external medicament for treating the red and swollen skin, so that the limitation of dosage forms such as original water decoction or medicine residue external application is broken through, the transdermal absorption and the curative effect are remarkably improved, the efficient local treatment of the skin abscess is realized, and the problems of systemic side effects and drug resistance of antibiotics caused by oral medicines are avoided; the applicable crowd is expanded.

Dichlofenac-based sustained release medical plasters, in particular medical plasters based on the sodium salt of dichlofenac, whose formulation allows the active ingredient to be released continuously and at a locally therapeutically active concentration over 24 hours, and also polymer adhesive matrices (PSA) for medical plasters based on the sodium salt of dichlofenac are described.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a traditional Chinese medicine composition for treating rhinitis, a preparation and a preparation method thereof. The traditional Chinese medicine composition follows the principle of compatibility of monarch, minister, assistant and guide, and is prepared from flos magnoliae, fructus xanthii, centipeda minima, radix angelicae, rhizoma atractylodis, rhizoma acori graminei, radix scutellariae, ligusticum wallichii and mint, the multiple components act on multiple pathogenesis of rhinitis in a synergistic manner, and both symptoms and root causes are treated. The traditional Chinese medicine composition ointment is prepared by mixing the traditional Chinese medicine composition extract, permeation enhancing auxiliary materials and pharmaceutically acceptable auxiliary materials, the permeation enhancing auxiliary materials have a synergistic effect, so that the transdermal permeation efficiency of the medicine can be improved, the medicine can be promoted to quickly and directly reach an inflammation part, the rhinitis related symptoms can be effectively improved, and the traditional Chinese medicine composition ointment is suitable for a wide range of people and has a good application prospect. And a safe and efficient local treatment scheme is provided for a nasal inflammation patient.

The invention relates to a nasal administration preparation containing extracellular vesicles and acellular matrix hydrogel and a preparation method of the nasal administration preparation, and belongs to the technical field of extracellular vesicles. According to the nasal administration preparation, the nasal administration preparation contains extracellular vesicles, acellular matrix hydrogel and auxiliary materials, and the auxiliary materials contain at least one of a lipophilic solvent, a humectant, a thickening agent and an osmotic pressure regulator. The EVs nasal administration dosage form is prepared, the EVs has the capacity of passing through a blood brain barrier, can be delivered to a brain central nervous system and has high brain administration capacity, the human placenta source ECM forms nanofibers through structural regulation and control, the nanofibers are used as a carrier material of the EVs, long-term storage of the biological activity of the EVs can be achieved, the local treatment time of the EVs is prolonged, and the EVs nasal administration dosage form can be applied to the brain. EVs can be efficiently absorbed in the nasal cavity, and compared with similar products, the effective component acting time is longer.

The invention discloses an electrode structure based on liquid ion polar molecules and a use method, and relates to the technical field of electrotherapy, the electrode structure comprises an insulating film, the upper end of the insulating film is provided with a solid-state electrode assembly, and the upper end of the solid-state electrode assembly is provided with a liquid ion polar molecule. The lower end of the insulating film is provided with an affected part auxiliary attaching assembly, the upper end of the insulating film is provided with a liquid inlet auxiliary assembly, the liquid electrode and the affected part can achieve complete surface contact, the contact resistance between the solid electrode and the affected part can be effectively reduced, and accurate local treatment of the affected part by in-vitro liquid can be achieved; the liquid electrode has a drug penetration effect on the skin tissue of the affected part; the liquid electrode can achieve the synergistic effect of various treatment means.

An injectable liquid containing bioactive molecules released from a powder comprising a neo-synthesized extracellular matrix for use in the treatment or prevention of cancer, in particular in the local treatment of solid tumors.

Disclosed herein are compositions for topical treatment that can include a therapeutic agent (preferably a topical antimicrobial or antifungal agent such as efinaconazole, tavaborole, or ciclopirox), a non-volatile organic solvent (preferably natural or synthetic vitamin E or vitamin E acetate), and optionally an emollient (such as cholesterol). Also disclosed herein are methods of treating diseases or disorders (preferably as a disease or disorder of the nail, nail bed, or skin, such as onychomychosis) by topically administering compositions that can include a therapeutic agent, a non-volatile organic solvent, and optionally an emollient.

The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w / v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

The present invention relates to a patch (1) for the topical treatment of sinusitis in a person to be treated, the patch (1) comprising at least one active section (2) with at least one active ingredient and at least one adhesive section (3), wherein the patch (1) is designed to be at least partially, preferably completely, occlusive in the at least one active section (2) and / or in the at least one adhesive section (3), wherein it is provided according to the invention that the at least one active section (2) contains a therapeutically effective amount of a non-steroidal anti-inflammatory drug and / or its physiologically compatible compounds / salts and / or physiologically compatible chemical derivatives as the at least one active ingredient, and that the patch (1) has a shape that is adapted to the anatomical conditions of the application site, wherein the application site is in the face in the area of ​​at least one of the paranasal sinuses,preferably located in the area of ​​the cheek of the person to be treated, in order to enable targeted percutaneous treatment of the sinusitis.

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.

Provided herein are compositions, systems, and methods for treating wounds with the combination of statins and cholesterol to help prevent and reduce scar formation.

The invention relates to the substances benfo-oxythiamine and / or oxythiamine for use as the active ingredient of a topically administered medicament for the therapeutic treatment of patients with a disease of the body surface skin (cutis and subcutis) and / or one or more mucous membranes (mucosa) caused by viruses. The medicament is administered at a time when viral replication has already taken place and viral release from the host cell(s) is imminent.Benfo-oxythiamine and / or oxythiamine cause (I) a slowing or prevention of the spread mechanisms of the viruses, so that the viruses remain in their host cells after replication and cell damage in the patient organism (host organism) is reduced or prevented, and (II) an immune response against the viruses remaining in the cells, so that the patient's immune system is activated or reactivated to generate an effective immune response against the viruses.

The present invention relates to a local targeting photodynamic therapy device for treating cancer. In more detail, an endoscope is disposed at the center of the end of a probe for photodynamic therapy, and a plurality of optical fibers are disposed along the edge to irradiate a plurality of lights to a lesion site, wherein the plurality of optical fibers of the probe receive light from independent light sources to independently perform light irradiation. The present invention is a device for minimizing damage to unnecessary normal tissue by adjusting the light irradiation area, i.e., each independent light source determines a light irradiation area including a lesion site in a real-time image provided by an endoscope disposed at the end of the probe, and only causes the independent light source that irradiates the determined light irradiation area to emit light, thereby achieving local light irradiation, etc. The local targeting photodynamic therapy device of the present invention can treat a variety of cancers or tumors, including cervical cancer, female cancers (endometrial cancer, ovarian cancer, breast cancer), skin cancer, brain cancer, etc., which are small and can be treated locally.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

The present invention relates to the to the field of pharmaceutical compositions for ocular diseases, in particular, retinal neurogenerative diseases. The invention provides pharmaceutical compositions to be applied topically in the eyes, including peptides and methods for preparing them thereof. This invention further relates to ophthalmic pharmaceutical composition for use in the topical eye treatment and / or prevention of a retinal neurodegenerative disease.

Apparatuses and methods configured to provide heat and cold to the skin along with a skin treatment to control rate of skin treatment flow to the skin are described. The disclosed apparatuses and methods include beneficially delaying the transition of skin treatments once skin penetration is achieved to improve the effectiveness of topical treatments to the skin. Accordingly, the disclosed apparatuses and methods are configured to enhance the benefits of topical treatments to the skin.

The invention provides a near-infrared light NIR response-based dual-regulation nano drug delivery system and application thereof, the nano drug delivery system takes mesoporous silica as a carrier, and alendronate sodium is coupled on the surface of the carrier to increase bone targeting; mesopores in the carrier are blocked by rhodamine RH, nitric oxide NO can be consumed to generate rhodamine B, and bioactive drugs in the carrier are released. The invention constructs a systemic drug carrier with bone targeting and diabetic bone microenvironment response release, and solves the problems that the bone healing ability of diabetic patients is significantly reduced, and traditional local treatment is difficult to effectively improve systemic bone microenvironment disorder; the problems that an existing local drug system cannot be released according to needs, local NO and NO in bone marrow are difficult to efficiently remove, and macrophages are difficult to transform to repair-promoting M2 type are solved.

This utility model relates to a therapeutic patch for liver, gallbladder, pancreas, and spleen care, belonging to the technical field of therapeutic patches. Its key technical features include: a temperature control structure and a patch body. The temperature control structure is movably positioned on top of the patch body. The patch body includes a substrate layer and a drug-releasing layer. The temperature control structure is located on top of the substrate layer, and the drug-releasing layer is located at the bottom of the substrate layer. Several drug placement slots are pressed onto the sidewall of the drug-releasing layer away from the substrate layer. The temperature control structure includes a piece of absorbent cotton cloth and Velcro. The Velcro is located on the back of the absorbent cotton cloth and adhered to the top of the substrate layer. A heating pad is placed between the absorbent cotton cloth and the substrate layer. The outer surface of the drug-releasing layer is coated with acrylic adhesive. The drug placement slots are arranged in a rectangular array. This utility model has a simple structure, is easy to use, and has good heat therapy and drug-releasing function. It can be used for local treatment of the liver, gallbladder, pancreas, and spleen areas, and has high comfort and clinical applicability.