93 results about "Topical treatment" patented technology

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

This needle assembly for a laser treatment directly radiates laser into skin by using a needle having an optical fiber inserted therein, and thus may effectively improve various skin problems such as elasticity, wrinkles, inflammation, and acne. In addition, local regional treatment is enabled so that side-effects resulting from the laser irradiation may be minimized and the pain of a subject being treated may be reduced. The needle assembly for a laser treatment comprises: a needle part comprising a hollow needle and a needle support part having one end portion of the needle passing therethrough and fixed therein; an optical fiber positioned inside the needle along the length direction such that one end of the optical fiber is not exposed to the outside of the tip portion of the needle; an optical fiber support part connected to the other end of the one end of the optical fiber; and a guide component positioned between the needle support part and the optical fiber support part so as to guide the insertion of the optical fiber into the hollow of the needle.

The present invention is in the field of ocular disease therapy. In particular, the invention relates to a composition comprising pimecrolimus for use in the topical treatment of moderate to severe blepharitis, in particular in a patient group comprising subjects with a clinical diagnosis of moderate to severe blepharitis, wherein the subjects to be treated have signs and symptoms of moderate to severe blepharitis characterised by swelling of the eyelid margin, ocular debris and ocular discomfort. In particular, the present invention relates to an ophthalmic composition that shows a high patient acceptance and a clinically meaningful improvement in the signs and symptoms of treated patients.

1. The name of the design product: beauty instrument (local care). 2. The use of the design product: for facial skin care. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention discloses a polygala tenuifolia aqueous extract as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) removing impurities from a polygala tenuifolia medicinal material, and crushing to obtain polygala tenuifolia coarse powder for later use; (2) putting the polygala tenuifolia coarse powder obtained in the step (1) and pure water into an extraction device according to a solid-liquid ratio of 1: (10-15) (g / mL), and extracting for 2-3 times while keeping a slight boiling state; (3) after each time of extraction in the step (2) is finished, filtering, and collecting filtrate of each time to obtain a polygala tenuifolia water extract; and (4) concentrating and drying the polygala tenuifolia water extract in the step (3) to obtain polygala tenuifolia water extract dry powder. The polygala tenuifolia aqueous extract is used as an effective component to prepare the external medicament for treating the red and swollen skin, so that the limitation of dosage forms such as original water decoction or medicine residue external application is broken through, the transdermal absorption and the curative effect are remarkably improved, the efficient local treatment of the skin abscess is realized, and the problems of systemic side effects and drug resistance of antibiotics caused by oral medicines are avoided; the applicable crowd is expanded.

An injectable liquid containing bioactive molecules released from a powder comprising a neo-synthesized extracellular matrix for use in the treatment or prevention of cancer, in particular in the local treatment of solid tumors.

Disclosed herein are compositions for topical treatment that can include a therapeutic agent (preferably a topical antimicrobial or antifungal agent such as efinaconazole, tavaborole, or ciclopirox), a non-volatile organic solvent (preferably natural or synthetic vitamin E or vitamin E acetate), and optionally an emollient (such as cholesterol). Also disclosed herein are methods of treating diseases or disorders (preferably as a disease or disorder of the nail, nail bed, or skin, such as onychomychosis) by topically administering compositions that can include a therapeutic agent, a non-volatile organic solvent, and optionally an emollient.

The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w / v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

The present invention relates to a patch (1) for the topical treatment of sinusitis in a person to be treated, the patch (1) comprising at least one active section (2) with at least one active ingredient and at least one adhesive section (3), wherein the patch (1) is designed to be at least partially, preferably completely, occlusive in the at least one active section (2) and / or in the at least one adhesive section (3), wherein it is provided according to the invention that the at least one active section (2) contains a therapeutically effective amount of a non-steroidal anti-inflammatory drug and / or its physiologically compatible compounds / salts and / or physiologically compatible chemical derivatives as the at least one active ingredient, and that the patch (1) has a shape that is adapted to the anatomical conditions of the application site, wherein the application site is in the face in the area of ​​at least one of the paranasal sinuses,preferably located in the area of ​​the cheek of the person to be treated, in order to enable targeted percutaneous treatment of the sinusitis.

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.

The present invention relates to a local targeting photodynamic therapy device for treating cancer. In more detail, an endoscope is disposed at the center of the end of a probe for photodynamic therapy, and a plurality of optical fibers are disposed along the edge to irradiate a plurality of lights to a lesion site, wherein the plurality of optical fibers of the probe receive light from independent light sources to independently perform light irradiation. The present invention is a device for minimizing damage to unnecessary normal tissue by adjusting the light irradiation area, i.e., each independent light source determines a light irradiation area including a lesion site in a real-time image provided by an endoscope disposed at the end of the probe, and only causes the independent light source that irradiates the determined light irradiation area to emit light, thereby achieving local light irradiation, etc. The local targeting photodynamic therapy device of the present invention can treat a variety of cancers or tumors, including cervical cancer, female cancers (endometrial cancer, ovarian cancer, breast cancer), skin cancer, brain cancer, etc., which are small and can be treated locally.

The invention provides composite hydrogel, photo-thermal response drug release composite hydrogel as well as a preparation method and application of the photo-thermal response drug release composite hydrogel, and belongs to the technical field of biomedical materials. The hydrogel is constructed by taking methylacryloyl gelatin as a matrix and combining lauric acid microspheres carrying an osteogenesis promoting drug baicalin, a reduced graphene oxide photothermal agent and a photoinitiator LAP. Under the irradiation of near-infrared light, the hydrogel can realize local mild temperature rise, induce the lauric acid microspheres to generate solid-liquid phase change, release the entrapped osteogenesis promoting drug as required, realize the synergistic effect of photothermal therapy and controlled release of the drug, and have a good osteogenesis repair effect. The hydrogel has good mechanical properties, biocompatibility and degradability, can be used for local treatment of bone defect parts, and effectively promotes regeneration and repair of oral and maxillofacial bone tissues. The invention provides a novel controllable and efficient treatment thought for bone tissue engineering and regenerative medicine.

The present invention relates to the to the field of pharmaceutical compositions for ocular diseases, in particular, retinal neurogenerative diseases. The invention provides pharmaceutical compositions to be applied topically in the eyes, including peptides and methods for preparing them thereof. This invention further relates to ophthalmic pharmaceutical composition for use in the topical eye treatment and / or prevention of a retinal neurodegenerative disease.

This utility model relates to a therapeutic patch for liver, gallbladder, pancreas, and spleen care, belonging to the technical field of therapeutic patches. Its key technical features include: a temperature control structure and a patch body. The temperature control structure is movably positioned on top of the patch body. The patch body includes a substrate layer and a drug-releasing layer. The temperature control structure is located on top of the substrate layer, and the drug-releasing layer is located at the bottom of the substrate layer. Several drug placement slots are pressed onto the sidewall of the drug-releasing layer away from the substrate layer. The temperature control structure includes a piece of absorbent cotton cloth and Velcro. The Velcro is located on the back of the absorbent cotton cloth and adhered to the top of the substrate layer. A heating pad is placed between the absorbent cotton cloth and the substrate layer. The outer surface of the drug-releasing layer is coated with acrylic adhesive. The drug placement slots are arranged in a rectangular array. This utility model has a simple structure, is easy to use, and has good heat therapy and drug-releasing function. It can be used for local treatment of the liver, gallbladder, pancreas, and spleen areas, and has high comfort and clinical applicability.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The utility model relates to the technical field of medical instruments, and discloses a rheumatism immunity traditional Chinese medicine fumigator which comprises a connecting block detachably connected to the top of a fumigation box, the upper end of the connecting block is fixedly connected with a conveying pipe used for circulation, and a spray head is fixedly installed at one end of the conveying pipe. One side of the fumigation box is detachably connected with a connecting frame used for positioning, and the side face of the connecting frame is fixedly connected with a storage shaft used for limiting. According to the traditional Chinese medicine fumigator for rheumatism immunity, through cooperative arrangement of the conveying pipe, the spray head, the connecting frame and the storage shaft, medical staff can convey steam emitted from the fumigating box to the part, needing to be treated, of a patient by using the conveying pipe and the spray head, so that the purpose of conducting local treatment on the patient is achieved, and meanwhile the connecting frame and the storage shaft are arranged, so that the traditional Chinese medicine fumigator is convenient to use. And after a patient is subjected to fumigation treatment, a conveying pipe can be wound on the surface of a storage shaft, so that a medical worker can conveniently play a role in storing the conveying pipe and a spray head.

The present invention provides a celecoxib cream and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the celecoxib cream comprises, by mass, 0.5%-2% of celecoxib, 1%-20% of an oily matrix, 1%-20% of an emulsifier, 0.1%-10% of a transdermal absorption enhancer, 1%-20% of a thickener, 2%-15% of a humectant, 0.1%-2% of a preservative, 0.1%-10% of a pH regulator, and the balance of deionized water. The prepared celecoxib cream is good in stability and high in bioavailability, and gastrointestinal reaction and oral first pass effect of a traditional oral dosage form are avoided. The celecoxib cream disclosed by the invention is also added with a transdermal absorption enhancer, so that medicine molecules can be helped to penetrate through a skin barrier and directly reach a focus part; the metabolism loss of the medicine on the skin surface can be reduced, more active ingredients enter blood circulation or deep tissues, the local treatment effect is enhanced, and the important clinical value is achieved.

The present invention relates to sitagliptin or a pharmaceutically or veterinary acceptable salt thereof for use in the local eye treatment of neovascular retinal diseases. The invention also encompasses pharmaceutical or veterinary compositions for use in the local treatment of these diseases.

This invention belongs to the field of pharmaceutical formulations and relates to a compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection, its preparation method, and its application. By weight percentage, the compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection comprises 0.1-2.0% of a nitroimidazole compound, 0.05-3.0% of an isoxazoline compound, 0.1-1.5% of a gelling polymer, 1.0-8.0% of a complex solubilizing system, 0.1-3.0% of pharmaceutically acceptable excipients, and the balance being water. The complex solubilizing system includes polyvinylpyrrolidone and cyclodextrin derivatives. This invention effectively solves the problem of poor solubility of isoxazoline drugs through a complex solubilizing system, and the combination of the two drugs has a significant synergistic acaricidal effect. Combined with a gelling polymer, it can achieve in-situ gelation on the ocular surface, prolong retention, and sustained drug release, with low ocular irritation, providing a highly effective, long-lasting, and safe new local treatment option for Demodex mite-related eye diseases.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus.The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses a periodontal brace for treating periodontitis in Uyghur medicine, and relates to the technical field of auxiliary devices for dental treatment. The tooth socket comprises a customized half-soft membrane tooth socket body, and a medicine storage groove is formed in the inner side of the tooth socket body corresponding to the periphery of gingiva and used for containing Uyghur medicine ointment. The tooth socket is ensured to be fit with the shape of the oral cavity through mold taking customization, the medicine storage groove can prolong the contact time of medicine and periodontium, the medicine storage groove is matched with pure natural Uyghur medicine to avoid the side effect of chemical medicine, and the tooth socket can be repeatedly used. The problems that an existing local treatment medicine is short in treatment effect and obvious in side effect are solved, the treatment effect and safety of chronic periodontitis are improved, and the traditional Chinese medicine composition is suitable for clinical periodontitis local medicine treatment scenes.

The invention discloses eye drops for treating vascular hyperplasia of eyes and a preparation method of the eye drops, and belongs to the technical field of biological pharmacy. The eye drops comprise a recombinant human angiostatin protein, an endostatin protein and a pharmaceutically acceptable carrier, wherein the recombinant human angiostatin protein and the endostatin protein are used for preparing the eye drops. Experiments show that the eye drops show remarkable vascular inhibition activity in a chick embryo chorioallantoic membrane model and a diabetic rat retina hyperplasia model, and the two proteins are combined for use to achieve a synergistic effect; the invention provides a safe and effective new way for local treatment of ocular vascular hyperplasia diseases.

The present invention relates to the technical field of medical materials. Provided are a topical cream or patch for scar treatment and a preparation method therefor. The cream or patch is a topical preparation for scar treatment that combines a hormone, an antibiotic and a chemotherapeutic drug. By means of the synergistic effect of the three components, the cream or patch realizes a variety of effects such as sterilization, anti-inflammation, inhibition of fibroblast proliferation and angiogenesis, inhibition of scar hyperplasia, promotion of scar softening, and prevention of infection, thereby improving the efficacy of scar treatment. The preparation can be simply applied topically or used as a patch without injection, which greatly facilitates patient use and achieves the aim of scar prevention and treatment, thereby providing a multi-functional, safe and effective approach for scar treatment.

The present invention relates to a cosmetic composition comprising a combination of nerve growth factor (NGF) inhibitors, that is particularly of use in the topical treatment of pruritus, in particular, that observed in the case of psoriasis or of atopic dermatitis, of chronic urticaria and also of senile pruritus. The invention is directed towards a composition comprising an ambora extract and a green tea extract.

The invention relates to a long-acting drug delivery freeze-soluble microneedle and a preparation method and application thereof, and the method is characterized in that a water-containing temperature-sensitive gel precursor system is cured and molded under a low-temperature condition to obtain a solid microneedle which has enough mechanical strength and can be punctured into a skin surface layer. The microneedle can be quickly converted from a solid state to a gel state after contacting with body temperature, and a local gel matrix is formed subcutaneously, so that in-situ retention and slow release of the carried medicine are realized. According to the technology, the formability and the penetration force of the microneedle are improved through freeze curing, and a subcutaneous drug storage cavern is constructed by utilizing the phase transformation characteristic of temperature-sensitive gel, so that the continuity and the targeting property of local drug delivery are improved. The method is simple in process and can be used for developing microneedle preparations in the field of skin and local treatment.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

The present disclosure provides a composition comprising about 0.01% w / v to about 5% w / v of resiquimod, gardiquimod, and / or their derivatives a penetration enhancer, at least 40% w / v of an aliphatic solvent, and a film forming excipient, wherein the film forming excipient is soluble at a pH between 1 and 10, wherein the composition is a solution which can be sprayed or applied using an applicator to the skin of children or adults and that forms protective and washable film when on skin and wherein the resiquimod, and gardiquimod, do not crystallize when the composition is applied to the skin surface. The disclosure provides a method of treating arboviral infections in a subject in need thereof, the method comprising topically administering to the subject the topical compositions as described herein.

Disclosed are topical compositions comprising hyaluronic acid or salts thereof and iota-carrageenan, preferably in a mucoadhesive matrix containing ascorbyl palmitate and choline alfoscerate. The compositions according to the invention are useful for topical treatment of Herpesvirus infections.

This invention relates to a compound gel for treating joint inflammation based on a modified ancient Chinese medicine formula, belonging to the fields of pharmaceutical preparations and traditional Chinese medicine. The compound gel consists of active ingredient extracts, a poloxamer thermosensitive gel matrix, a penetration enhancer, a humectant, and deionized water. The active ingredient extracts are obtained from *Terminalia chebula*, *Amla emblica*, lavender, wild watermelon, *Artemisia annua*, and chamomile through ultrasonic-microwave coupling extraction. Using ultrasonic-microwave coupling extraction combined with a low-temperature drying process, small-molecule active ingredients are obtained. A body temperature-responsive gel is constructed based on poloxamer 407 / 188, achieving in-situ phase transition on the skin surface and stable sustained release over 6-8 hours, significantly improving transdermal absorption. The gel is combined with an integrated medication container and biomimetic protective gear to form a synergistic drug delivery system, achieving closed-loop controlled release, leak-proof design, and motion adaptation. This gel is non-irritating and non-allergenic, suitable for topical treatment of osteoarthritis, rheumatoid arthritis, and soft tissue injuries caused by cold and dampness in high-altitude regions.