The invention discloses a sterile opening method and device of a medical 
ampoule bottle. The device is composed of a sealing box body, a clamping and rotating mechanism, a sawing mechanism, a cleaning and disinfecting mechanism, a 
chip removing mechanism, a breakoff mechanism, a waste collecting mechanism and an 
electric control system. By means of reasonable depth and length sawing, 
liquid gas disinfecting and outward-pulling breakoff on the 
ampoule bottle, negative pressure lower than the pressure in the 
ampoule bottle is generated outside the ampoule bottle, and fewest glass chips are generated by the ampoule bottle in the breakoff process, and the glass chips directionally flow towards the outer portion of the ampoule bottle to be collected by the 
chip removing mechanism and cannot fall into the ampoule bottle. After breakoff of the ampoule bottle is finished, the ampoule bottle is inflated with sterile 
nitrogen, medicines are free of 
pollution, and a broken-off bottle head is automatically recycled. According to the sterile opening method and device, the process of clamping, sawing, 
chip removing, cleaning, disinfecting, breakoff and gas inflation is automatically completed, manual operation is not needed, and operation damage is avoided; 
liquid gas spraying disinfecting is carried out, and 
pollution of scrubbing 
absorbent cotton residues on medicines is avoided. Full-
automatic control, safety, reliability and environment protection are achieved.