The invention discloses a network-based comprehensive video diagnosis and treatment supervision system, including: an online reservation diagnosis and treatment system, a video diagnosis and treatment system used by doctors, a video diagnosis and treatment system based on mobile handheld devices, a remote video consultation system, a doctor's word-of-mouth scoring and rating system, and a network hospital- Supervision system, drug supervision system and fee payment system for network doctors. The present invention is a set of complete large-scale diagnosis and treatment comprehensive system integrating diagnosis and treatment, consultation, supervision, scoring and rating. From booking a doctor for online diagnosis and treatment, offline diagnosis and treatment, multi-party consultation, to remote video diagnosis and treatment between patients and doctors, remote video multi-party consultation and video diagnosis and treatment, the PC terminal system and handheld device terminal system are also provided for doctors. Score evaluation, let other patients understand the doctor's word-of-mouth situation. In the process of diagnosis and treatment, a three-party (doctor, hospital, pharmacy) supervision system is also provided, which can effectively and timely deal with problems in the process of diagnosis, treatment and drug purchase.