8 results about "Polymeric scaffold" patented technology

A method of making a metallic component includes mounting a polymeric scaffold onto a mandrel, wherein the mandrel includes one or more chucks configured to secure the polymeric scaffold onto the mandrel and wherein the mandrel is configured to rotate the polymeric scaffold; depositing, with a second additive manufacturing (AM) technique using a material applicator, a component material onto the polymeric scaffold to form the metallic component on the polymeric scaffold, wherein the component has a shape that is the same as the polymeric scaffold; removing the polymeric scaffold; and the metallic component deposited on the polymeric scaffold from the mandrel; and removing the polymeric scaffold from the metallic component.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The present invention relates to a biomaterial comprising: —a membrane wound patch (a), made of a nanofibrous polymeric scaffold, —a hydrogel (b) including autologous or allogenic bone marrow-derived mesenchymal stem cells, and —a bone wound patch (c) being a nanofibrous scaffold made of polymers, wherein said scaffold has a surface coated with an interrupted coating made of multilayered droplets, said multilayered droplets being droplets composed of at least one layer pair consisting of a layer of polyanions and a layer of polycations, and wherein the bone wound patch (c) further comprises a bone growth factor; wherein the hydrogel (b) is included between the membrane wound patch (a) and the bone wound patch (c).

The present invention pertains to the field of targeted protein degradation (TPD) and target protein recruitment (TPR) providing a versatile platform for TPD, TPR and other applications dependent on cell surface ternary complex formation. In particular, the present invention provides a compound comprising a macromolecular hydrophilic polymer scaffold which is conjugated with several copies of at least two different protein binding ligands. The polymeric scaffold of the invention enables the use of small molecule ligands for target proteins of interest. Furthermore, the invention also relates to a composition comprising said polymeric scaffolds and uses thereof, e.g. for inhibiting or removing malignant or unwanted proteins; or for use in the targeted recruitment of effector cells such as CAR-T cells.

The invention lies in the field of delivery of nucleic acids into a cell. In particular, disclosed herein is a nucleic acid that is polyplexed with a polymeric scaffold, which is provided in combination with an endosomal escape-enhancing saponin that is covalently bound either to the polymeric scaffold or to a cell targeting ligand by a linker configured to release the saponin from the scaffold under conditions present in an endosome. The disclosed herein compositions and methods may be exploited in the treatment of various diseases and / or conditions by systemic delivery.

A polymeric scaffold useful for conjugating with a targeting moiety to form a targeting moiety-polymer-drug conjugate is described herein. Also disclosed is a targeting moiety-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their composition are also described.

The invention relates to a functionalized polyarylethersulfone copolymer (Pf) and to processes for preparing the functionalized copolymer (Pf). The functionalized copolymer (Pf) is derived from an unsaturated copolymer (Pu) which serves as polymeric scaffold containing C=C bonds which are permitted to react with a functionalization compound to form functional moieties in the copolymer (Pf). The copolymer (Pu) is made by polycondensation of an unsaturated aliphatic diol, another diol and a dihalodiarylsulfone. The present invention also relates to the use of the copolymer (Pf) in the preparation of an article, and to an article, such as membrane or chromatography material, comprising or made from the copolymer (Pf).

Provided herein are scaffolded chromophores and systems, methods, and uses thereof for nucleic acid detection. Certain embodiments relate to a nucleic acid probe comprising a nucleic acid complementary to a target sequence. The probe further comprises a dye structure attached to a first end of the nucleic acid and comprises a non-conjugated polymeric scaffold having one or more donor fluorophores and one or more acceptor fluorophores attached thereto, wherein the donor fluorophores and the acceptor fluorophores are in an energy transfer relationship. Such a probe can further comprise a quencher attached to a second end of the nucleic acid, wherein the quencher and the one or more acceptor fluorophores are in an energy transfer relationship. Other embodiments include a second nucleic acid probe comprising a second nucleic acid complementary to a different target sequence.