61 results about "Polymer scaffold" patented technology

The present invention refers to a method for coating a collagen like protein onto a surface of a polymer-scaffold comprising or consisting the following steps: a) plasma-treating the surface of the polymer-scaffold, b) providing a collagen like protein in a solvent, to obtain a collagen like protein-containing solution, c) bringing the plasma treated polymer-scaffold and the collagen like protein containing solution into contact followed by an optionally rinsing, d) removing the solvent and thereby obtaining a collagen like protein coated polymer-scaffold. Furthermore, the present invention refers to an article obtained by the method of the present invention. Moreover, the present invention refers to the use of the article according to the invention for wound healing and bone repair as well as for flask-coating and plate-coating in cell culture.

The present invention refers to a method for coating a collagen like protein onto a surface of a polymer-scaffold comprising or consisting the following steps: a) plasma-treating the surface of the polymer-scaffold, b) providing a collagen like protein in a solvent, to obtain a collagen like protein-containing solution, c) bringing the plasma treated polymer-scaffold and the collagen like protein containing solution into contact followed by an optionally rinsing, d) removing the solvent and thereby obtaining a collagen like protein coated polymer-scaffold. Furthermore, the present invention refers to an article obtained by the method of the present invention. Moreover, the present invention refers to the use of the article according to the invention for wound healing and bone repair as well as for flask-coating and plate-coating in cell culture.

A ready-to-assemble furniture (“RTA”) system in which a seat, such as a sofa, comprises a seat base with a seating portion having a pair of preattached arm rests on opposing sides of the seating portion, and a separate backrest. The sofa has a transport configuration where the backrest nests on the base between the arm rests and is convertible to a use configuration by a simple upward lifting of the backrest, a partial rotation of the backrest of about 90°, lowering of the backrest onto elongate polymer KD brackets having a rearward inclination on the arm rests until a pair of slots of the backrest panelar side members is seated on the KD brackets. Each KD bracket having a wedge portion at the arm rest surface and a flange portion displaced from the arm rest. The seat may be boxed with instructions for assembly attached to the sofa.

A method of forming a three-dimensional object is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid comprising a mixture of: (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the second solidifiable component; and then (d) solidifying and / or curing the second solidifiable component to form from said three-dimensional intermediate the three-dimensional object.

Photosensitive printing inks, methods of 3D printing those inks, and 3D-printed structures are provided. The printing inks comprise a polymer scaffold, a phase-separating monomer, a photoinitiator, and preferably a photoabsorber dispersed or dissolved in a solvent system. The polymer scaffold comprises a polymer functionalized with at least two chain transfer or RAFT agents. The polymer scaffold and solvent system are selected so that the polymer scaffold is soluble in that solvent system. Additionally, the phase-separating monomer and solvent system are selected so that the phase- separating monomer is insoluble in the solvent system and so that phase-separating monomer will undergo photoinitiated chain extension to form polymer chains that are soluble in the solvent system. The provided inks can be efficiently printed to form structures that lack (or substantially lack) chemical crosslinks, thus relying on physical crosslinking to maintain shape. The resulting structures have shorter and / or controlled dissolution rates, making them useful for biomedical and other applications.

A polymeric scaffold for binding to a targeting moiety to form a targeting moiety-polymer-drug conjugate. A targeting moiety-polymer-drug conjugate is provided, which is prepared from the stent. The composition comprises the combination. A method of treating various conditions with the conjugate or the composition, comprising administering the conjugate or the composition.

A method of making a metallic component includes mounting a polymeric scaffold onto a mandrel, wherein the mandrel includes one or more chucks configured to secure the polymeric scaffold onto the mandrel and wherein the mandrel is configured to rotate the polymeric scaffold; depositing, with a second additive manufacturing (AM) technique using a material applicator, a component material onto the polymeric scaffold to form the metallic component on the polymeric scaffold, wherein the component has a shape that is the same as the polymeric scaffold; removing the polymeric scaffold; and the metallic component deposited on the polymeric scaffold from the mandrel; and removing the polymeric scaffold from the metallic component.

The invention belongs to the technical field of radiography, and particularly relates to a tumor specific imaging probe and a preparation method thereof. The invention provides a novel bimodal imaging probe activated by gamma-glutamyltranspeptidase (GGT). The bimodal imaging probe synergistically integrates the functions of magnetic resonance imaging (MRI) and fluorescence imaging (FI). The probe is meticulously designed, and chiral Gd-DOTA and Cy5 fluorophores are connected to a polymer support through covalent bonds. The molecular structure comprises a GGT responsive part, and selective activation in a tumor microenvironment is ensured, so that the specific targeting ability to tumors is enhanced. Cy5 is a near-infrared fluorescent dye with definite characteristics, and when Cy5 is introduced into the probe, extremely high sensitivity is provided for fluorescence-based tumor molecular level visualization. Due to the high-performance magnetic resonance imaging function and the high-sensitivity fluorescence imaging function, the bimodal probe is endowed with extremely high accuracy in tumor detection and treatment monitoring.

Provided are methods and compositions for detecting a target molecule or particle suspected to be present in a sample using a polymer scaffold, a fusion molecule, and a pore.

A polymeric stent is disclosed that includes a polymeric tubular body extending from a distal region to a proximal region, the polymeric tubular body adapted to have a negative Poisson's ratio. A distal engagement feature is formed within the distal region and a proximal engagement feature is formed within the proximal region. Also disclosed is a delivery device for a polymeric stent, the delivery device comprising a tubular body having an outer surface adapted to receive the polymeric stent thereon. The distal stent engagement member is fixed relative to the tubular body and is adapted to releasably engage the distal engagement feature. The proximal stent engagement member is fixed relative to the tubular body and is adapted to releasably engage the proximal engagement feature. The tubular body is adapted to cause a change in distance between the distal stent-engaging member and the proximal stent-engaging member, thereby changing the length of the polymeric stent.

Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.

The utility model provides a polymer stent which comprises a connecting piece, a fixing piece and at least two connecting blocks, and the connecting blocks are connected through the connecting piece and fixed through the fixing piece. According to the technical scheme, the connecting piece, the fixing piece and the at least two connecting blocks are arranged, and the connecting blocks are connected through the connecting piece and fixed through the fixing piece; the service life of the polymer bracket is prolonged, and the potential safety hazard is reduced.

An in-vivo rapid recellularization tissue engineered blood vessel and a preparation method thereof are provided. The preparation method includes: dissolving polyglycolic acid and polyethylene glycol in an organic solvent to prepare a spinning solution, and performing electrostatic spinning according to a certain proportion to prepare a tubular polymer composite support of a special tube wall structure, the fiber on the outer side of the tube wall support containing a higher proportion of polyethylene glycol; planting seed cells on the tubular polymer support of the special tube wall structure, and under certain culture conditions, simulating body arteriopalmus flow conditions and performing perfusion culture for 3 weeks to 3 months; and removing cell components from the tube wall of the obtained engineered blood vessel by using a decellularization method to give a tissue engineered blood vessel composed of an extracellular matrix of a bionic structure.

Provided are a bioreactor support structure and a bioreactor system for mass production of cells, including for production of cultured meat and for mass production of stem cells. The bioreactor support structure has an outer wall and a plurality of inner walls within an interior space created by an inner edge of the outer wall. The plurality of inner walls are configured to form a channel that accommodates a polymeric scaffold, cells, and a fluid. The cross-section of the channel may have approximately circular, elliptical, or polygonal cross-sectional areas. The configuration of the bioreactor support structure addresses the problem of high cell density pressures that hinder large-scale and commercial mass cell production.

The present invention provides a nanoparticle, the nanoparticle comprises a scaffold, a single template site for binding a template polynucleotide to the scaffold, and a plurality of auxiliary sites for binding an auxiliary oligonucleotide to the scaffold, wherein the scaffold is selected from an asymmetric acrylamide polymer scaffold or a dendrimer comprising a lysyl constituent repeating unit, the single template site for binding a template polynucleotide to the scaffold is selected from a covalent template binding site and a non-covalent template binding site, and the plurality of auxiliary sites for binding an auxiliary oligonucleotide to the scaffold are selected from a covalent auxiliary oligonucleotide binding site and a non-covalent auxiliary oligonucleotide binding site. A method for using the nanoparticle is also provided.

The invention provides a 3D printing material loaded with a stem cell epimatrix as well as a preparation method and application of the 3D printing material, and belongs to the technical field of biological materials. Comprising the following components in parts by weight: 100 to 150 parts of modified silk fibroin peptide-polylactic resin, 20 to 40 parts of stem cell loaded extracellular matrix nanoparticles, 10 to 20 parts of slow-release chitosan microspheres, 150 to 200 parts of sodium hyaluronate and 50 to 100 parts of gelatin. Compared with a traditional chemically synthesized polymer scaffold, the 3D printing material loaded with the stem cell extracellular matrix prepared by the invention has better biocompatibility, high safety and excellent mechanical properties, promotes adhesion growth of cells, realizes slow and uniform release of drugs, adjusts cartilage growth and ossification by multiple signals, promotes cartilage repair, and has good application prospects. Wide application prospects are realized.

A packaged antenna includes: an elongate base station antenna having first and second ends and a plurality of mounting brackets extending from a lower surface thereof; a series of foamed polymer braces engaging and supporting the antenna; first and second support blocks engaging, respectively, the first and second boots; and a plurality of sleeves, each engaging a respective mounting bracket.

A composite membrane comprising: a microporous polymer scaffold having a polymer scaffold matrix and a plurality of scaffold pores having a scaffold pore volume, and a continuous ceramic phase of ceramic particles within the scaffold pore volume. The continuous ceramic phase comprises an interconnected ceramic phase pore volume defined by inter-particle pores between ceramic particles; and wherein the composite membrane comprises a metalized surface region. Also described is an electrochemical device for use in electrolysis comprising: an anode, a cathode and an electrochemical separator, wherein the electrochemical separator is the composite membrane disclosed herein.

The present invention discloses a polymer bracket development mark installation platform, comprising a base plate, a supporting platform, a lifting platform, a pressing platform and a bracket shaft; the supporting platform is installed on the base plate, a square groove is provided in the middle of the supporting platform, grooves are provided on both sides of the square groove, the bracket shaft is arranged in the groove, the pressing platform comprises a spring handle, a sliding block and a working block, the sliding block moves on the sliding track of the lifting platform, a limit block and a pressure block are provided below the working block, the height of the lower plane of the limit block is lower than the height of the lower plane of the pressure block, the present invention has a simple structure and is easy to operate, and through the height difference between the limit block and the pressure block, the polymer bracket can be not damaged when pressing the development marker, thereby reducing production costs, improving the accuracy of pressing the development marker, and improving the production qualification rate.

Systems and methods for delivering a therapeutic agent to target tissue using a plurality of drug delivery platforms each having a polymer scaffold and the therapeutic agent contained within the polymer scaffold. Each drug delivery platform of the plurality of drug delivery platforms is implanted into the target tissue, allowing the therapeutic agent to elute from each drug delivery platform of the plurality of drug delivery platforms for a target period of time, delivering a therapeutic dose of the therapeutic agent for the target period of time. Each drug delivery platform of the plurality of drug delivery platforms is allowed to biodegrade within the target tissue.

The invention belongs to the technical field of electronic paper display structures, and particularly relates to a nested electrophoretic display structure. Comprising an electrophoresis display module, the electrophoresis display module comprises a liner frame, a pixel electrode, an upper-layer flexible transparent substrate and an electrophoresis layer, the electrophoresis layer is arranged between the pixel electrode and the upper-layer flexible transparent substrate, and the liner frame is located on the pixel electrode and located on the peripheral side of the electrophoresis layer; the electrophoresis layer comprises a transparent porous polymer support, and a dichroic electrophoretic particle electrophoresis liquid system is arranged in holes of the transparent porous polymer support; an upper-layer transparent electrode is arranged between the upper-layer flexible transparent base material and the electrophoresis layer, conductive silver paste is arranged on the liner frame, and the upper-layer transparent electrode is in contact with the electrophoresis layer and the conductive silver paste. The chemical process problem that microcapsules in traditional electronic paper are complex in preparation and poor in stability is solved, the production efficiency is improved, and the manufacturing cost is reduced.

A system comprising an electrolyte and a composite membrane is described. The composite membrane comprises a microporous polymer scaffold comprising a plurality of scaffold pores, each of said scaffold pores having a pore volume and the microporous polymer scaffold having a scaffold pore volume, and a colloidal condensed phase within the plurality of scaffold pores. The colloidal condensed phase comprises sub-micron particles within the scaffold pore volume, and the composite membrane comprises a plurality of composite membrane pores which are defined at least in part by the colloidal condensed phase. The system may be useful as an electrochemical separator. Also described are an electrochemical device comprising an anode, a cathode, and the system of the disclosure, uses of the system, and methods of manufacturing the system. A supported liquid membrane comprising a composite membrane as described in the disclosure, and a liquid is also described.

The invention relates to the technical field of artificial bone materials, and discloses a hydrogel / polymer composite scaffold and a preparation method and application thereof, the composite scaffold comprises hydrogel, a porous polymer scaffold and optional living cells; wherein the living cells are encapsulated in hydrogel, pores of the porous polymer scaffold are filled with the hydrogel, and the hydrogel contains an aldehyde polymer and an amino-containing polymer; the weight ratio of the aldehyde polymer to the amino-containing polymer is (0.2-5): 1; the weight-average molecular weight of the material of the porous polymer scaffold is greater than 20,000 g / mol, the pore size of the porous polymer scaffold is 300-800 [mu] m, and the porosity is 40-70%. According to the hydrogel / polymer composite scaffold provided by the invention, living cells can be packaged, an extracellular matrix can be simulated, the defects of a traditional polymer scaffold are effectively overcome, and the biocompatibility is greatly improved.

A polymeric scaffold for bone repair and regeneration includes a body comprising a biodegradable polymer matrix and nanoparticles dispersed in the biodegradable polymer matrix, and a polydopamine surface coating on the body. A method of forming a composite scaffold for bone tissue engineering includes preparing a solution comprising a biodegradable polymer and a plurality of nanoparticles in a solvent, applying the solution to a surface of a mold and drying the solution to form a polymer matrix having nanoparticles dispersed therein, removing the mold from the polymer matrix to form an intermediate scaffold, and applying a polydopamine coating to the intermediate scaffold to form the composite scaffold.

The present invention generally relates to methods of producing magnetically induced secretomes with enhanced potency and stability, the methods comprise inter alia, employing polyacrylic acid based polymers, preferably a carbomer, to form a collapsible cell-encapsulating scaffold and dispersing donor cells within said scaffold prior to induction via a directionally-specific pulsing electromagnetic field (PEMF), or dispersing said donor cells in a "collapsed" polyacrylic acid based polymer scaffold prior to the PEMF induction. Also provided are the improved conditioned media thereof, suitable for use in medical and commercial applications.

The invention discloses a metal / alloy micro-nano three-dimensional structure preparation method based on complex reaction, and relates to the technical field of micro-nano three-dimensional structure preparation, and the specific method comprises the following steps: S1, synthesizing photoresist by taking acrylic acid as a polymerization monomer; s2, processing and forming photoresist through a femtosecond laser two-photon polymerization technology to obtain a three-dimensional polymer bracket; and S3, the three-dimensional polymer support is subjected to a complexation reaction in a metal salt solution, a sample is sintered after the reaction, and the metal / alloy micro-nano three-dimensional structure is obtained. The method is compatible with various metal elements, the machining resolution reaches the submicron level, and a solid foundation is laid for application of a metal / alloy micro-nano three-dimensional structure in the fields of nano optics, micro robots, mechanical metamaterials and the like.

The present application relates to a multi-stage antibacterial polymer colloidal particle, which comprises a polymer scaffold and at least one antibacterial polymer loaded on the polymer scaffold, wherein the polymer scaffold and the at least one antibacterial polymer form a hollow colloidal particle. An antibacterial core can be accommodated within the hollow colloidal particle. The present application also relates to an antibacterial screen and a method for manufacturing an antibacterial screen, and the multi-stage antibacterial polymer colloidal particles can be incorporated into an optically transparent acrylic material to form an antibacterial coating. The antibacterial coating can be coated onto substrates such as glass, metal or plastic and cured by ultraviolet light to form a screen with antibacterial properties for electronic devices and the like.

The present invention pertains to the field of targeted protein degradation (TPD) and target protein recruitment (TPR) providing a versatile platform for TPD, TPR and other applications dependent on cell surface ternary complex formation. In particular, the present invention provides a compound comprising a macromolecular hydrophilic polymer scaffold which is conjugated with several copies of at least two different protein binding ligands. The polymeric scaffold of the invention enables the use of small molecule ligands for target proteins of interest. Furthermore, the invention also relates to a composition comprising said polymeric scaffolds and uses thereof, e.g. for inhibiting or removing malignant or unwanted proteins; or for use in the targeted recruitment of effector cells such as CAR-T cells.

The invention lies in the field of delivery of nucleic acids into a cell. In particular, disclosed herein is a nucleic acid that is polyplexed with a polymeric scaffold, which is provided in combination with an endosomal escape-enhancing saponin that is covalently bound either to the polymeric scaffold or to a cell targeting ligand by a linker configured to release the saponin from the scaffold under conditions present in an endosome. The disclosed herein compositions and methods may be exploited in the treatment of various diseases and / or conditions by systemic delivery.

A polymeric stent is adapted for placement within a body cavity to provide a primary drainage passageway and a secondary drainage passageway for the body cavity. The polymeric stent includes a polymeric tubular body including a first end region, a second end region and an intervening intermediate region. The polymeric tubular body has a remembered configuration in which the intervening intermediate region of the polymeric tubular body forms a plurality of tightly arranged helical coil windings that define the primary drainage passageway and a delivery configuration different from the remembered configuration when constrained by a delivery device.