23 results about "Polymer scaffold" patented technology

A ready-to-assemble furniture (“RTA”) system in which a seat, such as a sofa, comprises a seat base with a seating portion having a pair of preattached arm rests on opposing sides of the seating portion, and a separate backrest. The sofa has a transport configuration where the backrest nests on the base between the arm rests and is convertible to a use configuration by a simple upward lifting of the backrest, a partial rotation of the backrest of about 90°, lowering of the backrest onto elongate polymer KD brackets having a rearward inclination on the arm rests until a pair of slots of the backrest panelar side members is seated on the KD brackets. Each KD bracket having a wedge portion at the arm rest surface and a flange portion displaced from the arm rest. The seat may be boxed with instructions for assembly attached to the sofa.

A method of forming a three-dimensional object is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid comprising a mixture of: (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the second solidifiable component; and then (d) solidifying and / or curing the second solidifiable component to form from said three-dimensional intermediate the three-dimensional object.

A method of making a metallic component includes mounting a polymeric scaffold onto a mandrel, wherein the mandrel includes one or more chucks configured to secure the polymeric scaffold onto the mandrel and wherein the mandrel is configured to rotate the polymeric scaffold; depositing, with a second additive manufacturing (AM) technique using a material applicator, a component material onto the polymeric scaffold to form the metallic component on the polymeric scaffold, wherein the component has a shape that is the same as the polymeric scaffold; removing the polymeric scaffold; and the metallic component deposited on the polymeric scaffold from the mandrel; and removing the polymeric scaffold from the metallic component.

The invention belongs to the technical field of radiography, and particularly relates to a tumor specific imaging probe and a preparation method thereof. The invention provides a novel bimodal imaging probe activated by gamma-glutamyltranspeptidase (GGT). The bimodal imaging probe synergistically integrates the functions of magnetic resonance imaging (MRI) and fluorescence imaging (FI). The probe is meticulously designed, and chiral Gd-DOTA and Cy5 fluorophores are connected to a polymer support through covalent bonds. The molecular structure comprises a GGT responsive part, and selective activation in a tumor microenvironment is ensured, so that the specific targeting ability to tumors is enhanced. Cy5 is a near-infrared fluorescent dye with definite characteristics, and when Cy5 is introduced into the probe, extremely high sensitivity is provided for fluorescence-based tumor molecular level visualization. Due to the high-performance magnetic resonance imaging function and the high-sensitivity fluorescence imaging function, the bimodal probe is endowed with extremely high accuracy in tumor detection and treatment monitoring.

A polymeric stent is disclosed that includes a polymeric tubular body extending from a distal region to a proximal region, the polymeric tubular body adapted to have a negative Poisson's ratio. A distal engagement feature is formed within the distal region and a proximal engagement feature is formed within the proximal region. Also disclosed is a delivery device for a polymeric stent, the delivery device comprising a tubular body having an outer surface adapted to receive the polymeric stent thereon. The distal stent engagement member is fixed relative to the tubular body and is adapted to releasably engage the distal engagement feature. The proximal stent engagement member is fixed relative to the tubular body and is adapted to releasably engage the proximal engagement feature. The tubular body is adapted to cause a change in distance between the distal stent-engaging member and the proximal stent-engaging member, thereby changing the length of the polymeric stent.

The utility model provides a polymer stent which comprises a connecting piece, a fixing piece and at least two connecting blocks, and the connecting blocks are connected through the connecting piece and fixed through the fixing piece. According to the technical scheme, the connecting piece, the fixing piece and the at least two connecting blocks are arranged, and the connecting blocks are connected through the connecting piece and fixed through the fixing piece; the service life of the polymer bracket is prolonged, and the potential safety hazard is reduced.

Provided are a bioreactor support structure and a bioreactor system for mass production of cells, including for production of cultured meat and for mass production of stem cells. The bioreactor support structure has an outer wall and a plurality of inner walls within an interior space created by an inner edge of the outer wall. The plurality of inner walls are configured to form a channel that accommodates a polymeric scaffold, cells, and a fluid. The cross-section of the channel may have approximately circular, elliptical, or polygonal cross-sectional areas. The configuration of the bioreactor support structure addresses the problem of high cell density pressures that hinder large-scale and commercial mass cell production.

A packaged antenna includes: an elongate base station antenna having first and second ends and a plurality of mounting brackets extending from a lower surface thereof; a series of foamed polymer braces engaging and supporting the antenna; first and second support blocks engaging, respectively, the first and second boots; and a plurality of sleeves, each engaging a respective mounting bracket.

A composite membrane comprising: a microporous polymer scaffold having a polymer scaffold matrix and a plurality of scaffold pores having a scaffold pore volume, and a continuous ceramic phase of ceramic particles within the scaffold pore volume. The continuous ceramic phase comprises an interconnected ceramic phase pore volume defined by inter-particle pores between ceramic particles; and wherein the composite membrane comprises a metalized surface region. Also described is an electrochemical device for use in electrolysis comprising: an anode, a cathode and an electrochemical separator, wherein the electrochemical separator is the composite membrane disclosed herein.

The invention belongs to the technical field of electronic paper display structures, and particularly relates to a nested electrophoretic display structure. Comprising an electrophoresis display module, the electrophoresis display module comprises a liner frame, a pixel electrode, an upper-layer flexible transparent substrate and an electrophoresis layer, the electrophoresis layer is arranged between the pixel electrode and the upper-layer flexible transparent substrate, and the liner frame is located on the pixel electrode and located on the peripheral side of the electrophoresis layer; the electrophoresis layer comprises a transparent porous polymer support, and a dichroic electrophoretic particle electrophoresis liquid system is arranged in holes of the transparent porous polymer support; an upper-layer transparent electrode is arranged between the upper-layer flexible transparent base material and the electrophoresis layer, conductive silver paste is arranged on the liner frame, and the upper-layer transparent electrode is in contact with the electrophoresis layer and the conductive silver paste. The chemical process problem that microcapsules in traditional electronic paper are complex in preparation and poor in stability is solved, the production efficiency is improved, and the manufacturing cost is reduced.

A system comprising an electrolyte and a composite membrane is described. The composite membrane comprises a microporous polymer scaffold comprising a plurality of scaffold pores, each of said scaffold pores having a pore volume and the microporous polymer scaffold having a scaffold pore volume, and a colloidal condensed phase within the plurality of scaffold pores. The colloidal condensed phase comprises sub-micron particles within the scaffold pore volume, and the composite membrane comprises a plurality of composite membrane pores which are defined at least in part by the colloidal condensed phase. The system may be useful as an electrochemical separator. Also described are an electrochemical device comprising an anode, a cathode, and the system of the disclosure, uses of the system, and methods of manufacturing the system. A supported liquid membrane comprising a composite membrane as described in the disclosure, and a liquid is also described.

The present invention pertains to the field of targeted protein degradation (TPD) and target protein recruitment (TPR) providing a versatile platform for TPD, TPR and other applications dependent on cell surface ternary complex formation. In particular, the present invention provides a compound comprising a macromolecular hydrophilic polymer scaffold which is conjugated with several copies of at least two different protein binding ligands. The polymeric scaffold of the invention enables the use of small molecule ligands for target proteins of interest. Furthermore, the invention also relates to a composition comprising said polymeric scaffolds and uses thereof, e.g. for inhibiting or removing malignant or unwanted proteins; or for use in the targeted recruitment of effector cells such as CAR-T cells.

The invention lies in the field of delivery of nucleic acids into a cell. In particular, disclosed herein is a nucleic acid that is polyplexed with a polymeric scaffold, which is provided in combination with an endosomal escape-enhancing saponin that is covalently bound either to the polymeric scaffold or to a cell targeting ligand by a linker configured to release the saponin from the scaffold under conditions present in an endosome. The disclosed herein compositions and methods may be exploited in the treatment of various diseases and / or conditions by systemic delivery.

A hardware mounting bracket is provided with a polymeric bracket body adapted to be mounted to a support surface, wherein an aperture is formed through a mounting surface of the bracket body. A rigid retainer is provided on one end of the bracket body to receive hardware supported thereon. A biasing retainer is provided on another end of the bracket body spaced apart from the rigid retainer, wherein the biasing retainer is formed integrally with the bracket body, and wherein the biasing retainer comprises a projection extending away from the bracket body. A hardware mounting bracket is provided with a bracket body with an inclined surface, and a slotted aperture is formed through the inclined surface. A hardware mounting bracket is provided with a bracket body. An angled ramp extends from the bracket body, wherein an aperture is formed through a mounting surface of the bracket body.

A battery separator for an alkali-metal or an alkali metal-ion rechargeable battery is described. The separator comprises a composite membrane having a microporous polymer scaffold and a continuous ceramic phase disposed within the scaffold pore volume, the continuous ceramic phase comprising a three-dimensional packing arrangement of sub-micron ceramic particles. Also described is a rechargeable battery comprising the separator, a method of manufacturing the battery separator and a method of manufacturing the rechargeable battery.

A polymer-ceramic composite membrane and methods of making the same. The composite membrane includes a polymer scaffold and a ceramic nanoparticle disposed within the polymer scaffold.

An aspect provides a biodegradable polymer scaffold for kidney regeneration, including basic ceramic particles, an extracellular matrix, zinc particles, a kidney regeneration-inducing material, and a biodegradable polymer. A biodegradable polymer scaffold for kidney regeneration, according to an aspect, includes a kidney regeneration-inducing material and / or extracellular vesicles that secrete a stem cell recruitment-inducing factor, thereby inducing stem cells to a damaged tissue site and enhancing kidney regenerative capacity, and thus can effectively induce the regeneration of kidney tissue. Therefore, the biodegradable polymer scaffold can contribute to the medical device industry, including the bioimplant market.

This invention is in the field of implantable polymer scaffolds. In particular, provided herein are methods, compositions, and uses of an implantable scaffold with a controlled structure allowing for precise recruitment and enrichment of analytes. For example, the methods and use relate to an efficient system of fabricating an implantable scaffold with preloaded ratios of conjugated polymers of disease-specific antigens to recruit and enrich disease-specific T-cells for diagnostic, therapeutic and research applications.

A polymeric scaffold useful for conjugating with a targeting moiety to form a targeting moiety-polymer-drug conjugate is described herein. Also disclosed is a targeting moiety-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their composition are also described.

Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.

The present invention is directed to a method of making a live cell construct or a support, comprising: (a) providing a non-cellular organic polymer support having a top surface, a bottom surface, and an intermediate portion there between, and (b) contacting a cross-linking agent to one surface of said support for a time sufficient to generate a gradient of cross-linking of said polymer in said intermediate portion. Also provided are live cell constructs, supports, and methods of use of the supports and live cell constructs.

To provide catheter blood pumps, and methods of use and manufacture.SOLUTION: Pumps 1600 may include an expandable and collapsible shroud that defines a blood lumen. The shroud may include a polymeric scaffold along at least a portion of a length of the shroud. The pumps 1600 may include one or more impellers 1606, 1616.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of biomedical materials and tissue engineering, and discloses a decellularized extracellular matrix complex of in-vitro tissue of a human-derived cell combined polymer scaffold and application of the decellularized extracellular matrix complex in a tissue engineering valve. The decellularized extracellular matrix complex of the in-vitro tissue of the human cells combined with the polymer scaffold comprises a sheet-shaped wall-shaped structure polymer scaffold and a human decellularized extracellular matrix attached to the scaffold. According to the invention, the extracellular matrix secreted by human cells is combined with the sheet-shaped wall-shaped structure polymer fiber scaffold, and the scaffold is fully paved with the cells by using transverse dense fibers and longitudinal sparse and staggered fibers in the scaffold, so that the extracellular matrix secreted by the human cells can be effectively compounded; the obtained decellularized extracellular matrix complex of the in-vitro tissue of the human cells combined with the polymer scaffold can effectively overcome the problems of immune rejection reaction and long-term calcification, and is particularly suitable for being applied to tissue engineering valves as bionic heart valves.