The invention discloses a five-axis linkage laser processing machine which comprises a base (1) and a machine body (2), wherein the machine body (2) comprises an upright column module (3) and a platform module (4) which are installed on the base (1), the upright column module (3) comprises a Z-axis submodule (8) and an A-axis rotary motion module (9), the Z-axis submodule (8) is provided with a Z-axis slide carriage (46) which moves in the vertical direction, the slide carriage is provided with the A-axis rotary motion module (9), a laser head (70) is installed at the end of an A axis and rotates along with the A axis, the platform module (4) consists of an XY workbench (11) and a C-axis rotary motion module (10) installed on the workbench, a C axis is driven by a torque motor (52) and is provided with a rotary workbench (53), and a workpiece is vertically installed on the rotary workbench through a special clamp. The invention has the advantages of novel structure layout, compact size and high processing accuracy and can also greatly enhance the processing efficiency.