3406 results about "Implant" patented technology

Apparatus and methods for an implant are provided. The implant may have a constrained configuration and a relaxed configuration. The implant may include a strut having an end that may be captured by a hub and may define a reference angle in the relaxed configuration. The implant may include a swivel body that may engage a shaft of a delivery cable and may be rotated through the reference angle. The apparatus may include a pusher catheter to push the implant. The delivery cable may engage the implant. The apparatus may include gauge handle that may include a force gauge to indicate the presence of a force acting on the implant. The apparatus may include a bushing that may be fixed to an end of a pusher catheter. The bushing may move along a delivery catheter lumen and may guide the implant to a keyed position at the bushing.

Apparatus and methods for an implant are provided. The implant may have a constrained configuration and a relaxed configuration. The implant may include an outer stent and an inner valve support. The inner valve support may be positioned within the outer stent. The implant may include a transition section spanning between the outer stent and the inner valve support.

An expandable intervertebral implant may include a superior endplate configured to engage a superior vertebra, and an inferior endplate configured to engage an inferior vertebra, wherein the inferior endplate may be spaced apart from the superior endplate by a gap. The expandable intervertebral implant may further include a first slider moveable along a first direction to urge linear expansion of the gap, and one or more cams each coupled to the first slider. The one or more cams may be configured to urge angular expansion of the gap in response to at least one of: rotation of the one or more cams about a rotation axis, and motion of the one or more cams along the first direction.

Embodiments described herein relate to an implant delivery system for delivering an implant for reducing heart valve regurgitation. The implant delivery system may include an implant catheter disposed in an inner lumen of a guide catheter. The implant catheter may include one or more hypotubes disposed therein, each hypotube configured to receive an elongate member such as a braided tether. A distal end of the implant catheter may be coupled to an implant holder configured to receive the implant. The implant holder may define one or more channels, each channel configured to receive a portion of a respective elongate member. The elongate members configured to couple the implant to the implant holder and transition the implant between configurations. The implant configured to be disposed around a portion of a leaflet of a heart valve to improve coaptation of the heart valve.

The invention discloses a porous titanium-based implant with a photo-thermal surface and a preparation method and application of the porous titanium-based implant, and belongs to the technical field of biomedical materials. The preparation method comprises the steps that a porous titanium substrate is prepared through 3D printing, then flowing acid etching treatment and anodic oxidation treatment are conducted in sequence, then the porous titanium substrate is placed in photo-thermal coating dispersion liquid for reaction, cleaning and drying are conducted, and the porous titanium-based implant with the photo-thermal surface is obtained. The photo-thermal coating dispersion liquid is obtained by dispersing MXene-ZnO composite particles in a dopamine hydrochloride solution. The porous titanium-based implant provided by the invention can be rapidly heated to a proper temperature under the irradiation of near-infrared light, and has good antibacterial, anti-tumor and osteogenesis promoting properties and biocompatibility.

The invention belongs to the technical field of artificial prosthesis materials, and particularly relates to a medical implant with a lithium disilicate coating and a preparation method thereof, and the preparation method comprises the following steps: (1) placing a prefabricated matrix in a high-temperature environment for staged sintering, and then carrying out surface polishing, cleaning and drying treatment; (2) mixing lithium ethoxide and tetraethoxysilane at room temperature, and reacting for 2-4 hours while stirring to obtain lithium disilicate sol; the preparation method comprises the following steps: preparing a prefabricated substrate, soaking the prefabricated substrate in lithium disilicate sol for 3-7 minutes, performing sol permeation for 3-10 minutes under the negative pressure of more than 30 mm Hg, adding an ethanol water solution to initiate gelation reaction, taking out the prefabricated substrate after the reaction is completed, drying and sintering to obtain the medical implant with the lithium disilicate coating. According to the method, the uniform and continuous lithium disilicate coating which is not easy to fall off can be formed on the surface of the prefabricated matrix of the implant, so that the surface performance of the implant is improved, and the osteogenesis promoting performance and the angiogenesis promoting performance of the implant are optimized.

A suture button system for fixing a syndesmotic injury comprises a flexible fixation implant and an inserter device used to deploy the implant across bones. The flexible fixation implant typically comprises a flexible connector and two suture buttons which interface with the bone surface or a bone plate or washer. The flexible connector comprises a plurality of suture strands. The buttons typically have a feature which allows them to interface with an instrument used to deploy the implant across the two bones. The inserter device is configured to interface with the flexible fixation implant and to position it across bones through a pre-drilled bone tunnel. The inserter device may comprise an cannulated insertion rod and a handle.

Embodiments described herein relate to an implant delivery system for delivering an implant for reducing heart valve regurgitation. The implant delivery system may include an implant catheter disposed in an inner lumen of a guide catheter. The implant catheter may include one or more hypotubes disposed therein, each hypotube configured to receive an elongate member such as a braided tether. A distal end of the implant catheter may be coupled to an implant holder configured to receive the implant. The implant holder may define one or more channels, each channel configured to receive a portion of a respective elongate member. The elongate members configured to couple the implant to the implant holder and transition the implant between configurations. The implant configured to be disposed around a portion of a leaflet of a heart valve to improve coaptation of the heart valve.

The invention relates in some aspects to a device for use in anchoring an implant, including anchors, sutures, implants, clips, tools, lassos, and methods of anchoring among other methods. Anchors as disclosed herein could be utilized to secure a coaptation assistance device, an annuloplasty ring, an artificial valve, cardiac patch, sensor, pacemaker, or other implants. The implant could be a mitral valve ring or artificial mitral valve in some embodiments.

The embodiment of the invention relates to the technical field of brain-computer interfaces, in particular to a brain-computer interface module, a digital skull implant and an integration method and related application of the digital skull implant. The digital skull implant comprises a skull prosthesis and a brain-computer interface module, wherein the brain-computer interface module and the skull prosthesis are integrated; the brain-computer interface module comprises an ultrasonic transducer used for sending ultrasonic signals to the brain and collecting brain echo signals. The brain-computer interface module comprises an ultrasonic transducer used for sending ultrasonic signals to the brain and collecting brain echo signals. The brain-computer interface module is configured to be integrated with a skull or a skull prosthesis. In this way, the implantation structure integrating the brain-computer interface module in the skull form can have good mechanical strength and biocompatibility, complete implantation and wireless design can be achieved, and ultrasonic waves penetrate through the skull to conduct precise stimulation on the brain area.

Provided is a delivery system for an artificial implant, comprising a control handle (400) and a catheter assembly (200) connected proximally to the control handle. The catheter assembly (200) comprises an outer sheath (240) and an inner shaft assembly located within the outer sheath (240), the artificial implant (100) being connected to the distal end of the inner shaft assembly and controlled by the control handle (400). The control handle (400) comprises a first handle (41) and a second handle (42) operatively cooperating with each other, the first handle (41) being configured to drive axial movement of the outer sheath (240) to achieve deployment and folding of the artificial implant, and the second handle (42) being configured to control release of the artificial implant to achieve detachment of the artificial implant from the delivery system.

The invention provides a recombinant humanized elastin with high biological activity as well as a preparation method and application thereof, and belongs to the technical field of genetic engineering and biological materials. 100% of the amino acid sequence of the elastin is derived from human elastin and is prepared by expression of genetically engineered bacteria; the protein has a typical beta-spiral hydrophobic structural domain and a lysine-rich hydrophilic structural domain, has a good bionic structure and functional characteristics, can significantly promote proliferation, adhesion and migration of human skin fibroblasts, also has excellent antioxidant, anti-wrinkle and anti-aging activities, and can be used for preparing a biomimetic protein. The hydrogel can be widely applied to the fields of skin repair dressings, injection implants, artificial skin, biomedical materials, functional skin care products and the like; in addition, the elastin is good in solubility, high in stability, mature in expression system and suitable for large-scale production.

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.

Decellularized and shaped corneal tissue lenticules from allograft and / or xenograft sources and methods of obtaining such lenticules are disclosed. The lenticules are particularly useful as intrastromal lenticular implants in keratoplasty procedures, in which a hinged flap is formed in a patient's cornea and folded back along its hinge to expose the stromal bed of the cornea. The shaped lenticule is then applied to the stromal bed and the flap returned to its original position yielding a new curvature for the cornea and resulting in a desired refractive correction. Fine-tuning of the new refractive power can be achieved by laser ablation either at the same time as implantation or at later time in the event of regression or tonus changes. Methods of decellularizing cornea tissue are disclosed to reduce potential immunogenic reactions on the part of the patient to the implanted lenticule. The lenticules can be further treated to remove immunogenic epitopes. In addition, the posterior and / or anterior surfaces of the lenticule can be treated to assist in intrastromal seating of the lenticule and / or to reduce the likelihood of dislodgement. The methods of forming lenticules can further include preserving at least a portion of the Bowman's membrane. The smoothness of the Bowman's membrane surface also makes it less likely that reopening the flap will dislodge the lenticule.

The invention relates to a delivery device for delivering a self-expanding tubular implant and a system comprising the same. The conveying device comprises a pushing rod; at least one expandable body disposed at a distal end of the push rod, the expandable body configured to: axially elongate in a radially constrained contracted state; under the expansion state of releasing the constraint, radial expansion and axial contraction are realized; the elastic core wire is arranged in the expandable body in a penetrating mode and connected with the two ends of the expandable body, and the core wire is kept in a straight line shape in the natural state and the contraction state of the expandable body. The conveying device provided by the invention can be matched with a small-size micro catheter and can provide enhanced axial pushing force in the conveying process, so that the pushing efficiency and the operation stability of the tubular implant are improved; meanwhile, the radial expansion force provided by the expandable body can form effective auxiliary support for the implant, rapid wall attachment and stable expansion of the implant are promoted, and therefore the release effect of the implant is improved.

The invention relates to the technical field of implant processing, and discloses a processing device and method for efficiently producing implants.The processing device for efficiently producing the implants.The processing device for efficiently producing the implantscomprises a base, driving mechanisms are arranged on the front side and the rear side of the top of the base correspondingly, and a transmission mechanism and a lifting mechanism are arranged on the top of each driving mechanism; the top end of the lifting mechanism is connected with tool handles, a turning tool and a milling tool are arranged in the two tool handles respectively, the transmission mechanism comprises a driving plate, a sealing box, a sealing plate and a piston plate, a push plate is fixedly installed between the driving plate and the sealing plate, and the sealing plate and the piston plate are installed in the sealing box in a sliding and sealing mode. The design is reasonable, dynamic self-adaptive adjustment of clamping force is achieved through linkage of centrifugal force and a hydraulic system, when the rotary drum rotates at a high speed, the balance weight plate moves outwards under the centrifugal effect, hydraulic oil is pushed to enter the sliding groove, the pressure on the sliding plate is increased, and therefore the fastening force of the clamping plate on raw materials is automatically increased.

A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

An expandable intervertebral implant may include a superior endplate configured to engage a superior vertebra, and an inferior endplate configured to engage an inferior vertebra, wherein the inferior endplate may be spaced apart from the superior endplate by a gap. The expandable intervertebral implant may further include a first slider moveable along a first direction to urge linear expansion of the gap, and one or more cams each coupled to the first slider. The one or more cams may be configured to urge angular expansion of the gap in response to at least one of: rotation of the one or more cams about a rotation axis, and motion of the one or more cams along the first direction.

Intervertebral spacer implants with dynamic load spreading features responsive to external loads and having attachment mechanisms. The dynamic load spreading features having a native state and a loaded state, which complements vertebral end plate geometry and disperses load to the epiphyseal rim.

A sacroiliac fusion implant device assembly has an implant body and a pair of bone fasteners. The implant body has a distal end and a proximal end with a longitudinal axis extending between a center of the distal end and a center of the proximal end. The distal end has cutting edges configured to cut tissue as the implant is pressed into a joint between a sacrum and an ilium. The proximal end has two bone fastener receiving apertures, each configured to receive a bone fastener and the implant body has a pair of sidewalls connecting the distal and proximal ends. The pair of bone fasteners can be a pair of threaded fasteners, or a pair of spike fasteners or a combination of one threaded fastener and one spike fastener.

An apparatus, system, and method may be used to replace a natural or artificial articular surface of a joint, and to repair a bone that is associated with the joint. In some embodiments, the apparatus, system, and method may include a joint replacement prosthesis with a prosthetic articular surface, a support structure securable to the bone, and a first attachment interface. The system may also include a bone plate with a bone engagement surface securable to the bone on either side of a fracture formed in the bone, or a damaged area of the bone. The bone plate may include a second attachment interface that is attachable to the first attachment interface of the joint replacement prosthesis in order to couple the bone plate to the joint replacement prosthesis.

The present invention relates to a part (2) intended to be used in association with an implant (4) which is itself intended to be secured in a jaw, this part comprising, in series from its distal end (20) towards its proximal end (21), a distal portion (22) for securing in the implant, an intermediate portion (23) for attachment to the epithelial and / or connective tissue, and a proximal portion (24), this part also comprising at least two zones whose surfaces have a different structure, the structure of the surface of at least one of these two zones, located in said intermediate portion (23), said first zone being ordered and repetitive, adapted to the growth of the epithelial tissue and / or the connective tissue and having engravings forming corrugations with a depth of less than 0.5 microns.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention provides a preparation method and application of medical grade agarose with different molecular weights, and belongs to the technical field of biomedical materials. According to the invention, the crude agarose product is treated by DMSO, EDTA-Na2 and DEAE-cellulose, and then the acid concentration, the acid treatment temperature, the acid treatment time and the like in the acid treatment stage are finely regulated, so that the medical-grade agarose with medium-high molecular weight (3000-100000), medium molecular weight (3000-3000) and low molecular weight (1t, 3000) is successfully prepared. The medium-high molecular weight and medium molecular weight medical grade agarose provided by the invention has excellent gel performance, adjustable mechanical strength and injection performance, and is suitable for the fields of skin implants, gel dressings, tissue engineering and the like; the low-molecular-weight medical grade agarose shows good water solubility, fluidity and oxidation resistance, and has significant application potential in the fields of medical skin care products and functional dressings.

The invention discloses an administration agent in-vivo release and absorption visualization method based on a CFD-PBM coupling model. The method comprises the following steps: constructing a CFD model of a physiological environment of an injection site; establishing a population balance model (PBM) of the drug particles; the PBM is embedded into a CFD model solver, multi-scale coupling simulation is carried out, and a CFD-PBM coupling model is obtained; the three-dimensional visualization engine dynamically displays drug concentration distribution and particle behaviors; reversely adjusting preparation prescription parameters by using a multi-parameter optimization algorithm; and calibrating model parameters, and generating a key data report. According to the method, the prediction precision and the research and development efficiency can be remarkably improved, and the method is suitable for development of long-acting preparations such as microspheres and implants.

The invention relates to the technical field of biomedical materials, and discloses a thrombectomy stent support material and a preparation process thereof, the thrombectomy stent support material comprises the following components by mass: 60-70% of a polysebacic diglyceride prepolymer; 25-35% of a dynamic covalent bond cross-linking agent; 5%-10% of carboxylated nano-diamond; 3 to 5 percent of temperature-sensitive and photo-thermal dual-response microspheres; the dynamic covalent bond cross-linking agent is composed of 4-formyl phenylboronic acid and hexamethylenediamine according to a molar ratio of 1: (1-3); the microsphere is prepared from poly (N-isopropylacrylamide), a gold nanorod and a recombinant tissue type plasminogen activating agent, and by combining a low-temperature 3D printing technology, the material can form a complex bionic structure, the mechanical strength is dynamically adjusted along with the physiological environment after implantation, and the material is safely degraded after functions are completed. The material is suitable for the scenes of cardiovascular and cerebrovascular stents, bone repair instruments and the like, has treatment accuracy, manufacturing suitability and clinical safety, and solves the problems of non-degradability, sudden drug release, mechanical mismatch and the like of traditional implants.

The present technology includes patient-specific spinal fusion devices, which may include an interbody implant that is designed to be positioned within a disc space between two vertebral bodies and one or more fixation elements that can anchor the interbody implant to the vertebral bodies. The fusion devices include one or more retention mechanisms for retaining the fixation elements within corresponding lumens or bore holes extending through the interbody implant. Methods for designing and manufacturing patient-specific spinal fusion devices are also described herein.

An implant for implantation at a native atrioventricular valve of a subject, includes a frame assembly, including a valve frame and an outer frame coupled to each other. The valve frame includes a tubular portion that circumscribes a longitudinal axis of the valve frame so as to define a lumen along the axis, and an upstream support portion including a plurality of arms. Each arm extends radially outward from the tubular portion to engage tissue in the atrium. The outer frame includes a ring that circumscribes the tubular portion, and a plurality of ventricular anchors that extend radially outward from the ring and are configured to anchor the implant to tissue of the ventricle. In an expanded state of the frame assembly, the implant defines a toroidal space between the plurality of ventricular anchors and the upstream support portion. Other embodiments are also described.

The invention relates to the field of implant state simulation, and discloses an implant state simulation method and system based on machine learning, and the method comprises the following steps: data collection: collecting multi-modal data related to the implant state through an implantable sensor and an external monitoring device; processing fusion: performing feature extraction and cross-modal fusion on the multi-modal data through tensor decomposition and a graph convolutional network to obtain fusion data; and model training: inputting the fusion data into a deep learning model fusing the space-time double-flow convolutional neural network and the capsule network, and setting a variational reasoning module behind an output layer of the model. A deep learning model fusing a space-time double-flow convolutional neural network and a capsule network is constructed, tensor decomposition and a graph convolutional network are combined to realize high-order feature extraction and cross-modal fusion of multi-modal data, and a variational reasoning module is introduced to quantify model parameter uncertainty.

Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.