59results about How to "Reduce allergic reactions" patented technology

The invention belongs to the technical field of preparation of retinol derivatives, and particularly relates to a preparation method and application of a retinol derivative. The preparation method provided by the invention comprises the following steps: 1) mixing hydroxyethyl cellulose powder, water, inorganic acid and an oxidizing agent, carrying out heating reaction, and after the reaction is finished, cooling, filtering, washing and drying to obtain oxidized cellulose; 2) mixing and stirring retinol powder and hydroxyl silicone oil, and filtering after stirring to obtain hydroxyl silicone oil coated retinol; and 3) mixing the oxidized cellulose, the hydroxyl silicone oil coated retinol, a catalyst and a first organic solvent, carrying out a heating reaction, carrying out ultrasonic treatment on the reaction liquid after the reaction is finished, filtering after the ultrasonic treatment is finished, concentrating the filtrate, extracting with a second organic solvent, and drying the extract liquid to obtain the retinol derivative. The retinol derivative prepared by the invention has excellent photo-thermal stability.

The invention provides a biological combined preparation for allergic rhinitis and a preparation method of the biological combined preparation. The preparation comprises antibacterial polysaccharide, a centipeda minima extract, anti-allergic probiotics, an active polypeptide compound, sodium hyaluronate, an immunomodulator, a penetration enhancer, a biological adhesive and the like. Wherein the antibacterial polysaccharide can be selected from various natural polysaccharides; the centipeda minima extract is obtained by a specific ethanol reflux method; the antiallergic probiotics comprise lactobacillus acidophilus, lactobacillus rhamnosus and lactobacillus reuteri; the active polypeptide compound consists of thymosin, glutathione and osteogenic peptide. The preparation method comprises the following steps: sequentially mixing the components, carrying out high-pressure homogenization treatment, carrying out ultrasonic treatment, adding probiotics, stirring, intercepting with an ultrafiltration membrane, freeze-drying and the like. The preparation disclosed by the invention can form a uniform nano-scale particle suspension, so that the release rate and the absorption efficiency of the medicine are further improved, and an efficient, safe and convenient novel method is provided for treating the allergic rhinitis.

The invention relates to hydrogel containing all-type sun-screening agent microbeads, a preparation method and application, and belongs to the technical field of sun screening. Mixing, heating and dissolving the oil-soluble organic sun-screening agent to obtain the sun-screening oil; the preparation method comprises the following steps: mixing a sodium alginate solution, a PVA solution and an inorganic sun-screening agent (zinc oxide and titanium dioxide) to form a turbid liquid, and uniformly stirring to form a first mixture; preparing oil-in-water microspheres from the obtained sunscreen oil and the first mixture through a microfluidic technology, and dripping the oil-in-water microspheres into a calcium chloride solution to form light yellow sunscreen microspheres; adding carbomer sodium into water to form gel, then adding the water-soluble organic sun-screening agent, adding the pH regulator while heating and dissolving until the solution is transparent, then adding the active substance, and continuously stirring until the mixture is uniformly mixed to obtain a third mixture; adding a thickening agent to prepare hydrogel; and adding the sunscreen microbeads into the hydrogel to obtain a dispersion system containing all types of sunscreen microbeads. The invention solves the technical problem that the product in the existing sunscreen system is greasy and easily causes anaphylactic reaction.

The invention belongs to the technical field of bioengineering, and particularly relates to a cat hair allergy recombinant fusion protein as well as a preparation method and application thereof. The method comprises the following steps: analyzing and screening B cell epitopes of the cat hair allergic protein, carrying out series fusion expression on Feld1, Feld3, Feld4, Feld7 and Feld8 and the B cell epitopes of the allergic protein, optimizing escherichia coli codons, and realizing high-efficiency expression in an escherichia coli expression system; the fusion expression scheme not only has higher protein expression, but also enhances the immunogenicity due to the connection with the own B cell epitope. A plurality of cat hair allergy recombinant fusion proteins with strong immunogenicity are adopted to carry out subcutaneous immunization on laying hens to obtain corresponding high-titer broad-spectrum egg yolk antibodies, allergy proteins can be effectively neutralized, the egg yolk antibodies are used for preparing functional cat food or additives, and allergic reactions of animals and contact personnel can be reduced.

The invention discloses an anti-allergic probiotic composition as well as a preparation method and application thereof. The probiotic composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of lactobacillus reuteri PG-LRL116, 10 to 50 parts of lactobacillus acidophilus, 10 to 50 parts of lactobacillus rhamnosus, 10 to 30 parts of lactobacillus gasseri, 10 to 30 parts of lactobacillus salivarius, 5 to 15 parts of cordyceps militaris aqueous extract, 5 to 15 parts of rosemary aqueous extract and 5 to 15 parts of dendrobium huoshanense yeast. The preparation method of the probiotic composition comprises the following steps: preparing the cordyceps militaris aqueous extract, the rosemary aqueous extract and the dendrobium huoshanense yeast; the preparation method comprises the following steps: uniformly mixing lactobacillus reuteri PG-LRL116, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus gasseri, lactobacillus salivarius, a cordyceps militaris aqueous extract, a rosemary aqueous extract and a dendrobium huoshanense fermentation product, so as to prepare the anti-allergic probiotic composition. The probiotic composition disclosed by the invention can be used for effectively inhibiting the occurrence of food sensitization reaction.

The invention discloses bifidobacterium bifidum and application of the bifidobacterium bifidum in relieving ovalbumin-induced food allergy, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium bifidum CCFM1063 is screened out, and the bifidobacterium bifidum CCFM1063 has the effects of relieving weight loss and allergic symptoms of mice caused by OVA; according to the present invention, with the application of the loratadine, the high mMCP-1 level caused by OVA can be significantly reduced, the IgE level can be reduced, the mRNA level of the jejunum allergy related cytokines such as TSLP, IL-4 and IL-33 can be significantly reduced, and the partial effect is superior to the loratadine; when the bifidobacterium bifidum CCFM1063 is combined with breast milk oligosaccharide 3 '-SL, the bifidobacterium bifidum CCFM1063 has a synergistic effect on improving food allergy symptoms, and the effect of the bifidobacterium bifidum CCFM1063 is obviously superior to that of a single strain.

The invention discloses a low-irritation oral antibacterial spray and a preparation method thereof.The low-irritation oral antibacterial spray is prepared from, by mass, 85-89 parts of an antibacterial agent, 0.1-0.4 part of stevioside, 2-6 parts of a humectant, 1-2 parts of sodium bicarbonate, 0.2-0.8 part of citric acid and 1-2.5 parts of a solubilizing agent, the oral spray provided by the invention is an ecologically healthy plant formula, does not contain alcohol, is suitable for being carried in multiple scenes such as airplanes, has pleasant aroma and palatable mouth feel, and can effectively eliminate bacteria and peculiar smells in the oral cavity and the nasal cavity while providing low-irritation disinfection and sterilization effects.

The present disclosure relates to a medical device comprising a specially heat treated component and a method of heat treating a metal alloy for the medical device.

The invention provides stem cell-derived apoptotic extracellular vesicles (ApoEVs) with an iron homeostasis regulation effect and application of the stem cell-derived apoptotic extracellular vesicles in preparation of a medicine for treating iron-deficiency anemia, and belongs to the technical field of biological medicines. The ApoEVs is an outer vesicle separated from apoptotic cells derived from human periodontal ligament stem cells, and can effectively recover the iron level in low-iron cells induced by DFOM, up-regulate the expression of iron storage protein and regulate the level of iron export protein, thereby improving the iron homeostasis of the cells. Meanwhile, the ApoEVs have good biocompatibility and safety, and a new strategy is provided for treatment of iron-deficiency anemia.

The invention relates to a beauty injection method for eliminating neck lines and a beauty injection for regenerating and assisting skin, and belongs to the technical field of plastic cosmetology. Hyaluronic acid is a substance originally existing in a human body after being injected into a region A, a region B, a region C, a region D, a region E, a region F, a region G and a region H through a three-axis three-dimensional sculpture injection method; the skin care product can help the skin to retain moisture and make the skin more moisturized and elastic, hyaluronic acid in the skin can be effectively supplemented through hyaluronic acid injection, so that wrinkles are reduced, the skin is recovered to a young state, the skin care product takes effect immediately after hyaluronic acid injection, improvement of the wrinkles can be seen quickly after hyaluronic acid injection, the maintenance time is long, and in addition, the skin care product has no side effect. The injection operation is simple and quick, an operation is not needed, a long-term recovery period does not exist, and the preparation can be used for various wrinkles, including static wrinkles such as nasolabial wrinkles and canthus fine wrinkles, and parts needing to be plump and moistened such as lips and cheeks.

The invention discloses a preparation method and application of an anti-aging vaccine, and relates to the technical field of medical treatment. Comprising the following steps: 1, synthesizing a polypeptide with a specific sequence; 2, coupling the polypeptide with a carrier protein; adding an immunologic adjuvant, and fully and uniformly mixing at room temperature to obtain a polypeptide solution; 3, freeze-drying the polypeptide solution to obtain a freeze-dried pure product; and dissolving the freeze-dried pure product in ultrapure water, filling into a sterile EP tube, and storing at-20 DEG C to obtain the anti-aging polypeptide vaccine. The anti-aging polypeptide vaccine has the beneficial effects that the polypeptide sequences (A: RRGDGRWKD, B: RSQHLRFPDR, and C: TGRRLFCYS) are designed to create the polypeptide vaccine, and the polypeptide vaccine can effectively act on cells with high expression of GPNMB, so that the anti-aging effect is achieved.

The invention relates to a gouty arthritis acute-stage traditional Chinese medicine cold compress patch as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine cold compress patch for the acute stage of gouty arthritis is prepared from the following raw materials in parts by mass: 25 to 35 parts of radix et rhizoma rhei, 45 to 55 parts of mirabilite, 15 to 25 parts of herba speranskiae tuberculatae, 15 to 25 parts of rhizoma arisaematis preparata, 15 to 25 parts of rhizoma curcumae longae, 15 to 25 parts of herba violae, 25 to 35 parts of herba taraxaci, 25 to 35 parts of rhizoma smilacis glabrae, 25 to 35 parts of fructus gardeniae, 15 to 25 parts of cortex phellodendri and 15 to 25 parts of radix gentianae macrophyllae. The traditional Chinese medicine cold compress patch for the acute stage of the gouty arthritis can effectively relieve red, swollen and heat pain of the acute stage of the gouty arthritis, and is convenient to prepare, easy to store and less in anaphylactic reaction.

The present invention provides a medicine-food homologous composition for allergic rhinitis and its preparation and preparation method, and belongs to the technical field of Chinese medicine preparations. The present invention, through the study of the treatment mechanism and treatment principle of allergic rhinitis, based on the characteristics of the onset of allergic rhinitis in children, selects the reasonable compatibility of medicine-food homologous medicinal materials such as houttuynia, angelica dahurica, honeysuckle, coix seed, polygonatum, astragalus, codonopsis, bergamot, ebony, platycodon, mint, licorice, and honey, and highlights the efficacy of the medicine in lung purgation, heat-clearing and detoxification, improving spleen deficiency and enhancing immunity. Multiple raw materials are synergistically compatible to jointly improve the related symptoms of allergic rhinitis such as nasal congestion, nasal itching, eye itching, clear nasal discharge, and hyposmia. It has been verified by experiments that the composition has a definite efficacy, and the clinical behavior index, blood IgE index and comprehensive index are all good, providing a long-term safe and non-toxic treatment plan for patients with allergic rhinitis, which is particularly suitable for the use of children.

The invention discloses a skin tendering essence and a preparation method thereof, and belongs to the technical field of cosmetics, the skin tendering essence comprises the following raw materials: 1, 3-butanediol, glycerin, nicotinamide, polyglycerol-6, 1, 2-hexanediol, p-hydroxyacetophenone, a plant extract, cassava starch, 1-methyl hydantoin-2-imide, carbomer, arginine, other trace components and water. The invention further discloses a preparation method of the skin tendering essence. The skin tendering essence prepared by the invention is rich in plant essence and various other active ingredients, can timely supplement nutrition required by skin, brings bright, smooth and soft skin feeling to the skin, and enables the skin to be transparent, full, moist, tender and smooth.

The utility model relates to face mask base cloth technical field discloses a kind of seaweed fibre face mask base cloth, including face mask base cloth, the outside of face mask base cloth is provided with fitting mechanism, the outside of face mask base cloth is equipped with connecting mechanism, the fitting mechanism includes nose paste, the side of nose paste is fixedly connected in the side of face mask base cloth, the both sides of nose paste are fixedly connected with nose side covering paste, the outside of face mask base cloth is equipped with mouth slot, the inner wall of mouth slot is provided with mouth covering paste, the bottom of face mask base cloth is equipped with mounting assembly, the mounting assembly includes support block, the top of support block is bonded in the bottom of face mask base cloth.In the utility model, ensure that face mask is closely fitted nose curve, mouth covering paste is adapted according to mouth profile, optimize the absorption effect of essence, the adjustable design of eye slot meets the demand of eye, overall improvement comfort, make skin care effect reach best.

The invention provides a traditional Chinese medicine composition for treating allergic rhinitis and application thereof, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition consists of cicada slough, centipede, divaricate saposhnikovia root, stiff silkworm, astragalus membranaceus, bighead atractylodes rhizome, magnolia flower, radix angelicae, asarum, centipeda minima, mint, burdock, earthworm, cocklebur fruit, endothelium corneum gigeriae galli and honey. The traditional Chinese medicine composition can significantly improve clinical symptoms of allergic rhinitis model mice, down-regulate expression of Ig E, Ig G1 and OVA-sIg E in serum, inhibit Th2 cell activation, improve Th17 / Treg cell balance and relieve anaphylaxis; clinical test results show that the traditional Chinese medicine composition can obviously reduce the content of Ig E and IL-6 in serum of patients with allergic rhinitis, correct immune disorder, reduce adverse reactions and improve the total effective rate of clinical treatment, and a new scheme which is good in treatment effect, quick in effect and high in safety is provided for treatment of allergic rhinitis.

This invention proposes a culture medium and cultivation method for Tremella fuciformis, belonging to the field of Tremella fuciformis cultivation technology. It is prepared from the following raw materials in parts by weight: 0.5-1 parts antibacterial agent, 5-7 parts traditional Chinese medicine residue, 3-5 parts sugarcane bagasse, 2-3 parts fermentation extract, 30-40 parts cottonseed hulls, 7-10 parts wheat bran, 0.5-1 part gypsum, and 50-60 parts sterile water. The Tremella fuciformis culture medium obtained by this invention can significantly inhibit the growth of pathogenic bacteria during cultivation, reduce the pathogenicity rate, and increase the yield of Tremella fuciformis. Simultaneously, it increases the content and efficacy of active substances in Tremella fuciformis, producing selenium-enriched Tremella fuciformis polysaccharide. The active substances exhibit excellent antioxidant, anti-inflammatory, anti-tumor, moisturizing, hypoglycemic, hypolipidemic, and cardiovascular protective effects. Using this invention's culture medium, along with a suitable ratio of Tremella fuciformis and Clematis chinensis symbiotically, provides a new method and material for Tremella fuciformis cultivation, resulting in Tremella fuciformis with better utilization value and broad application prospects.

The invention discloses a method for preparing low-sensitization protein peptide through microwave combined enzymolysis composite modification and application, and relates to the technical field of food processing. The treatment method comprises the following steps: preparing protein powder into a solution, adding tea polyphenol into the solution, and uniformly mixing to prepare a protein solution; carrying out microwave modification treatment on the protein solution; adding compound protease into the protein solution subjected to microwave treatment for enzymolysis and enzyme deactivation; and filtering the enzymolysis product, and drying the filtrate to obtain the low-sensitization protein peptide. According to the method, microwave and enzymolysis combined composite modification is adopted, so that the sensitization of protein can be reduced, the reaction time is shortened, and the method is simple in process, free of pollution and high in safety. In the enzymolysis process, active peptide substances which are easy to digest and absorb, can enhance immunity and delay senescence are synchronously generated, and tea polyphenol added in the formula can synergistically relieve anaphylactic reaction and play an anti-oxidation role, so that multi-element synergy of desensitization, function enhancement and flavor optimization is realized, and the added value and market application potential of the product are improved.

The utility model discloses a cutter which comprises a cutter body, the cutter body comprises a blade, at least part of the area of the cutting edge of the cutter body is connected with a cutting edge reinforcing piece, and the hardness of the cutting edge reinforcing piece is larger than that of the cutter body. The cutting edge reinforcing piece is arranged on the cutter, so that the cutter has enough hardness to cut food materials, the cutter body does not need to be made of a high-hardness material, the cutter body can be made of a material which is relatively low in hardness or high in biocompatibility but soft in texture, and therefore the manufacturing cost of the cutter body is reduced while punching on the cutter body is facilitated; due to the fact that the knife body does not need to have high hardness so as to meet the requirement for fitting food materials, the knife body can be selectively designed to be light and thin, the light weight of the knife is facilitated, and the use experience of a user is improved; and the cutting edge reinforcer is high in strength and durability, so that the service life of the cutter is prolonged.

The invention discloses a low-allergenic textile filling flake for infants and a preparation method thereof, and relates to the field of textiles. The low-allergenic textile filling flake for infants is composed of anti-mite fiber, antibacterial fiber and low-melting-point fiber. The preparation method of the low-allergenic textile filling flake for infants comprises the following steps: step 1, preparing anti-mite fiber, antibacterial fiber and low-melting-point fiber; step 2, mixing the anti-mite fiber, antibacterial fiber and low-melting-point fiber to obtain infant textile mixed fiber after mixing; step 3, combing the infant textile mixed fiber into a flake state to obtain the low-allergenic textile filling flake for infants. The invention has a long lasting effective antibacterial effect.

The invention relates to a traditional Chinese medicine external application ointment for rheumatism and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine external application ointment. The externally-applied traditional Chinese medicine ointment is prepared from the following raw materials: 20 to 25 parts of rhizoma arisaematis powder, 20 to 25 parts of rhizoma pinelliae powder, 20 to 25 parts of rhizoma chuanxiong powder, 20 to 25 parts of radix aconiti kusnezoffii powder, 10 to 15 parts of menthol powder, 10 to 15 parts of camphor powder, 10 to 15 parts of pepper powder, 50 to 70 parts of rosin powder, 20 to 25 parts of honeysuckle flower extracting solution, 30 to 40 parts of beewax and 30 to 40 parts of peanut oil. A preparation process of the honeysuckle flower extracting solution comprises the following steps: (1) crushing honeysuckle flowers, putting the crushed honeysuckle flowers into a distillation kettle of a distillation device, and then adding water, so that the honeysuckle flower powder is fully soaked in the water; by adding anti-allergy components into the externally-applied traditional Chinese medicine ointment, the function of an immune system is adjusted, release of allergy media is reduced, irritation of the ointment to skin is reduced, allergic reactions are effectively reduced, and the safety of the ointment is effectively improved.

The present application is suitable for the technical field of traditional Chinese medicine preparation, and provides a pediatric fever relieving and lung relieving and cough stopping gel plaster and a preparation method thereof.The gel plaster is prepared by mixing a traditional Chinese medicine extract prepared from gardenia, bitter almond, peach kernel and safflower and a gel base;the present application adopts a double-reduced-pressure process of reduced-pressure reflux extraction and reduced-pressure low-temperature concentration, avoids the damage of heat-sensitive active ingredients;after concentration, a pH adjusting step is additionally arranged, the pH of thick immersion paste is adjusted to 5.0-7.0, the stimulation of strong acidity to children's skin is eliminated, and the cross-linking stability of the base is ensured;the pure aqueous gel base is composed of sodium polyacrylate, aluminum glyceryl hydroxy, and glycerol, and mixing, cross-linking and coating are completed under room temperature conditions;the obtained gel plaster has the advantages of fever relieving and cough stopping synergistic effect, skin-friendly and non-irritating, stable plaster body, and green and controllable process, and is particularly suitable for children.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

The invention provides an all-natural plant extract compound feed additive. Comprising the following plant extracts in parts by weight: 3-12 parts of a folium cortex eucommiae extract, 5-12 parts of an alfalfa extract, 8-10 parts of a crude and old tea leaf extract, 3-10 parts of a ramie root and leaf extract, 6-10 parts of a mushroom root extract, 2-9 parts of a purslane extract, 1-8 parts of a wild chrysanthemum flower extract, 5-8 parts of a pericarpium citri reticulatae extract, 6-8 parts of a centella asiatica extract, 12-26 parts of achyranthes bidentata polysaccharide and 15-60 parts of a perilla frutescens extract. The feed is prepared from 35-55 parts of yeast cell wall extract, 8-16 parts of freeze-dried bacillus subtilis powder, 35-60 parts of corn flour, 45-60 parts of bran powder, 70-85 parts of protein mulberry plant powder and 15-40 parts of egg yolk oil. According to the present invention, with the characteristics of heat clearing and detoxification, the added centella asiatica extract, the achyranthes bidentata polysaccharide, the perilla frutescens extract, the yeast cell wall extract, the bacillus subtilis freeze-dried powder and the egg oil are matched, such that the common pathogenic bacteria can be resisted, the anaphylactic reaction can be reduced, the diarrhea effect caused by bacteria, fungi and nutritional antigens can be controlled, and the immune function can be enhanced.

This invention discloses a method for preparing purslane exosomes with anti-allergic effects and their applications, specifically relating to the field of natural active substances. The method includes washing fresh purslane and then juicing or homogenizing it, separating solid residue from the liquid juice to obtain a plant homogenate supernatant as a precursor. The precursor is then subjected to low-temperature differential centrifugation to remove cell debris and large particulate impurities, and the clarified supernatant is collected. The clarified supernatant is then filtered through one or more multi-stage filter membranes, with pore sizes selected from 5 μm, 1.2 μm, 0.45 μm, 0.22 μm, and 100 nm. Through optimized extraction processes, such as specific enzymatic hydrolysis steps, centrifugation conditions, and ultrafiltration technology, the extraction efficiency and purity of exosome-like nanovesicles are significantly improved. Compared to traditional extraction methods, this method can more accurately remove impurities, preserve the integrity and bioactivity of exosome-like nanovesicles, and ensure their stability and effectiveness in subsequent applications.

The utility model provides a novel anti-slip headset, and relates to the technical field of head-mounted equipment, the novel anti-slip headset comprises a shell and a multifunctional mechanism, the top end and the bottom end of the shell are both provided with cover plates, and one side of the shell is provided with the multifunctional mechanism. The device is fixed to a connector of the protective shell and the first magnetic block through the connecting assembly, it is prevented that a certain part is lost in the use process, and normal use of the device is affected, meanwhile, skin-friendly rubber is friendly to skin, anaphylactic reaction caused by material stimulation is reduced, and more comfortable hand feeling experience can be brought to a user; the device is fixed on the auricle through the magnetic force between the first magnetic block and the second magnetic block, the headset can be tightly attached to the ear by utilizing the characteristic that the magnetic blocks attract each other, the headset is prevented from falling off due to vibration or friction in sports or daily activities, meanwhile, the pressure on the auricle is reduced through the magnetic force fixing mode, and comfort can be kept even if the headset is worn for a long time.

The utility model discloses a novel neurosurgery head accessory which comprises an accessory area, an incision area and an exposed layer. The auxiliary material area is located on the incision area, the auxiliary material area is located on the exposed layer on the scalp and used for being arranged on the incision area, the auxiliary material area is of a composite structure, the composite structure is in a long strip shape and is divided into a main dressing area, an auxiliary dressing area, a main sealing edge and an auxiliary sealing edge, and the auxiliary dressing area is provided with a medicine for removing necrotic tissue and promoting tissue regeneration and can promote blood circulation and promote tissue regeneration; and wound infection is prevented. Compared with the prior art, the auxiliary material fixing device has the advantages that due to the reasonable coverage range and the reasonable fixing mode, displacement of auxiliary materials is reduced, and the probability of pollution to an incision is reduced.

The invention discloses a reinforcing paste for a wearable product, which is composed of a single-sided adhesive tape 1 and a single-sided adhesive tape 2, the size of the single-sided adhesive tape 1 is larger than that of the single-sided adhesive tape 2, and the adhesive surface of the single-sided adhesive tape 2 and the adhesive surface of the single-sided adhesive tape 1 are attached to each other; at least one through hole is formed along the edge line of the single-sided adhesive tape II, or the inner side of the edge line of the single-sided adhesive tape II, or the outer side of the edge line of the single-sided adhesive tape II; the reinforcing paste covers the wearable product, the second single-face adhesive tape makes contact with the wearable product, and the first single-face adhesive tape extends to the adhesive face on the periphery of the second single-face adhesive tape to be pasted to the body surface. According to the reinforcing patch for the wearable product, the multiple through holes are formed in the position where water is prone to accumulating, internal accumulated water can flow out in time through the through holes, the through holes can help internal air to circulate, moisture can be rapidly volatilized, the skin can be dried in a shorter time, skin ulceration is avoided, and local itching can be effectively relieved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a baricitinib-containing clathrate compound as well as a preparation method and application thereof. The invention provides a baricitinib clathrate compound. The baricitinib clathrate compound comprises cyclodextrin and an active ingredient clathrated in the cyclodextrin, the baricitinib is included by cyclodextrin, so that the solubility and stability of the baricitinib are remarkably improved, and meanwhile, the preparation process is simplified. The local administration preparation of the baricitinib clathrate compound can quickly reach the focus, enhances the local administration efficiency, makes the pharmacological activity fully exerted, reduces the adverse reaction of the whole body, effectively reduces the level of inflammatory factors, and provides a safe and efficient new treatment method for local lesions such as rhinitis and nasosinusitis.

The invention provides an anti-allergic cosmetic composition containing sodium gualenate as an active ingredient. The composition comprises sodium gualenate, sodium gualenate and a surfactant, the surfactant is selected from PEG-7 olive oil sodium carboxylate; dipotassium glycyrrhizinate; phenoxyethanol, vitamin E; hyaluronic acid and the balance of deionized water are used as solvents; according to the cosmetic composition, the stability of the sodium gualenate is improved, the skin irritation caused by the sodium gualenate is reduced and the sodium gualenate is prevented from being allergic to a small number of sensitive skin while the effective components of the sodium gualenate have the effects of resisting inflammation, resisting allergy and repairing and regenerating.