20 results about "Dust mites" patented technology

This invention discloses a method, system, equipment, and medium for real-time detection of the overall performance of a mite remover, specifically relating to the field of performance testing technology. The method includes sealing and connecting the mite remover under test with a test sample chamber containing a built-in standard dust mite test sample block; continuously acquiring instantaneous input power and instantaneous wind speed through a power acquisition unit and a hot-wire anemometer, and calculating the instantaneous intake flow rate based on the cross-sectional area of ​​the duct; continuously acquiring a sequence of microscopic images of the upper surface of the fiber fabric layer within a set detection period; extracting individual dust mite displacement events using the inter-frame difference method, counting the total number of events, and calculating the average displacement velocity value; and using the average intake power, the total number of individual dust mite displacement events, and the average displacement velocity value as input variables, generating a comprehensive evaluation value of the overall machine's performance through a performance judgment model. This invention integrates power, flow rate, and the dynamic response parameters of live dust mites, achieving real-time and accurate quantitative evaluation of the overall performance of the mite remover.

The invention relates to the field of allergen detection, in particular to an anti-Der p 2 antibody and application thereof. The invention provides an anti-Der p 2 antibody. A heavy chain variable region of the anti-Der p 2 antibody comprises an amino acid sequence of a complementarity determining region: CDR1 as shown in SEQ ID No.1, CDR2 as shown in SEQ ID No.2, and CDR3 as shown in SEQ ID No.3; or the amino acid sequence of the heavy chain variable region is as shown in SEQ ID No.8. According to the protein, a New Zealand rabbit is immunized by utilizing Der p 2 protein of a main allergen of Dermatophagoides pteronyssinus, and a group of monoclonal antibodies with high affinity and high sensitivity to Der p 2 are obtained through screening. The antibody is further subjected to humanized IgE modification and is applied to a magnetic particle chemiluminescence quantitative detection reagent of Der p 2 specific IgE. According to the reagent, a standard curve for Der p 2 independent calibration can be established, so that accurate and repeatable absolute quantitative analysis is realized, and the detection sensitivity can reach 0.1 IU / mL. The detection method formed on the basis of the anti-Der p 2 antibody provided by the invention has important value for clinical diagnosis of anaphylactic reaction.

The application relates to the technical field of allergy detection, in particular to an inhaled allergen specific IgE antibody detection kit and application thereof. The kit is a colloidal gold detection kit; the detection object is pollen, dust mites and animal dander; the kit comprises colloidal gold labeled mouse anti-human lgE antibodies arranged on a test strip combination pad; and pollen antigens (Art v1, Amb a1, Bet v2), dust mite antigens (Der f1, Der p1) and animal dander antigens (Can f1) arranged on a test strip nitrocellulose membrane. The kit provided by the application can quickly identify the allergen of inhaled allergic symptoms, classify the severity of allergic symptoms, and the identification result has a high accuracy.

The invention relates to a method for obtaining a probiotic product for neutralizing allergens, released by house dust mites, product composition and method of use, which is from the technical field of providing a healthy microclimate based on a probiotic product. The product concerns the maintenance of household stuff in immediate and direct use by humans, such as shoes, blankets, upholstered furniture, clothes, carpets and mats, the air in domestic and office premises, as well as in bathrooms, toilets and vehicles. The product composition consists of a spore concentrate, containing minimum of 1x109 CFU / ml fermentation bacteria class 1 (one), ethanol, hypoallergenic perfume mixture, preservative and water, softened, processed by reverse osmosis and cavitation, ultra-filtered, and microbiologically clean in terms of bacteria and viruses.

The invention discloses portable equipment for improving and preventing rhinitis with small-particle-size negative ions and a use method, and relates to the technical field of rhinitis prevention, the portable equipment comprises a product front shell, the equipment can release small-particle-size and high-activity negative ions by selecting an ecological negative ion generation chip technology, and the negative ions enter the nasal cavity through breathing and act on blood capillaries and nerve endings, so that the rhinitis is improved and prevented. The traditional Chinese medicine composition can regulate vasomotor, improve nasal cavity blood circulation, relieve mucous membrane hyperemia and swelling and relieve nasal obstruction, has the mucous membrane repairing function, promotes nasal mucous membrane epithelial cell regeneration, recovers ciliary movement and secretion functions, enhances the self-cleaning capacity of the nasal cavity, and can regulate whole body immunity, reduce the sensitivity of nerves to mechanical stimulation and reduce anaphylactic reactions such as sneezing. The medicine can activate the reticuloendothelial system, enhance the disease resistance of the organism, reduce rhinitis recurrence and remove environmental allergens, small-particle-size negative ions can adsorb and settle allergens such as dust mites and pollen in air, nasal cavity stimulation is reduced from the source, and double barriers for treatment and prevention are formed.

1. The name of the design product: dust mite suction cleaner (base station). 2. The use of the design product: for dust removal and mite removal. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model provides a dust cup structure and acarus killing instrument, wherein the dust cup structure comprises: a main body, the main body has an opening, the opening is provided with a cover body, the main body is internally and detachably provided with a separator, the separator divides the inner cavity of the main body into a first chamber and a second chamber, the second chamber is internally provided with a separating assembly, and the separating assembly is provided with an opening. And the first chamber is communicated with the second chamber. According to the dust cup, the technical problem that in the prior art, the dust cup of the acarus killing instrument needs to be cleaned through an external tool, and cleaning operation is troublesome can be solved.

The invention provides bacillus amyloliquefaciens capable of degrading allergens and application of the bacillus amyloliquefaciens. The bacillus amyloliquefaciens is preserved in the China General Microbiological Culture Collection Center (CGMCC) on October 9, 2025, the preservation number is CGMCC No.36139, and the bacillus amyloliquefaciens can be used for degrading dust mite allergens, cat allergens and dog allergens.

The invention provides modified hydroxyapatite for adsorbing dermatophagoides pteronyssinus allergens as well as a synthesis method and application of the modified hydroxyapatite. Dermatophagoides pteronyssinus allergen in the air is mainly suspended in the form of protein, and when exposed in the environment, a human body passively inhales or contacts with the dermatophagoides pteronyssinus allergen to induce allergic rhinitis, asthma and other diseases. The modified hydroxyapatite has a unique porous crystal structure, the content of the main component Ca10 (PO4) 6 (OH) 2 is larger than or equal to 99 wt%, the surface of the modified hydroxyapatite is rich in hydroxyl (-OH), functional groups such as amino (-NH2) and carboxyl (-COOH) can be introduced through targeted modification, and the modified hydroxyapatite is in a sheet-shaped or rod-shaped crystal shape. The dust mite allergens in air are removed through the synergistic effect of physical adsorption and chemical adsorption, and the removal rate of the dust mite allergens Der p 1 and Der f 1 is increased under the room temperature condition. The invention further discloses a synthesis method of the modified hydroxyapatite and application of the modified hydroxyapatite in the field of air purification, and an efficient solution is provided for indoor allergen prevention and control.

The application discloses a preparation method of an inhaled mixed allergen storage solution. The storage solution is used for storing mixed allergens composed of house dust mites, dust mites, cat dander, horse dander, dog hair, timothy grass, cladosporium, common birch, olive, artemisia and medicinal wall grass, and the storage solution comprises the following components in the form of mass fractions: (1) 5mM-50mM PBS buffer solution, pH 7.0-8.0, 0.5%-5% salt, 5%-30% human serum albumin, 0.05%-0.2% preservative, and 0.1%-1% protein stabilizer. The preparation method and application of the inhaled mixed allergen storage solution effectively solve the cross reaction between various proteins, and realize more sensitive detection of common inhaled allergens in samples.

The invention relates to an IgG4 antibody specifically combined with dermatophagoides pteronyssinus extract and a preparation method thereof. The screening method comprises the following steps: 1) stimulating a lymph node organ with an antigen; 2) analyzing the stimulated lymph node organoid by combining single cell sequencing and an immune repertoire, and screening a potential IgG4 sequence; (3) preparing the potential IgG4 sequence into potential antibody protein in an in-vitro expression manner; and 4) respectively carrying out ELISA detection and biological layer interference technology verification on the potential antibody protein, wherein the antibody which can be specifically combined with the antigen is the IgG4 antibody. An antigen binding fragment of the obtained IgG4 antibody is formed by connecting a heavy chain fragment and a light chain through a disulfide bond, the nucleotide sequence of the heavy chain fragment is shown as any one of SEQ ID No: 1 to SEQ ID No: 3, and the nucleotide sequence of the light chain is shown as any one of SEQ ID No: 4 to SEQ ID No: 6.

The present invention relates to a method for producing an aging model skin cell line by using house dust mites and, more specifically, to a method for producing an aging model skin cell line, and an aging model skin cell line produced using same, the method comprises the steps of: culturing isolated skin cells in a medium comprising fetal bovine serum; and adding a purified house dust mite extract at a concentration of 10 to 300 μg / ml to the cultured skin cells so as to induce aging of the cultured skin cells. The present invention provides the aging model skin cell line, which can be used as an alternative to animal experiments and has the effect of not causing a decrease in copy number even upon subculture.

The present application relates to the technical field of air purification, and discloses a mite-removing air purifier and a control method, a control device and a storage medium thereof. The mite-removing air purifier comprises: a purification body having a purification air inlet, an air outlet and a purification air duct connecting the purification air inlet and the air outlet; and a mite-removing device arranged in the air purification body, wherein the mite-removing device has a mite-removing air duct, one end of the mite-removing air duct is formed into a mite-removing inlet matched with an article to be mite-removed, the other end of the mite-removing air duct is communicated with the air outlet, and the mite-removing device has an unfolded state and a contracted state. The mite-removing air purifier has a purification air mode and a mite-removing mode. When the mite-removing air purifier is in the purification air mode, the mite-removing device is in the contracted state. When the mite-removing air purifier is in the mite-removing mode, the mite-removing device is in the unfolded state, and the mite-removing device is in contact with the article to be mite-removed after being unfolded, so as to remove mites from the article to be mite-removed. The mite-removing air purifier has the functions of purification and mite removal, and has a high utilization rate.

The present invention relates to a purified veterinary allergen extract enriched. In particular, the invention relates to a purified veterinary allergen extract enriched with Der f 15 and Der f 18. The invention further relates to use of the allergen extract as a veterinary product, and its use in treating allergy, in particular house dust mite allergy in mammals, more particularly, dogs.

A recombinant lactic acid bacterium and a method thereof for simultaneous treatment and / or prevention of dust mite and cockroach allergies. The recombinant lactic acid bacterium has a gene fragment with nucleotide coded as SEQ ID No: 1 to be capable of expressing the D2P2 protein with amino acid sequence of SEQ ID No: 2. Therefore, by administering an effective amount of the recombinant lactic acid bacterium to an individual is capable of effectively causing the individual's body to produce antibodies against dust mite and / or cockroach allergens, thereby achieving an efficacy of preventing and / or treating an allergic disease caused by dust mite and / or cockroach allergens.

The invention discloses a recombinant dermatophagoides pteronyssinus allergen fusion protein as well as a preparation method and application thereof. The dermatophagoides pteronyssinus allergens comprise dermatophagoides pteronyssinus allergens Der p 1 or a fragment thereof, Der p 2 or a fragment thereof, Der p 10 or a fragment thereof, Der p 21 or a fragment thereof and Der p 23 or a fragment thereof, and the dermatophagoides pteronyssinus allergens or fragments thereof are connected through flexible connecting peptides. According to the recombinant dermatophagoides pteronyssinus allergen fusion protein provided by the invention, five main sensitization components are connected in series and expressed into one protein, so that the protein can have the advantages of natural crude extracts and recombinant components, the active components are various and high in purity, the components accurately target the main sensitization protein, the quality is easier to control, and the safety is higher. When the recombinant dermatophagoides pteronyssinus allergen fusion protein is applied to in-vitro diagnosis detection, the detection efficiency can be effectively improved, the omission ratio and the false positive rate are reduced, and a more reliable detection result is provided for clinic.

The invention relates to an acarus killing instrument. The acarus killing instrument comprises a shell, a steam assembly, a steam outlet part, a rolling brush assembly and a dust collection assembly, the steam assembly is provided with a steam outlet capable of outputting steam; a gas channel is formed in the steam outlet piece, the gas channel communicates with the steam outlet of the steam assembly, a steam exhaust hole communicating with the outside is formed in the gas channel, and steam flowing out of the steam outlet can be exhausted from the steam exhaust hole; the steam exhaust hole is formed towards the to-be-cleaned surface; the rolling brush assembly comprises a rolling brush, the shell is provided with a first containing cavity, the rolling brush is rotatably arranged in the first containing cavity, and the rolling brush can make rolling contact with a to-be-cleaned face; the dust collection assembly is provided with a dust collection opening communicating with the first containing cavity, and the dust collection opening is used for sucking dust mites brought up by rolling contact of the rolling brush and the to-be-cleaned face. The acarus killing agent has a good acarus killing effect.

The invention belongs to the technical field of air purification, and discloses a detection device and a detection method for testing a dust mite removal rate based on a non-circulating pipeline. According to the method, synchronous sampling (liquid impact type capture and double-antibody sandwich ELISA) is carried out in front and back channels of a filtering module, so that real-time comparison of upstream and downstream allergens is realized, and further calculation of the dust mite antigen filtering efficiency of a filtering material is realized; turbulence interference is avoided through standardized sampling point positioning, the technical blank of biological safety dynamic evaluation of a large ventilation system is filled, and static physical parameters are upgraded to biological health risk management and control. Meanwhile, according to the method, an ultrafiltration centrifugal tube is used for concentrating liquid sampled by a liquid impact method under proper parameters, so that the collection time of a liquid impact bottle is shortened, the sensitivity of dust mite antigen detection is improved, the use amount of dust mite antigen aerosol is reduced, and the test cost is greatly reduced.

This invention relates to the field of antibodies, and particularly to an anti-Der p 1 antibody and its uses. The invention provides an anti-Der p 1 antibody comprising a heavy chain variable region and a light chain variable region. The amino acid sequence of the complementarity-determining region (CDR1) of the heavy chain variable region is as shown in SEQ ID No. 1, CDR2 of SEQ ID No. 2, and CDR3 of SEQ ID No. 3; or, the amino acid sequence of the heavy chain variable region is as shown in SEQ ID No. 8. The anti-Der p 1 antibody provided by this invention is a high-affinity, high-sensitivity monoclonal antibody. After humanizing this monoclonal antibody with IgE, it is applied to a magnetic particle chemiluminescent quantitative detection reagent for Der p 1-specific IgE of house dust mite allergens. This allows for the generation of a separately calibrated standard curve for Der p 1, achieving truly accurate and reproducible absolute quantification. It can detect Der p 1-specific IgE at a concentration of 0.1 IU / mL, and has clinical diagnostic significance for identifying allergic reactions.