The invention discloses a
traditional Chinese medicine composition with a function of
pulmonary fibrosis resistance and a preparation method of the
traditional Chinese medicine composition with the function of
pulmonary fibrosis resistance. The
traditional Chinese medicine composition with the function of
pulmonary fibrosis resistance is prepared from, by weight, 2-10 parts of Radix
Ginseng, 2-20 parts of Cortex Mori, 2-20 parts of Cortex Lycii, 1-10 parts of Radix Glycyrrhizae, 2-20 parts of Rhizoma Anemarrhenae, 2-20 parts of Exocarpium Citri Rubrum, 2-20 parts of Radix Asparagi and 2-20 parts of Radix Salviae Miltiorrhizae. The traditional Chinese
medicine composition is prepared by matching of traditional Chinese medicines through a large amount of experiments according to
syndrome differentiation and treatment theories and traditional Chinese
medicine theories. According to experimental results, the traditional Chinese
medicine composition has remarkable functions of alleviating pulmonary
fibrosis and other pulmonary lesions caused by
bleomycin and improving pulmonary functions and is capable of remarkably lowering pulmonary
fibrosis closely related biological indicators such as pulmonary
hydroxyproline content and
bronchoalveolar lavage fluid PDGF, NF-kB, TNF-alph and IFNgamma levels and reducing pulmonary tissue TGFbeta,
Smad3mRNA and
protein expression. Furthermore, the traditional Chinese medicine composition with the function of pulmonary
fibrosis resistance can be used for treatment of various idiopathic and secondary pulmonary fibrosis and has significant
social benefits and
economic benefits.