27 results about "Acute injury" patented technology

The invention discloses application of poplatin in preparation of a medicine for treating muscle injury. The research finds that the poplatin has the effects of promoting mouse myoblast differentiation and promoting mouse muscle regeneration under various pathological conditions such as acute injury, obesity, diabetes mellitus and hereditary dystrophy.

The application discloses a traditional Chinese medicine external application powder and a preparation method and application thereof. The traditional Chinese medicine external application powder is prepared from the following raw medicinal materials in parts by weight: Herba Reineckiae 10-14 parts, Herba Vaccariae 18-22 parts, Radix et Rhizoma Rhei 4-6 parts, Olibanum 8-12 parts, Dried Dragon's Blood 4-6 parts, Myrrha 8-12 parts, Fructus Zanthoxyli 4-6 parts, Fructus Amomi Rotundus 13-17 parts, Cortex Mori 8-12 parts, Resina Commiphorae 8-12 parts and Mirabilite 0.5-1.5 parts. The traditional Chinese medicine external application powder has the effects of activating blood circulation to dissipate stasis, removing swelling and pain, relaxing tendons and recovering injury, and removing stasis without damaging normal body functions. The traditional Chinese medicine external application powder is used in the clinical treatment of 8 cases of acute sprain of joints accompanied by edema of soft tissues, and the swelling and pain are obviously relieved within one treatment course (5 times), and the joint function is recovered, and the total effective rate and the cure rate are both 100%. In the 8 cases, the symptoms of 7 cases disappear in 5 days, and the swelling and pain of 1 case of acute exacerbation of old injury are basically relieved in 5 days, and the old injury is cured in 3 days. The traditional Chinese medicine external application powder has the advantages of fast effect, short treatment course, good effect on acute injury and recurrence of old injury.

The invention relates to the technical field of clinical nursing, and discloses a neurological clinical cold and hot compress nursing device for relieving pain, which comprises a shell and a cold and hot compress component arranged in the shell, the temperature transmission part is arranged on the cold and hot compress part in the shell, and the fixing parts are arranged at the bottoms of the two ends of the shell. According to the clinical cold and hot compress nursing device for relieving the pain based on the neurology department, the semiconductor chilling plate is installed on the installation frame, then the semiconductor chilling plate can be turned over through the rotary fixing assembly, and when a patient possibly needs cold compress in the early stage of acute injury to relieve swelling and pain, the patient can be subjected to cold compress; in the later period, hot compress is possibly needed to promote blood circulation and rehabilitation, the cold end and the hot end of the semiconductor chilling plate can be turned over at will, the functionality of the device is improved, and the modes can be rapidly switched in the treatment process where cold compress and hot compress are needed.

The invention also discloses application of the bovine-derived SYPL2 gene in regulation and control of animal muscle development and regeneration. According to the invention, the SYPL2 gene is found to be a key regulatory factor for muscle development, and an intervention strategy based on the gene is developed, so that a part of technical problems are effectively solved, and an innovative solution is provided for livestock breeding and muscle regeneration medicine. The invention discovers that the SYPL2 gene has high specific expression in bovine skeletal muscle tissues for the first time, and has the capability of promoting proliferation and differentiation of bovine myoblasts cultured in vitro. More importantly, when the bovine SYPL2 gene overexpression plasmid is locally injected into a mouse with acute muscle injury, a remarkable muscle injury regeneration and repair treatment effect is shown, so that a brand new target and a solution are provided for livestock molecular breeding and muscle regeneration medicine; and an important basis is provided for improving the production efficiency of animal husbandry and developing a novel muscle repair therapy.

Provided are alcohol amine derivatives, a preparation method therefor and the use thereof, and a drug for treating organ fibrosis or pulmonary inflammations caused by acute injury, belonging to the technical field of medicine. The alcohol amine derivatives have structures represented by formula R-1 or formula R-2 and are R-configuration compounds, and exhibit good therapeutic effects on organ fibrosis or pulmonary inflammations caused by acute injury. The results in the pharmacological embodiments show that the alcohol amine derivatives have excellent pharmaceutical effects both on pulmonary inflammations caused by acute injury and various types of organ fibrosis models, the pharmaceutical effects thereof being overall superior to that of S-configuration compounds and positive drugs Nintedanib and Pirfenidone.

An injury mitigation and prevention support device is provided including flexible support material configured to wrap around a predetermined joint, tendon, ligament, or muscle of a mammal and nitinol elements included in or on the support material, wherein the nitinol elements are configured to be set into an austenite super-elastic phase by a body temperature of the mammal when the support material is wrapped around the joint, tendon, ligament, or muscle and the nitinol elements are located and configured to provide a counteracting force to a force exerted on the joint when the joint, tendon, ligament, or muscle is bent or stretched beyond a normal angle of extension of the joint, tendon, or muscle. As a result, the device acts dynamically and instantaneous with super-elasticity to prevent or minimize acute injury insult, and also acts to continuously to support and reduce fatigue to minimize acute and chronic injury.

The invention provides a construction device and a construction method of a radioactive intestinal injury animal model, which are characterized in that a backscattering layer is placed below a mouse body, a dose construction layer covers the mouse body, and the radioactive intestinal injury animal model is established by irradiation of a linear accelerator. The method mainly solves the problem that the high-energy X-ray dose build-up area effect affects non-uniform local irradiation dose distribution of the abdominal cavity of the mouse, a standard irradiation scheme is established by comprehensively considering the high-energy X-ray dose build-up area effect and the backscattering effect, the dose distribution of the abdominal cavity of the mouse irradiated by the scheme is more uniform, and the irradiation efficiency is improved. The induced intestinal injury shows recoverable acute injury and chronic intestinal injury characteristics, and can be used for screening and testing medicines for relieving the intestinal injury caused by radiotherapy.

The invention discloses a motion plan generation method, system and device based on AI driving, and relates to the technical field of data processing. The method comprises the following steps: obtaining an initial motion scheme; performing height development prediction association optimization based on the initial exercise scheme to obtain a first exercise scheme; performing acute injury risk prediction on the target user to obtain an exercise acute injury risk coefficient; performing chronic strain risk prediction to obtain an exercise chronic strain risk coefficient; performing excessive fatigue risk prediction to obtain an excessive fatigue risk coefficient of exercise; performing exercise risk optimization adjustment on the first exercise scheme to obtain a second exercise scheme; and performing nutritional feature compensation on the second exercise scheme to obtain a third exercise scheme, and performing exercise execution rewarding on the target user based on the third exercise scheme. The technical problem of insufficient safety of the exercise scheme caused by lack of systematic risk assessment in exercise planning in the prior art is solved, and the technical effect of improving the safety of the exercise scheme is achieved.

The invention belongs to the technical field of biological medicines, and particularly discloses a polypeptide for protecting lung vascular endothelial cells and relieving lung injury and application of the polypeptide. The polypeptide is Humanin-G (HNG), and the amino acid sequence of the polypeptide is MAPRGFSCLLLLTGEIDLPVKRRA. The polypeptide is targeted to mitochondria of pulmonary vascular endothelial cells, provides protection from energy supply and cell survival roots, and has profound significance in improving functions of the pulmonary vascular endothelial cells and reducing the death rate of sepsis-induced acute lung injury (ALI). Researches show that when the polypeptide is used in the acute injury stage, lung inflammation of a model animal can be relieved by 25%-50%, the lung injury HE score can be reduced by about 50%, pulmonary edema can be relieved by about 30%, mitochondrial functions can be recovered by about 70%, the ATP yield can be increased by 30%, and the effect is excellent. Therefore, the invention provides a brand new strategy for maintaining the mitochondrial homeostasis by using the polypeptide so as to relieve lung injury.

The application relates to the technical field of clinical nursing, and discloses a cold and hot compress nursing device for pain relief based on neurology clinical treatment, wherein the cold and hot compress nursing device for pain relief based on neurology clinical treatment comprises a shell, a cold and hot compress component arranged in the shell, a temperature transmission component arranged on the cold and hot compress component in the shell, and fixing components arranged at the bottoms of the two ends of the shell. The cold and hot compress nursing device for pain relief based on neurology clinical treatment is characterized in that: the semiconductor refrigerating sheet is installed on the mounting frame, and the semiconductor refrigerating sheet can be turned over by using the rotary fixing assembly. When a patient needs cold compress to reduce swelling and pain in the early stage of acute injury, and needs hot compress to promote blood circulation and recovery in the later stage, the cold and hot ends of the semiconductor refrigerating sheet can be turned over at will, so that the functionality of the device is improved, and the mode can be quickly switched during the treatment process when cold compress and hot compress are needed.

The invention relates to the field of ophthalmology, in particular to application of an NK1.1 scavenger (cloned PK136) in preparation of a medicine for treating and / or relieving acute retinal injury. The invention provides application of an NK1.1 scavenger in preparation of a medicine for treating and / or relieving acute retinal injury. According to the invention, emergency treatment can be carried out during acute retinal injury (such as traffic accidents and retinal detachment), retinal injury is relieved, sufficient time is provided for treatment methods such as operations, and injury is reduced to the minimum.

Dianophore Long-Lasting Modifications of oligonucleotides with immunomodulatory and homeostatic properties (including the proliferation of pluripotent mesenchymal stem cells (MSC) of animals, including humans). Different ONs were synthetized with a modification at their backbone structure and chemically combined with some specific organic molecules, modifying the original dianophore (but not the pharmacophore) of the original ON, yielding several long-lasting conjugates. The obtained conjugates are not susceptible to in vivo hydrolytic cleavage and have enhanced in vivo half-life, also in its natural phosphodiester form and have shown much more biological potency (hundred to thousand times). These modified oligonucleotides are used in a wide range of clinical treatments involving the immune system and / or regeneration of mesenchymal tissues which have been damaged through acute injury, abnormal genetic expression or acquired disease. In addition, relates to the impact of LLONC (Long-lasting Oligonucleotide Conjugates) inoculation, having biologically active oligonucleotides (phosphodiester or partially / fully phosphorothioated) with various dianophore modifications.

The invention belongs to the technical field of medical instruments, and provides a wearable magnetic guide lung targeted therapy vest aiming at the problems that a current lung disease targeted therapy method cannot cover diseases without clear targets, is lack of universality and has no capability of actively orienting a drug to a certain organ or part to migrate, and the wearable magnetic guide lung targeted therapy vest comprises a therapy vest body, the treatment vest body is in a waistcoat shape, a plurality of flexible magnetic pole pieces are movably arranged in the treatment vest body at intervals in the circumferential direction, and the flexible magnetic pole pieces form a cylindrical Halbach array structure. The magnetic field array is designed based on the lung anatomical features, can cover the double-lung alveolar area, is suitable for various scenes such as chronic lung diseases and acute injuries, and expands the targeting range and universality; in addition, directional migration and local high-concentration enrichment of drugs / cells are achieved through magnetic field guidance, the whole-body exposure amount is reduced, the treatment effect can be achieved under the low dosage, and the side effect risk is remarkably reduced.

A novel temporary knee-splint is disclosed herein. The invention provides an apparatus to immobilize a knee joint following an acute injury in order to maintain the stability of the knee. The knee-splint allows for a variable angle of knee flexion in order to increase comfort. The preferred embodiment of the knee-splint is formed from a thermoplastic polymer and is secured when in use via straps having a hook and loop arrangement. Anchor bars, also secured by the same straps, are used to maintain the desired angle of knee flexion when in use.

This invention discloses an adaptive drug delivery system for ischemic stroke, its preparation method, and its application. MMP-2 responsive peptide-drug dimers are loaded onto the surface of mesoporous polydopamine for intervention or treatment of cerebral ischemia-reperfusion injury. The system allows for targeted drug delivery based on individual differences in disease progression among patients, precisely promoting brain injury repair. This invention applies MMP-2 responsive peptides to the treatment of ischemic stroke, using mesoporous polydopamine as a drug carrier, providing reactive sites and loading space for efficient drug loading. The chemical reaction between catechol on the polydopamine surface and the thiol groups on the MMP-2 responsive peptides loads the peptide-drug dimers, thereby achieving responsive drug release on the carrier surface. Simultaneously, this invention utilizes the ability of polydopamine to scavenge reactive oxygen species (ROS), rapidly clearing local ROS and reducing acute damage caused by ischemic stroke.

The invention provides an application of a substance for up-regulating the expression level of at least one biomarker in a signal channel of a protease activated receptor 2 (PAR2)-mediated lysosome function in preparation of a composition for one or more of the following: (1) regulating lysosome acidification in a cell; (2) regulating the autophagy function in the cells; (3) regulating autophagosome-lysosome fusion in the cells; (4) the accumulation of reactive oxygen species (ROS) in cells is reduced; (5) reducing the DNA damage level in the cells; (6) reducing the expression level of inflammatory factors in cells; (7) improving or treating acute injury of colitis in the subject; (8) improving or treating the inflammatory bowel disease of the subject; (9) preventing, ameliorating or treating inflammatory cancer transformation in a subject; and (10) preventing, ameliorating or treating colorectal cancer in the subject; wherein the biomarker is selected from PAR2 (Protein Activated Receptor 2), FOXA2 (Forkhead Frame Protein A2) and a lysosome V-type proton pump subunit ATP6V0E1.

The present disclosure relates to compositions and methods of modulating B lymphocyte activity, and organ protection after acute injury. In particular, PEG-Pirfenidone has increased half-life, improved bioavailability and is equipotent in modulating B cell activity and is particularly useful as protective agents from acute organ damage and disease caused by dysregulation of B cell activity.

The invention belongs to the field of biological medicines, and discloses application of nicotinamide mononucleotide in preparation of a medicine for preventing acute kidney injury. Through NMN intervention in the acute stage, the NAD < + > metabolic level and SIRT1 protein expression in the kidney of a mouse can be remarkably improved, inflammatory response is relieved, acute injury of renal tubules is reduced, and therefore acute kidney injury caused by cis-platinum is improved.

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine ointment for treating hyperostosis and soft tissue injury and a preparation method thereof, the traditional Chinese medicine ointment is prepared by combining raw material medicines and auxiliary materials, the raw material medicines comprise knoxia root, lilac daphne flower bud, euphorbia kansui, liquorice and seaweed, and the auxiliary materials comprise oil and yellow lead. According to the external-use analgesic plaster, the euphorbia pekinensis, the lilac daphne flower bud and the euphorbia kansui have a synergistic effect, the effects of softening bone spurs of hyperosteogeny and resolving local phlegm stasis and retardation are remarkable, and compared with a conventional external-use analgesic plaster for hyperosteogeny, the external-use analgesic plaster can improve the hyperplasia state from the pathogenesis level; meanwhile, the formula is superior to a conventional safflower oil preparation in the aspects of absorption of hematoma caused by soft tissue injury and relieving speed and depth of swelling and pain caused by meridian blocking, and the recovery phase of acute injury can be shortened.

The present application aims to develop an animal model which can focus on the core symptoms of acute lung injury and can well evaluate the drug efficacy of acute lung injury. The rat acute lung injury model constructed in the present application shows a high success rate and stability in inducing classic symptoms of acute injury (dyspnea, pulmonary edema and pulmonary fibrosis, etc.), as well as symptoms such as depression, alveolar atrophy, alveolar inflammatory infiltration, and reduced blood oxygen of acute lung injury. In the construction method of the rat acute lung injury model of the present application, the rat acute lung injury model is obtained by intraperitoneal injection of cholic acid and mixed solution of polyethylene glycol and polysorbate + heat stress + silica intake + exercise induction. This non-single factor induced acute lung injury animal model is consistent with the etiology that acute lung injury is induced by multiple factors, and can better simulate the characteristics of human acute lung injury.

The application belongs to the technical field of biomedicine, and discloses a construction method of a mouse model simulating senile osteoarthritis and application thereof, wherein mouse bone marrow cells are induced to differentiate into bone marrow-derived macrophages in vitro, the macrophages are treated with an induction medium containing 100nM doxorubicin for 2 days, and then cultured in a conventional medium for 5 days to obtain senescent macrophages with a stable senescence phenotype; 1x10 6 The senescent macrophages are injected into the knee joint cavity of a mouse once a week for a total of 4 times to induce chronic low-grade inflammation and characteristic osteoarthritis lesions in the joint. The model constructed by the application has high pathological simulation degree, good repeatability, and a modeling cycle of only 4 weeks, thereby reducing the interference of acute injury factors, and can be widely applied to the research on pathogenesis of senile osteoarthritis, screening of therapeutic targets, and evaluation of the efficacy of candidate drugs.

The present application relates to a kind of drugs for treating sports injury and its application, a kind of construction method of tendon injury repair animal model, the treatment sports injury is at least one of acute injury and chronic injury, preferably, the treatment sports injury is the treatment tendon injury, more preferably, the treatment tendon injury is to promote tendon healing and / or inhibit tendon adhesion formation.The advantages of the present application (1) good drug screening effect.(2) the drug screened can prevent and treat tendon adhesion and has less effect on tendon healing.

The invention belongs to the field of biological medicine, and particularly relates to application of hydrophobic modified polypeptide in preparation of a lung-targeted drug delivery system. The technical problem to be solved by the invention is that efficient and accurate lung targeting delivery of drugs is difficult to realize. The technical scheme for solving the technical problem is to provide the hydrophobic modified cationic polypeptide for preparing a lung-targeted drug delivery system or a drug composition. The hydrophobic modified cationic polypeptide as a drug delivery system efficiently delivers siRNA and other drugs to the lung through intravenous injection or aerosol inhalation, inhibits acute lung injury, lung fibrosis and lung tumors, is high in targeting property, low in toxicity, safe and short in preparation period, and has a very good clinical application prospect.

This article provides information on mutant reverse tetracycline transactivator (rtTA) protein and engineered nucleic acids (e.g., viral vectors, including lentiviral vectors, adenovirus vectors, AAV vectors, herpesvirus vectors, and retroviral vectors; and non-viral vectors, including RNA and plasmid DNA) encoding mutant rtTA, which can be used for, for example, regulating gene expression, inducing cell reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, treating diseases (e.g., acute injury, neurodegenerative diseases, chronic diseases, proliferative diseases, cardiovascular diseases, genetic diseases, inflammatory diseases, autoimmune diseases, neurological diseases, hematological diseases, pain conditions, mental disorders, metabolic disorders, cancer, aging, age-related diseases, and diseases affecting any tissue in a subject), or any combination thereof. This article also provides recombinant viruses comprising engineered nucleic acids (e.g., lentiviruses, adenoviruses, alphaviruses, vaccinia viruses, retroviruses, herpesviruses, or AAVs), and methods for modulating (e.g., inhibiting or inducing) cell reprogramming, tissue repair, tissue regeneration, or any combination thereof by applying engineered nucleic acids or recombinant viruses comprising them to cells, tissues, or subjects (e.g., cells or tissues of subjects with a condition, said condition including any disease (e.g., eye disease), aging, neurodegenerative diseases, cancer, and age-related diseases), said application including the application of a mutant rtTA and an inducible nucleic acid encoding a transgene (e.g., engineered nucleic acid, including an expression vector).

The application provides a selenium-rich traditional Chinese medicine composition, an oral liquid and application in prevention of alcoholic acute gastric mucosal injury. The selenium-rich traditional Chinese medicine composition comprises, in mass parts, 25-40 parts of a selenium-treated traditional Chinese medicine, 5-10 parts of cuttlefish bone, 5-10 parts of saussurea costus, 5-10 parts of fructus aurantii, 5-8 parts of modified coptis, 5-10 parts of evodia, 10-15 parts of bletilla striata, 5-10 parts of salvia miltiorrhiza, 10-20 parts of flos paeoniae, 10-20 parts of radix puerariae, 5-15 parts of amomum kravanh, 5-15 parts of litsea cubeba, 10-20 parts of hovenia dulcis thunb, and 10-20 parts of schisandra chinensis. The synergistic design of the selenium-rich traditional Chinese medicine composition achieves preventive protection on alcoholic acute gastric mucosal injury, and provides a new selection for prevention and treatment of alcohol-related gastric mucosal injury.

A method for determining and presenting a recommendation for assisting an interviewee party in a state in need of help solving a problem, such as experiencing a cardiac arrest or an acute injury or disease such as meningitis, during an interview between an inter-viewing party and said interviewee party. The method determines a recommendation as a function of the sound of the interviewee party without an automatic speech recognition routine, i.e. in the processing the sound of the interviewee party is not converted to text (text strings), but instead a feature model is used and the output of that goes direct into a recommendation model.

The invention provides an application of a composite hydrogel loaded with C3G. Specifically, the invention provides an application of the C3G-loaded arabinoxylan / casein hydrogel in preparation of an ophthalmic preparation. The ophthalmic preparation is used for protecting blue light damage of eyes, especially blue light damage of retinal pigment epithelium cells (RPE cells). Experiments prove that the C3G-loaded composite hydrogel can maintain slow release for at least 12 hours, corresponds to an acute injury stage of blue light injury, and effectively improves RPE cell apoptosis and mitochondrial injury caused by blue light through oxidation resistance and inflammation inhibition.