16 results about "Chronic injury" patented technology

The invention discloses a hangover alleviating and liver protecting composition, which is prepared from the following components in parts by mass: 5 to 20 parts of radix puerariae extract, 5 to 20 parts of semen hoveniae extract, 5 to 20 parts of silybum marianum extract, 1 to 20 parts of rhizoma curcumae longae extract, 1 to 20 parts of rhizoma gastrodiae extract, 1 to 10 parts of lucid ganoderma extract, 1 to 20 parts of folium cortex eucommiae extract, 1 to 10 parts of fructus corni extract and 1 to 30 parts of corn oligopeptide powder. 1-50 parts of maltodextrin, 1-10 parts of microcrystalline cellulose, 1-2 parts of silicon dioxide and 1-2 parts of magnesium stearate. The total alcoholism-relieving and liver-protecting composition has the following beneficial effects: for acute drunkenness, the discomfort of drunkenness is obviously reduced, the chronic injury of alcohol to the liver is reduced, the systematic effect from alcohol metabolism to organ protection is realized through multi-target regulation and control, and the three-in-one effect of relieving alcoholism, protecting cells and regulating metabolism is achieved. The invention also discloses a preparation method of the alcohol effect dispelling and liver protecting composition.

The invention provides a construction method of an animal model of chronic low-dose cadmium exposure induced hepatic fibrosis, and provides a research basis for the reason of chronic cadmium exposure induced hepatic fibrosis and the drug efficacy analysis of the chronic cadmium exposure induced hepatic fibrosis. The method simulates a chronic low-dose cadmium exposure condition, is convenient to operate and stable, can help scientific researchers to visually observe the occurrence and development process of chronic liver injury and hepatic fibrosis induced by heavy metal exposure, and can provide a powerful basis for mechanism research of heavy metal poisoning. According to experimental results, in the body shape, living state, liver appearance and liver tissue pathological change process of a mouse, the mouse shows the mouse liver chronic injury and fibrosis change process under the chronic low-dose cadmium exposure environment, the direct relation between the cadmium exposure time and the liver fibrosis progress can be directly obtained, and the obtained animal model is stable. Researchers can create a disease process similar to human diseases through construction of the animal model in the future, the disease process can be quickly simulated, mass copying can be performed in a short time, the research period can be shortened, the animal model can be used for large-scale experimental research, and powerful support is provided for drug research and development and treatment strategies.

The present disclosure is directed to novel therapeutic approaches for the prevention, treatment and / or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of an organ. Specifically disclosed are agents for use in increasing homodimer-formation of ARNT in an organ in the prevention, treatment and / or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of said organ, as further defined in the claims. In embodiments, said agent may be (i) an inhibitor of protein phosphatase 2A (PP2A) activity, (ii) an inhibitor of the transcriptional repressor complex FKBP12 / YY1, or (iii) an expression construct, which is capable of over-expressing ARNT in said organ, as well as combinations of (i), (ii), and / or (iii).

An injury mitigation and prevention support device is provided including flexible support material configured to wrap around a predetermined joint, tendon, ligament, or muscle of a mammal and nitinol elements included in or on the support material, wherein the nitinol elements are configured to be set into an austenite super-elastic phase by a body temperature of the mammal when the support material is wrapped around the joint, tendon, ligament, or muscle and the nitinol elements are located and configured to provide a counteracting force to a force exerted on the joint when the joint, tendon, ligament, or muscle is bent or stretched beyond a normal angle of extension of the joint, tendon, or muscle. As a result, the device acts dynamically and instantaneous with super-elasticity to prevent or minimize acute injury insult, and also acts to continuously to support and reduce fatigue to minimize acute and chronic injury.

This invention discloses a method for monitoring spinal curvature in a smart seat and an in-vehicle health cloud system. The method includes: real-time acquisition of spinal curvature data of an occupant sitting in the seat and vehicle acceleration during vehicle movement; demodulation and curvature reconstruction of the real-time acquired spinal curvature data to obtain a three-dimensional spinal curvature curve of the occupant; and, based on a vibration-posture coupled fatigue algorithm and combined with the real-time acquired vehicle acceleration, determining the risk level of spinal injury to the occupant during vehicle movement; and triggering an intervention strategy corresponding to the risk level. This invention constructs a three-dimensional spinal curvature curve based on the occupant's spinal curvature data, accurately identifies the occupant's sitting posture, and, combined with vehicle acceleration during vehicle movement, calculates the cumulative fatigue caused by the superposition of vehicle vibration and poor posture in real time. This effectively identifies the risk of chronic injury caused by the long-term superposition of vehicle vibration and poor posture, achieving accurate predictive risk assessment before pain occurs.

The utility model discloses an elbow supporting device capable of relieving chronic injury of a sonographer, which comprises a sickbed, a self-adaptive embedding and fixing device capable of sliding in an embedding manner is arranged on the side wall of the sickbed, and a supporting structure capable of relieving elbow fatigue and used for placing an arm is arranged on the self-adaptive embedding and fixing device. The utility model belongs to the technical field of elbow supporting equipment. The utility model provides an elbow supporting device for relieving chronic injury of an ultrasonography doctor in order to not influence a patient to get on and off a detection bed, ensure that the elbow of the doctor is effectively supported and further facilitate the doctor to move the position of the elbow along the bed edge according to detection requirements. The fixing effect of the elbow supporting equipment on the edge of a sickbed is achieved through the clamping structure, the equipment can horizontally slide along the edge of the sickbed and can be conveniently detached from the edge of the sickbed, the elbow supporting equipment can be installed on the sickbed according to needs, the elbow supporting effect of a doctor is guaranteed, and the effect that a patient gets on and gets off the sickbed is not affected.

The invention discloses a spine curvature monitoring method of an intelligent seat and a vehicle-mounted health cloud system. The method comprises the steps that spine curvature data of a passenger sitting on the seat and vehicle acceleration in the vehicle running process are collected in real time; demodulation and curvature reconstruction are conducted on spine curvature data collected in real time, and a spine three-dimensional curvature curve of the passenger is obtained; in combination with the vehicle acceleration collected in real time, based on a vibration-posture coupling fatigue algorithm, the risk level of injury to the spine of the passenger in the vehicle driving process is judged; and triggering an intervention strategy corresponding to the risk level. The spine three-dimensional curvature curve is constructed according to the spine curvature data of the passenger, the sitting posture of the passenger is accurately recognized, the vehicle acceleration in the vehicle driving process is combined, and the accumulated fatigue generated by superposition of vehicle vibration and the bad sitting posture is calculated in real time; the chronic injury risk caused by long-term superposition of vehicle vibration and poor sitting postures is effectively recognized, and accurate predictive risk judgment before pain occurs is achieved.

The utility model discloses a semi-automatic carton sealing machine for paper extraction, which relates to the technical field of paper extraction carton sealing and comprises a base, a limit block and a carton sealing machine head, the limit block is arranged above the base, the carton sealing machine head is arranged at the bottom of the limit block, a positioning component for positioning a paper extraction box is arranged on the base, and the carton sealing machine head is arranged at the bottom of the limit block. A supporting assembly for supporting the base is arranged at the bottom of the base, and an adjusting assembly is arranged on the supporting assembly. By means of the positioning assembly arranged on the base, the effect that a paper extraction box can be located at the center position is achieved, the situations that when the paper extraction box is sealed, box sealing is not correct and not firm, and cracking occurs in the transportation process are avoided, the effect of adjusting the height of the base is achieved through the supporting assembly and the adjusting assembly, and the paper extraction box is convenient to use. The device can adapt to operators with different heights, and the situation that muscle fatigue, arthralgia and even chronic injury are caused by the fact that the operators keep unnatural postures for a long time is avoided.

The present invention discloses a TRADD inhibitor derivative, its preparation method, and application. The general structural formula of the TRADD inhibitor derivative is: #imgabs0#. Based on structural biology, the present invention designs and obtains a series of TRADD inhibitor derivatives with high biological activity. The TRADD inhibitors provided by the present invention have similar activity to commercially available TNF-α biological inhibitors, but exhibit significantly lower adverse reactions, improved safety, and lower cost. Overall, they are superior to TNF-α biological inhibitors and can be used to treat acute and chronic kidney damage, with broad clinical application prospects.

1. The name of the design product: bone curet. 2. The use of the design product: for treating chronic injury and pain of soft tissue such as muscle, fascia, ligament, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A use of a drug which removes IgG / IgM antibodies or B cells. IgG antibodies or B cells are removed via the drug, antibody aggregation is reduced, and muscle fibers can gradually change from a state of chronic injury to a state of promoting healing. By means of construction of an animal model, the drug which removes IgG antibodies or B cells is found to effectively reduce muscle injury, inflammation, and fibrosis levels in Duchenne muscular dystrophy mice, improve muscle strength, and to have no obvious side effects. Therefore, targeting B cells and antibody aggregation via the drug which removes antibodies or B cells can be used as a new method for treating incurable DMD.

1. The name of the design product: desktop shock wave therapy instrument. 2. The use of the design product: for the treatment of human bone tissue diseases, soft tissue chronic injury and other diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

From traditional Chinese medicine, the human tissue due to the formation of chronic injury because of fatigue and external force injury, through the knocking of human body related acupoints and specific parts, can achieve the treatment, reduce pain, blood circulation, rapid recovery and fitness effect. The principle of the present application (see figure 3 and figure 4) is that the electromagnet coil is under the action of electric pulse, the magnet core is attracted by magnetic closed loop and generates impact force, and then the force is transmitted to the human body acupoint and specific part through a spherical surface. The present application uses microprocessor and its programming software, changes the speed and force in the form of voice by changing the frequency square wave and duty cycle, to adapt to different diseases and people.

1. The name of the design product: trolley type shock wave therapeutic instrument. 2. The use of the design product: for treating human bone tissue diseases, soft tissue chronic injury and other diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The present application relates to a kind of drugs for treating sports injury and its application, a kind of construction method of tendon injury repair animal model, the treatment sports injury is at least one of acute injury and chronic injury, preferably, the treatment sports injury is the treatment tendon injury, more preferably, the treatment tendon injury is to promote tendon healing and / or inhibit tendon adhesion formation.The advantages of the present application (1) good drug screening effect.(2) the drug screened can prevent and treat tendon adhesion and has less effect on tendon healing.

The invention relates to a simulated vein network chip-based renal tubule and peripheral microenvironment simulation system and a construction method and application thereof. The system comprises a simulated vein network micro-fluidic chip, immortalized human proximal renal tubule epithelial cells, human umbilical vein endothelial cells and a cell culture medium, the method comprises the following steps: respectively pouring cell suspensions of immortalized human near-end renal tubular epithelial cells and immortalized human near-end renal tubular epithelial cells and human umbilical vein endothelial cells into a chip, and continuously injecting a cell culture medium to simulate an in-vivo liquid flowing microenvironment after the cells are adhered to the wall, so as to obtain a corresponding simulation system; the system can effectively simulate close cell interaction and signal communication between a renal tubule and a peripheral capillary in a dynamic fluid environment, and provides a high-fidelity in-vitro research tool for renal tubule physiological mechanism research, chronic injury pathological change analysis and a hereditary nephropathy model; meanwhile, the method can also be used for evaluating the kidney clearance rate characteristic and the kidney toxicity risk of the medicine.