75 results about "Chronic injury" patented technology

An apparatus and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.

A system and method for detecting swallowing activity is provided. In an embodiment, a method includes receiving an electronic signal from an acceleronic signal from an accelerometer that represents swallowing activity, extracting at least two features from the signal, classifying the signal as a type of swallowing activity based on the extracted features, and generating an output of the classification. Exemplary activities include swallows, aspirations, movement and vocal artifacts. By indicating whether an activity is a swallow or an aspiration, the manner in which a patient afflicted with an increased likelihood for aspirations is fed can be adjusted to increase the likelihood of achieving a swallow instead of an aspiration during feeding. In turn this could reduce hospitalizations for aspiration pneumonia in patients with acute or chronic injury.

The present invention relates to novel inhibitors of p21. These inhibitors are useful as therapeutic agents for promot ing cell regeneration and in the treatment of cancer. Improvement of cell regeneration is particularly desirable in patients of old age or in patients suffering from chronic diseases, acute or chronic injuries.

The invention relates the congenital heart disease plugging device, comprising the bevel support 1 and polyester fibre 2. The bevel support 1 is weaved by the nickel-cemented tantalum carbide, and the diameter of 1 is between 0.002-0.003 inch, the 1 is filled with 2, and around the metal wire of 1 there is polydactyl acid, silica gel, polyurethane or other degradable consistency high polymer materials. The invention has the advantages of reducing heavy metal toxicity, low vessel chronic injury and mechanical stimulation, and safety.

The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.

Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.

The invention relates to the field of drugs, in particular to an external-use drug for treating pain in waist and lower extremities, a process and application. The external-use drug is prepared from radix clematidis, rhizoma et radix notopterygii, radix angelicae pubescentis, rhizoma curcumae, radix notoginseng, radix aconiti, radix aconiti kusnezoffii, black pepper, radix angelicae dahuricae, herb of tuberculate speranskia, frankincense, myrrh, unprocessed rhizoma pinelliae, unprocessed arisaema cum bile, herbal asari, rhizoma drynariae, radix dipsaci, semen strychni, sophorra flavescens, cortex dictamni and fructus kochiae. The external-use drug can efficiently and rapidly treat cervical spondylosis, protrusion of lumbar intervertebral disc, lumbar muscle degeneration, chronic injury diseases and multiple kinds of internal and external rheumatic arthritis, and is wide in disease adaptation range.

Belonging to the pharmaceutical field, the invention relates to application of nicotinamide phosphoribosyltransferase (NAMPT) in preparation of neuroprotective and rehabilitation drugs. Experiments of the invention show that NAMPT recombinant protein can penetrate the blood-brain barrier to significantly reduce the volume of ischemic brain injury and alleviate white matter injury after ischemic brain injury; the NAMPT recombinant protein can significantly improve long-term behaviors after ischemic brain injury; the NAMPT recombinant protein can raise revascularization related factors to enhance revascularization after brain hypoxia and neuron regeneration after brain hypoxia, and promote post-injury neurologic function reestablishment; and by mediating oligodendrocyte regeneration and alleviating the demyelination effect of local lysolecithin, the NAMPT recombinant protein can promote restoration of white matter after injury and strengthen post-injury neurologic function reestablishment. Results show that the NAMPT recombinant protein plays a long-term neuroprotective role in drugs treating cerebral stroke, traumatic brain injury and multiple sclerosis, and can be used as a neuroprotective drug to treat acute and chronic injury caused by brain stroke.

Compositions for topical application based on natural products, specifically dried pulverized plants suspended in bees honey, in which the ingredients are combined in proportions predetermined to provide three different types of preparations to be applied at various stages of repair and regeneration of injured tissues. The application of the compositions shortens the stages of healing in the treatment of acute and chronic injuries of any degree of depth and breadth, and of any etiology.

The properties of the preparations include an hemorheological and systemic vascular activity which extends for a certain period even after the end of topical treatment.

The invention provides a pharmaceutical composition for treating or preventing nerve damage. The pharmaceutical composition comprises the following components: asiaticoside, an Aloe vera extract, a sweetsop seed extract, a leontopodium alpinum extract, and a vascular endothelial growth factor (VEGF). The pharmaceutical composition of the invention is useful for inducing neurite outgrowth, for promoting stem cell function, and/or for promoting functional recovery and enhancing synapse formation and synaptic plasticity in damaged and/or injured neurons in acute and chronic injury, and can significantly alleviate impaired sciatic nerve function, increase nerve conduction velocity, increase axon count, and repair axons. Clinical studies show that the pharmaceutical composition of the inventioncan improve muscle strength, accelerate repair of damaged nerve tissue, and improve nerve tissue transmission and metabolic disorders in patients with peripheral nerve injury.

The invention discloses an external application type traditional Chinese medicine and an application method thereof. The external application type traditional Chinese medicine is prepared from the following medicines in parts by mass: 3 to 8 parts of flos caryophylli, 2 to 10 parts of cortex cinnamomi, 2 to 10 parts of fennel, 2 to 10 parts of rhizoma zingiberis recens, 1 to 10 parts of rhizoma zingiberis, 2 to 10 parts of fructus chaenomelis, 2 to 10 parts of semen sinapis albae, 2 to 10 parts of rhizoma polygonati, 2 to 10 parts of fructus mume, 3 to 8 parts of fructus cannabis, 1 to 3 partsof semen pruni, 3 to 8 parts of Chinese prickly ash, 3 to 8 parts of fructus alpiniae oxyphyllae, 1 to 2 parts of semen persicae, 2 to 10 parts of radix angelicae dahuricae, 2 to 8 parts of orange peel and 2 to 10 parts of raspberry fruit. The external application type traditional Chinese medicine can be used for improving the body immunity, has health-maintenance and health-care functions, has the effects of strengthening muscles and bones and warming waist and knees and has prevention and health-care effects on back pain, lumbar disc herniation, bone spur, belly flatulence, irregular menstruation, dysmenorrhea, cold wombs, pelvic inflammation, appendagitis, osteoproliferation, knee aching and limp, knee crymodynia and sounds, dropsy, pains, ache and swelling, numbness, synovitis, meniscus injuries, gonitis, knee chronic injuries, sciatica and the like.

The invention belongs to the field of medical technology, and relates to an application of n-3 unsaturated fatty acid in preparation of a medicine for preventing and treating traumatic brain injury. The experimental results about the function of n-3PUFAs (polyunsaturated fatty acids) in resisting traumatic brain injury show that the n-3 unsaturated fatty acid can remarkably improve sense and motor functions of a mice after traumatic brain injury, slightly reduces the deletion of brain tissue after injury, inhibits the inflammatory response from excessive activation, promotes the repair of white matter damage, obviously reduces the degeneration and necrosis of nerve cells of CA3 area of hippocampus, and improves the study and memory functions. The n-3PUFAs has a definite neuroprotective effect in resisting brain injury, can be used for preparing nerve protective medicines, and can be used for preventing and treating acute or chronic injury caused by the traumatic brain injury.