145 results about "Silybum" patented technology

The invention relates to a novel process for the isolation of a hepatoprotective agent Silymarin from the seeds of the plant Silybum marianum comprising (i) Precooling the seeds to (-) 20° C. for 24 hours in a deep freezer / cold room. (ii) Powdering the cooled seeds in a hammer mill, fitted with about 40 mesh discharge screen. (iii) Defatting the seeds by extracting with hexane in a soxhlet type extractor to remove the total quantity of fatty oil without using a scrain. (iv) Extracting the defatted seeds with acetonitrile at 20-30° C. to extract silymarin fraction. (v) Concentration of the sensitive silymarin fraction under vacuum in a agitated wiped thin film evaporator (vi) stirring the silymarin such dry powder with cold dichloromethane at 5° C. followed by filtration and drying with a slow purge of nitrogen gas. (vii) Further purification of silymarin by suspending in 5 times its weight of acetonitrile and precipitating by 8-12 times its weight of water at 20° C. (viii) Filtering the precipitated silymarin in a closed vacuum filter and having 1-2 mum screen washing the cake three times with distilled water (ix) Drying of Silymarin cake in vacuum oven to obtain substantially pure silymarin.

The invention discloses a Chinese herbal medicine health oral liquid with an efficacy of relieving visual fatigue. 1,000 parts of health oral liquid comprise the following Chinese herbal medicine materials in parts by weight: 5-10 parts of ginseng, 10-15 parts of semen cuscutae, 8-12 parts of rhodiola rosea, 10-15 parts of polygonum multiflorum, 15-20 parts of manyprickle acanthopanax root, 10-13 parts of mulberry, 8-12 parts of dried radix rehmanniae, 10-15 parts of radix ophiopogonis, 10-16 parts of wolfberry, 10-18 parts of herba epimedii, 15-20 parts of semen cassia, 10-15 parts of chrysanthemum, 12-18 parts of honeysuckle, 10-15 parts of houttuynia cordata, 8-12 parts of angelica sinensis, 5-10 parts of silybum marianum, 5-10 parts of mulberry leaves, 10-15 parts of glossy privet fruit, 10-15 parts of rhizoma atractylodis macrocephalae and 10-15 parts of stevia rebaudiana. The Chinese herbal medicine health oral liquid is prepared by an ultrasonic wave-assisted extraction technology, a volatile oil distillation technology, a decoction technology and an alcohol extraction technology. The Chinese herbal medicine health oral liquid has the advantages of being good in visual fatigue relieving efficacy, safe, free of side effects, convenient to drink and the like.

Disclosed is a topical skin cleanser comprising Silybum marianum fruit extract, Momordica grosvenorii fruit extract, and a cosmetic vehicle comprising at least 50% by weight of the composition of water and disodium EDTA, glycerin, phenoxyethanol, triethanolamine, 3-Iodo-2-propynyl butyl carbamate, and benzyl alcohol.

The present invention relates to the use of silymarin, or of the main constituents thereof alone or as a mixture, chosen from silybin (or 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine), isosilybin, silydianin, silychristin, silandrin, silymonin and taxifolin, isolated enantiomers thereof and also salts thereof, for the manufacture of compositions for inducing, restoring or stimulating pigmentation of the skin, body hair or head hair. The invention also relates to the use of these agents for the manufacture of compositions for preserving the integrity of the hair, for limiting its loss and for stimulating hair regrowth. Silymarin or the constituents thereof alone or as a mixture are obtained by extraction of a plant of the genus Silybum.

The invention relates to a method for producing a bio-protein feedstuff through solid-state fermentation of a dreg which is a silybum marianum dreg. The invention belongs to the technical field of solid-state fermented bio-protein feedstuffs. According to the invention, a mixed microbial agent composed of microbial strains of aspergillus niger and candida tropicalis is adopted. Certain amounts of urea, glucose and potassium dihydrogen phosphate are added into silybum marianum dreg, bran, and corn flour with a certain ratio, and the materials are mixed, such that a solid-state fermentation culture medium is obtained; fermentation is carried out for 48-120h under a temperature of 28-32 DEG C; the material is dried, and a bio-protein feedstuff is obtained. Crude protein content in the protein feedstuff can reach 42%, such that the feedstuff can be applied as an animal culturing protein feedstuff, and can be used for replacing fish meal, meat-bone meal, soybean meal, and the like. The preparation method is simple, and the cost is low. With the method, large-scale productions can be realized. The invention also provides a novel approach for high-efficiency comprehensive utilizations of silybum marianum resources.

The present invention discloses a kind of flavone composition with the function of reducing the body damage caused by excessive indigestion of alcohol obviously, and the composition consists of pueraria flavonid and silybum marianum flavone. Research shows that pueraria flavonid and silybum marianum flavone have obvious cooperative effects of resisting oxidation, protecting liver and promoting elimination of alcohol in body. The present invention also discloses the application of the composition in health food and medicine.

The invention relates to a Chinese medicinal composition for preventing alcoholic liver injury, which comprises the following components in part by mass: 3 to 30 parts of cordyceps militaris polysaccharide, 1 to 3 parts of ganoderma lucidum polysaccharide and 1 to 3 parts of silybum marianum extract. The Chinese medicinal composition comprises polysaccharide ingredients and water extract of silybum marianum, which have the advantages of good dissolubility, quick disintegration and good adsorption in gastrointestinal tracts and high bioavailability. For adults, 0.48 gram of Chinese medicinal composition can enhance certain immunity and have the auxiliary protection effect on the alcoholic liver injury.

The invention relates to biodiesel prepared by non-edible vegetable oil and a method thereof, which belong to the biodiesel field. By-product milk thistle oil produced during the production process of Silibinin serves as a raw material for preparing the biodiesel. The biodiesel is obtained by transesterification of the milk thistle oil and methyl alcohol under the condition of a catalyst. Gas chromatography-mass spectrometry analysis results show that main components of the biodiesel prepared by the milk thistle oil serving as the raw material are methyl oleate and methyl linoleate. The biodiesel is high in cetane number, excellent in performance and capable of meeting China current biodiesel standard. In addition, the biodiesel is simple in process, mild in reaction condition, low in cost and capable of achieving large-scale production.

The invention discloses duck feed containing ramie root and a production method thereof. The duck feed comprises the following raw materials in parts by weight: maize, wheat bran, bean pulp, buckwheat, soybean protein powder, silkworm chrysalis, vinegar residue, euphorbia thymifolia, silybum marianum, cowherb seed, eclipta, rhodiola sachalinensis, salvia prionitis, gynostemma pentaphylla, the ramie root, sweet potato leaf, elaeagnus pungens, fried barley, salt, a premix compound, rose essence essential oil, ferrous sulfate, lysine, threonine, a probiotic preparation and choline. According to a formula of the duck feed, the buckwheat, the soybean protein powder, the silkworm chrysalis and the vinegar residue are high in nutrient content and can be used for improving the growth state of ducks and the quality of duck meat; the eclipta, the gynostemma pentaphylla and the elaeagnus pungens can be used for enabling the duck body to be strong, improving the resistance to diseases and reducing the occurrence rate of duck diseases; the euphorbia thymifolia and the ramie root have the effect of removing endotoxin and can be used for reducing the infection probability of duck diseases; and the whole formula is scientific and reasonable.

The invention discloses a milk thistle seed hulling and hull and kernel separating method. The milk thistle seed hulling and hull and kernel separating method comprises the steps of removing impurities mixed in milk thistle seeds, feeding the milk thistle seeds without impurities into a hulling machine, enabling damage cracks to be gradually accumulated in the seeds through multiple short-range centrifugal throwing and achieving low-smashing-rate hulling. Hulled materials are separated into kernels, hulls and seeds containing broken matter and a little amount of kernel mixtures by a gravity sieve. The mixture portions are respectively separated into the hulls, the kernels and a seed and kernel mixture by an efficient wind power separating machine. Separated hulls and kernels are respectively used for pharmaceuticals and pharmaceutical application, the separated seed and kernel mixture is separated into seeds and kernels containing a little amount of small-grain-size seeds by a bag pit type roller classificatory, the separated seeds return to the hulling machine to be subjected to hulling treatment, the separated kernels containing the little amount of small-grain-size seeds flow back to the gravity sieve to obtain kernels again, and accordingly hulling of the milk thistle seeds and complete separation and recovery of the hulls and the kernels are achieved.

The invention discloses a method for refining silybum marianum seed oil by enzymic-method degumming and relates to the technical field of oil refining. The method includes the following steps: squeezing or leaching silybum marianum seeds to prepare silybum marianum seed oil, utilizing the principle that suspension impurities and oil have different densities to separate the impurities and the oil under the standing state or placing the silybum marianum seed oil into a 50 DEG C drying box for 1h, filtering to prepare crude oil, degumming the silybum marianum seed oil through phospholipase and conducting deacidification, decoloration and deodorization to obtain the refined silybum marianum seed oil. The enzymic-method degumming method adopts key technology for refining of the silybum marianum seed oil, remarkably reduces phospholipid content in the degummed silybum marianum seed oil, and is high in degumming efficiency, mild in reaction condition, low in energy consumption and easy to control. Silica gel is utilized as adsorbent to conduct decoloration and deodorization processing, high temperature vacuum decoloration and high temperature vacuum deodorization processing in the prior art are avoided, loss of effective components in the silybum marianum seed oil is reduced, and process flow is shortened.

The invention relates to a Chinese medicament for treating hepatitis B which is prepared from astragalus root, pilose asiabell root, white atractylodes rhizome, poria cocos, artemisia capillaris thumb, rhubarb horsetails, giant knotweed rhizome, amomum fruit, Chinese angelica root, flavescent sophora root, hairy deerhorn, root of red rooted saliva, paris rhizome, schisandra fruit, capsule of weeping forsythia, subprostrate sophora root, oldenlandia, barbat skullcap, Bupleurum root, silybum mariamum, Xuanju, creeping euphorbia, polyporus umbellatus, turtle shell, jordonet snyder, epimeddium, wolferry fruit, cornus officinalis, ganoderma lucidum, cantharis, grub, notoginseng, buthus martensi karsch, wasp's nest and licorice root.

The invention discloses a radiation-resistant milk vinegar green tea healthcare beverage and aims at the current situation that electromagnetic radiation is serious increasingly. Milk, green tea and Chinese herbal medicines such as silybum marianum, dendrobium nobile and polygonum aviculare serve as raw materials. A two-stage type production process of digesting the green tea, fermenting the green tea and healthcare vinegar and synchronously performing microbial fermentation and extraction is adopted, and solid-liquid fermentation and acetic fermentation processes are also adopted. The produced milk vinegar green tea healthcare beverage has the effects of resisting radiation, engendering liquid to allay thirst, tonifying middle-Jiao and Qi, reducing blood fat, reducing blood pressure, reducing blood glucose, enhancing immunity, resisting fatigue and the like, so that the multi-level demands of consumers for healthcare, influence, taste and the like are met. The color of the beverage is reddish brown; the beverage tastes sour, sweet, soft, cool, smooth and mellow; the juice is clear, bright and free from impurities; the composite fragrance of the green tea and medlar is retained, and the beverage has flavor substances such as acids and esters generated by microbial fermentation, has the advantages of good healthcare effect, short production time, low labor intensity, excellent flavor, low production cost and facilitation to industrial production.

Dispersive silybum marianum with obviously raised bioavailability is prepared by combining sold dispersing technology and particle technology and adopting dispersive tablet as carrier. Compared with available technology, the present invention has fast disintegration, fast seepage, high bioavailability and effectively raised clinical treating effect. After mixing with water, the dispersive silybum marianum tablet can disintegrate into suspension, so that it is convenient in taking, especially for aged people and children in patients.

The invention provides a production method of high-purity silibinin. Silybum marianum seed is used as a raw material according to the method. The method comprises the steps of husking silybum marianum seeds, extracting by using an organic solvent aqueous solution, carrying out reduced-pressure concentration for recovering the solvent, diluting with water, removing precipitate, absorbing by using gel-type hydrogen bond adsorbent resin, washing for removing impurities, desorbing through a high-concentration organic solvent aqueous solution, decolorizing the desorption solution, concentrating and crystallizing the solution, recrystallizing and drying the solution to obtain a high-purity silibinin product, wherein the content of silibinin is more than 95%. The product is applicable to development of healthcare products, functional food and medicines. The method has the advantages that the product has high purity and stable quality and is free of residue of toxic and harmful solvent; the process is simple, convenient and rapid, and production cost is low; no toxic organic solvent is used in the processes; the production process is safe and environment-friendly.

The present invention relates to a botanical drug or dietary supplement for use in the treatment of patients suffering from Hepatitis C virus infection. More particularly, it relates to a botanical drug consisting essentially of four botanical drug substances, optionally formulated with excipients, for use either in alleviating the symptoms of Hepatitis, particularly chronic Hepatitis C, and / or inhibiting the activity of the causative Hepatitis C virus. The botanical raw -materials, botanical drug substances or botanical ingredients used are from a species of each of the genera: (a) Silybum; (b) Astragalus or Hedysarum; (c) Salvia; and (d) Schisandra.

The present invention relates to further medical uses for a botanical drug or dietary supplement consisting essentially of four botanical drug substances, optionally formulated with excipients. The botanical raw materials, botanical drug substances or botanical ingredients used are from a species of each of the genera: (a) Silybum; (b) Astragalus or Hedysarum; (c) Salvia; and (d) Schisandra.

The invention relates to a microorganism fermentation filtrate, and the application thereof to degradation of pesticide residues in soil. According to the microorganism fermentation filtrate and the application thereof, by treating a silybum marianum shell with cellulase and adding active dry yeast, the microorganism fermentation filtrate which can be used for degrading the pesticide residues in the soil effectively is obtained; and the obtained microorganism fermentation filtrate can be used for not only degrading organophosphorus and pyrethroid pesticides in the soil effectively, but also replacing common NPK compound fertilizer as well as promoting the growth of crops.

The present invention relates to a kind of instant noodles and the production process. The instant noodles are produced with flour 45-60 wt%, water 12-21 wt%, the horse radish tree leaf and silybum mariamum fruit extract 15-25 wt%, and food additive. Of the horse radish tree leaf and silybum mariamum fruit extract, the horse radish tree leaf extract accounts for 0-99 wt% and the silybum mariamum fruit extract 1-100 wt%. The instant noodles of the present invention have obviously higher nutritive and health functions compared with common instant noodles. The instant noodles of the present invention can provide human body with calcium for strengthening bone and preventing osteoporosis.

The invention relates to the field of application of plant products, particularly an optimized scheme for comprehensively utilizing silybum mariamum. The invention solves the problems of poor comprehensive utilization effect of silybum mariamum, complex technique, high organic solvent consumption, low production efficiency, great potential safety hazard and the like, breaks through the restriction of the existing technical field; and the scheme of oil pressing after drying seeds extracted by ethanol simplifies the technique, enhances the production efficiency, improves the product quality, and is suitable for popularization.

The invention relates to a preparation method for extracting high-purity silymarin from silybum marianum seed husk. The preparation method comprises the following steps: separating silybum marianum seeds from seed husk, radiating by ultraviolet, carrying out the enzymolysis, extracting by absolute ethyl alcohol, volatilizing a solvent in an extracting solution, and washing solids to obtain a silymarin crude product; dissolving in absolute ethyl alcohol, obtaining supernatant, treating by adopting the reversed phase partition chromatography, carrying out the gradient elution by using water-ethyl alcohol, collecting eluate of the absolute ethyl alcohol part, concentrating the eluate, and vacuum-drying by virtue of microwaves to obtain a product. The method is simple in process, high in production efficiency and simple to operate, the product purity can reach up to 93 percent or more, and basically no solvent remains.

The invention provides a traditional Chinese medicine composition for treating acute sinusitis and a preparation method thereof. The traditional Chinese medicine composition comprises an oral medicine and an external-use medicine. The oral medicine comprises the following raw materials: fortune eupatorium herb, Chinese angelica, biond magnolia flower, manchurian wildginger, long pepper, small centipeda herb, Siberian cocklour fruit, honeysuckle flower, suberect spatholobus stem, lilac pink herb, ginseng leaves, astragalus root, coptis, gentian root, lycium berry, pueraria root, arctium fruit, prunella spike, feather cockscomb seeds, radix liriopes, dendrobium, silybum marianum, rhizoma polygonati, radix acanthopanacis senticosi and licorice root; and the external-use medicine comprises the following raw materials: the biond magnolia flower, the manchurian wildginger, the long pepper, the small centipeda herb, the Siberian cocklour fruit, perilla leaves, mint, ephedra, lygodium spore, ligusticum root, Yuzhou uniflower swisscentaury root, achyranthes root, cowherb seeds, folium ilicis purpurea, radix bupleuri, cornu bubali, Japanese ampelopsis root, coptis, akebia fruit, tangerine peel, musk and the licorice root. The traditional Chinese medicine composition has the advantages that the efficiency for treating the acute sinusitis is high, the time of taking effect is faster, the pain of a patient can be quickly relieved within a short time, the cure rate is high, and the recurrence rate is low.

The invention provides a quality controlling method of medicinal preparation for treating liver and kidney diseases, wherein the preparation is prepared from the following raw materials (by weight percent): silybum mariamum 13.6-40.9%, Wurenchun extract 59.1-86.4%. The preparation can be made into the dosage forms of capsules, drop pills or dispersant tablets.

The invention discloses a Chinese herbal medicine health oral solution with the radiation resistance function. The Chinese herbal medicine healthoral solution is prepared by the compatibility of Chinese herbal medicines such as silybum marianum, dendrobium nobile, rhodiola rosea, astragalus, spina date seed, buddleja officinalis, rehmannia root, gardenia, lycium barbarum, epimedium herb, jasmine, chrysanthemum, cistanche deserticola, houttuynia cordata, green tea, coix seed, rhizoma anemarrhenae, glossy privet fruit, ligusticum wallichii and polygonum aviculare, a formula is optimized, and a process of decocting the medicines with water, extracting alcohol and distilling volatile oil is adopted. The Chinese herbal medicine healthcare oral solution has the advantages as follows: firstly, by virtue of the scientific compatibility of various Chinese herbal medicines, the injury to a human body caused by electromagnetic radiation can be effectively resisted, and the immunity function of the human body and the anti-aging effect are improved; secondly, the combined process of decocting the medicines with the water, extracting the alcohol and distilling the volatile oil is adopted in the preparation process of the oral solution, functional active ingredients for resisting the electromagnetic radiation in the Chinese herbal medicines are fully mixed, and the treatment effect is improved; thirdly, the oral solution is safe, free from side effects and convenient to drink.

A quality control method for the medicine 'Dangfeiliganning' includes such areas as testing its characters, examining its appearance, thin-layer chromatographic determination of silibinin, oleanolic acid and gentiopicroside, and measuring the contents of silibinin and gentiopicroside.

The invention discloses an anti-allergic composition, which comprises the following ingredients (by weight): 0.5-20 parts of a silybum marianum ethanol extract used for inhibiting generation of inflammatory cytokines, 0.5-20 parts of ocimum sanctum leaf ethanol extract used for inhibiting generation of inflammatory cytokines, 15-45 parts of an upland cotton water extract used for improving DNA repair, and 25-40 parts of a mushroom ethanol extract used for moisturizing the skin and accelerating skin barrier repair. The invention has the following technical effect: the product can well relieve the allergic parts and enhance the skin barrier effect. The invention also provides an anti-allergic compound preparation and a preparation method thereof.

The invention discloses an obstetrics and gynecology drug for treating endocrine dyscrasia and a preparation method thereof. The obstetrics and gynecology drug for treating endocrine dyscrasia is prepared from the following materials of dahurian patrinia herb, coix seeds, fructus meliae toosendan, Chinese thorowax roots, radix scutellariae, red paeony roots, dried tangerine or orange peel, pilose asiabell roots, turmeric root-tuber, Chinese angelica, white paeony roots, costus roots, Sichuan lovage rhizome, Chinese magnoliavine fruit, virgate wormwood herb, safflowers, chrysanthemum, Chinese dates, glossy privet fruit, milkvetch roots, common selfheal fruit-spike, royal jelly, eucommia barks, angelica roots, lotus leaves, platycladi seeds, holy thistle, sessile stemona roots, seaweed, frankincense, fructus liquidambaris, cape jasmine fruits, herba violae, immature tangerine peel, Chinese honeylocust spine, dwarf lilyturf tuber, manchurian wild ginger, radix aconiti preparata, pinellia ternate and ginseng. The obstetrics and gynecology drug for treating endocrine dyscrasia has the advantages of being obvious in curative effect and few in side effects.

The invention belongs to the field of foods or health-care products, and particularly relates to a food composition having the health-care effects of protecting the liver and neutralizing the effect of alcoholic drinks. The components of the food composition comprise substances of silybum marianum seeds, cortex eucommiae male flowers, dandelions, hoveniae semoveniae semen, roselle, hyriopsis cumingii polysaccharide and the like. Through extraction of effective components, mixing and drying, paste is made and can be eaten. A food made from the food composition having the health-care effects ofprotecting the liver and neutralizing the effect of alcoholic drinks provided by the invention utilizes the advantage of each component, on one hand, through mutual synergistic reaction of the components, the food has the effects of neutralizing the effect of alcoholic drinks, removing toxicity and protecting the liver, and on the other hand, the immunity of bodies can be enhanced. Besides, all the components are food raw materials, so that the food composition is healthy, free from toxic and side effects, and suitable for people to take for a long time.

The invention discloses a flavone 3 beta-hydroxylase mutant with improved catalytic activity and application thereof, and belongs to the technical field of gene engineering. According to the invention, the flavonoid 3beta-hydroxylase mutant capable of increasing the eriodictyol yield is obtained by mutating flavonoid 3beta-hydroxylase from silybum marianum and screening. When the flavone 3 beta-hydroxylase mutant is applied to production of eriodictyol, the eriodictyol yield can be respectively increased to 1017.8 mg / L and 1046.5 mg / L from 805.6 mg / L of an original strain at a shake flask level, and is respectively increased by 26.3% and 29.9% compared with the original flavone 3 beta-hydroxylase yield.