25 results about "Silybum" patented technology

The invention relates to an application of a silybum marianum extract for improving, preventing or treating fatty liver, wherein the bioavailability of silymarin is improved. In the present invention, a silybum marianum extract of the present invention having improved bioavailability is prepared by subjecting silybum marianum seeds to enzyme treatment and low-concentration ethanol solvent extraction, and it is confirmed that the silybum marianum extract of the present invention has high bioavailability and exhibits excellent efficacy in improving, preventing or treating fatty liver.

The invention discloses a nutrition intervention composition with functions of regulating liver metabolism, promoting liver repair and resisting hepatic fibrosis. The nutrition intervention composition comprises purple perilla micro-capsule powder, a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component, corn oligopeptide powder, oat powder and a fermentation product of germinated brown rice powder. According to the nutrition intervention composition disclosed by the invention, the microencapsulated perilla frutescens extract is organically integrated with antioxidant, regeneration-promoting and metabolism-regulating components such as a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component and corn oligopeptide, so that the stability and bioavailability of fat-soluble active components are improved; the functions of exogenous anti-oxidation, endogenous anti-oxidation supplement, hepatocyte repair and intestinal-hepatic axis regulation are synergistically enhanced, so that the synergistic and lasting liver protection, repair and anti-fibrosis effects are realized.

The invention relates to the field of traditional Chinese medicine synthesis and preparation, in particular to a preparation device and method of a silybum marianum phospholipid complex. According to the preparation method of the silybum marianum phospholipid complex, the preparation device of the silybum marianum phospholipid complex is used, the steps of compounding treatment, filtering and drying are optimized, the compounding rate of the prepared silybum marianum phospholipid complex is increased, and the yield of the silybum marianum phospholipid complex is improved. The prepared silybum marianum phospholipid complex product has the advantages of low solvent residue and good water solubility and fat solubility, in addition, on the basis of completing two different filtering treatment in sequence, the silybum marianum phospholipid complex can be rapidly switched to a drying treatment mode after completing the second filtering treatment, the steps of the silybum marianum phospholipid complex preparation treatment process are reduced, and the production cost is reduced. The preparation process is simple, low in cost and suitable for industrial production, the technical defects that the preparation steps of the silybum marianum phospholipid complex are complex and tedious, and the preparation treatment efficiency is poor are greatly overcome, and the preparation work efficiency of the silybum marianum phospholipid complex is improved.

The invention belongs to the field of feed, and discloses a feed additive for improving stress resistance of laying hens, which comprises laccase, silybum marianum, catalase, anthocyanin and selenium yeast. Wherein the addition amount of each material in the feed is as follows: laccase is 300-500g / ton; 3-5 kg / ton of silybum marianum; catalase is 0.5 to 1 kg / ton; 30 to 60 mg / ton of anthocyanin; the selenium yeast is 80 to 240 milligrams per ton. The additive disclosed by the invention is based on toxin control, and effectively realizes control on oxidative stress of laying hens from four aspects of improving the oxidation resistance of the organism, reducing the oxidative stress of the organism, protecting the liver and improving the immunity. Meanwhile, the invention further discloses application of the additive.

The invention relates to a silybum marianum extract with a natural activity ratio, a preparation method of the silybum marianum extract and application of the silybum marianum extract in preparation of anti-aging products, and belongs to the technical field of natural products. The invention provides a preparation method of a silybum marianum extract, which comprises the following steps: performing dynamic countercurrent extraction on silybum marianum seed powder to obtain degreased powder; mixing the obtained degreased powder with a compound enzyme preparation, and after reaction, centrifugally collecting precipitate to obtain the silybum marianum seeds after enzymolysis; extracting the silybum marianum seeds subjected to enzymolysis by utilizing a subcritical fluid extraction technology, and separating by utilizing a decompression separation technology to obtain a crude extract; and carrying out macroporous resin selective adsorption purification on the obtained crude extract to obtain a purified product, wherein the purified product is the silybum marianum extract. The silybum marianum seed extract is mildly prepared at low temperature in the whole process through low-temperature degreasing, mild enzymolysis, subcritical fluid extraction and macroporous resin selective adsorption and purification, and meanwhile the natural activity proportion of the silybum marianum extract is kept.

This utility model provides a milk thistle separation device, belonging to the field of milk thistle separation technology. It includes a separation cylinder, with an inlet pipe connected to its upper side and an outlet pipe connected to its upper middle section. A separation groove is integrally formed on the periphery of the separation cylinder, and a first outlet is provided at the lower end. Several nozzle groups are provided on the inner wall of the separation cylinder, and a flow guide is provided on the inner wall. This utility model solves the problems of existing traditional separation methods, which are not conducive to separating milk thistle seed shells and kernels, easily causing a large amount of kernel to adhere to the shell, leading to waste of milk thistle seed kernels. Furthermore, it cannot effectively separate shells, intact seeds, and damaged seeds, thus affecting the economic benefits of the product and having certain limitations.

The invention belongs to the field of skin care products, and discloses an anti-aging skin care product composition containing plant extracts and application of the anti-aging skin care product composition. The anti-aging composition containing the plant extract comprises a tricholoma matsutake extract, a silybum marianum seed extract, ergothioneine and a flaxseed extract, wherein the mass ratio of the tricholoma matsutake extract to the silybum marianum seed extract to the ergothioneine to the flaxseed extract is (4-8): (3-6): (0.02-0.05): (2-4). According to the anti-aging skin care product composition, various substances have a synergistic effect, non-enzymatic glycosylation reaction is inhibited to the maximum extent, the raw materials are wide in source and relatively low in price, and the anti-aging skin care product composition has an extremely good application prospect in the field of anti-aging skin care products.

Nutritional supplements and compositions for activating cellular signaling genes in innate inflammatory pathways are described in this application. In particular, this application describes a composition containing a solid portion comprising Bacopa monnieri extract having a least 20 percent bacosides, Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, milk thistle extract, Withania somnifera (ashwagandha) extract, Camellia sinensis (green tea) extract containing at least 40 percent epigallocatechin gallate and about 98 percent polyphenols; and Curcuma longa (turmeric) extract containing at least about 95 percent curcumin. The compositions also comprise a liquid portion comprising fish collagen peptides comprising about 90 percent protein and Formosa ruby quinoa water extract containing about 10 wt % extract and about 90 wt % water. These compositions improved the skin and impacted key regulatory genes associated with several important cellular pathways. Other embodiments are also described.

The present invention relates to an extract of Silybum marianum (L.) Gaertn. akenes, as well as compositions containing this extract for application in the fields of cosmetics and dermatology for promoting hair growth.

The invention discloses a silybum marianum lipidosome applied to a liver protection tablet product and a preparation method, the silybum marianum lipidosome comprises a core material, and an internal wall material and an external wall material which sequentially wrap the surface of the core material; the core material is a silybum marianum extract; the inner wall material is modified soybean phospholipid; the outer wall material is a combination of starch sodium octenylsuccinate and polyethylene glycol. A lipidosome membrane embedding technology is adopted, the silybum marianum extract and soybean modified phospholipid are mixed according to a certain proportion and emulsified into a membrane, phospholipid bimolecular membrane embedding is formed, and then high-molecular compounds including starch sodium octenylsuccinate and polyethylene glycol are used as external wall materials to further include the phospholipid compound of the silybum marianum extract. The prepared lipidosome can be uniformly dispersed in an aqueous solution, the angle of repose is less than or equal to 40 degrees, the fluidity and the tabletting effect are better, the lipidosome is prepared into a sustained-release tablet, the bioavailability of the lipidosome can be improved, and the application of the lipidosome in a liver protection factor system can be expanded.

The present invention provides an immediate volumizing effect, a refreshing sensation, and wrinkle removal effects by including hyaluronic acid and peptides, and provides long-term improvement in lip volume and reverse skin aging effects by including an extract of Silybum marianum petals and an extract of Glycyrrhiza glabra leaves. In addition, the purpose of the present invention is to provide a natural plumping effect through long-term improvement in lip volume, amelioration of wrinkles, and increased blood flow by mixing an extract of Silybum marianum petals, which is an anti-aging component that removes and inhibits senescent cells, with ingredients such as hyaluronic acid and peptides that induce a natural plumping effect by ameliorating wrinkles and increasing blood flow.

The invention relates to a method for preparing silybum marianum from silymarin, which comprises the following steps of: heating the silymarin in an inert atmosphere with the pressure of 15-19 Mpa at the temperature of 140-170 DEG C to obtain a product with high silybum marianum content. The method has the advantages of simple steps, high yield, easy purification of the crude product, and high product purity.

This invention provides a method for monitoring the flowering period and assessing the consistency of milk thistle in field settings. High-resolution remote sensing images are acquired by using a drone to cruise and photograph the target area. A deep learning-pre-trained milk thistle flower recognition model is then used to accurately extract milk thistle flower information from the remote sensing images. Based on the recognition results, a flowering period display map is generated, enabling visualized monitoring of the dynamic flowering period of milk thistle within the study area. Simultaneously, a flowering period consistency evaluation index system is constructed to quantitatively assess the synchronicity of flowering periods among different plots or varieties. This method provides scientific and objective decision support for milk thistle variety breeding, adaptability evaluation, and yield prediction.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

The embodiment of the present application discloses a kind of silybum marianum peptide and its preparation method and application, belong to the technical field of bioactive peptide.The silybum marianum peptide includes peptide chain 1, peptide chain 2 and peptide chain 3, the peptide chain 1 includes the amino acid sequence shown in SEQ ID NO:1, peptide chain 2 includes the amino acid sequence shown in SEQ ID NO:2, and peptide chain 3 includes the amino acid sequence shown in SEQ ID NO:3.The silybum marianum peptide of the present application has the effect of significantly improving or relieving non-alcoholic liver injury, can effectively regulate lipid metabolism, reduce oxidative stress and inflammatory response, and provides a new effective means for the treatment of non-alcoholic liver injury.The silybum marianum peptide of the present application is derived from natural silybum marianum, has high safety, small side effect, can be used in medicine, health food and other fields, has good social and economic benefits.The preparation method of the present application is simple, low in cost, suitable for large-scale industrial production, and has wide market application prospect.

The utility model discloses a kind of milk thistle raw material squeezing pretreatment devices, belong to milk thistle processing technical field, including impurity removal box, the top of the impurity removal box is provided with air-drying mechanism. In the utility model, after putting milk thistle raw material into cleaning basket and washing and removing impurities, the first motor drives the upper installation box and cleaning basket to rotate at high speed, the rotation of cleaning basket drives the milk thistle raw material in its inner cavity to rotate at high speed, so as to use the centrifugal force generated by the rotation of cleaning basket to throw out the water spots attached to the milk thistle raw material, realize the function of preliminary dehumidification of milk thistle raw material, and through the cooperation of blowing fan, electric heating tube, blowing box and blowing hole, the milk thistle raw material in cleaning basket is blown, so as to air dry the milk thistle raw material, realize the function of drying the washed milk thistle raw material by two ways.

The invention belongs to the technical field of nutritional compositions and biological medicines, and particularly relates to application of a composition containing ackermania muciniphila and silybum marianum in liver protection products. The composition disclosed by the invention is prepared from Akkermania muciniphila and a silybum marianum extract, wherein the weight ratio of the Akkermania muciniphila to the silybum marianum extract is (1 to 3) to (1 to 10). The composition disclosed by the invention can be used for preparing liver protection products, including functional foods or health care products with an auxiliary protection effect on chemical liver injury, and medicines for preventing and treating alcoholic liver injury, chemical liver injury and the like. The composition provided by the invention has a better liver protection effect than a single component, and can synergistically exert the effects of protecting liver cells, regulating intestinal tract-liver axis and the like.

The invention discloses an application of silybin in treating androgenetic alopecia. Silybin is a main active component extracted from Silybum marianum, and the component has a remarkable effect in the aspects of liver protection and oxidation resistance. Experiments show that when a mouse is taken as an object, a silibinin group can quickly promote hair growth. The silybin can be used as a unique active component and is used for preparing a medicine or a reagent special for androgenetic alopecia and promoting hair growth. Silybin is high in safety and small in toxic and side effects, has extremely wide application prospects in the fields of prevention, nursing and treatment of the problems of alopecia and development of pharmaceutical preparations, cosmetics and the like for promoting healthy growth of hair, and is expected to bring new breakthrough and development to related fields.

Cosmetic Uses of a Hydrolyzed Extract of Silybum marianum Seed Cake: The invention relates to the cosmetic use of a hydrolyzed extract of Silybum marianum seed cake to maintain and / or enhance the biomechanical properties of skin appendages. Another object of the invention is a cosmetic treatment method comprising the topical application of the hydrolyzed seed cake extract or a composition containing it.

The invention provides a sugar-free sea-buckthorn and silybum marianum seed oil gel candy for tonifying kidney, strengthening yang and conditioning chronic diseases. The sugar-free sea-buckthorn and silybum marianum seed oil gel candy is prepared from the following raw materials: mixed plant seed oil, a plant extraction active auxiliary agent, a sugar-free gel matrix, a compound emulsifier and a stabilizer, the mixed plant seed oil is formed by compounding a plurality of oils and fats, and the plant extraction active auxiliary agent is formed by compounding a mulberry leaf extract, oyster peptide and a maca extract according to a specific proportion. The preparation method comprises the following steps: preparing an oil phase and a water phase, emulsifying and mixing, degassing and pouring and the like. The candy is good in stability, strong in antioxidant activity, capable of remarkably improving the testosterone level of serum, improving the sperm quality and assisting in conditioning chronic cardiovascular and cerebrovascular diseases, high in safety and capable of providing a new choice for health-care food with related functions.

The present invention relates to the cosmetic use of a hydrolyzed extract of milk thistle (Silybum marianum) seed cake to maintain and / or enhance the biomechanical properties of the skin's outer layer. Another subject of the present invention is a cosmetic care process comprising topical application of the hydrolyzed cake extract or a composition containing the same.

The invention discloses a fat-reducing and liver-protecting traditional Chinese medicine compound composition as well as a preparation method and application thereof. Five specific components including the propolis extract, the schisandra chinensis extract, the hovenia dulcis thunb extract, the silybum marianum oil and the beewax are scientifically matched, and the synergistic effect of the components is remarkable. Meanwhile, aiming at two major core pathological links of lipid metabolism disorder and oxidative inflammation injury of the fatty liver, the fat-reducing and liver-protecting tea has dual powerful functions of reducing fat and protecting the liver. All the components are natural sources, have no toxic or side effect, have both nutrition and support effects, and are suitable for long-term taking for conditioning. A large number of modern researches prove that the activity and combinatorial logic of each component are clear, and the scientific basis is sufficient.

The application provides a composition with liver protection efficacy and a preparation method and application thereof. The composition with liver protection efficacy comprises the following ingredients by mass fraction: 10-30 parts of Silybum marianum powder, 15-40 parts of Pueraria lobata powder, 20-35 parts of Salvia miltiorrhiza powder, 5-15 parts of freeze-dried Rubus corchorifolius fruit powder, and 8-20 parts of Hovenia dulcis fruit powder. The preparation method comprises the following steps: mixing the above-mentioned raw materials, subjecting the mixture to enzymolysis by using a composite enzyme, subjecting the enzymolysis product to fermentation by using a composite strain, obtaining a fermentation product, and freeze-drying the fermentation product to obtain the composition with liver protection efficacy. The composite enzyme comprises cellulase and pectinase, and the composite strain comprises Bacillus pumilus and Sporolactobacillus inulinus. The composition with liver protection efficacy obtained by the application can effectively improve the liver function level.

This invention belongs to the technical field of traditional Chinese medicine cultivation, specifically relating to a method for rapidly cultivating milk thistle. By regulating the milk thistle plant with auxin, the photosynthetic rate is increased, enabling it to quickly break through the rosette stage and enter the bolting stage. This enhances the plant's absorption of water and fertilizer, promoting its growth and development, allowing milk thistle to complete a full growth cycle in Hainan Province. A reagent preparation device specifically designed for this rapid milk thistle cultivation method is also provided, facilitating the aforementioned experiments and offering highly portable operation. This cultivation method significantly shortens the milk thistle's growth cycle, increases yield and efficacy, while reducing labor costs and environmental impact. Through scientific management and technological application, this method can yield high-quality milk thistle products in a shorter time, meeting the market demand for high-efficiency, high-quality traditional Chinese medicine.

The invention provides a probiotic compound preparation with double effects of short-term hangover alleviating and long-term liver protection. The silybum marianum and hovenia dulcis thunb compound is fermented through the bifidobacterium animalis subsp. Animalis HX-BA21, and the concentration of the anti-inflammatory protein P75, the dihydromyricetin and the silybin which serve as core functional components is remarkably increased; and further compounding with corn oligopeptide, glutathione yeast and turmeric to construct a multi-channel synergistic system of anti-inflammation, metabolism acceleration, oxidation resistance, hepatocyte repair and lipid metabolism regulation. On one hand, alcohol metabolism is accelerated, the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) is improved, and rapid alcohol effect dispelling is achieved; on the other hand, the antioxidant capacity is enhanced (SOD and GSH-Px are remarkably improved, and MDA is reduced), intestinal tract-derived inflammation signals are synergistically inhibited (IL-6 and TNF-alpha are reduced), hepatocytes are synergistically repaired, and lipid metabolism is regulated (TC and TG of the liver and ALT and AST of serum are reduced) through P75 protein, so that long-term protection and hepatocyte repair of alcoholic liver injury are realized while the acute drunkenness symptom is relieved. The method has the advantages of high efficiency, safety and multi-target intervention, and is obviously superior to a single component or a simple physical mixture.