54 results about "Silybum" patented technology

The application discloses a low-residual extractive method of silymarin and a preparation method thereof. The low-residual extractive method of silymarin comprises the following steps: eluting oil and fat; crushing silybum seed, soaking and eluting oil and fat by using n-hexane, and obtaining a soaking solution; adding ethanol into the soaking solution, filtering after standing, adding water into the concentrated filtrate, and taking the lower layer solution and the precipitate; and crystallizing and drying, filtering after crystallizing again, and drying the silymarin crystals. The low-residual extractive method of silymarin provided by the application has the effect of reducing the solvent residue in silymarin.

The invention relates to an application of a silybum marianum extract for improving, preventing or treating fatty liver, wherein the bioavailability of silymarin is improved. In the present invention, a silybum marianum extract of the present invention having improved bioavailability is prepared by subjecting silybum marianum seeds to enzyme treatment and low-concentration ethanol solvent extraction, and it is confirmed that the silybum marianum extract of the present invention has high bioavailability and exhibits excellent efficacy in improving, preventing or treating fatty liver.

The invention relates to the technical field of compound extraction, in particular to a silybum marianum extract and a preparation method thereof. The preparation method of the silybum marianum extract comprises the following steps: S1, carrying out subcritical extraction on a silybum marianum seed shell raw material, and extracting the silybum marianum seed shell raw material subjected to subcritical extraction by adopting an organic solvent to obtain an extracting solution; s2, concentrating the extracting solution until the specific gravity is 0.90 g / ml to 0.99 g / ml, so as to obtain a first concentrated solution; and S3, performing supercritical extraction on the first concentrated solution, and then performing desolvation and drying. The preparation method disclosed by the invention is high in extraction rate, energy-saving, environment-friendly and pollution-free, the obtained silymarin is low in pesticide residue and high in product content, and large-scale, industrial and continuous production of the high-quality silymarin can be realized.

The invention relates to the technical field of hair nourishing and caring products, and discloses a gorse hair nourishing essence and a preparation method thereof.The gorse hair nourishing essence is prepared from, by weight, 25-30 parts of polygonum multiflorum, 15-18 parts of eclipta alba, 14-16 parts of rhizoma zingiberis, 13-15 parts of black sesame, 12-14 parts of roses, 16-20 parts of fructus psoraleae, 18-23 parts of angelica sinensis, 23-16 parts of pine needles, 10-13 parts of saffron crocus, 13-15 parts of folium mori, 18-20 parts of black beans and 15-18 parts of cacumen biotae. Through the synergistic effect of various herbaceous plant raw materials, the gorse hair nourishing essence disclosed by the invention can achieve multiple effects of fixing hair, smoothening hair, losing hair, turning white into black and the like, nourish scalp, promote hair growth, improve hair quality, promote scalp blood circulation and provide sufficient nutrition for hair follicles.

The present invention relates to a composition for preventing hair loss or promoting hair growth containing a milk thistle flower extract as an active ingredient. More specifically, the present invention relates to a cosmetic composition, pharmaceutical composition and food composition containing a milk thistle flower extract as an active ingredient, which are able to promote hair growth by inducing the proliferation of dermal papilla cells reduced due to senescence, and activate dermal papilla cells by inhibiting the senescence of dermal papilla cells through inhibition of the activity of senescence-associated β-galactosidase (SA-β-Gal) and the production of senescence-associated secretory phenotypes, thereby preventing hair loss or promoting hair.The composition according to the present invention has no skin irritation and cytotoxicity, and thus has excellent safety for the human body, and at the same time, is very effective in promoting the proliferation of dermal papilla cells and inhibiting the senescence of dermal papilla cells. Thus, it may be useful as an active ingredient in a cosmetic composition, a pharmaceutical composition or a food composition for preventing hair loss or promoting hair growth.

The invention discloses a nutrition intervention composition with functions of regulating liver metabolism, promoting liver repair and resisting hepatic fibrosis. The nutrition intervention composition comprises purple perilla micro-capsule powder, a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component, corn oligopeptide powder, oat powder and a fermentation product of germinated brown rice powder. According to the nutrition intervention composition disclosed by the invention, the microencapsulated perilla frutescens extract is organically integrated with antioxidant, regeneration-promoting and metabolism-regulating components such as a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component and corn oligopeptide, so that the stability and bioavailability of fat-soluble active components are improved; the functions of exogenous anti-oxidation, endogenous anti-oxidation supplement, hepatocyte repair and intestinal-hepatic axis regulation are synergistically enhanced, so that the synergistic and lasting liver protection, repair and anti-fibrosis effects are realized.

The application discloses a capsule for assisting in protecting chemical liver injury and a preparation method thereof, and belongs to the technical field of health-care food. The capsule is composed of curcuma longa extract 100g, silybum marianum extract 70g, schisandra chinensis extract 60g, microcrystalline cellulose 109.5g, silicon dioxide 7g and magnesium stearate 3.5g, and 1000 capsules are taken as a unit. The curcuma longa extract contains curcumin, the content of which is greater than or equal to 10% (10:1), the silybum marianum extract contains silybin, the content of which is greater than or equal to 20% (25:1), and the schisandra chinensis extract contains schisandrin, the content of which is greater than or equal to 1.5% (12.5:1). The three kinds of plant extracts are scientifically compounded, and the effects of antioxidation, anti-inflammation, liver cell membrane protection and bile secretion regulation are synergistically exerted. Through systematic screening of the types and dosages of the filling agent, the flow agent and the lubricant, the technical problems of poor flowability of the mixed plant extract powder, large filling difference and easy jamming are solved.

The invention belongs to the technical field of traditional Chinese medicine and application thereof, and particularly relates to application of silybum marianum alcohol extract in preparation of medicine for treating deep II-degree burns and scalds. When the silybum marianum alcohol extract is applied to preparation of the medicine for treating deep II-degree burns and scalds, oxidative stress injury is improved by activating an Nrf2 / HO-1 pathway, and fibrosis is inhibited by regulating a TGF-beta / Smad pathway so as to promote repair of the deep II-degree burns and scalds. According to the method, the yield of the silybum marianum alcohol extract is improved by optimizing the extraction conditions of the silybum marianum; it is clear that the silybum marianum alcohol extract has multiple mechanisms of resisting oxidation, inhibiting fibrosis and resisting inflammation, the silybum marianum alcohol extract has a remarkable promoting effect on treatment and repair of deep II-degree burns and scalds, and theoretical basis and experimental support are provided for silybum marianum serving as a potential treatment medicine for scar-free healing after deep II-degree scalds.

The invention relates to the field of traditional Chinese medicine synthesis and preparation, in particular to a preparation device and method of a silybum marianum phospholipid complex. According to the preparation method of the silybum marianum phospholipid complex, the preparation device of the silybum marianum phospholipid complex is used, the steps of compounding treatment, filtering and drying are optimized, the compounding rate of the prepared silybum marianum phospholipid complex is increased, and the yield of the silybum marianum phospholipid complex is improved. The prepared silybum marianum phospholipid complex product has the advantages of low solvent residue and good water solubility and fat solubility, in addition, on the basis of completing two different filtering treatment in sequence, the silybum marianum phospholipid complex can be rapidly switched to a drying treatment mode after completing the second filtering treatment, the steps of the silybum marianum phospholipid complex preparation treatment process are reduced, and the production cost is reduced. The preparation process is simple, low in cost and suitable for industrial production, the technical defects that the preparation steps of the silybum marianum phospholipid complex are complex and tedious, and the preparation treatment efficiency is poor are greatly overcome, and the preparation work efficiency of the silybum marianum phospholipid complex is improved.

The invention belongs to the field of feed, and discloses a feed additive for improving stress resistance of laying hens, which comprises laccase, silybum marianum, catalase, anthocyanin and selenium yeast. Wherein the addition amount of each material in the feed is as follows: laccase is 300-500g / ton; 3-5 kg / ton of silybum marianum; catalase is 0.5 to 1 kg / ton; 30 to 60 mg / ton of anthocyanin; the selenium yeast is 80 to 240 milligrams per ton. The additive disclosed by the invention is based on toxin control, and effectively realizes control on oxidative stress of laying hens from four aspects of improving the oxidation resistance of the organism, reducing the oxidative stress of the organism, protecting the liver and improving the immunity. Meanwhile, the invention further discloses application of the additive.

The invention relates to a silybum marianum extract with a natural activity ratio, a preparation method of the silybum marianum extract and application of the silybum marianum extract in preparation of anti-aging products, and belongs to the technical field of natural products. The invention provides a preparation method of a silybum marianum extract, which comprises the following steps: performing dynamic countercurrent extraction on silybum marianum seed powder to obtain degreased powder; mixing the obtained degreased powder with a compound enzyme preparation, and after reaction, centrifugally collecting precipitate to obtain the silybum marianum seeds after enzymolysis; extracting the silybum marianum seeds subjected to enzymolysis by utilizing a subcritical fluid extraction technology, and separating by utilizing a decompression separation technology to obtain a crude extract; and carrying out macroporous resin selective adsorption purification on the obtained crude extract to obtain a purified product, wherein the purified product is the silybum marianum extract. The silybum marianum seed extract is mildly prepared at low temperature in the whole process through low-temperature degreasing, mild enzymolysis, subcritical fluid extraction and macroporous resin selective adsorption and purification, and meanwhile the natural activity proportion of the silybum marianum extract is kept.

This utility model provides a milk thistle separation device, belonging to the field of milk thistle separation technology. It includes a separation cylinder, with an inlet pipe connected to its upper side and an outlet pipe connected to its upper middle section. A separation groove is integrally formed on the periphery of the separation cylinder, and a first outlet is provided at the lower end. Several nozzle groups are provided on the inner wall of the separation cylinder, and a flow guide is provided on the inner wall. This utility model solves the problems of existing traditional separation methods, which are not conducive to separating milk thistle seed shells and kernels, easily causing a large amount of kernel to adhere to the shell, leading to waste of milk thistle seed kernels. Furthermore, it cannot effectively separate shells, intact seeds, and damaged seeds, thus affecting the economic benefits of the product and having certain limitations.

The invention belongs to the field of skin care products, and discloses an anti-aging skin care product composition containing plant extracts and application of the anti-aging skin care product composition. The anti-aging composition containing the plant extract comprises a tricholoma matsutake extract, a silybum marianum seed extract, ergothioneine and a flaxseed extract, wherein the mass ratio of the tricholoma matsutake extract to the silybum marianum seed extract to the ergothioneine to the flaxseed extract is (4-8): (3-6): (0.02-0.05): (2-4). According to the anti-aging skin care product composition, various substances have a synergistic effect, non-enzymatic glycosylation reaction is inhibited to the maximum extent, the raw materials are wide in source and relatively low in price, and the anti-aging skin care product composition has an extremely good application prospect in the field of anti-aging skin care products.

Nutritional supplements and compositions for activating cellular signaling genes in innate inflammatory pathways are described in this application. In particular, this application describes a composition containing a solid portion comprising Bacopa monnieri extract having a least 20 percent bacosides, Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, milk thistle extract, Withania somnifera (ashwagandha) extract, Camellia sinensis (green tea) extract containing at least 40 percent epigallocatechin gallate and about 98 percent polyphenols; and Curcuma longa (turmeric) extract containing at least about 95 percent curcumin. The compositions also comprise a liquid portion comprising fish collagen peptides comprising about 90 percent protein and Formosa ruby quinoa water extract containing about 10 wt % extract and about 90 wt % water. These compositions improved the skin and impacted key regulatory genes associated with several important cellular pathways. Other embodiments are also described.

The utility model discloses a silybum marianum seed squeezing device facilitating solid-liquid separation, and relates to the technical field of silybum marianum seed processing. The device comprises a squeezing pipe, a smashing pipe is arranged on the upper side of the squeezing pipe, the smashing pipe is communicated with the squeezing pipe, a primary filter screen is arranged at one end of the smashing pipe, a smashing mechanism is arranged at the other end of the smashing pipe, a feeding mechanism is arranged on the smashing mechanism, a liquid drainage hole is formed in the lower side wall of the squeezing pipe, and the liquid drainage hole is communicated with the squeezing pipe. A liquid discharging hole is formed in the side wall of the squeezing pipe, a residue filtering net is arranged in the liquid discharging hole, an extruding mechanism is arranged at one end of the squeezing pipe, a pressure bearing mechanism is arranged at the other end of the squeezing pipe, and a liquid collecting mechanism is arranged on the side wall, located on one side of the liquid discharging hole, of the squeezing pipe. According to the utility model, the extrusion plate is matched with the T-shaped pressure-bearing block to extrude crushed materials, so that the oil outlet efficiency is higher, and the squeezing time can be saved.

The present invention relates to an extract of Silybum marianum (L.) Gaertn. akenes, as well as compositions containing this extract for application in the fields of cosmetics and dermatology for promoting hair growth.

The invention discloses a silybum marianum lipidosome applied to a liver protection tablet product and a preparation method, the silybum marianum lipidosome comprises a core material, and an internal wall material and an external wall material which sequentially wrap the surface of the core material; the core material is a silybum marianum extract; the inner wall material is modified soybean phospholipid; the outer wall material is a combination of starch sodium octenylsuccinate and polyethylene glycol. A lipidosome membrane embedding technology is adopted, the silybum marianum extract and soybean modified phospholipid are mixed according to a certain proportion and emulsified into a membrane, phospholipid bimolecular membrane embedding is formed, and then high-molecular compounds including starch sodium octenylsuccinate and polyethylene glycol are used as external wall materials to further include the phospholipid compound of the silybum marianum extract. The prepared lipidosome can be uniformly dispersed in an aqueous solution, the angle of repose is less than or equal to 40 degrees, the fluidity and the tabletting effect are better, the lipidosome is prepared into a sustained-release tablet, the bioavailability of the lipidosome can be improved, and the application of the lipidosome in a liver protection factor system can be expanded.

The invention provides an ultrasonic extraction method of silymarin, and relates to the technical field of silymarin production. The ultrasonic extraction method of silymarin comprises the following steps: S1, selecting silybum marianum, cleaning and squeezing oil to obtain silybum marianum cake powder; s2, taking organic solvents such as acetone and ethyl acetate as extraction solvents for the silybum marianum cake powder, and applying ultrasonic waves to an extracted substance for extraction to obtain an extracting solution; s3, concentrating the extracting solution to obtain a concentrate flow extract; s4, degreasing the concentrate flow extract to obtain a degreased extract; s5, refining the degreased extract to obtain a refined extract; and S6, carrying out low-pressure and low-temperature drying on the refined extract to form a dry extract, and carrying out intermediate inspection. According to the ultrasonic extraction method for silymarin, the characteristic that silymarin can be rapidly and completely dissolved into an extraction solvent under the action of ultrasonic waves in the extraction solvent is utilized, so that the extraction time is greatly shortened, the production efficiency is improved, the labor intensity is reduced, and the production safety is improved.

The invention provides a composition with a liver protection effect as well as a preparation method and application thereof. The composition with the liver protection effect is prepared from the following substrates in parts by mass: 10 to 30 parts of silybum marianum powder, 15 to 40 parts of radix puerariae powder, 20 to 35 parts of radix salviae miltiorrhizae powder, 5 to 15 parts of aronia fruit freeze-dried powder and 8 to 20 parts of hovenia dulcis thunb powder. The preparation method comprises the following steps: mixing the raw materials of the substrate, performing enzymolysis by using a compound enzyme, fermenting an enzymolysis product by using a compound strain to obtain a fermentation product, and freeze-drying the fermentation product to obtain the composition with the liver protection effect. Wherein the compound enzyme comprises cellulase and pectinase; the composite strains are acetobacter pasteurianus and bacillus inulin. The composition with the liver protection effect can effectively improve the liver function level.

A silybum marianum aeration hydroponic device for experiments belongs to the technical field of plant culture devices and comprises a hydroponic frame, hydroponic pipes, a water tank and an aeration pump, the hydroponic pipes are placed on the hydroponic frame, the water tank is placed at the bottom of the hydroponic frame, water inlets are formed in the left ends of the hydroponic pipes, water level adjusting valves are arranged at the right ends of the hydroponic pipes, and a plurality of holes are formed in the hydroponic pipes. The water tank is connected with the water inlet through a water pipe, the aeration pump is connected with a hole in the water culture pipe through a pipeline, and a water level sensor is arranged in the water culture pipe. The aeration system is additionally arranged, normal breathing of the roots of the silybum marianum can be maintained, the metabolic activity of the roots is accelerated, absorption and transportation of nutrient substances are promoted, and the growth speed and the health condition of the silybum marianum are improved. According to the utility model, the water level sensor is additionally arranged, so that high-precision water level measurement data can be provided, small changes of the water level can be monitored, and the high-precision measurement data is beneficial to improving the accuracy and the reliability of an experiment.

The present invention provides an immediate volumizing effect, a refreshing sensation, and wrinkle removal effects by including hyaluronic acid and peptides, and provides long-term improvement in lip volume and reverse skin aging effects by including an extract of Silybum marianum petals and an extract of Glycyrrhiza glabra leaves. In addition, the purpose of the present invention is to provide a natural plumping effect through long-term improvement in lip volume, amelioration of wrinkles, and increased blood flow by mixing an extract of Silybum marianum petals, which is an anti-aging component that removes and inhibits senescent cells, with ingredients such as hyaluronic acid and peptides that induce a natural plumping effect by ameliorating wrinkles and increasing blood flow.

The invention discloses an extraction method and a preparation method of low-residue silymarin, and the extraction method of the low-residue silymarin comprises the following steps: elution of grease: crushing silymarin seeds, soaking the crushed silymarin seeds with n-hexane, and eluting the grease to obtain a soaking solution; ethanol replacement: adding ethanol into the soak solution, standing, filtering, concentrating the filtrate, adding water, standing, and taking the lower solution and precipitate; and crystallizing and drying: concentrating the lower-layer solution and the precipitate, recrystallizing, filtering, and drying and crystallizing to obtain the silymarin. The extraction method of the low-residue silymarin, provided by the invention, has the effect of reducing solvent residues in the silymarin.

The invention belongs to the technical field of biology, and discloses a saccharomyces cerevisiae engineering strain capable of efficiently producing dihydroquercetin, a mutant, a construction method and application. The mutant is obtained by performing point mutation on a flavonoid 3-hydroxylase gene CsF3H from citrus and a flavonoid 3 '-hydroxylase gene SmF3' H from silybum marianum which are subjected to heterologous expression, and the mutation sites of the point mutation are selected from any one, two or three sites of the 198th site, the 388th site and the 389th site. Finally, the yield of dihydroquercetin in a shake flask is increased by 15%-25% compared with that of a control strain (saccharomyces cerevisiae strain for overexpressing CsF3H and SmF3 'H). The engineering bacterium provided by the invention not only has the advantage of high yield, but also can be fermented through relatively simple method conditions, is easy to implement and control in industry and low in investment cost, and lays a foundation for efficient synthesis and further industrialization of dihydroquercetin.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for preventing and treating myocardial ischemia reperfusion injury, a preparation and a preparation method. The traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 15-25 parts of radix salviae miltiorrhizae, 15-25 parts of radix astragali, 10-15 parts of ground beetles, 10-15 parts of cornu bubali, 10-20 parts of poria cocos, 10-20 parts of semen plantaginis, 10-15 parts of honeysuckle stems, 10-20 parts of radix polygonati officinalis, 10-20 parts of radix asparagi, 10-15 parts of herba asari, 10-20 parts of gypsum, 10-20 parts of rhizoma anemarrhenae, 10-15 parts of allium macrostemon, 10-15 parts of geranium wilfordii and 10-15 parts of silybum marianum seeds. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to the formula dosage, and then adding water for decoction to obtain a traditional Chinese medicine decoction; combining the traditional Chinese medicine decoction, filtering and concentrating to obtain traditional Chinese medicine extract; and adding auxiliary materials into the traditional Chinese medicine extract, and preparing by adopting a conventional preparation mode. Combined use of monarch, minister, assistant and guide drugs can fully relieve myocardial ischemia reperfusion injury.

The present invention belongs to the technical field of quality inspection of traditional Chinese medicine preparations, and specifically relates to a characteristic fingerprint spectrum of milk thistle and its aqueous extract pharmaceutical preparation. Further disclosed are methods for constructing the characteristic spectrum and quality inspection methods for milk thistle and its pharmaceutical preparation. The method for constructing the characteristic spectrum of milk thistle and its preparation described in the present invention establishes a characteristic spectrum method for milk thistle raw medicinal material and milk thistle aqueous extract pharmaceutical preparation based on the UPLC method. Furthermore, by optimizing the mobile phase composition, mobile phase gradient, and test sample and reference material processing methods, the method comprehensively displays the chemical components of milk thistle, thereby broadening the application of milk thistle.

The utility model relates to the technical field of pest control, in particular to a silybum marianum disease and insect pest comprehensive control device which comprises a fixed vertical plate used for silybum marianum disease and insect pest comprehensive control, side seats are symmetrically arranged on the two sides of the fixed vertical plate, and an obliquely-arranged solar panel is installed on the top of a rain shielding top seat. The fixed vertical plate is arranged, the interior of the fixed vertical plate is hollow, the two sides of the fixed vertical plate are each of a transparent structure, a plurality of sets of insect attracting lamp tubes which are evenly arranged at equal intervals can be conveniently installed, and the insect attracting lamp tubes can attract insects to get close to achieve the effect of trapping the insects; the side seats symmetrically arranged on the two sides of the fixed vertical plate provide support for mounting the transparent detachable plate; the detachable plate is convenient to install and replace, meanwhile, the yellow insect trapping sticky plate installed on the outer wall of the detachable plate can further attract and stick pests, and the pest control effect is enhanced; the solar panel which is obliquely arranged is installed on the top of the rain sheltering top base and can convert solar energy into electric energy, power support is provided for devices such as the insect attracting lamp tube, and energy conservation and environment protection are achieved.

The invention relates to a method for preparing silybum marianum from silymarin, which comprises the following steps of: heating the silymarin in an inert atmosphere with the pressure of 15-19 Mpa at the temperature of 140-170 DEG C to obtain a product with high silybum marianum content. The method has the advantages of simple steps, high yield, easy purification of the crude product, and high product purity.

This invention provides a method for monitoring the flowering period and assessing the consistency of milk thistle in field settings. High-resolution remote sensing images are acquired by using a drone to cruise and photograph the target area. A deep learning-pre-trained milk thistle flower recognition model is then used to accurately extract milk thistle flower information from the remote sensing images. Based on the recognition results, a flowering period display map is generated, enabling visualized monitoring of the dynamic flowering period of milk thistle within the study area. Simultaneously, a flowering period consistency evaluation index system is constructed to quantitatively assess the synchronicity of flowering periods among different plots or varieties. This method provides scientific and objective decision support for milk thistle variety breeding, adaptability evaluation, and yield prediction.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

The embodiment of the present application discloses a kind of silybum marianum peptide and its preparation method and application, belong to the technical field of bioactive peptide.The silybum marianum peptide includes peptide chain 1, peptide chain 2 and peptide chain 3, the peptide chain 1 includes the amino acid sequence shown in SEQ ID NO:1, peptide chain 2 includes the amino acid sequence shown in SEQ ID NO:2, and peptide chain 3 includes the amino acid sequence shown in SEQ ID NO:3.The silybum marianum peptide of the present application has the effect of significantly improving or relieving non-alcoholic liver injury, can effectively regulate lipid metabolism, reduce oxidative stress and inflammatory response, and provides a new effective means for the treatment of non-alcoholic liver injury.The silybum marianum peptide of the present application is derived from natural silybum marianum, has high safety, small side effect, can be used in medicine, health food and other fields, has good social and economic benefits.The preparation method of the present application is simple, low in cost, suitable for large-scale industrial production, and has wide market application prospect.