106 results about "Liver metabolism" patented technology

The invention provides a functional food set meal capable of losing weight scientifically and healthily. The functional food set meal comprises a conjugated protein meal replacement solid combination, a momordica grosvenori dietary fiber composite solid combination, a chia seed solid combination, a chitosan oligosaccharide solid combination, a fruit, vegetable and grain solid combination, a probiotics solid combination and a wheat seedling dietary fiber solid combination. Compared with the prior art, the functional food set meal is a nutritional food set meal which is beneficial to losing weight and is studied and developed based on the scientific weight losing theory and method, and according to the design and development theory of the set meal, on the premise of guaranteeing health, intake and consumption of energy are reasonably controlled, calorie supply and demand balance is set up, a biont has no redundant energy accumulation, meanwhile, internal fat is mobilized to be decomposed, energy is released to meet the need of the biont, and therefore the aim of losing weight is achieved. The functional food set meal has the advantages of adopting body health as the premise, balancing nutrition, reasonably controlling the energy and consumption, setting up energy negative balance, protecting the liver, adjusting the liver metabolism, mobilizing fat decomposition to release energy and the like.

The invention discloses an alcohol relieving tea, which includes kudzu vine root, pueravia flower. The character lies in it also includes one or many of Chinese white olive, honeysuckle, malt, tea, hawthorn, job's-tears kernel. The tea has functions of alcohol relieving and liver protecting, blood vessel expanding, digestion advancing, and diuresis, the alcohol can be discharged quickly when the alcohol enters the liver, and it will not do harm to liver. For long time use, it can protect liver, reduces the blood pressure and blood fat, maintains the best state of human. The product in the invention May uses tea as carrier, it will represent black and yellow clear transparent liquid after being immersed, and it has fragrant of honeysuckle. It is convenient, and it can act quickly.

The present invention relates to isolated liver progenitor stem cells, and cell population thereof, wherein said progenitor stem cells originate from adult liver, esp. of human. The present invention also relates to the use of said isolated progenitor stem cells in medicine, hepatology, inborn errors of liver metabolism, transplantation, infectious diseases, liver failure. The present invention also relates to methods of isolating these cells, their culture, characterization before and after differentiation, and their use for transplantation, animal models of human disease, toxicology and pharmacology.

The invention relates to the technical field of health-care foods, in particular to a solid beverage having health-care functions and a preparation method of the solid beverage. The solid beverage ismade from raw materials of rhizoma polygonati, Chinese wolfberry fruits, radix astragali, radish seeds, fructus momordicae, poria, glossy privet fruits, gordon euryale seeds, wild honey, bananas, apples, coix seeds, haws, red jujubes, licorice roots, millets, small black beans, black sesame seeds, lotus seeds, sorghum and corn. The raw materials are in compatibility according to a five-element theory, the operation regularity of yin, yang, five elements, and meridian and vessels of human bodies is balanced and adjusted, and the immunity and the resistance of the human bodies are repaired and promoted. A manner of combining solid state fermentation with liquid state fermentation is adopted, and effective components in the raw materials are extracted out in the form of micromolecule bioactive peptide, so that the absorption and utilization rate of the effective components is increased, the prepared solid beverage does not need gastric enzyme decomposition and liver metabolism hardly, babies, old people or patients, having weak digestion functions, can well digest and absorb the solid beverage, the immunity and the resistance are improved, and the solid beverage can assist in preventing and treating diseases.

The invention relates to a puffing feed for California perch. The puffing feed is prepared from the following raw materials in percentage by weight: 10-16% of gluten powder, 5-8% of yeast powder, 4-8% of superior shrimp powder, 25-35% of imported fish meal, 18% of national superior degreased fish meal, 5% of chicken meat powder, 12% of soybean meal, 3% of fish oil, 1.5% of liquid phosphatide, 1.5% of calcium dihydrogen phosphate and 3% of a self-made California perch special premix, wherein the percentage is the mass percentage of the components of the puffing compound feed accounting for the total quantity of the puffing compound feed. The nutritive indexes of the puffing feed for California perch disclosed by the invention can reach that the moisture content is smaller than or equal to 12.5%, the crude protein is larger than or equal to 46.0%, the crude fat is larger than or equal to 5.0%, the crude fibers are smaller than or equal to 18.0%, the calcium is 1.0-4.0%, the total phosphorus is larger than or equal to 1.0%, the sodium chloride is 0.3-4.0%, and the lysine is larger than or equal to 2.6%; all the nutritional requirements of the California perch are met, the characteristics of the limit of the California perch for carbohydrate metabolism and liver metabolism functions are explored, the prepared feed with the formula can be fed to the California perch in the whole course until the California perch appears on the market, fish like to eat the feed so that the fish can grow quickly, the somatotype of the fish is uniform, the dorsal meat is thick, the internal organs such as the livers are healthy, and the mouth feel of the fish meat is better than that of fish fed with iced fresh.

Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver. The isolated progenitor stem cells have uses in medicine, hepatology, inborn errors of liver metabolism transplantation, infectious diseases and liver failure. Methods of isolating these cells and their culture is described. The isolated cells are characterized before and after differentiation. Their use for transplantation and as animal models of human disease, toxicology and pharmacology is disclosed.

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

The invention relates to a butylphthalide- and edaravone-containing compound injection and a preparation method thereof. The injection of every 100 ml contains 25-50 mg of active ingredient butylphthalide, 12.5-50 mg of edaravone, as well as absolute ethyl alcohol, hydroxypropyl-beta-cyclodextrin, an osmotic pressure regulator, an antioxidant and the like. With the adoption of the butylphthalide- and edaravone-containing compound injection, the administration dosage is greatly lowered, the burden of liver metabolism is reduced, and the incidence rate of liver adverse reactions is lowered. According to determination, with the adoption of the butylphthalide- and edaravone-containing compound injection, the administration dosage of the edaravone can be reduced by at least 20%, besides, the compound injection has a better curative effect, and the incidence rate of the liver adverse reactions is also remarkably lowered.

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

The invention discloses an animal feed additive, which comprises lecithin, monostearin, sucrose ester and water-soluble starch. By means of the technical scheme, the animal feed additive has strong emulsifying capacity and stability, improves digestion, absorption and utilization ratio of poultry to animal oil and fat, facilitates improvement of fat emulsification in the animal digestive tract, especially the animal fat, increases the contacting area of fat particles and lipase, enhances a digestive function of the gastrointestinal tract and a liver metabolism function, promotes the fat emulsification and fat absorption, improves body nutrition metabolism, obviously improves the animal production performance, improves digestion, absorption and utilization ratio of animals to the oil and the fat, can reduce oil-fat using amount and the cost, promotes absorption of fat-soluble vitamin and decreases digestive tract diseases including diarrhea, enteritis and the like caused by fat indigestion.

Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver. The isolated progenitor stem cells have uses in medicine, hepatology, inborn errors of liver metabolism transplantation, infectious diseases and liver failure. Methods of isolating these cells and their culture is described. The isolated cells are characterized before and after differentiation. Their use for transplantation and as animal models of human disease, toxicology and pharmacology is disclosed.

The invention provides a micro-fluidic chip-based multiple-organ tumor targeting drug testing platform and application thereof. A micro-fluidic chip consists of an upper layer chip, a lower layer chip and a porous filter membrane, wherein the upper part of the porous filter membrane is connected with the upper layer chip, and the lower part of the porous filter membrane is connected with the lower layer chip; the structure of the upper layer chip is of a large cell culture chamber, and the structure of the lower layer chip is of independent multiple channels, wherein the number of the channels is 1-9. A construction method of the micro-fluidic chip-based multiple-organ tumor targeting drug testing platform comprises the following steps: (1) manufacturing and modifying the chip; (2) inoculating and culturing cells in the upper layer chip; (3) inoculating and culturing cells in the lower layer chip. The upper layer chip is inoculated with hepatocytes so as to simulate the process of liver metabolism in a body, the lower layer chip is inoculated with different tumor cells and normal tissue cells, so that the effect of drugs, subjected to liver metabolism, on the different cells can be observed, and the effects of drugs, subjected to liver metabolism, on multiple groups of cells can be also observed; therefore, the screening and testing of the tumor targeting drugs can be realized, and the medicine formation rate of the screened drugs is greatly improved.

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

The present invention relates to an interferon livestock and poultry micro-ecology additive, which comprises, by mass, 18-22% of lactic acid bacteria, 20-30% of Bacillus subtilis, 10-14% of glucose, 0.5-1.5% of interferon-alpha, and 40-45% of plasma protein powder. According to the present invention, the product is based on the livestock and poultry body health, the probiotic and interferon combination way is used, and the body immunity improving and the in vivo virus purification are considered, such that the livestock and poultry disease occurrence is effectively reduced, and the death rate is reduced; after the used interferon-alpha is intaken by the livestock and poultry, the interferon can be bound with the receptor on the oral mucosa so as to be rapidly used by the body and avoid the gastric and hepatic metabolism, wherein the utilization rate is up to 90%, and no toxic-side effect exists; and after the lactic acid bacteria and the Bacillus subtilis enter the gastrointestinal tract, the intestinal tract microorganism balance can be adjusted, the intestinal tract health can be promoted, the nutrient absorption can be helped, and the body health level can be improved.

The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a definitive endodermal phenotype, a liver-committed endodermal phenotype, a hepatoblast phenotype, and hepatocyte phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of liver deficiency, liver metabolism studies, and liver toxicity studies.

The present disclosure provides nucleic acid molecules comprising a first inverted terminal repeat (ITR), a second ITR, and a genetic cassette encoding a target sequence. In some embodiments, the target sequence encodes a miRNA and / or a therapeutic protein. In certain embodiments, the therapeutic protein comprises a clotting factor, a growth factor, a hormone, a cytokine, an antibody, a fragment thereof, and a combination thereof. In some embodiments, the first ITR and / or the second ITR is an ITR of a non-adeno-associated virus (AAV). The present disclosure also provides methods of treating a metabolic disorder of the liver in a subject comprising administering to the subject the nucleic acid molecule or a polypeptide encoded thereby.

The invention relates to a pharmaceutical composition with the effects of relieving alcoholism and protecting the liver, and the composition is composed of cape jasmine fruit, common floweringquince fruit, flos puerariae, raisin tree seed and grape seed. The invention can effectively prevent being drunk when the invention is taken before drinking. The invention has good improvement effect for headache, dizziness and vomit symptoms which are caused by excessive drinking. The invention can improve the abnormal metabolism of the liver which is caused by alcohol. The invention can be made into the drugs or health care foods, foods and health care supplies with the effects of relieving alcoholism and protecting the liver.

The invention relates to a vegetable protein bioactive peptide solid beverage and a preparation method thereof. According to the vegetable protein bioactive peptide solid beverage, soy protein isolate, soybean peptide powder, wheat oligopeptide powder, corn oligopeptide powder, fructo-oligosaccharide, malt extracts, resistant dextrin, konjaku flour, vitamins, stevioside and milk essence are used as raw materials and are compounded by appropriate weight, and finally the solid beverage which can repair liver function and adjust body metabolism and is healthy and capable of reducing fat is prepared. According to the vegetable protein bioactive peptide solid beverage disclosed by the invention, under the synergistic reaction of raw material components, micromolecule peptides are easy to absorband utilize by human bodies, the content of trace elements is rich, absorption of nutrient substances can be quickly and comprehensively promoted, cell metabolism capacity is activated, balanced nutrition is provided for the human bodies, liver metabolism of the human bodies is adjusted, and the effects of adjusting the fat and reducing weight can be achieved. The preparation method of the product disclosed by the invention is simple, easy to operate and easy in popularization.

The present invention provides a sustained-release creatine preparation, which comprises 30-95% of creatine compound in weight percent and 5-70% of sustained-release material in weight percent. The creatine sustained-release preparation is executed with sustained-release processing and causes that the creatine is released slowly and continuously in vivo. The absorption rate is increased. Furthermore the gastrointestinal tract reaction caused by the simultaneously releasing of large amount of creatine in the stomach is prevented. The liver-kidney burden increasing caused by the discharging of redundant creatine by liver metabolism and urine is prevented. Compared with the common creatine, the sustained-release creatine has better effect in the aspects of increasing explosive force, promoting the growth of muscle, etc.

There is a need to develop a treatment for metabolic syndrome, which is directed to maintaining healthy liver metabolism and not indirectly through weight loss. The present invention provides a composition comprising whey protein for supporting and improving liver metabolism, especially in connection with fatty liver. The composition can further comprise Ca and health improving components such as probiotics and prebiotics. The composition can be in the form of food, health food, food supplement or drugs. Furthermore, due to the complexity of choice of a valid biomarker and sample matrix, there is a special need to find out specific biomarkers for fatty liver and metabolic syndrome. This invention also relates to a diagnostic method for determining fatty liver on the basis of metabolomic profiling. Statistical modelling methods are used on the metabolomic profiles to identify the biomarkers.

The invention belongs to the technical field of health-care products, and particularly relates to an alcohol effect dispelling and liver protecting health-care product and a preparation method thereof. The alcohol effect dispelling and liver protecting health-care product comprises the following components in parts by weight: 15-25 parts of coconut oil powder, 60-70 parts of konjac powder, 5-10 parts of semen hoveniae, 5 parts of fructus amomi, 4.5-5 parts of fructus citri and 0-0.5 part of citric acid. The preparation method of the health-care product comprises the following steps: (1) respectively crushing and sieving the coconut oil powder, the konjac powder, the semen hoveniae, the fructus amomi and the fructus citri, wherein the size of a sieve is 100 meshes; (2) weighing the components according to the parts by weight, and mixing uniformly; and (3) adding an additive to prepare capsules or tablets. The alcohol effect dispelling and liver protecting health-care product provided by the invention can be used for reducing the emptying speed of alcohol which enters the small intestines and increasing the residual rate of the alcohol in the stomach, so that the rate of the alcohol adsorbed in the stomach is increased, the amount of the alcohol which enters the blood is reduced, the intensity of liver metabolism is greatly alleviated, and the rate of the adsorbed alcohol can be increased above 90% from 60%-70%.

The invention discloses an enzyme jelly, which is prepared from the following raw materials: a plant comprehensive enzyme powder solid beverage, fructo-oligosaccharide, xylooligosaccharide, lactitol, prune concentrated juice, a compound thickening agent, caramel color, lactobacillus acidophilus, sodium citrate, citric acid, food essence, potassium sorbate and water. The enzyme jelly prepared by the invention has the functions of repairing intestinal mucosa, balancing intestinal flora, increasing toxin discharge, increasing harmful bacterium discharge, promoting food to decompose more nutrients, promoting intestinal water metabolism and the like, and meanwhile, can regulate the levels of glycometabolism, lipid metabolism, water metabolism, nutrient metabolism, intestinal mucosa cell metabolism and liver metabolism. The adopted raw materials are safe and high in quality, the technical process is advanced, and various requirements such as intestine moistening, intestine nourishing and body lightening can be met at the same time according to the fundamental principle; and the enzyme jelly prepared by the invention has uniqueness, is suitable for all people, and is simple to produce and convenient to transport and store.

There is a need to develop a treatment for metabolic syndrome, which is directed to maintaining healthy liver metabolism and not indirectly through weight loss. The present invention provides a composition comprising whey protein for supporting and improving liver metabolism, especially in connection with fatty liver. The composition can further comprise Ca and health improving components such as probiotics and prebiotics. The composition can be in the form of food, health food, food supplement or drugs. Furthermore, due to the complexity of choice of a valid biomarker and sample matrix, there is a special need to find out specific biomarkers for fatty liver and metabolic syndrome. This invention also relates to a diagnostic method for determining fatty liver on the basis of metabolomic profiling. Statistical modelling methods are used on the metabolomic profiles to identify the biomarkers.

The present invention provides a method of normalizing blood glucose levels in mammals utilizing liver-selective glucokinase activators. The present invention also provides a method of increasing liver metabolism and decreasing apoptosis independent of glucose normalization or hyperglycemic conditions.

The invention relates to the technical field of cat food preparation, and particularly relates to a composition for removing cat tear stains, a product for removing cat tear stains and a preparation method thereof. The composition is prepared from 20-30 parts of fresh chicken, 20-30 parts of rice flour, 10-15 parts of duck meat powder, 5-10 parts of chicken oil, 5-10 parts of fermented soybean meal, 5-10 parts of corn flour, 1-2 parts of pumpkin powder, 0.5-1 part of marigold, 0.1-0.5 part of semen cassiae, 0.3-0.5 part of fructus schizandrae and 1-2 parts of tea polyphenol powder. The functions of enhancing the liver metabolic capability of a pet cat, improving the anti-stress capability of the pet cat, relieving the immunosuppressive state of the pet cat, reducing tears of the pet cat and gradually eliminating the problem of the tear stains of the pet cat are achieved. The problems that the liver burden of the pet cat is too heavy, the pet cat is in a sub-health state, the pet cat is prone to stress, and the tears and eye droppings of the pet cat are too much are solved.

Substance for intestinal tract lavation and toxin expelling and a preparation method thereof are used for human intestinal tract toxin expelling. The substance for intestinal tract lavation and toxin expelling comprises stachyose, coffee bean, lactobacillus fermentation liquid, inorganic salt extract, natural lemon freeze drying powder and pure water. The substance for intestinal tract lavation and toxin expelling can adjust acid-base balance, flora balance and electrolyte balance in intestinal tract, a preparing and using method for intestinal tract lavation and toxin expelling can reinforce liver metabolism, promote bile secrete, protect liver, remove blood toxin, adjust intestinal tract of human to ideal state, make function of the intestinal tract more health and the metabolic of the intestinal tract more smooth, so that the intestinal tract has no dependence.

The invention discloses a tilapia mossambica precision-cut liver slice injury model and a construction method thereof. The method adopts cyclophosphamide to induce tilapia mossambica precision-cut liver slices, and the concentration of the cyclophosphamide is 25mM or below. Compared with the prior art, the method disclosed by the invention has the following advantages: (1) the cyclophosphamide-induced tilapia mossambica precision-cut liver slices are adopted for the first time to construct an injury model, and a basis is provided for researching a fish liver injury mechanism and screening and developing liver protection drugs; and (2) a tilapia mossambica precision-cut liver slice is adopted as an induction object of the method, the in-vivo state is simulated to the maximum extent, and the method is a more reliable model system for researching liver metabolism and in-vitro induction toxicity.

Experiment researches find that the expression quantity of GPR31 protein is gradually increased along with the prolonging of tissue ischemia time, and a positively related relationship exists between the expression quantity of GPR31 protein and tissue ischemia reperfusion injury severity. The overexpression of GPR31 can increase the activity of liver cells, cardiac muscle cells and kidney cells caused by H / R treatment. Moreover, the decrease of GPR31 expression in the liver cells can inhibit cellular lipid accumulation caused by palmitate and oleic acid stimulation. The overexpression of GPR31 in the cardiac muscle cells can increase cardiac hypertrophy caused by Angiotensin II. Therefore, the GPR31 inhibitor can be used for preparing drugs, and the drugs can be used for curing related diseases of ischemia reperfusion injury, cardiac hypertrophy and related diseases and liver metabolism diseases.

The invention discloses enzyme beer, which belongs to the technical field of the preparation of beer. The enzyme beer is prepared from the following ingredients by weight percent: 8 to 15 percent of beer stock solution, 55 to 65 percent of fresh fruits, 8 to 15 percent of brown sugar, 5 to 15 percent of rock candy, 3 to 8 percent of enzyme microorganism, and 3 to 8 percent of active proteins. The enzyme beer can effectively remove medicine toxicity and residual heavy metal in the body, can alleviate the burden of the liver metabolism, can promote the blood circulation, can increase the blood oxygen content, can promote the heart function, and is beneficial to the health of the human body after being frequently drunk.

The invention discloses a Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus, comprising: preparing Herba Phyllanthi Urinariae, Herba Origani Vulgaris and Herba Salviae Plebeiae into powder according to a weight ratio of 3:2:1, mixing the powder and feed according to a weight ratio of 1:100, and feeding a diseased pig; or adding distilled water 10 times as heavy as the powder, soaking for 1 h before 1 h of heating and refluxing, filtering with gauze while temperature is high, adding water 8 time as heavy as residue and water 6 times as heavy as the residue respectively to the residue for 1 h of heating and refluxing, combining three filtrates, concentrating under reduced pressure to obtain liquid medicine 1 g / mL in concentration, and intramuscularly injecting the diseased pig. TFF3 content can be significantly increased, thus improving mucosal defensive function of animal small intestines, decreasing NO level, improving intestinal peristalsis and intestinal juice electrolyte balance, enhancing animal physique, and decreasing bodily urea level can be decreased; ALB level can be significantly increased to improve bodily liver metabolism, GLO level can be significantly increased to enhance body immunity.