Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus

A technology for porcine epidemic diarrhea and viral diseases, applied in antiviral agents, pharmaceutical formulations, drug combinations, etc., can solve the problems of decreased vaccine effect and high cost of preventive measures, to improve defense function, speed up metabolism, and improve body immunity effect of function

Inactive Publication Date: 2016-08-24
JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a compound Chinese herbal medicine for preventing and treating porcine epidemic diarrhea

Method used

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  • Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus
  • Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus
  • Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The basic diet was provided by Nanjing Hejia Jisheng Agriculture and Animal Husbandry Development Co., Ltd. The composition and nutritional level of the basic diet are shown in Table 1. The traditional Chinese medicine Phyllostachys phylloxera, oregano, and lychee grass purchased from Tongrentang Pharmacy were made into powders at a mass ratio of 3:2:1, and then mixed with the basic diet at a mass ratio of 1:100 to conduct in vivo experiments on piglets.

[0019] Table 1 Basic diet composition and nutritional level (air-dried basis)

[0020]

[0021]

[0022] 40 weaned piglets of normal grade "Du × Da × Chang" triple cross, 35 days old, were purchased from the Jiangpu Experimental Pig Farm of Nanjing Agricultural University. After adapting to the environment, they were randomly divided into 4 groups, 10 in each group, half male and half female. The blank group and PEDV group were fed the basal diet without Chinese medicine compound, the prevention group and the d...

Embodiment 2

[0027] The traditional Chinese medicine Ye Xiazhu, oregano, and lychee grass purchased from Tongrentang Pharmacy are made into powders at a mass ratio of 3:2:1, and 10 times of distilled water is added to a round-bottomed flask, soaked for 1 hour, heated to reflux for 1 hour, and filtered with gauze while it is hot . Add 8 times of water and 6 times of water to the dregs of medicine and heat to reflux for 1 hour. The three filtrates were combined, concentrated under reduced pressure to obtain a drug solution with a crude drug concentration of 1 g / mL, and tested in piglets.

[0028] 40 weaned piglets of normal grade "Du × Da × Chang" triple cross, 35 days old, were purchased from the Jiangpu Experimental Pig Farm of Nanjing Agricultural University. After adapting to the environment, they were randomly divided into 4 groups, 10 in each group, half male and half female. PEDV group and treatment group with 10 6 TCID 50 / mL PEDVAH2012 / 12 strain challenged, each head was fed with...

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Abstract

The invention discloses a Chinese herbal compound for preventing and treating porcine epidemic diarrhea virus, comprising: preparing Herba Phyllanthi Urinariae, Herba Origani Vulgaris and Herba Salviae Plebeiae into powder according to a weight ratio of 3:2:1, mixing the powder and feed according to a weight ratio of 1:100, and feeding a diseased pig; or adding distilled water 10 times as heavy as the powder, soaking for 1 h before 1 h of heating and refluxing, filtering with gauze while temperature is high, adding water 8 time as heavy as residue and water 6 times as heavy as the residue respectively to the residue for 1 h of heating and refluxing, combining three filtrates, concentrating under reduced pressure to obtain liquid medicine 1 g/mL in concentration, and intramuscularly injecting the diseased pig. TFF3 content can be significantly increased, thus improving mucosal defensive function of animal small intestines, decreasing NO level, improving intestinal peristalsis and intestinal juice electrolyte balance, enhancing animal physique, and decreasing bodily urea level can be decreased; ALB level can be significantly increased to improve bodily liver metabolism, GLO level can be significantly increased to enhance body immunity.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a compound Chinese herbal medicine for preventing and treating porcine epidemic diarrhea virus disease. Background technique [0002] Porcine epidemic diarrhea, abbreviated as PED (Porcine Epidemic Diarrhea), is a contagious intestinal infectious disease caused by porcine epidemic diarrhea virus, characterized by vomiting, diarrhea, and dehydration. Clinical changes and symptoms are very similar to porcine transmissible gastroenteritis. It first appeared in the UK in 1971, and the disease occurred successively in my country in the early 1980s. In my country, it mostly occurs from December to January to February of the following year, mostly in the cold season, and there are also reports of onset in summer. [0003] Porcine epidemic diarrhea virus (PEDV) belongs to the genus Coronaviridae of the Coronaviridae family. The disease only occurs in pigs, and pigs of all ages can b...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P1/12A61P31/14
CPCA61K36/53A61K36/47A61K2236/333A61K2300/00
Inventor 胡屹屹茅爱华何孔旺温立斌倪艳秀郭容利范宝超
Owner JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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