132 results about "Weaned piglets" patented technology

The invention discloses swine bacillus velezensis YB-X-733 and application thereof, and relates to the technical field of microorganisms. The swine-derived bacillus velezensis YB-X-733 is preserved in the China General Microbiological Culture Collection Center on September 24, 2024, the preservation number is CGMCC No.32057, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the swine-derived bacillus velezensis YB-X-733 is classified and named as bacillus velezensis. The swine bacillus velezensis YB-X-733 disclosed by the invention has a good inhibition effect on escherichia coli, staphylococcus aureus and salmonella, and can be used for preparing a piglet inflammation resisting product. The swine-origin bacillus velezensis YB-X-733 disclosed by the invention can be used for obviously improving the metabolic capability of weaned piglets and improving the physiological status of the piglets; the immunocompetence of weaned piglets is improved, and inflammation is reduced; the microbial flora in the intestinal tracts of the weaned piglets can be obviously improved, the growth of harmful bacteria is inhibited, and the growth of beneficial bacteria is promoted.

The invention belongs to the technical field of microorganisms, and particularly discloses bacillus velezensis DZ-4-002 and application thereof. According to the bacillus velezensis DZ-4-002 provided by the invention, the Latin name is bacillus velezensis, and the preservation number of the bacillus velezensis DZ-4-002 is CGMCC (China General Microbiological Culture Collection Center) No.25955. The strain not only can produce nitrite reductase at high yield, but also can improve the growth performance of animals and the milk production performance of cows. Within the experimental range of the invention, the bacillus velezensis provided by the invention not only can improve the egg production increase rate, the average egg weight and the feed utilization rate of laying hens, but also can improve the average daily gain, the average daily feed intake and the feed utilization rate of weaned piglets, and the average milk yield, the milk-feed ratio and the lactose content in milk of dairy cows. The method has a good application prospect in the fields of nitrite degradation agents, feeds, additives of the feeds and the like.

The invention relates to the field of preparation of animal husbandry vaccines, in particular to a porcine circovirus, mycoplasma hyopneumoniae and haemophilus parasuis triple vaccine which comprises 30-50 parts of first bacterial liquid containing inactivated haemophilus parasuis; an adjuvant; 40 to 60 parts of a culture solution of a mycoplasma hyopneumoniae culture; 30-40 parts of a second bacterial liquid containing inactivated porcine circovirus; 1 to 10 parts of tween-80; 2-6 parts of aluminum stearate; 1 to 3 parts of interleukin; and 2-4 parts of squalane. The vaccine is mainly applied to prevention of porcine circovirus, mycoplasma hyopneumoniae and haemophilus parasuis for boars and piglets in a pig farm, reduces the multi-system failure syndrome, mycoplasma hyopneumoniae, polyserositis, arthritis and meningitis of weaned piglets in the pig farm and the morbidity of multi-infection-source successive infection, and improves the survival efficiency of the piglets.

The invention provides a streptococcus suis vaccine recombinant fusion protein and a preparation method and application thereof, the recombinant fusion protein is a recombinant protein formed by series fusion of B cell epitopes of Sao, SLY and PepO proteins of streptococcus suis, and the amino acid sequence of the fusion protein is as shown in SEQ ID NO.1. After four-week-old weaned piglets are immunized by the fusion expression protein for 28 days, 80% and 60% of challenge protection rates can be provided for challenge of streptococcus suis type 2 and type 9 virulent strains respectively. The invention has great potential for clinical prevention and control of streptococcus suis infection.

The invention relates to the technical field of agricultural waste recycling and feed industry, in particular to a traditional Chinese medicine residue feed additive as well as a preparation method and application thereof. The preparation method comprises the following steps: drying traditional Chinese medicine residues, crushing to obtain a crushed material, mixing the crushed material with a compound enzyme, carrying out enzymolysis to obtain an enzymolysis material, mixing the enzymolysis material with lactobacillus plantarum LP-01, carrying out anaerobic fermentation to obtain a fermented material, mixing the fermented material with a yeast extract and manganese sulfate to obtain a mixture, mixing the mixture with water, extracting, filtering to obtain a filtrate, concentrating, and carrying out freeze drying to obtain a finished product. The traditional Chinese medicine residue feed additive is obtained. By adopting the traditional Chinese medicine residue feed additive provided by the invention, the diarrhea rate of weaned piglets can be reduced, the stress resistance of aquatic animals is improved, and the growth performance of poultry is improved.

The invention relates to the technical field of microorganisms, in particular to ruminococcus buchneri and application of in-vitro pure culture metabolic supernate of the ruminococcus buchneri in promoting intestinal development of piglets. The invention relates to ruminococcus buchneri, and the collection number of the ruminococcus buchneri is ATCC (American Type Culture Collection) 51896. The ruminococcus buchneri and the in-vitro pure culture metabolic supernate thereof can obviously improve the unit intestinal weight of the cecum of the weaned piglets, and have the trend of increasing the unit intestinal weight of the jejunum and the ileum of the piglets, increasing the average daily feed intake and reducing the feed-to-gain ratio. The in-vitro organoid culture result also shows that the amplification efficiency of the jejunum organoid of the piglet is remarkably improved.

The invention relates to a model for evaluating the demand amount of dynamically suitable standard ileum digestible Lys of weaned piglets, which comprises a fold-linear model and a fold-linear quadratic model, wherein the fold-linear model is Y = L + U * (R-X), and X is less than R; y = L, X > = R, Y = L + U * (R-X) 2, and X < R; y is equal to L, X is larger than or equal to R, a weaned piglet lysine demand amount dynamic model of weaned piglets with 7-25 kg of weaned piglets or weaned piglets with 20-25 kg of weaned piglets is established, and a weaned piglet dynamic suitable standard ileum digestible Lys demand amount calculated according to the dynamic model is provided. According to the method, the dynamic evaluation model for the lysine demand amount of the weaned piglets is established, the SID lysine demand amount of the weaned piglets is optimized based on ADG, G: F and body protein deposition indexes, the nutritional requirements of the piglets are accurately evaluated, the balance of feeding cost, piglet growth performance and environmental pollution is achieved, and the problems of high feeding cost, environmental pollution and the like are effectively relieved.

The invention discloses a compound feed for weaned piglets and a preparation method thereof, relates to the technical field of feeds, and solves the problems of high stress, low food consumption, slow weight gain, intestinal damage, high diarrhea rate and low survival rate of weaned piglets. Each ton of compound feed for weaned piglets comprises the following raw materials: corn, broken rice, soybean meal, super steam fish meal, extruded soybeans, fermented soybean meal, peanut meal, flour, whey powder, glucose, white sugar, soybean oil, linseed oil, coconut oil, calcium formate, calcium hydrophosphate, amino acid, a vitamin additive, a trace element premix, composite dietary fibers, auxiliary materials and the like. The feed additive can improve the feed intake of piglets, protect the intestinal health of the piglets, enhance the immunity, relieve the weaning stress of the piglets, reduce the incidence rate of diarrhea and disease of the piglets and improve the weight gain rate of the piglets.

The invention discloses a piglet intestinal health targeting probiotic engineering bacterium compound as well as preparation and application thereof. The compound is FP (at) EcN-pnirNKL, wherein a) the EcN-pnirNKL is an engineering strain which is constructed by taking escherichia coli Niss1917 (EcN) as a host and carrying a recombinant plasmid pnirBMisL-NK-Lysin, and a) the EcN-pnirNKL is an engineering strain which is constructed by taking escherichia coli Niss1917 (EcN) as a host and carrying a recombinant plasmid pnirBMisL-NK-Lysin; b) the recombinant plasmid pnirBMisL-NK-Lysin comprises an NK-Lysin gene optimized by a codon, and the NK-Lysin gene is integrated into the anaerobic inducible plasmid pnirBMisL through homologous recombination; c) the FP is a composite nano-particle which takes nano mesoporous silica (MSN) as a core and is formed by crosslinking fucoidin and rhodiola rosea polysaccharide; and d) the FP (at) EcN-pnirNKL is an oral delivery system which is formed by encapsulating the engineering bacterium EcN-pnirNKL in the FP nano particles. When the compound is applied to prevention and treatment of stress response of weaned piglets, various typical symptoms, including weight loss, colon shortening, histopathological injury and colitis disease response, of the piglets induced by dextran sodium sulfate can be remarkably relieved, and meanwhile, the integrity and functions of an intestinal barrier structure are effectively protected.

The invention relates to the technical field of biology, in particular to application of lactobacillus reuteri RZ-D15L14 and a metagen to reduction of the diarrhea rate and the death and culling rate of weaned piglets, the lactobacillus reuteri is lactobacillus reuteri, the strain number of the lactobacillus reuteri is RZ-D15L14, the lactobacillus reuteri is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO: M 20231503. After 500mg / kg of lactobacillus reuteri RZ-D15L14 is added into daily ration, the antioxidant function of the body and the intestinal health can be enhanced by improving the activity of antioxidant enzyme, reducing the content of oxidation products and improving the content of short-chain fatty acid in the intestinal tract, so that the effect of reducing the diarrhea rate and the death and culling rate of the piglets is achieved, and the positive effect is particularly outstanding in weak piglets.

The invention belongs to the technical field of additives, and particularly relates to application of osthole in preparation of an additive for preventing diarrhea of weaned piglets. Aiming at the problem that the influence of the cnidium lactone on the piglet diarrhea is not found at present, the invention firstly discovers that the piglet diarrhea can be prevented by adding the cnidium lactone into the daily ration of the weaned piglets, so that the invention provides the application of the cnidium lactone in preparing the additive for preventing the weaned piglet diarrhea. The invention further finds that the coated cnidium lactone coated by a specific method has a better effect of preventing piglet diarrhea. A brand new additive substance cnidium lactone is developed for weaned piglet diarrhea, and the cnidium lactone serving as a plant extract is safe, free of toxic and side effects, remarkable in effect of preventing weaned piglet diarrhea and suitable for large-scale application and popularization.

The invention provides a traditional Chinese medicine composition for improving the survival rate of piglets and a preparation method and application thereof, and belongs to the technical field of feed additives. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6 to 10 parts of fructus forsythiae, 15 to 22 parts of radix isatidis, 15 to 22 parts of radix scutellariae, 8 to 12 parts of honeysuckle flower, 5 to 8 parts of herba taraxaci, 10 to 15 parts of rhizoma atractylodis macrocephalae, 8 to 12 parts of poria cocos, 6 to 10 parts of rhizoma dioscoreae, 12 to 18 parts of radix astragali seu hedysari, 8 to 12 parts of radix bupleuri, 5 to 8 parts of liquorice root and 3 to 6 parts of semen ziziphi spinosae. Based on the traditional Chinese medicine theory of supporting healthy energy and giving consideration to both symptoms and root causes, a three-dimensional synergistic system of clearing heat, resisting bacteria, invigorating spleen, benefiting intestines, tonifying qi and resisting stress is constructed to adapt to the physiological characteristics of weaned piglets, so that the problems of low survival rate, slow growth and substandard quality in weaned piglet breeding are solved, and the survival rate of the weaned piglets is remarkably improved.

The invention relates to application of acremonium terricola F2652 in preparation of a preparation for improving the production performance, immunity or antioxidation of weaned piglets, and belongs to the technical field of strain fermentation. The contents of active components such as cordycepin, polysaccharide and the like in secondary metabolites of the acremonium terricola F2652 are obviously increased, so that the conversion and enrichment of the polysaccharide of the acremonium terricola strain can be realized while the content of a symbolic component cordycepin of cordyceps fungi is increased. The acremonium terricola F2652 is subjected to liquid submerged fermentation to obtain a fermentation culture, the advantages of amphiphilic parents are fused, the excellent compound polysaccharide synthesis capacity is reserved, the good cordycepin accumulation potential is also fused, and the acremonium terricola culture with the high cordycepin content can be developed; the practical application of the feed additive as a functional feed additive in different animals can be enriched.

This invention discloses the application of a porcine-derived Bacillus in antioxidant activity, wherein the porcine-derived Bacillus is used to prepare antioxidant products. The porcine-derived Bacillus is Bacillus subtilis YB-X-721, classified as Bacillus subtilis, and was deposited at the China General Microbiological Culture Collection Center on November 10, 2023, with accession number CGMCC No. 28942. The fermentation supernatant, bacterial suspension, and cell-free extract of the porcine-derived Bacillus subtilis YB-X-721 of this invention all possess certain DPPH free radical, superoxide anion free radical, and hydroxyl free radical scavenging abilities, as well as a certain reducing ability, and can be used to prepare antioxidant products. Furthermore, when the porcine-derived Bacillus subtilis YB-X-721 of this invention is added to piglet feed as an animal feed additive, it can improve the growth performance of weaned piglets, significantly increasing average daily weight gain, and significantly reducing average daily feed intake, feed conversion ratio, and diarrhea rate.

The invention discloses a preparation method of portulaca oleracea polysaccharide. The preparation method comprises the following steps: S1, pretreating portulaca oleracea; s2, degreasing treatment; s3, extraction of crude purslane polysaccharide; s4, removal of alcohol soluble impurities; s5, removing pigments; s6, removal of protein; s7, removing small molecular impurities; and S8, separation and purification. The purslane polysaccharide extracted by the method disclosed by the invention is applied to preparation of a feed additive which has a growth promoting effect and / or a diarrhea preventing and treating effect on piglets. The extraction method provided by the invention can effectively improve the extraction efficiency of the active components, and ensures that the extract has relatively strong biological activity and protective effect. The portulaca oleracea polysaccharide disclosed by the invention has relatively strong water retention effect and thermal stability, good solubility and good adsorption effect, has a remarkable growth promoting effect on piglets, can be used for remarkably reducing the diarrhea rate of weaned piglets, and has a good application prospect in livestock breeding.

The invention discloses application of an aromatic hydrocarbon receptor stimulant in preparation of a medicine for treating diarrhea of weaned piglets and / or inhibiting inflammation, and belongs to the field of biological medicine. According to the present invention, with the PAS-B structural domain of the AHR as the target, the virtual screening technology, the target verification test and the weaned piglet diarrhea pharmacodynamic evaluation test are performed to determine the arctigenin as the AHR strong agonist and the anti-inflammatory drug, and the arctigenin has the good treatment effect on the weaned piglet diarrhea. Experimental results show that 10 mg / kg of arctigenin can significantly relieve diarrhea and hemafecia symptoms of weaned piglets, reduce the content of inflammatory factors in serum and intestinal tissues and improve the intestinal structure of weaned piglets, has no significant cytotoxicity, hepatorenal toxicity and intestinal epithelial cell growth inhibition effect, and can be used for preparing a feed additive for weaned piglets. The compound can be used for preparing medicines for treating diarrhea of weaned piglets. The invention provides a new raw material medicine for treating diarrhea of weaned piglets, and has great economic value and wide application prospect.

The invention provides application of D-mannose in preparation of a product for improving intestinal mucosa immunity and / or intestinal flora homeostasis of weaned piglets, and particularly belongs to the technical field of weaned piglet breeding. The invention provides application of D-mannose in preparation of a product for improving intestinal mucosal immunity and / or intestinal flora homeostasis of weaned piglets. The D-mannose is derived from a natural plant, can stably and efficiently improve intestinal mucosa immunity and intestinal flora homeostasis of the weaned piglets, relieves diarrhea, and improves the growth performance of the weaned piglets at the same time. Specifically, D-mannose can improve the growth performance of weaned piglets, reduce the diarrhea rate, improve the intestinal structure, enhance the chemical barrier function of the intestinal tract, reduce the abundance of harmful bacteria in the intestinal tract and increase the content of short-chain fatty acid producing bacteria.

The invention relates to the technical field of preparation of feed additives, in particular to a traditional Chinese medicine compound feed additive for preventing stress syndromes of early weaned piglets and a preparation method of the traditional Chinese medicine compound feed additive. The medicine specifically comprises the following components: rhizoma osmundae, astragalus membranaceus, mangnolia officinalis, hawthorn, medicated leaven, pericarpium citri reticulatae, polygala tenuifolia, Chinese pulsatilla root, cortex fraxini, poria cocos, liquorice and spina date seed. The traditional Chinese medicine compound feed additive provided by the invention has a remarkable technical effect in the aspect of preventing the early-stage weaned piglet stress syndrome. Through scientific compatibility of various traditional Chinese medicine components, the additive can effectively improve the digestive function of the weaned piglets, enhance the immunity, relieve the stress response and remarkably reduce the diarrhea rate and the death rate. Experimental results show that piglets using the additive are superior to a blank control group and other substitution groups in the aspects of weight gain, oxidation resistance, serum hormone level, immune globulin indexes and the like, and the additive is proved to have a comprehensive physiological regulation function.

The invention relates to the field of veterinary biological products, in particular to a porcine epidemic diarrhea virus attenuated strain and a vaccine and application thereof. The porcine epidemic diarrhea virus attenuated strain provided by the invention is obtained through in-vitro separation culture and continuous five rounds of plaque purification and screening technology, and has stable culture characteristics. Meanwhile, the virulence of the strain on newborn piglets and weaned piglets is remarkably reduced, and the virulence does not have the phenomenon of reversion after continuous passage for five times in a pig body. The strain has good immunogenicity, and mucosal immunity and systemic immune response of an organism can be activated at the same time by adopting an oral immunization mode. A neutralizing antibody of 1: 8-1: 16 can be detected in oral fluid and serum after the piglets are immunized for 14 days, and a large amount of sIgA is generated in milk after the pregnant sows are immunized, so that the piglets obtain effective passive immune protection.

The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.

The invention relates to the technical field of feed additives, in particular to a traditional Chinese medicine composition for preventing and treating weaning stress of piglets as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 4-12 parts of acanthopanax, 3-9 parts of plantain herb, 3-9 parts of red peony root, 1-3 parts of elecampane and 1-3 parts of fructus aurantii. The traditional Chinese medicine composition can improve stress diarrhea caused by the fact that weaned piglets leave sows and do not adapt to new environments, and the stress reaction of the weaned piglets is relieved by taking the sedative and tranquillizing acanthopanax as a monarch drug; the herba plantaginis for dredging and regulating water channels is used as a ministerial drug to promote diuresis, expel toxins and improve viscera functions of piglets, and the radix paeoniae rubra is used as a ministerial drug to promote blood circulation, remove blood stasis and promote excretion of metabolites; the radix aucklandiae is used as an adjuvant drug, and the fructus aurantii is used as an envoy drug to promote qi and eliminate stagnation, promote gastrointestinal excretion of weaned piglets and improve gastrointestinal functions. Through scientific compatibility, the medicine effect can be synergistically enhanced, and the weaning stress reaction of piglets is relieved.

The invention relates to the technical field of microbial fermentation, in particular to a preparation method and application of a digestible biological protein fermentation material. According to the fermentation method, candida utilis serves as a fermentation strain, industrial and agricultural waste glucose mother liquor and corn steep liquor serve as substrates, high-yield mycoprotein is obtained under the relative low-temperature fermentation condition of 20-25 DEG C, and the obtained fermentation liquor is subjected to single enzymolysis, so that a fermentation material easier to digest is obtained. When weaned piglets are fed with the obtained fermented material, the diarrhea rate of the piglets can be effectively reduced.

The invention discloses a strain for preventing diarrhea of weaned piglets and application of the strain, relates to the field of animal husbandry, and aims to solve the problem of frequent weaning diarrhea of piglets in the current pig raising industry. The enterococcus monteilii PL86 disclosed by the invention is currently preserved in the China Center for Type Culture Collection, the preservation address is Luojia Mountain, Luojia Mountain, eight road, Wuchang District, Wuhan City, Hubei Province, the preservation date is July 10, 2023, and the preservation number is CCTCC NO: M 20231246. On the basis of research on the occurrence mechanism of piglet weaning diarrhea, main dominant microorganisms in excrement of weaning piglets are separated and identified, biological characteristic research is carried out on the dominant microorganisms, a scientific theoretical basis is provided for production of probiotic preparations capable of preventing weaning piglet diarrhea, and the beneficial effects of reducing use of drugs in the animal breeding process and improving the production efficiency are achieved. And the production of functional animal products has great significance in protecting human health.

The invention aims to disclose a feed suitable for weaned piglets and application thereof, and can effectively solve the technical problem of diarrhea caused by stress of the weaned piglets due to the fact that the gelatinization degree and the hardness of an existing superfine grinding feed cannot be well coordinated by adopting a specific ration component proportion and combining a specific nutritional index level. The piglet feed containing superfine ground corn is prepared by adopting a specific processing technology and combining with a specific raw material ratio, a unique expanded feed daily ration system is constructed, the diarrhea condition of weaned piglets is effectively improved, digestion and absorption of nutritional ingredients of the piglets are promoted, the utilization efficiency of the feed is improved, and the survival rate and growth performance of the piglets are improved; and the overall health management of the farm and the improvement of economic benefits can be indirectly promoted.

The invention relates to a low-residual zinc complex feed additive and a preparation method and application thereof, and belongs to the technical field of feed additives. The zinc element in the feed additive exists in the form of a small peptide zinc complex, the chelating strength coefficient of the small peptide zinc complex is not lower than 850, and the zinc retention rate after the small peptide zinc complex is digested in simulated gastric juice for 2 hours is not lower than 95%. The preparation method comprises the following steps: carrying out enzymolysis on protein to obtain a small peptide solution, then carrying out complex reaction on the small peptide solution and zinc salt under the coupling condition of pulse ultrasound and gradient heating, and then carrying out dynamic pH refining and drying. Through a unique coupling technology, the problems that conventional organic zinc gastric juice is poor in stability and poor in effect under the low addition amount are solved, the prepared additive can achieve the anti-diarrhea effect equivalent to that of 1200-1600 mg / kg zinc oxide with the low addition amount of 300-600 mg / kg (in terms of zinc element) in daily ration of weaned piglets, meanwhile, the zinc discharge amount of excrement is reduced by 80% or above, and the production cost is reduced. Unification of efficient replacement and low residue is realized.

The invention discloses a pig feed containing nano-selenium and a preparation method of the pig feed. The pig feed is specifically prepared by mixing corn, soybean meal, fermented soybean meal, extruded soybeans, whey powder, an amino acid premix, calcium citrate, monocalcium phosphate, a vitamin premix, a trace element premix, compound enzymes, nano-selenium composite fibers, protein modified loaded nano-selenium and the like. The feed contains nano-selenium, is scientific in formula, meets the nutritional requirements of weaned piglets, and promotes the growth of the piglets.

The invention belongs to the technical field of animal nutrition and feed, discloses an application of a Fuzhuan tea extract in prevention of vomitoxin-caused piglet health injury, and particularly relates to an application of the Fuzhuan tea extract as a feed additive in prevention or improvement of piglet health injury. The feed additive can effectively reduce negative effects on weaned piglets caused by excessive vomitoxin in the feed, wherein the negative effects comprise growth performance reduction, diarrhea rate increase, intestinal morphology damage, intestinal cell proliferation inhibition, intestinal epithelial barrier injury, immune disorder, abnormal liver function and excessive oxidative stress and inflammatory response.

The invention discloses a feed additive for relieving diarrhea of weaned piglets and improving intestinal health and application of the feed additive. According to the invention, it is found for the first time that the growth performance of the weaned piglets can be improved and the diarrhea rate can be reduced by adding wormwood polysaccharides with different concentrations into daily ration of the weaned piglets; the apparent nutrient digestibility is improved, and the utilization rate of the piglets on nutrient substances such as protein, fat and mineral substances in the feed is promoted; the antioxidant capacity of serum is improved; the microbial flora structure is improved; the content of short-chain fatty acid is increased; the metabolic capability of intestinal microorganisms of piglets is improved. The application of the feed additive is expected to improve the efficiency and quality of piglet breeding, and the feed additive is more suitable for popularization and application in the breeding industry and has a wide application prospect. In addition, the invention provides a new solution thought and method for livestock production and animal growth.

The present invention discloses a Pichia kudriavzevii yeast having the function of protecting intestinal health and its application, and belongs to the field of microbial technology. The Pichia kudriavzevii FZ12 has been deposited in the China Center for Type Culture Collection on January 4, 2023, with the deposit number CCTCCM2023022. The present invention finds that the strain has strong tolerance to temperature, pH, bile salts and artificial gastric juice, and its bacteria and metabolites have strong DPPH free radical scavenging ability. Further animal experiments have found that the strain can significantly improve the growth performance of weaned piglets, reduce diarrhea rate, enhance piglets' immune response ability, promote intestinal development, regulate intestinal microbial balance and increase intestinal short-chain fatty acid concentration, and has the function of protecting intestinal health.

The invention discloses clostridium butyricum, a clostridium butyricum preparation for preventing and controlling African swine fever virus and application of the clostridium butyricum preparation, and belongs to the technical field of microorganisms. The clostridium butyricum JBH-KOLONIZER BD-10 serving as a fermentation strain is preserved in the China Center for Type Culture Collection, and the preservation number of the clostridium butyricum JBH-KOLONIZER BD-10 is CCTCC (China Center for Type Culture Collection) NO: M 20231636. The clostridium butyricum fermentation liquor disclosed by the invention has an obvious inhibition effect on the replication of the African swine fever virus. The clostridium butyricum is used as a fermentation strain to prepare the clostridium butyricum microbial preparation, and the clostridium butyricum microbial preparation is added into pig complete feed, so that African swine fever virus replication can be effectively inhibited, oxidative stress can be relieved, the non-specific antibody level of weaned piglets can be improved, and pig herd health can be promoted. In addition, the clostridium butyricum preparation is free of drug resistance and toxic and side effects after being applied to swinery and has the advantages of being low in cost, high in safety and environmentally friendly.