98 results about "Magnolol" patented technology

The invention provides transparent shampoo with fluffy and anti-dandruff effects and a preparation method of the transparent shampoo. The shampoo comprises the following components in percentage by weight: 10%-20% of sodium laureth sulfate; 0.5% to 10% of ammonium laureth sulfate; 0.5%-10% of cocamidopropyl betaine, 0.5%-10% of 0.5%-10% of coconut oil fatty acid monoethanolamide; 0.5% to 10% of decyl glucoside; 0.6% to 1.5% of capryloyl glycine; 0.1% to 1% of cationic guar gum; 0.1% to 1% of polyquaternium-10; 0.1% to 1% of polyquaternium-11; 0.1% to 1% of polyquaternium-51; 0.01% to 2% of magnolol; 0.01% to 2% of menthol; 0.1%-1% of sodium chloride; 0.1%-1% of citric acid; and 0.1%-1% of disodium EDTA. The shampoo disclosed by the invention has the effect of improving the combing performance in a dry hair state, can effectively improve the smoothness of hair and the touch comfort during use, and also has a supporting effect and antibacterial and anti-dandruff effects. According to the shampoo process, the clarity and appearance stability of the product are remarkably improved, and the shampoo can be kept in a transparent and uniform state for a long time.

The invention relates to the technical field of plastics, and discloses an anti-aging modified plastic and a preparation method thereof.The preparation method comprises the following steps that low-density polyethylene, maleic anhydride grafted polyethylene, an antioxidant 168, calcium stearate, calcium carbonate, 2-(2 '-hydroxy-3', 4 '-dihydroxyphenyl)-1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate and a plasticizer are mixed, stirred and stirred, and The preparation method comprises the following steps: uniformly mixing 4, 5 '-di-tert-butylphenyl)-benzotriazole, quaternary phosphonium salt modified chitosan and modified magnolol in a high-speed mixer, carrying out extrusion granulation in a twin-screw extruder at a blending temperature of 190-195 DEG C and an extrusion temperature of 170-180 DEG C, drying, and carrying out injection molding by an injection molding machine to obtain the anti-aging modified plastic. The anti-aging modified plastic disclosed by the invention has relatively good anti-aging, flame-retardant and antibacterial effects.

The invention provides fluorenyl magnolol light-cured solder resist ink and a preparation method thereof, the solder resist ink comprises the following raw material components by mass: 20%-60% of fluorenyl magnolol light-cured resin, 10%-25% of a reactive diluent, 10%-30% of a nano filler, 1%-5% of a photoinitiator, 0.1%-5% of an auxiliary agent, and the balance of a solvent, the fluorenyl magnolol light-cured resin is prepared by reacting 9-fluorenylidene acetic acid with thionyl chloride to generate an intermediate product fluorenyl anhydride, and then reacting the intermediate product fluorenyl anhydride with magnolol. Wherein the molar ratio of magnolol to thionyl chloride to 9-fluorenylidene acetic acid is 1: (2-4): (2-4). The preparation process is simple, toxic by-products are avoided, the prepared solder resist ink has excellent flame retardance, heat resistance and adhesive force, low dielectric constant and high hardness, the problems of high dielectric loss, insufficient flame retardance and BPA toxicity of traditional ink are solved, and the solder resist ink is completely suitable for production and manufacturing of PCB substrates for high-frequency communication.

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The invention particularly relates to oral cavity anti-inflammatory toothpaste and a preparation method thereof. Comprising the following components in parts by weight: 20-30 parts of a friction agent, 1-2 parts of a surfactant, 1-2 parts of a thickening agent, 20-30 parts of a humectant, 0.1-0.55 part of a sweetening agent, 0.1-0.3 part of a preservative, 3-5 parts of an anti-inflammatory nano-composite, 0.3-0.35 part of lysozyme, a pH regulator for maintaining the pH value of the toothpaste to be 6.5-7.4, and the balance of water added to 100 parts. The anti-inflammatory nano compound is a nano compound formed by encapsulating patchouli alcohol, magnolol and a Zn-chlorogenic acid complex by using Eudragit E100 / chitosan. The intelligent pH response core-shell structure Eudragit E100 / chitosan is adopted, anti-inflammatory active ingredients can be accurately released at the oral inflammation part, the targeted delivery effect of efficient release of the inflammation part is achieved, a lysozyme pH response nano system is combined, the antibacterial spectrum is enhanced while targeted release is achieved, and the anti-inflammatory effect is achieved. The patchouli alcohol (antibacterial), the magnolol (anti-inflammatory) and the Zn-chlorogenic acid complex (repair promoting) form a composite efficacy system, and experiments prove that the inhibition rate on inflammatory factors such as TNF-alpha and IL-6 is about 70%.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention relates to the technical field of phenolic resin, and discloses high-temperature-resistant phenolic resin and a preparation method thereof.Polytetrahydrofuran ether glycol and diphenylmethane diisocyanate are used for synthesizing a polyurethane prepolymer, a flexible chain segment is introduced, then a phenolic hydroxyl terminated polymer containing cyano groups is prepared through a condensation reaction of magnolol and dichlorobenzonitrile, and the high-temperature-resistant phenolic resin is prepared. Introducing a heat-resistant functional group into the system, and then combining the two prepolymers under the action of a catalyst to form a phenol-based intermediate; and then carrying out polycondensation on the intermediate, phenol and formaldehyde under an acidic condition to generate the cyano-modified phenolic resin. And finally, blending with boron phenolic resin to obtain the high-temperature-resistant phenolic resin. The high-temperature-resistant phenolic resin provided by the invention has better heat resistance and the preparation method thereof.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The invention discloses a method for determining four mangnolia officinalis extracts in import and export cosmetics, which is used for detecting magnolol, honokiol, magnoflorine and magnoliavine, and comprises the following steps: S1, uniformly mixing a cosmetic sample with a solvent; s2, after uniform mixing, carrying out vortex oscillation treatment on the sample; s3, after vortex oscillation treatment, carrying out ultrasonic extraction on the sample at room temperature to obtain an extracting solution; s4, mixing the extracting solution with an adsorbent to obtain a purified to-be-detected solution; and S5, filtering the to-be-detected liquid, and determining the to-be-detected liquid through LC-MS / MS to obtain a detection result. According to the present invention, the target object in the cosmetics with different matrix types can be effectively represented, the core functional components such as magnolol and honokiol in the cortex magnoliae officinalis extract can be detected, the qualitative and quantitative analysis can be further performed on the potential supervision risk substance, and the dual functions of quality evaluation and safety supervision can be provided for the cosmetics.

The invention discloses a sugarcane polyphenol and magnolol compound raw material as well as a preparation method and application thereof. The compound raw material is prepared from the following components in percentage by mass: 30 to 60 percent of sugarcane polyphenol extract (polyphenol is more than or equal to 20 percent), 10 to 30 percent of pure magnolol (the purity is more than or equal to 98 percent), 5 to 15 percent of cosolvent, 2 to 8 percent of stabilizer and the balance of deionized water. The preparation method comprises the following steps: extracting and purifying the sugarcane polyphenol and magnolol, dissolving the auxiliary materials, mixing, and sterilizing to obtain the finished product. The compound raw material can be used for oral care products such as toothpaste, can synergistically inhibit streptococcus mutans, destroy bacterial plaque, prevent caries and protect gingiva, is safe and stable, and is suitable for long-term use.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a method for preparing a honokiol derivative and an intermediate thereof. The preparation method comprises: reacting compound M2 with ethyltriphenylphosphonium bromide under alkaline conditions to prepare a compound of formula I; allylating the compound of formula I to prepare compound M3; demethylating compound M3 under acidic conditions to prepare compound M4; and rearranging compound M4 to prepare a compound of formula II. This method utilizes readily available, inexpensive raw materials, is low cost, has simple steps, mild reaction conditions, low purification requirements, high purity, high yield, is environmentally friendly, safe, and suitable for industrial production, thus possessing significant application value.

The invention discloses a magnesium hydride-magnolol composite polymer microneedle system as well as a preparation method and application thereof. The magnesium hydride-magnolol composite polymer microneedle system is (PVA-PVP)-x (MgH2-Mag), the mass ratio of PVA to PVP is (1: 2)-(1: 0.25); the ratio of MgH2 to Mags is 1: 1-1: 0.05; x is 1: 20-1: 5, the magnesium hydride-magnolol composite polymer microneedle (PVA-PVP)-x (MgH2-Mag) for treating androgenic alopecia is in a three-dimensional microneedle form, the height is 120-950 [mu] m, the substrate width is 80-500 [mu] m, and the needle tip diameter is 6-80 [mu] m. Through unique structural design and material combination, efficient co-delivery and synergistic release of the two active components are realized, and a brand new solution is provided for AGA treatment.

This invention discloses a traditional Chinese medicine composition for combating mandarin fish double RNA virus, comprising at least one of geniposide, baicalin, luteolin, magnolol, and mangiferin as active ingredients. The invention also discloses a method for preparing the traditional Chinese medicine composition and its applications. This invention can significantly inhibit the proliferation and replication of mandarin fish double RNA virus and significantly improve the survival rate of mandarin fish.

The invention discloses an application of magnolol in prevention and treatment of sweet potato rot, magnolol is used as a bactericide to be applied to prevention and treatment of sweet potato pathogenic fungal diseases, the diseases are sweet potato rot, and the pathogen is Trichoderma hamatum. Bacteriostatic plant source compound screening is carried out on novel sweet potato pathogenic fungi, it is found that magnolol shows the best inhibitory activity on trichoderma hamatum, and in addition, the fungicidal composition with magnolol as the active ingredient shows a good protection effect on sweet potato rot caused by the novel pathogen. The magnolol has relatively high safety and environmental compatibility and can inhibit various pathogenic fungi, the magnolol is taken as an active component, a green and safe prevention and control method for the trichoderma hamatum rot of the sweet potatoes is formulated, an important reference is provided for disease management after the sweet potatoes are harvested, and the method is suitable for popularization and application of the trichoderma hamatum rot of the sweet potatoes. The magnolol as the botanical fungicide has high application potential in prevention and control of plant diseases. And an important reference is provided for disease management after sweet potato harvesting.

The invention belongs to the technical field of organic synthesis, and discloses a dialkylated cationic derivative based on honokiol mother nucleus as well as a preparation method and antibacterial application of the dialkylated cationic derivative. The preparation method comprises the following steps: mixing honokiol, potassium carbonate, dibromoalkane and acetone, and carrying out first reaction to obtain an intermediate product; and mixing the intermediate product, a compound R1H and acetonitrile, and carrying out a second reaction to obtain the honokiol mother nucleus-based dialkylated cationic derivative. A series of novel amphiphilic derivatives are designed and synthesized by reasonably modifying a natural product honokiol, and the novel amphiphilic derivatives show effective in-vitro antibacterial activity on gram-positive bacteria.

This invention proposes a bio-based epoxy resin coating for marine engineering and its preparation method, relating to the technical field of marine engineering anti-corrosion coatings. The coating is composed of two components, A and B. Component A, by weight, includes: 30-32 parts of a bio-based epoxy resin, 6-8 parts of a reactive diluent, 0.2-0.4 parts of a defoamer, 0.2-0.4 parts of a dispersant, 1.6-1.8 parts of an anti-settling agent, 44-48 parts of a filler, 4-6 parts of zinc phosphate, and 7-9 parts of aluminum tripolyphosphate; and component B includes: 0.4-0.6 parts of a drier and 25-28 parts of a curing agent. The bio-based epoxy resin is a magnolol-based epoxy resin with a molecular weight of 2400-6500. Magnolol-based epoxy resin takes advantage of the characteristics of the molecular structure of magnolia phenol and introduces a more flexible acrylic-based structure to adjust the flexibility and viscosity of the resin molecules. Adding it to the coating makes it easy to apply and can cure quickly, meeting the construction environment of the marine environment. The paint film formed has high strength and good flexibility and can withstand long-term wave erosion.

The invention discloses a bactericide and device for improving wheat stem rot resistance in the field of agricultural biocides, and the bactericide comprises the following components in parts by weight: 10-15 parts of magnolol, 30-50 parts of carvacrol and 1 part of ethapyroxad, and the bactericide comprises the following components in parts by weight: 10-15 parts of magnolol, 30-50 parts of carvacrol and 1 part of ethapyroxad. And the bactericide comprises the following components in parts by weight: 15 parts of magnolol, 40 parts of carvacrol and 1 part of ethapyroxad, or 10 parts of magnolol, 30 parts of carvacrol and 1 part of ethapyroxad. The biological activity of the bactericide and the affinity of succinate dehydrogenase are improved by modifying ethane on amino nitrogen of pydiflumetofen, the inhibition effect and stability are improved by mixing natural plant phenol, meanwhile, environmental pollution is reduced, and the mutation speed of pathogenic bacteria is delayed.

The present application relates to a high-refractive material based on biomass magnolol and honokiol. Specifically, the high-refractive material of the present application can be obtained by photo-curing reaction of a photo-curable monomer and a plurality of mercaptans / mercaptanols under photo-initiation, wherein the photo-curable monomer is derived from a monomer containing an allyl functional group derived from biomass magnolol and honokiol. The high-refractive material provided by the present application has good optical performance, in particular, it not only has a high refractive index (1.67-1.71) but also has a relatively high Abbe number (35-24).

The application discloses a kind of carbon fiber material for unmanned aerial vehicle and preparation method thereof, belong to unmanned aerial vehicle material technical field.The carbon fiber material, by mass fraction, including following raw materials:PA612 100 parts, PA6T / 6I 30-40 parts, modified carbon fiber 10-30 parts, flame-retardant compatibilizer 6-10 parts, lubricant 1-5 parts, antioxidant 0.5-1.5 parts, wherein the modified carbon fiber is prepared by silane coupling agent grafting mercapto after surface oxidation of carbon fiber, and then combined with magnolol epoxy monomer by click reaction of mercapto and double bond;Flame-retardant compatibilizer contains phenyl phosphoramide structure and terminal aldehyde group.The carbon fiber material prepared by the application uses PA612 and PA6T / 6I as blended nylon matrix resin, synchronously adds modified carbon fiber and flame-retardant compatibilizer, and by intermolecular interaction, the material has excellent mechanical strength and reliable flame-retardant safety.

The present disclosure relates to a pharmaceutical composition for treatment of muscle disease, comprising a Magnolia officinalis extract. The Magnolia officinalis extract contains various ingredients other than magnolol and honokiol, and inhibits cisplatin-induced weight loss, muscle mass reduction, grip strength reduction, and muscle fiber damage, and promotes the repair of damaged muscle fibers through macrophage polarization from M1 to M2 without interfering with an antitumor function of cisplatin, and thus can be effectively used for prevention and treatment of muscle disease, especially, anticancer drug-induced muscle disease.

The present invention relates to a method for manufacturing at least one single-strand filament-resin composite comprising filaments embedded in a cross-linked resin, using a magnolol-based resin composition. The present invention also relates to a composite based on at least one reinforcing element and said resin composition.

The application provides a nano bactericide and a preparation method and application thereof. The Mag@ZIF-8 nano composite material synthesized based on a competitive coordination strategy and containing two coordination structures of zinc ion-2-methyl imidazole and zinc ion-magnolol simultaneously, significantly increases the inhibition of ZIF-8 on pathogenic fungi. In addition, the results of the synergistic effect experiment show that there is a synergistic effect between Mag@ZIF-8 and the bactericide fludioxonil, which provides a new idea for the synergistic effect of the bactericide in a reduced amount.

The application belongs to the technical field of content detection, and discloses a kind of HPLC detection methods for simultaneously determining the content of multiple components in semen Cannabis capsules.The detection method includes mixing reference solution, chrysophanol and methanol to obtain mixed reference solution.The reference solution includes physcion solution, magnolol solution, houpo chrysophanol solution, emodin solution, rhein solution, nobiletin solution, aloe emodin solution, hesperidin solution and paeoniflorin solution;The contents of semen Cannabis capsules are mixed with methanol, and the test solution is obtained after heating and refluxing;The mixed reference solution and test solution are respectively sucked and injected into high performance liquid chromatograph.The detection method can simultaneously determine the content of multiple index components, can comprehensively reflect the quality of the preparation, and the test method has excellent precision, repeatability, stability and high sample recovery rate.

This invention belongs to the field of pharmaceutical technology and relates to a preparation process of a modified Huoxiang Zhengqi compound. The preparation process is as follows: Pinellia ternata and Angelica dahurica are percolated; Pogostemon cablin, Perilla frutescens, Citrus reticulata peel, Magnolia officinalis, and Atractylodes macrocephala are extracted in groups for 2-5 hours, and the total volatile oil is collected. The residues of each group are decocted with water, and the decoctions of each group are collected; Poria cocos, Platycodon grandiflorus, Glycyrrhiza uralensis, Areca catechu peel, Ziziphus jujuba, and Zingiber officinale are decocted with water to obtain a decoction; the total volatile oil is added to an inclusion material, and inclusion is obtained using an ultrasonic-assisted method; the percolation and decoctions are combined, concentrated, and centrifuged to obtain a supernatant; a preservative is added to the supernatant and the inclusion material to obtain the final product. This invention extracts medicinal materials containing volatile oils in groups and uses a cyclodextrin inclusion complexation process, which not only improves the total extraction rate of volatile oils, but also increases the content of hesperidin, hydrated oxypenicillin, magnolol, honokiol, patchouli flavonol, and baicalein, while improving the taste and flavor of the flavored patchouli flavonoid compound.

The present invention relates to an anti-aging composition containing a Magnolia officinalis extract or magnolol, honokiol and 4-O-methlyhonokiol compounds. The extract or compound restores mitochondrial functions of senescent cells, reduces damaged DNA in cells, and restores senescent cells to a youthful cell state, and thus can be effectively used as a multifunctional cosmetic composition, a pharmaceutical composition, or a health functional food for inhibiting aging.

The present application relates to a magnolol rhamnoside, a preparation method and application thereof, and belongs to the technical field of glycoengineering. The magnolol rhamnoside, also known as magnolol-2-O-alpha-rhamnoside, is a novel derivative compound of natural product magnolol through glycosylation modification. In the present application, the water solubility and tumor cell growth inhibition activity of the magnolol rhamnoside are determined for the first time, and the results show that the magnolol rhamnoside has higher water solubility and tumor cell growth inhibition activity than magnolol, and has important application value for the research and development of new anti-tumor drugs. In the present application, a recombinant Escherichia coli co-expressing an rfbBDAC operon for synthesizing dTDP-Rha and a rhamnosyltransferase Ss-RhaT is constructed, and the magnolol rhamnoside is prepared by microbial fermentation conversion method. The recombinant Escherichia coli is used to efficiently synthesize the magnolol rhamnoside by fermentation method with magnolol added in the culture medium as a substrate.

The invention discloses preparation and application of a novel magnolol and jatrorrhizine conjugate, relates to the technical field of medicines, and aims to overcome the defects of poor drug resistance and insufficient activity of a single-target anti-cancer drug. According to the technical scheme, acetone or acetonitrile is used as a solvent, and through a two-step substitution reaction, the magnolol and jatrorrhizine conjugate is obtained; the preparation method comprises the following steps: reacting magnolol with dibromo-alkane to generate an intermediate B, and conjugating the intermediate B with jatrorrhizine to obtain a final product with a general formula C; or the jatrorrhizine reacts with dibromo alkane to generate an intermediate E, and then the intermediate E is conjugated with magnolol to obtain the final product of the general formula C. In the preparation process, reaction conditions (such as potassium carbonate alkaline environment and 82 DEG C reflux) are optimized, and high yield and purity are realized. The conjugate disclosed by the invention is widely applied to the anti-tumor field, has remarkable inhibitory activity on various cancer cells (such as non-small cell lung cancer cells HCC827 and human lung adenocarcinoma cells H1975), has better effects than magnolol and jateorhizine monomers, and provides a new candidate for research and development of multi-target drugs.