155 results about "Magnolol" patented technology

The invention provides transparent shampoo with fluffy and anti-dandruff effects and a preparation method of the transparent shampoo. The shampoo comprises the following components in percentage by weight: 10%-20% of sodium laureth sulfate; 0.5% to 10% of ammonium laureth sulfate; 0.5%-10% of cocamidopropyl betaine, 0.5%-10% of 0.5%-10% of coconut oil fatty acid monoethanolamide; 0.5% to 10% of decyl glucoside; 0.6% to 1.5% of capryloyl glycine; 0.1% to 1% of cationic guar gum; 0.1% to 1% of polyquaternium-10; 0.1% to 1% of polyquaternium-11; 0.1% to 1% of polyquaternium-51; 0.01% to 2% of magnolol; 0.01% to 2% of menthol; 0.1%-1% of sodium chloride; 0.1%-1% of citric acid; and 0.1%-1% of disodium EDTA. The shampoo disclosed by the invention has the effect of improving the combing performance in a dry hair state, can effectively improve the smoothness of hair and the touch comfort during use, and also has a supporting effect and antibacterial and anti-dandruff effects. According to the shampoo process, the clarity and appearance stability of the product are remarkably improved, and the shampoo can be kept in a transparent and uniform state for a long time.

The invention discloses a dental plaque display type anti-caries invisible appliance based on synergism of iron-based nano-enzyme catalysis and traditional Chinese medicine caries inhibition, and belongs to the field of oral medical instruments. The preparation method of the appliance diaphragm comprises the following steps: preparing a composite material with the functions of catalytically degrading a bacterial biofilm matrix barrier and killing internal bacteria from polyethylene glycol terephthalate-1, 4-cyclohexanedimethanol (PETG) and a Fe3O4 nano-enzyme filler in a solution blending manner; and after the composite material is subjected to thermoplastic molding, a layer of molecularly imprinted polymer (MIP)-spiropyrane and chitosan-magnolol are coated with the fluorescent display agent which is prepared by mixing the molecularly imprinted polymer (MIP)-spiropyrane and the chitosan-magnolol. The iron-based nano-enzyme can catalytically degrade a bacterial biofilm matrix barrier and kill internal bacteria, and the MIP-spiropyrane fluorescent display agent can specifically display the accumulation condition of cariogenic bacterial plaque in the oral cavity under ultraviolet irradiation. The invisible orthodontic appliance can reduce or prevent caries while having the same orthodontic effect as other orthodontic appliances in the market.

The invention discloses a preparation process and application of magnolol-loaded plant exosomes, and relates to the technical field of plant exosomes. Magnolol is extracted from a magnolia officinalis plant material through ultrasonic assistance, the plant exosomes are obtained from fresh ginger by using an ultracentrifugation method, and the plant exosomes are further modified through palmitic acid and polyethylene glycol, so that the magnolol-loaded plant exosomes are obtained. And finally, preparing the magnolol-loaded plant exosome by virtue of an incubation method. The magnolol can be protected from being damaged by gastric acid and digestive enzymes through membrane structure wrapping of the plant exosome, the stability of the magnolol in the digestive tract is improved, and it is further verified through mouse experiments that the magnolol-loaded plant exosome can be beneficial to regulation of intestinal flora.

The invention discloses a preparation method and application of a polyhexamethylene biguanide hydrochloride / magnolol co-assembled anti-ultraviolet nano preparation. The preparation method of the polyhexamethylene biguanide hydrochloride / magnolol co-assembled anti-ultraviolet nano pesticide preparation comprises the following steps: dissolving polyhexamethylene biguanide hydrochloride in deionized water to obtain a polyhexamethylene biguanide hydrochloride solution, dissolving magnolol in an alkaline aqueous solution to obtain a magnolol solution, and adding the magnolol solution into the polyhexamethylene biguanide hydrochloride solution to obtain the polyhexamethylene biguanide hydrochloride / magnolol co-assembled anti-ultraviolet nano pesticide preparation. The preparation method comprises the following steps: slowly dropwise adding a magnolol solution into a polyhexamethylene biguanide hydrochloride solution, stirring in a dark place at a certain temperature, centrifuging, discarding supernate, freeze-drying and precipitating to obtain powder, and dissolving the powder into deionized water to obtain the polyhexamethylene biguanide hydrochloride / magnolol co-assembled anti-ultraviolet nano pesticide preparation. The nano preparation is prepared by a co-assembly method in water, and has better ultraviolet resistance. Compared with an existing method, the preparation method is simple in condition, convenient to operate and low in cost.

The invention relates to the technical field of plastics, and discloses an anti-aging modified plastic and a preparation method thereof.The preparation method comprises the following steps that low-density polyethylene, maleic anhydride grafted polyethylene, an antioxidant 168, calcium stearate, calcium carbonate, 2-(2 '-hydroxy-3', 4 '-dihydroxyphenyl)-1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate and a plasticizer are mixed, stirred and stirred, and The preparation method comprises the following steps: uniformly mixing 4, 5 '-di-tert-butylphenyl)-benzotriazole, quaternary phosphonium salt modified chitosan and modified magnolol in a high-speed mixer, carrying out extrusion granulation in a twin-screw extruder at a blending temperature of 190-195 DEG C and an extrusion temperature of 170-180 DEG C, drying, and carrying out injection molding by an injection molding machine to obtain the anti-aging modified plastic. The anti-aging modified plastic disclosed by the invention has relatively good anti-aging, flame-retardant and antibacterial effects.

The invention relates to the field of cosmetics, in particular to a multi-channel efficient oil-control acne-removal composition and application thereof in cosmetics. The oil-controlling and acne-removing composition is prepared from the following components in parts by weight: 1 to 5 parts of capryloyl salicylic acid, 0.5 to 2 parts of magnolol and 0.5 to 10 parts of white willow bark extract. Capryloyl salicylic acid, magnolol and white willow bark extract are compounded to achieve a synergistic effect, so that the oil-control acne-removing composition has remarkable oil-control acne-removing effects and can be applied to cosmetics of different dosage forms. In addition, the invention also discovers that after the white willow bark extract is subjected to enzyme modification, the oil control and acne removal effects of the white willow bark extract can be further improved.

The invention provides functional compound feed for sows in the perinatal period as well as a preparation method and application of the functional compound feed, and relates to the technical field of livestock breeding. The functional compound feed for the sows in the perinatal period is prepared from the following raw materials in parts by mass: 55 to 60 parts of corn, 13 to 15 parts of soybean meal, 1 to 5 parts of fish meal, 6 to 8 parts of extruded soybeans, 2 to 8 parts of barley bran, 0.5 to 1.5 parts of soybean oil, 0.5 to 1.5 parts of glucose, 2 to 8 parts of wheat bran, 1 to 1.5 parts of dicalcium phosphate, 0.5 to 1.5 parts of calcium carbonate, 0.2 to 0.6 part of table salt, 0.05 to 0.2 part of baking soda, 0.05 to 0.2 part of 50 percent choline chloride and 2 to 5 parts of premix. 0.1 to 0.5 part of a composite additive; the compound additive is prepared from the following raw materials in parts by mass: 0.5 to 1 part of ligustrazine, 1 to 5 parts of aloe-emodin glycoside, 0.5 to 2 parts of magnolol and 3 to 5 parts of probiotic microcapsules. Aiming at the perinatal syndrome of the sows, by adjusting the composition and proportion of the raw materials of the compound feed and the preparation method of important raw materials, many problems caused by the perinatal syndrome of the sows are solved, and the compound feed has a good industrial application prospect.

The invention relates to the technical field of medical, dental or dressing preparations, in particular to a preparation method of ertapenem sodium for injection. The preparation method comprises the following steps: S1, adding a prescription amount of sodium bicarbonate into water, cooling and stirring to obtain a sodium bicarbonate solution; and S2, adding half of the prescription amount of ertapenem sodium into water, stirring at low temperature for dissolving, then adding a sodium bicarbonate solution, then adding the rest of ertapenem sodium, adjusting the pH value with the sodium hydroxide solution, then adding the modified magnolol, adding water to a certain amount, and then carrying out sterile filtration, subpackaging and freeze drying to obtain the ertapenem sodium injection. The preparation with better stability is obtained through the method, so that the stability of the preparation in the preparation process, transportation and long-term storage can be ensured.

The invention provides fluorenyl magnolol light-cured solder resist ink and a preparation method thereof, the solder resist ink comprises the following raw material components by mass: 20%-60% of fluorenyl magnolol light-cured resin, 10%-25% of a reactive diluent, 10%-30% of a nano filler, 1%-5% of a photoinitiator, 0.1%-5% of an auxiliary agent, and the balance of a solvent, the fluorenyl magnolol light-cured resin is prepared by reacting 9-fluorenylidene acetic acid with thionyl chloride to generate an intermediate product fluorenyl anhydride, and then reacting the intermediate product fluorenyl anhydride with magnolol. Wherein the molar ratio of magnolol to thionyl chloride to 9-fluorenylidene acetic acid is 1: (2-4): (2-4). The preparation process is simple, toxic by-products are avoided, the prepared solder resist ink has excellent flame retardance, heat resistance and adhesive force, low dielectric constant and high hardness, the problems of high dielectric loss, insufficient flame retardance and BPA toxicity of traditional ink are solved, and the solder resist ink is completely suitable for production and manufacturing of PCB substrates for high-frequency communication.

The invention relates to intrinsic flame-retardant bio-based epoxy resin and a synthesis method thereof.The intrinsic flame-retardant bio-based epoxy resin takes magnolol as a main raw material, and the molecular structure contains biphenyl units and ester bonds, so that the intrinsic flame-retardant bio-based epoxy resin has excellent flame retardance and thermal performance. The synthesis method comprises the following three steps: firstly, reacting magnolol with halogenated alkane to generate a precursor; secondly, reacting the precursor with acyl chloride to generate an intermediate; finally, oxidizing the intermediate to generate the target epoxy resin. The method does not need to add a large amount of flame retardant, and avoids negative influence on the performance of the epoxy resin. The synthesized epoxy resin shows excellent flame retardance and heat resistance, has high carbon residue rate, glass transition temperature and thermal decomposition temperature, and has the flame retardant level reaching V-0 level which is superior to that of general epoxy resin.

A patchouli Qi-rectifying tablet, and a preparation method therefor and a qualitative and quantitative determination method therefor. The patchouli Qi-rectifying tablet comprises the following components in parts by mass: 0.5-1.5 parts of patchouli oil; 0.1-1 part of perilla leaf oil; 150-250 parts of common aucklandia root; 100-150 parts of rhizome of swordlike atractylodes; 10-100 parts of root of Ural licorice; 150-250 parts of Indian bread; 100-150 parts of dried tangerine peel; 100-150 parts of prepared tuber of pinellia; 100-150 parts of officinal magnolia bark; and 100-150 parts of fresh ginger. The qualitative and quantitative determination method for multiple components in the patchouli Qi-rectifying tablet comprises: performing qualitative determination of ten components, i.e., liquiritin, hesperidin, honokiol, costunolide, dehydrocostus lactone, magnolol, atractylodin, perilla ketone, nobiletin, and tangeretin, in the patchouli Qi-rectifying tablet; and performing quantitative determination of seven components, i.e., liquiritin, hesperidin, honokiol, costunolide, dehydrocostus lactone, magnolol, and atractylodin, in the patchouli Qi-rectifying tablet. According to the method, the operation is simple, the detection time is short, the linear relationship is good, the repeatability is good, the precision is high, the accuracy is high, and the stability is good.

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The invention discloses a preparation method of novel environment-friendly full bio-based epoxy resin, a bio-based epoxy resin curing agent (AEESN) is derived from eugenol and cysteamine, and a bio-based epoxy monomer is derived from a magnolol-based epoxy monomer (EP1) of magnolol and a furfural-based aniline epoxy resin (EP2) of furfural. The full-bio-based epoxy resin is wide in source, low in price, green, environmentally friendly, low in polymerization temperature and high in biomass content, and a new thought and method are provided for development and application of bio-based materials.

The invention particularly relates to oral cavity anti-inflammatory toothpaste and a preparation method thereof. Comprising the following components in parts by weight: 20-30 parts of a friction agent, 1-2 parts of a surfactant, 1-2 parts of a thickening agent, 20-30 parts of a humectant, 0.1-0.55 part of a sweetening agent, 0.1-0.3 part of a preservative, 3-5 parts of an anti-inflammatory nano-composite, 0.3-0.35 part of lysozyme, a pH regulator for maintaining the pH value of the toothpaste to be 6.5-7.4, and the balance of water added to 100 parts. The anti-inflammatory nano compound is a nano compound formed by encapsulating patchouli alcohol, magnolol and a Zn-chlorogenic acid complex by using Eudragit E100 / chitosan. The intelligent pH response core-shell structure Eudragit E100 / chitosan is adopted, anti-inflammatory active ingredients can be accurately released at the oral inflammation part, the targeted delivery effect of efficient release of the inflammation part is achieved, a lysozyme pH response nano system is combined, the antibacterial spectrum is enhanced while targeted release is achieved, and the anti-inflammatory effect is achieved. The patchouli alcohol (antibacterial), the magnolol (anti-inflammatory) and the Zn-chlorogenic acid complex (repair promoting) form a composite efficacy system, and experiments prove that the inhibition rate on inflammatory factors such as TNF-alpha and IL-6 is about 70%.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention relates to the technical field of phenolic resin, and discloses high-temperature-resistant phenolic resin and a preparation method thereof.Polytetrahydrofuran ether glycol and diphenylmethane diisocyanate are used for synthesizing a polyurethane prepolymer, a flexible chain segment is introduced, then a phenolic hydroxyl terminated polymer containing cyano groups is prepared through a condensation reaction of magnolol and dichlorobenzonitrile, and the high-temperature-resistant phenolic resin is prepared. Introducing a heat-resistant functional group into the system, and then combining the two prepolymers under the action of a catalyst to form a phenol-based intermediate; and then carrying out polycondensation on the intermediate, phenol and formaldehyde under an acidic condition to generate the cyano-modified phenolic resin. And finally, blending with boron phenolic resin to obtain the high-temperature-resistant phenolic resin. The high-temperature-resistant phenolic resin provided by the invention has better heat resistance and the preparation method thereof.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The invention discloses a method for determining four mangnolia officinalis extracts in import and export cosmetics, which is used for detecting magnolol, honokiol, magnoflorine and magnoliavine, and comprises the following steps: S1, uniformly mixing a cosmetic sample with a solvent; s2, after uniform mixing, carrying out vortex oscillation treatment on the sample; s3, after vortex oscillation treatment, carrying out ultrasonic extraction on the sample at room temperature to obtain an extracting solution; s4, mixing the extracting solution with an adsorbent to obtain a purified to-be-detected solution; and S5, filtering the to-be-detected liquid, and determining the to-be-detected liquid through LC-MS / MS to obtain a detection result. According to the present invention, the target object in the cosmetics with different matrix types can be effectively represented, the core functional components such as magnolol and honokiol in the cortex magnoliae officinalis extract can be detected, the qualitative and quantitative analysis can be further performed on the potential supervision risk substance, and the dual functions of quality evaluation and safety supervision can be provided for the cosmetics.

The present invention provides a composition for treating hyperglycemia caused by SARS-CoV-2 infection, a preparation method, an application and a medicine, and relates to the field of pharmaceutical compositions. The composition comprises, by weight, 10-40 parts of rhein, 15-60 parts of magnolol, 2.5-10 parts of quercetin, 10-40 parts of licorice chalcone and 10-20 parts of formononetin. The composition of the present invention has the effect of treating hyperglycemia caused by SARS-CoV-2 infection. OGTT and ITT experimental results show that the composition can significantly improve fasting blood sugar and glucose tolerance in mice, effectively reduce the adverse effects of SARS-CoV-2 infection on the endocrine system, and improve the quality of life of patients.

The invention discloses an isoxazoline hybridized neolignan compound as well as a preparation method and application of the isoxazoline hybridized neolignan compound. The neolignan compound disclosed by the invention is one of isoxazoline magnolol, isoxazoline honokiol, isoxazoline nitrated magnolol and isoxazoline nitrated honokiol derivatives, and has the following chemical general formula: # imgabs0. The neolignan compound disclosed by the invention takes one of magnolol, honokiol, nitrated magnolol or nitrated mangnolia officinalis as a raw material; the preparation method comprises the following steps: by taking triethylamine as alkali and dichloromethane as a solvent, carrying out 1, 3-dipolar cycloaddition reaction on a raw material and alpha-chlorooxime, and separating and purifying to obtain the isoxazoline hybridized neolignan compound. The compound disclosed by the invention has relatively good insecticidal activity on plutella xylostella Linnaeus and Mythimna separata Walker, can be used for preparing a novel efficient insecticide, and is applied to prevention and treatment on the plutella xylostella Linnaeus and the Mythimna separata Walker.

The invention belongs to the technical field of natural plant active products, and particularly relates to a magnolol clathrate compound for inhibiting vibrio in aquaculture and a preparation and application of the magnolol clathrate compound. Magnolol is high-purity magnolol obtained by separating and purifying an active component extracted from a natural plant raw material mangnolia officinalis through a subcritical process. Molecular clathration is carried out on magnolol by adopting a molecular clathration technology to prepare a magnolol clathrate compound, the magnolol clathrate compound is further prepared into different dosage forms such as powder, granules and a liquid preparation to obtain an anti-vibrio preparation product, and tests prove that the anti-vibrio effect of the preparation product is remarkable. The raw materials are low in price and easy to obtain, the magnolol extraction process is simple, green and environmentally friendly, magnolol is clathrated through the molecular clathration technology, the water solubility and oral utilization rate of magnolol are increased, the prepared preparation can be added into feed, the use of antibiotics is reduced, healthy development of green fishery is promoted, and the economic benefit is increased. And a foundation is laid for development of antibiotic-free aquatic natural plant feed additive system products.

The invention discloses a sugarcane polyphenol and magnolol compound raw material as well as a preparation method and application thereof. The compound raw material is prepared from the following components in percentage by mass: 30 to 60 percent of sugarcane polyphenol extract (polyphenol is more than or equal to 20 percent), 10 to 30 percent of pure magnolol (the purity is more than or equal to 98 percent), 5 to 15 percent of cosolvent, 2 to 8 percent of stabilizer and the balance of deionized water. The preparation method comprises the following steps: extracting and purifying the sugarcane polyphenol and magnolol, dissolving the auxiliary materials, mixing, and sterilizing to obtain the finished product. The compound raw material can be used for oral care products such as toothpaste, can synergistically inhibit streptococcus mutans, destroy bacterial plaque, prevent caries and protect gingiva, is safe and stable, and is suitable for long-term use.

The invention discloses a preparation method and application of a ZnO-ZIF-8 composite material loaded with honokiol, belonging to the technical field of agricultural plant protection. The method comprises the following steps: (1) mixing 2-methylimidazole and N,N-dimethylformamide to obtain a preheating solution; preparing a zinc oxide suspension from nano zinc oxide; (2) preparing a mixed solution from honokiol; (3) preparing a sodium alginate solution from sodium alginate, and then heating the sodium alginate solution, the mixed solution, the preheating solution and the zinc oxide suspension for reaction for 2 hours, collecting the precipitate by centrifugation and drying to obtain a ZnO-ZIF-8 composite material loaded with honokiol. The composite material prepared by the invention solves the problems of low honokiol loading rate and poor control effect under acidic conditions, and the prepared composite material can reduce the harm to soil or animals and plants.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a method for preparing a honokiol derivative and an intermediate thereof. The preparation method comprises: reacting compound M2 with ethyltriphenylphosphonium bromide under alkaline conditions to prepare a compound of formula I; allylating the compound of formula I to prepare compound M3; demethylating compound M3 under acidic conditions to prepare compound M4; and rearranging compound M4 to prepare a compound of formula II. This method utilizes readily available, inexpensive raw materials, is low cost, has simple steps, mild reaction conditions, low purification requirements, high purity, high yield, is environmentally friendly, safe, and suitable for industrial production, thus possessing significant application value.

The invention discloses a magnolol targeting nanoparticle with high drug loading capacity, which is composed of a magnolol nanocrystal and a polydopamine layer wrapping the magnolol nanocrystal, and folic acid is modified on the surface of the polydopamine layer. The preparation can slowly release magnolol and target breast cancer cells, and has the advantages of high drug loading capacity and high accumulative release rate.

The invention discloses a magnesium hydride-magnolol composite polymer microneedle system as well as a preparation method and application thereof. The magnesium hydride-magnolol composite polymer microneedle system is (PVA-PVP)-x (MgH2-Mag), the mass ratio of PVA to PVP is (1: 2)-(1: 0.25); the ratio of MgH2 to Mags is 1: 1-1: 0.05; x is 1: 20-1: 5, the magnesium hydride-magnolol composite polymer microneedle (PVA-PVP)-x (MgH2-Mag) for treating androgenic alopecia is in a three-dimensional microneedle form, the height is 120-950 [mu] m, the substrate width is 80-500 [mu] m, and the needle tip diameter is 6-80 [mu] m. Through unique structural design and material combination, efficient co-delivery and synergistic release of the two active components are realized, and a brand new solution is provided for AGA treatment.

This invention discloses a traditional Chinese medicine composition for combating mandarin fish double RNA virus, comprising at least one of geniposide, baicalin, luteolin, magnolol, and mangiferin as active ingredients. The invention also discloses a method for preparing the traditional Chinese medicine composition and its applications. This invention can significantly inhibit the proliferation and replication of mandarin fish double RNA virus and significantly improve the survival rate of mandarin fish.