124 results about "Magnolol" patented technology

The invention provides transparent shampoo with fluffy and anti-dandruff effects and a preparation method of the transparent shampoo. The shampoo comprises the following components in percentage by weight: 10%-20% of sodium laureth sulfate; 0.5% to 10% of ammonium laureth sulfate; 0.5%-10% of cocamidopropyl betaine, 0.5%-10% of 0.5%-10% of coconut oil fatty acid monoethanolamide; 0.5% to 10% of decyl glucoside; 0.6% to 1.5% of capryloyl glycine; 0.1% to 1% of cationic guar gum; 0.1% to 1% of polyquaternium-10; 0.1% to 1% of polyquaternium-11; 0.1% to 1% of polyquaternium-51; 0.01% to 2% of magnolol; 0.01% to 2% of menthol; 0.1%-1% of sodium chloride; 0.1%-1% of citric acid; and 0.1%-1% of disodium EDTA. The shampoo disclosed by the invention has the effect of improving the combing performance in a dry hair state, can effectively improve the smoothness of hair and the touch comfort during use, and also has a supporting effect and antibacterial and anti-dandruff effects. According to the shampoo process, the clarity and appearance stability of the product are remarkably improved, and the shampoo can be kept in a transparent and uniform state for a long time.

The invention discloses a dental plaque display type anti-caries invisible appliance based on synergism of iron-based nano-enzyme catalysis and traditional Chinese medicine caries inhibition, and belongs to the field of oral medical instruments. The preparation method of the appliance diaphragm comprises the following steps: preparing a composite material with the functions of catalytically degrading a bacterial biofilm matrix barrier and killing internal bacteria from polyethylene glycol terephthalate-1, 4-cyclohexanedimethanol (PETG) and a Fe3O4 nano-enzyme filler in a solution blending manner; and after the composite material is subjected to thermoplastic molding, a layer of molecularly imprinted polymer (MIP)-spiropyrane and chitosan-magnolol are coated with the fluorescent display agent which is prepared by mixing the molecularly imprinted polymer (MIP)-spiropyrane and the chitosan-magnolol. The iron-based nano-enzyme can catalytically degrade a bacterial biofilm matrix barrier and kill internal bacteria, and the MIP-spiropyrane fluorescent display agent can specifically display the accumulation condition of cariogenic bacterial plaque in the oral cavity under ultraviolet irradiation. The invisible orthodontic appliance can reduce or prevent caries while having the same orthodontic effect as other orthodontic appliances in the market.

The invention relates to the technical field of plastics, and discloses an anti-aging modified plastic and a preparation method thereof.The preparation method comprises the following steps that low-density polyethylene, maleic anhydride grafted polyethylene, an antioxidant 168, calcium stearate, calcium carbonate, 2-(2 '-hydroxy-3', 4 '-dihydroxyphenyl)-1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate and a plasticizer are mixed, stirred and stirred, and The preparation method comprises the following steps: uniformly mixing 4, 5 '-di-tert-butylphenyl)-benzotriazole, quaternary phosphonium salt modified chitosan and modified magnolol in a high-speed mixer, carrying out extrusion granulation in a twin-screw extruder at a blending temperature of 190-195 DEG C and an extrusion temperature of 170-180 DEG C, drying, and carrying out injection molding by an injection molding machine to obtain the anti-aging modified plastic. The anti-aging modified plastic disclosed by the invention has relatively good anti-aging, flame-retardant and antibacterial effects.

The invention provides functional compound feed for sows in the perinatal period as well as a preparation method and application of the functional compound feed, and relates to the technical field of livestock breeding. The functional compound feed for the sows in the perinatal period is prepared from the following raw materials in parts by mass: 55 to 60 parts of corn, 13 to 15 parts of soybean meal, 1 to 5 parts of fish meal, 6 to 8 parts of extruded soybeans, 2 to 8 parts of barley bran, 0.5 to 1.5 parts of soybean oil, 0.5 to 1.5 parts of glucose, 2 to 8 parts of wheat bran, 1 to 1.5 parts of dicalcium phosphate, 0.5 to 1.5 parts of calcium carbonate, 0.2 to 0.6 part of table salt, 0.05 to 0.2 part of baking soda, 0.05 to 0.2 part of 50 percent choline chloride and 2 to 5 parts of premix. 0.1 to 0.5 part of a composite additive; the compound additive is prepared from the following raw materials in parts by mass: 0.5 to 1 part of ligustrazine, 1 to 5 parts of aloe-emodin glycoside, 0.5 to 2 parts of magnolol and 3 to 5 parts of probiotic microcapsules. Aiming at the perinatal syndrome of the sows, by adjusting the composition and proportion of the raw materials of the compound feed and the preparation method of important raw materials, many problems caused by the perinatal syndrome of the sows are solved, and the compound feed has a good industrial application prospect.

The invention provides fluorenyl magnolol light-cured solder resist ink and a preparation method thereof, the solder resist ink comprises the following raw material components by mass: 20%-60% of fluorenyl magnolol light-cured resin, 10%-25% of a reactive diluent, 10%-30% of a nano filler, 1%-5% of a photoinitiator, 0.1%-5% of an auxiliary agent, and the balance of a solvent, the fluorenyl magnolol light-cured resin is prepared by reacting 9-fluorenylidene acetic acid with thionyl chloride to generate an intermediate product fluorenyl anhydride, and then reacting the intermediate product fluorenyl anhydride with magnolol. Wherein the molar ratio of magnolol to thionyl chloride to 9-fluorenylidene acetic acid is 1: (2-4): (2-4). The preparation process is simple, toxic by-products are avoided, the prepared solder resist ink has excellent flame retardance, heat resistance and adhesive force, low dielectric constant and high hardness, the problems of high dielectric loss, insufficient flame retardance and BPA toxicity of traditional ink are solved, and the solder resist ink is completely suitable for production and manufacturing of PCB substrates for high-frequency communication.

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The invention discloses a preparation method of novel environment-friendly full bio-based epoxy resin, a bio-based epoxy resin curing agent (AEESN) is derived from eugenol and cysteamine, and a bio-based epoxy monomer is derived from a magnolol-based epoxy monomer (EP1) of magnolol and a furfural-based aniline epoxy resin (EP2) of furfural. The full-bio-based epoxy resin is wide in source, low in price, green, environmentally friendly, low in polymerization temperature and high in biomass content, and a new thought and method are provided for development and application of bio-based materials.

The invention particularly relates to oral cavity anti-inflammatory toothpaste and a preparation method thereof. Comprising the following components in parts by weight: 20-30 parts of a friction agent, 1-2 parts of a surfactant, 1-2 parts of a thickening agent, 20-30 parts of a humectant, 0.1-0.55 part of a sweetening agent, 0.1-0.3 part of a preservative, 3-5 parts of an anti-inflammatory nano-composite, 0.3-0.35 part of lysozyme, a pH regulator for maintaining the pH value of the toothpaste to be 6.5-7.4, and the balance of water added to 100 parts. The anti-inflammatory nano compound is a nano compound formed by encapsulating patchouli alcohol, magnolol and a Zn-chlorogenic acid complex by using Eudragit E100 / chitosan. The intelligent pH response core-shell structure Eudragit E100 / chitosan is adopted, anti-inflammatory active ingredients can be accurately released at the oral inflammation part, the targeted delivery effect of efficient release of the inflammation part is achieved, a lysozyme pH response nano system is combined, the antibacterial spectrum is enhanced while targeted release is achieved, and the anti-inflammatory effect is achieved. The patchouli alcohol (antibacterial), the magnolol (anti-inflammatory) and the Zn-chlorogenic acid complex (repair promoting) form a composite efficacy system, and experiments prove that the inhibition rate on inflammatory factors such as TNF-alpha and IL-6 is about 70%.

The present invention belongs to the technical field of medicine. Disclosed are a class of magnolol / honokiol derivatives, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed in the present invention are magnolol / honokiol nitrone derivatives as represented by general formulas (I) and (II). Such derivatives are prepared by means of artificial synthesis. Further provided are a pharmaceutical composition containing same, and the use thereof against inflammation, against cerebral infarction, in the treatment of amyotrophic lateral sclerosis, and against cerebral trauma.

The present application relates to a kind of composition capable of relieving fatigue-related emotional fluctuation and anxiety and its application.The composition includes: and magnolol, ergothioneine, ginsenoside and plant extract;The plant source of the plant extract includes eucommia leaf and schisandra chinensis.The above components cooperate with each other, and have significant synergistic effect in relieving tension, anxious mood and anti-depression.

The invention relates to the technical field of anti-cancer drugs, and provides a traditional Chinese medicine multi-component nano drug delivery system as well as a preparation method and application thereof. According to the invention, honokiol (HN) is entrapped by adopting lipid nanoparticles formed by a berberine (BR)-disulfide bond-caprylic capric triglyceride compound, the surface of the lipid nanoparticles is coated with a gelatin layer, and quercetin (QE) is entrapped in the gelatin layer, so that simultaneous delivery of HN, BR and QE and programmed release outside and inside cells are realized. Furthermore, the surface of the gelatin layer is modified with PEG, so that the long circulation of the drug delivery system in blood is improved; furthermore, cRGD is connected to PEG, and the synergistic lung cancer resisting effect of HN, BR and QE is greatly improved through the targeting effect of cRGD. In conclusion, the drug delivery system provided by the invention can give full play to the effect of synergistically treating lung cancer by HN, QE and BR, and has a wide application prospect.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention relates to the technical field of phenolic resin, and discloses high-temperature-resistant phenolic resin and a preparation method thereof.Polytetrahydrofuran ether glycol and diphenylmethane diisocyanate are used for synthesizing a polyurethane prepolymer, a flexible chain segment is introduced, then a phenolic hydroxyl terminated polymer containing cyano groups is prepared through a condensation reaction of magnolol and dichlorobenzonitrile, and the high-temperature-resistant phenolic resin is prepared. Introducing a heat-resistant functional group into the system, and then combining the two prepolymers under the action of a catalyst to form a phenol-based intermediate; and then carrying out polycondensation on the intermediate, phenol and formaldehyde under an acidic condition to generate the cyano-modified phenolic resin. And finally, blending with boron phenolic resin to obtain the high-temperature-resistant phenolic resin. The high-temperature-resistant phenolic resin provided by the invention has better heat resistance and the preparation method thereof.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The invention discloses a method for determining four mangnolia officinalis extracts in import and export cosmetics, which is used for detecting magnolol, honokiol, magnoflorine and magnoliavine, and comprises the following steps: S1, uniformly mixing a cosmetic sample with a solvent; s2, after uniform mixing, carrying out vortex oscillation treatment on the sample; s3, after vortex oscillation treatment, carrying out ultrasonic extraction on the sample at room temperature to obtain an extracting solution; s4, mixing the extracting solution with an adsorbent to obtain a purified to-be-detected solution; and S5, filtering the to-be-detected liquid, and determining the to-be-detected liquid through LC-MS / MS to obtain a detection result. According to the present invention, the target object in the cosmetics with different matrix types can be effectively represented, the core functional components such as magnolol and honokiol in the cortex magnoliae officinalis extract can be detected, the qualitative and quantitative analysis can be further performed on the potential supervision risk substance, and the dual functions of quality evaluation and safety supervision can be provided for the cosmetics.

The present invention provides a composition for treating hyperglycemia caused by SARS-CoV-2 infection, a preparation method, an application and a medicine, and relates to the field of pharmaceutical compositions. The composition comprises, by weight, 10-40 parts of rhein, 15-60 parts of magnolol, 2.5-10 parts of quercetin, 10-40 parts of licorice chalcone and 10-20 parts of formononetin. The composition of the present invention has the effect of treating hyperglycemia caused by SARS-CoV-2 infection. OGTT and ITT experimental results show that the composition can significantly improve fasting blood sugar and glucose tolerance in mice, effectively reduce the adverse effects of SARS-CoV-2 infection on the endocrine system, and improve the quality of life of patients.

The invention discloses a sugarcane polyphenol and magnolol compound raw material as well as a preparation method and application thereof. The compound raw material is prepared from the following components in percentage by mass: 30 to 60 percent of sugarcane polyphenol extract (polyphenol is more than or equal to 20 percent), 10 to 30 percent of pure magnolol (the purity is more than or equal to 98 percent), 5 to 15 percent of cosolvent, 2 to 8 percent of stabilizer and the balance of deionized water. The preparation method comprises the following steps: extracting and purifying the sugarcane polyphenol and magnolol, dissolving the auxiliary materials, mixing, and sterilizing to obtain the finished product. The compound raw material can be used for oral care products such as toothpaste, can synergistically inhibit streptococcus mutans, destroy bacterial plaque, prevent caries and protect gingiva, is safe and stable, and is suitable for long-term use.

The invention discloses a preparation method and application of a ZnO-ZIF-8 composite material loaded with honokiol, belonging to the technical field of agricultural plant protection. The method comprises the following steps: (1) mixing 2-methylimidazole and N,N-dimethylformamide to obtain a preheating solution; preparing a zinc oxide suspension from nano zinc oxide; (2) preparing a mixed solution from honokiol; (3) preparing a sodium alginate solution from sodium alginate, and then heating the sodium alginate solution, the mixed solution, the preheating solution and the zinc oxide suspension for reaction for 2 hours, collecting the precipitate by centrifugation and drying to obtain a ZnO-ZIF-8 composite material loaded with honokiol. The composite material prepared by the invention solves the problems of low honokiol loading rate and poor control effect under acidic conditions, and the prepared composite material can reduce the harm to soil or animals and plants.

The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to a method for preparing a honokiol derivative and an intermediate thereof. The preparation method comprises: reacting compound M2 with ethyltriphenylphosphonium bromide under alkaline conditions to prepare a compound of formula I; allylating the compound of formula I to prepare compound M3; demethylating compound M3 under acidic conditions to prepare compound M4; and rearranging compound M4 to prepare a compound of formula II. This method utilizes readily available, inexpensive raw materials, is low cost, has simple steps, mild reaction conditions, low purification requirements, high purity, high yield, is environmentally friendly, safe, and suitable for industrial production, thus possessing significant application value.

The invention discloses a magnesium hydride-magnolol composite polymer microneedle system as well as a preparation method and application thereof. The magnesium hydride-magnolol composite polymer microneedle system is (PVA-PVP)-x (MgH2-Mag), the mass ratio of PVA to PVP is (1: 2)-(1: 0.25); the ratio of MgH2 to Mags is 1: 1-1: 0.05; x is 1: 20-1: 5, the magnesium hydride-magnolol composite polymer microneedle (PVA-PVP)-x (MgH2-Mag) for treating androgenic alopecia is in a three-dimensional microneedle form, the height is 120-950 [mu] m, the substrate width is 80-500 [mu] m, and the needle tip diameter is 6-80 [mu] m. Through unique structural design and material combination, efficient co-delivery and synergistic release of the two active components are realized, and a brand new solution is provided for AGA treatment.

This invention discloses a traditional Chinese medicine composition for combating mandarin fish double RNA virus, comprising at least one of geniposide, baicalin, luteolin, magnolol, and mangiferin as active ingredients. The invention also discloses a method for preparing the traditional Chinese medicine composition and its applications. This invention can significantly inhibit the proliferation and replication of mandarin fish double RNA virus and significantly improve the survival rate of mandarin fish.

The invention provides a nano bactericide as well as a preparation method and application thereof. The magnolol / ZIF-8 nano composite material Magat ZIF-8 synthesized on the basis of a competitive coordination strategy simultaneously contains two coordination structures of zinc ion-2-methylimidazole and zinc ion-magnolol, so that the inhibition effect of the ZIF-8 on pathogenic fungi is remarkably improved. Besides, a compound synergistic experiment result shows that a synergistic effect exists between the MagatZIF-8 and the bactericide fludioxonil, and a new thought is provided for reduction and synergism of the bactericide.

The invention discloses a high-heat-resistance intrinsic flame-retardant bio-based bismaleimide resin and a preparation method of the high-heat-resistance intrinsic flame-retardant bio-based bismaleimide resin. Firstly, a 4, 4 '-dithiodiphenylamine bismaleimide monomer (S-BMI) containing a disulfide bond is designed and synthesized, then a renewable biomass compound magnolol (MG) and the S-BMI in different proportions are copolymerized, three kinds of novel resins (BG-1, BG-2 and BG-3) are prepared, and the comprehensive performance of the BG novel resin is systematically investigated. The novel BG resin provided by the invention has a multiphase structure, and the Tg of all BG resins is between 298 DEG C and 374 DEG C. In addition, the novel BG resin not only has good impact and bending properties, but also shows excellent flame retardancy, and is at the top level in the currently reported intrinsic flame-retardant polymer. The BG resin disclosed by the invention has excellent heat resistance and flame retardance, and can be used as a key basic material urgently needed in emerging strategic fields such as new energy, electronic information, aerospace and the like.

The invention discloses an application of magnolol in prevention and treatment of sweet potato rot, magnolol is used as a bactericide to be applied to prevention and treatment of sweet potato pathogenic fungal diseases, the diseases are sweet potato rot, and the pathogen is Trichoderma hamatum. Bacteriostatic plant source compound screening is carried out on novel sweet potato pathogenic fungi, it is found that magnolol shows the best inhibitory activity on trichoderma hamatum, and in addition, the fungicidal composition with magnolol as the active ingredient shows a good protection effect on sweet potato rot caused by the novel pathogen. The magnolol has relatively high safety and environmental compatibility and can inhibit various pathogenic fungi, the magnolol is taken as an active component, a green and safe prevention and control method for the trichoderma hamatum rot of the sweet potatoes is formulated, an important reference is provided for disease management after the sweet potatoes are harvested, and the method is suitable for popularization and application of the trichoderma hamatum rot of the sweet potatoes. The magnolol as the botanical fungicide has high application potential in prevention and control of plant diseases. And an important reference is provided for disease management after sweet potato harvesting.

The invention belongs to the technical field of organic synthesis, and discloses a dialkylated cationic derivative based on honokiol mother nucleus as well as a preparation method and antibacterial application of the dialkylated cationic derivative. The preparation method comprises the following steps: mixing honokiol, potassium carbonate, dibromoalkane and acetone, and carrying out first reaction to obtain an intermediate product; and mixing the intermediate product, a compound R1H and acetonitrile, and carrying out a second reaction to obtain the honokiol mother nucleus-based dialkylated cationic derivative. A series of novel amphiphilic derivatives are designed and synthesized by reasonably modifying a natural product honokiol, and the novel amphiphilic derivatives show effective in-vitro antibacterial activity on gram-positive bacteria.

This invention proposes a bio-based epoxy resin coating for marine engineering and its preparation method, relating to the technical field of marine engineering anti-corrosion coatings. The coating is composed of two components, A and B. Component A, by weight, includes: 30-32 parts of a bio-based epoxy resin, 6-8 parts of a reactive diluent, 0.2-0.4 parts of a defoamer, 0.2-0.4 parts of a dispersant, 1.6-1.8 parts of an anti-settling agent, 44-48 parts of a filler, 4-6 parts of zinc phosphate, and 7-9 parts of aluminum tripolyphosphate; and component B includes: 0.4-0.6 parts of a drier and 25-28 parts of a curing agent. The bio-based epoxy resin is a magnolol-based epoxy resin with a molecular weight of 2400-6500. Magnolol-based epoxy resin takes advantage of the characteristics of the molecular structure of magnolia phenol and introduces a more flexible acrylic-based structure to adjust the flexibility and viscosity of the resin molecules. Adding it to the coating makes it easy to apply and can cure quickly, meeting the construction environment of the marine environment. The paint film formed has high strength and good flexibility and can withstand long-term wave erosion.

The invention discloses a bactericide and device for improving wheat stem rot resistance in the field of agricultural biocides, and the bactericide comprises the following components in parts by weight: 10-15 parts of magnolol, 30-50 parts of carvacrol and 1 part of ethapyroxad, and the bactericide comprises the following components in parts by weight: 10-15 parts of magnolol, 30-50 parts of carvacrol and 1 part of ethapyroxad. And the bactericide comprises the following components in parts by weight: 15 parts of magnolol, 40 parts of carvacrol and 1 part of ethapyroxad, or 10 parts of magnolol, 30 parts of carvacrol and 1 part of ethapyroxad. The biological activity of the bactericide and the affinity of succinate dehydrogenase are improved by modifying ethane on amino nitrogen of pydiflumetofen, the inhibition effect and stability are improved by mixing natural plant phenol, meanwhile, environmental pollution is reduced, and the mutation speed of pathogenic bacteria is delayed.

The present application relates to a high-refractive material based on biomass magnolol and honokiol. Specifically, the high-refractive material of the present application can be obtained by photo-curing reaction of a photo-curable monomer and a plurality of mercaptans / mercaptanols under photo-initiation, wherein the photo-curable monomer is derived from a monomer containing an allyl functional group derived from biomass magnolol and honokiol. The high-refractive material provided by the present application has good optical performance, in particular, it not only has a high refractive index (1.67-1.71) but also has a relatively high Abbe number (35-24).

The application discloses a kind of carbon fiber material for unmanned aerial vehicle and preparation method thereof, belong to unmanned aerial vehicle material technical field.The carbon fiber material, by mass fraction, including following raw materials:PA612 100 parts, PA6T / 6I 30-40 parts, modified carbon fiber 10-30 parts, flame-retardant compatibilizer 6-10 parts, lubricant 1-5 parts, antioxidant 0.5-1.5 parts, wherein the modified carbon fiber is prepared by silane coupling agent grafting mercapto after surface oxidation of carbon fiber, and then combined with magnolol epoxy monomer by click reaction of mercapto and double bond;Flame-retardant compatibilizer contains phenyl phosphoramide structure and terminal aldehyde group.The carbon fiber material prepared by the application uses PA612 and PA6T / 6I as blended nylon matrix resin, synchronously adds modified carbon fiber and flame-retardant compatibilizer, and by intermolecular interaction, the material has excellent mechanical strength and reliable flame-retardant safety.

A nicotine liquid preparation, and a preparation method therefor and the use thereof. The raw material components of the nicotine liquid preparation comprise nicotine, an additive capable of simulating the head-rush feeling of nicotine, an atomization solvent and an organic acid. The additive capable of simulating the head-rush feeling of nicotine is selected from at least one of cytisine, magnolol and 6-methylnicotine. The nicotine liquid preparation has a nicotine content of 10-20 mg / g.