27196results about How to "Improve survival rate" patented technology

A method is disclosed for enhanced vaccination and genetic vaccination of mammals. The vaccination is accomplished by delivering molecules such as proteins and nucleic acids into skeletal muscle and other cells residing in the skeletal muscle in vivo. The protein or nucleic acid is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.

Compounds of formula (I) or their salts or esters:have excellent sialidase inhibitory activity and are therefore useful for the treatment and prevention of influenza and other viral diseases where the replication of the virus is susceptible to sialidase inhibitors.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

A method of applying electrotherapy to the heart of a patient includes positioning electrodes in communication with the heart of the patient; monitoring the patient's heart to determine if its fibrillating; and providing a first signal with a current generator to the heart through the electrodes in response to an indication that the heart is fibrillating. The first stimulus signal reduces the amount of fibrillation.

It is intended to provide a drug for improving prognosis for subarachnoid hemorrhage which contains, as the active ingredient, at least one member selected from the group consisting of eicosapentaenoic acid (EPA) and pharmaceutically acceptable salts and esters thereof, and a method of improving prognosis for subarachnoid hemorrhage which comprises orally or gastrically administering the above drug.

The present invention discloses a method for improving growth and survival of single human embryonic stem cells. The method includes the step of obtaining a single undifferentiated HES cell; mixing the single undifferentiated cell with an extracellular matrix (ECM) to encompass the cell; and inoculating the mixture onto feeder cells with a nutrient medium in a growth environment. Therefore the single cells can survive, proliferate and grow in vitro.

Described herein are chimeric Newcastle disease viruses engineered to express a heterologous interferon antagonist and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer.

The invention provides compounds of the general formula (I)which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and / or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.

A biologic deodoring and cleaning agent for treating the refuse to prepare fertilizer and cleaning and activating water area contains high-safety yeast, lactobacillus, nitrogen-fixing bacteria, functional bacillus, and photosynthetic bacteria.

The invention discloses an unmanned aerial vehicle (UAV) emergency medical rescue system and a UAV emergency medical rescue method, and belongs to the field of UA air rescue. The system comprises an emergency center ground scheduling subsystem, a UAV subsystem, and a user terminal. The emergency center ground scheduling subsystem receives emergency information sent by the user terminal, plans an emergency rescue task, selects an appropriate emergency unmanned aerial vehicle, transmits remote guidance audio and video information to the emergency unmanned aerial vehicle, and receives vital sign data transmitted back by the emergency unmanned aerial vehicle. The UAV subsystem comprises the emergency unmanned aerial vehicle and vehicle-borne emergency medicines and medical tools. The emergency unmanned aerial vehicle receives and executes the emergency rescue task, and transmits on-site audio and video information and vital sign data back. By using the unmanned aerial vehicle which flies at high speed and can carry emergency medicines and medical tools to the place where an acute critical patient is located quickly, people around the patient can be remotely guided to treat the patient scientifically, and therefore, the survival rate of the acute critical patient is further increased.

The invention discloses a seedling planting method in an alkaline land. The method comprises the steps of: digging planting pits, laying a salt and alkali isolating layer, laying a water storage layer, laying a percolation layer, backfilling planting soil and cultivating seedlings. By adopting the seedling planting method in the alkaline land disclosed by the invention, the salt and alkali are effectively isolated, drought defying and waterlogging control are realized, the survival rate of the seedling is improved, and the normal growth of the seedlings is ensured; large-area consolidation of the alkaline land is not needed, and only the local plot, in which the seedlings are planted, is needed to be consolidated, so that the seedlings can be planted; and the method is simple, feasible and worthy of popularizing.

The invention relates to an airline routing algorithm of an unmanned plane in a large-range complicated three-dimensional space. The algorithm comprises the following steps: first dividing a three-dimensional space on the basis of a 2.5-dimensional grid (each grid point includes longitude, altitude and elevation information); improving the A* cost function by comprehensively considering the influence factors such as airline height, detected probability, airline distance under the constraint conditions of radar, disaster weather and forbidden areas, and determining an initial airline on the basis of an algorithm search flow; serially processing the initial airline to obtain a final flying airline for meeting the performance constraint of the unmanned plane (such as minimal step length, turning radius, climbing rate, safety height). The algorithm is good in stability and astringency, high in efficiency, capable of meeting the wide-range low-altitude airline routing requirement and applicable to relevant fields such as military, national defense, emergency relief.

A method for decellularizing separated skin is provided, the method involving simultaneous treatment with a protease and a surfactant. A highly reliable acellular dermal matrix and an optimum allogeneic acellular dermal matrix for simultaneous grafting with an autologous skin graft are also provided. Furthermore, there is provided a method for producing an acellular dermal matrix, the method including a decellularizing step of treating separated skin simultaneously with a protease and a surfactant, and there is also provided a composite cultured skin employing as a substrate the acellular dermal matrix.

The present invention provides compositions that contain magnesium and threonate, or a threonate precursor molecule, formulated for extended or modified release to provide physiological concentrations over a desired time period. The extended release or modified release form is particularly useful in providing Mg to a subject while avoiding adverse side effects such as diarrhea.

A device and method of use for a partial occlusion device (POD) for matter and liquid flow control. More specifically, a device relating to the partial occlusion of blood vessels to affect the flow of blood through the blood vessels is disclosed. The POD may be formed from a mesh material and includes one or more lumens. The POD may be particularly useful in treating Hypoplastic Left Heart Syndrome, by reducing pulmonary blood flow to decrease the risk of pulmonary hypertension. The POD may also be used to deliver therapeutic agents to a specific site. The POD can be retrieved after placement.

The invention relates to a fertilizer and soil conditioner, wherein the compound fertilizer contains a slow-release fertilizer additive adjustable based on soil and plant requirement, which comprises compound microorganism - organic carrier 2-50%, inorganic carrier 1-30%, ureacondensate 1-50%, primary nutrient 1-60%, trace element 1-10%, and inorganic soil conditioner 1-50%.

The invention discloses a layer feed containing a traditional Chinese medicine additive. The layer feed comprises the following components in parts by weight: 60-80 parts of corn powder, 8-10 parts of bran, 8-10 parts of bean pulp, 8-10 parts of fish meal, 8-10 parts of shell powder, and 2-12 parts of traditional Chinese medicine additive, wherein the traditional Chinese medicine additive comprises the crude drugs in parts by weight: 5-10 parts of dandelion, 3-5 parts of herba andrographitis, 3-5 parts of rhizoma atractylodis, 5-10 parts of honeysuckle, 5-10 parts of fructus cnidii, 10-15 parts of selfheal, 10-15 parts of baical skullcap root, 10-15 parts of astragalus root, 10-15 parts of Polygonum multiflorum Thunb, 5-10 parts of hawthorn, 0.5-1 part of lucid ganoderma, 10-15 parts of codonopsis pilosula, 10-15 parts of angelica sinensis, 5-10 parts of semen cuscutae, 5-8 parts of clove, 5-8 parts of pericarpium citri reticulatae, 5-8 parts of hawthorn and 5-8 parts of cinnamon. The immunoreactive substance can enhance the immune function of organism, improves the anti-stress ability and the disease resistance of the animal, improves the production performance of the animal, and simultaneously has the advantages of small toxic and side effects, no drug-resistance, no residue and the like; the survival rate of chicken is greatly improved; the lecithin content of the egg is obviously improved; the cholesterol content of the egg is reduced; and the nutritive value of the egg is improved.

The invention relates to the transplantation field of trees, in particular to a big-tree transplantation method for achieving a high survival rate. The big-tree transplantation method comprises the following steps that (1) big trees growing strongly are selected, and according to design requirements and the principle of matching species with the site, tree forms, pest and disease damage situations, growth habits, and longitude, latitude and altitude related technical indexes are selected; (2) branches and leaves of the big trees are trimmed; (3) roots of the big tree are cut; (4) the big trees are transplanted; (5) management is conducted after transplantation. According to the technical scheme, the big-tree transplantation method has the advantages that the survival rate is high, and rooting powder is applied to the roots so as to facilitate root growth and prevent rot and insect damage. The big-tree transplantation method is frequently suitable for transplanting Chinese junipers, Chinese pines, white bark pines, cedrus deodara, dragon junipers, platycladus orientalis, picea asperata, fir, pinus armandii and the like, and transplanting deciduous trees and precious flowering trees such as Chinese scholar trees, goldenrain trees, fraxinus sogdiana bunge, acer truncatum bunge, ginkgoes and magnolia denudate.

The invention discloses a preservation solution for mesenchymal stem cells and application thereof. The cell preservation solution contains human albumin and heparin as the main components, and other auxiliary reagents such as human cytokine, phosphate ion, metal ions or monosaccharide are contained in a buffer solution for preserving human mesenchymal stem cells. The preservation solution can keep high survival rate of human mesenchymal stem cells in transportation process, reduce adhesion between cells and between the cell and the inner wall of a container, and reduce the possible occurrence of cell mass embolism in blood vessel while clinically infusing human mesenchymal stem cells. The mesenchymal stem cells can be maintained in a state of single-cell suspension at an environment temperature of 4 to 15 DEG C for 24 h, thus greatly enlarging the clinic application range of the human mesenchymal stem cells. The components used in the solution accord with the clinic application, and can meet the requirement for clinic use of the human mesenchymal stem cells.

The invention relates to a laying hen feed prepared from bran, salt, corn grit, fish meal, ground oyster shells, rice bran, bean dregs and a traditional Chinese medicine feed additive, wherein the traditional Chinese medicine feed additive comprises the following components: honeysuckle, common cnidium fruit, corydalis tuber, small fennel, motherwort, self-heal, houttuynia, baikal skullcap root, dyers woad leaf, dangshen, astragalus root, angelica sinensis, medical stone, eclipta, dodder, barbat skullcap and weeping forsythia. The feed additive provided by the invention has both medicinal and nutritional actions, can prevent diseases and can also improve the production performance; the feed additive can directly sterilize and inhibit bacteria, adjusts the immunity function of of the organism, has non-specific antibacterial action, and greatly improves the survival rate of chicken; and the feed additive eliminates chemical damage to the chicken, can effectively improve the production performance of animals, simultaneously has small toxic side effects and no drug resistance, can effectively improve the egg quality, achieves the requirements of purely natural green food, and can acquire good economic benefit.

The present invention relates to an active peptide feed addictive, as a mixture of one or more plant protein and animal protein, which is the product of the following steps: fermenting and degrading the mixture through bacillus and the like, controlling the degree of hydrolysis at 20-35%, obtaining a fermentation supernatant after a separation post-processing process, concentrating drying the supernatant or directly adsorbing the supernatant onto the carrier, and then low temperature drying it. Said active peptide feed addictive is capable of obviously depressing development of bacillus coli and salmonella, and can prevention and cure diarrhea caused by bacilli or lienteric diarrhea; can exert its functions at a very low concentration, with a very intense effect; can regulate stomach and intestine bacterium group and promote animals digestion functions; can excite animal immune function, reinforce animal disease resistance against a plurality of epidemic diseases and greatly reduce the morbidity and death rate; can promote animal development and improve the growth velocity; can improve the feed use ratio and reduce production costs. Applications of the microorganism fermentation degradation method provided by the present invention have a low fabricating cost, and the obtained peptides have many kinds and high content, without environment pollutions.

The invention relates to a Paris polyphylla var. yunnanensis scale seedling culturing method. The method comprises the following steps of: selecting Paris polyphylla var. yunnanensis plants more than 10 years old and reserving seeds for planting; collecting mature seeds; washing the collected seeds to remove episperm; spreading and drying the seeds in a shade and ventilating place within 12 hours, wherein a temperature is maintained and an accumulation thickness is less than or equal to 6 cm; spreading the seeds uniformly and drying; filling the seeds into a ventilating container; storing the container in a shade environment with a suitable temperature, wherein the storage time is no more than 2 months; clearing impurities and residues in a seedling culturing field; fertilizing decayed farm manure and calcium superphosphate; plowing and raking soil; forming a furrow; spreading humus soil on the furrow surface; flatting the furrow surface; sowing in early June next year; taking the stored seeds, and after sterilizing, broadcasting the seeds uniformly according to the thickness of sowing; earthing after broadcasting; covering mantle on the furrow surface; irrigating sufficiently and performing seedling management. A method for drying the seeds of the Paris polyphylla var. yunnanensis in shade in an environment without direct sunlight is adopted, the dormancy of the seeds of the Paris polyphylla var. yunnanensis is broken, and the scale production of Paris polyphylla var. yunnanensis seedlings is realized, so that germchit guarantee is provided for large-area popularization and cultivation of the Paris polyphylla var. yunnanensis. The method has the characteristics of simple and easily-learned operation, high survival rate of germchit, low production cost, healthy and strong germchit, stable and reliable technology, high repeatability, and capacity of effectively solving the problem of scale seedling cultivation of the Paris polyphylla var. yunnanensis.

The invention discloses a method for tissue-culture breeding and wild-simulated cultivation of dendrobium candidum, which comprises: inoculating dendrobium candidum tender straw slices onto a culturemedium for culture under conditions of a temperature of 22 to 24 DEG C and an illuminance of 1,000 to 1,500 Lx to first induce the growth of calles to form protocorms and then promote the multiplicative growth of the protocorms into 5 to 8 centimeter strong seedlings; and moving the seedlings out of a culture room, hardening the seedlings at a normal temperature for 3 to 5 days and transplanting the seedlings into the ground in a green house. The plane basic layer of a cultivation check field in the green house are provided with spaced breather holes; the upper layer of the cultivation check field is a cultivation medium; the seedlings are planted at a row spacing of 12*8cm and a spacing in the row of 12*8cm; in the green house, the temperature is 0 to 28 DEG C, the humidity is 60 to 70 percent and the shade density is 70 to 80 percent; and disease and pest prevention and control are carried out periodically and the dendrobium candidum can be harvested in 3 to 4 years. The method improves the civil year breeding coefficient of the dendrobium candidum by about 10 times, provides enough seedlings for large-scale cultivation, solves the problem of wild-simulated cultivation and realizes scale cultivation.

The invention relates to a compound feed for a first-born nursing sow, and aims to effectively solve the problems of poor reproductive performance, poor body condition and influence on the reproductive performance of first-born sows. The technical scheme for solving the problems is that: the feed is prepared from maize or puffed maize, wheat or puffed wheat, bean pulp, mountain flour, calcium hydrogen phosphate, common salt, carrier-containing nursing sow complex vitamin, carrier-containing nursing sow complex mineral and auxiliary materials, wherein one kilogram of feed comprises 50 to 650 grams of maize, puffed maize or a mixture thereof, 50 to 650 grams wheat, puffed wheat or a mixture thereof, 100 to 300 grams of bean pulp, 8 to 18 grams of mountain flour, 10 to 28 grams of calcium hydrogen phosphate, 3 to 6 grams of common salt, 8 to 12 grams of carrier-containing nursing sow complex vitamin, 8 to 12 grams of carrier-containing nursing sow complex mineral and the auxiliary materials. The feed can completely meet the requirement of the first-born sow for suckling pigs on nutrition and ensure fast weight gaining of the suckling pigs during the nursing and high survival rate so as to improve the annual sell rate of a pig farm, increase the survival rate and increase the total sell rate of each sow throughout the life.

The invention discloses a carbon-based compound fertilizer containing probiotic organisms. The carbon-based compound fertilizer comprises biomass carbon black and probiotics, wherein the biomass carbon black is prepared by the following method: carrying out low-temperature carbonization on agricultural wastes as biomass raw materials to form porous biomass carbon black. The probiotics are prepared by the following method: carrying out amplification culture on beneficial microorganisms and fermenting to form probiotic liquid; and mixing and then carrying out solid-liquid separation and expansion drying to form the probiotics, wherein the beneficial microorganisms are selected from one or more of peanibacillus ploymyxa, trichoderma, nitrogen-fixing bacteria, root nodule bacteria, phosphate-solubilizing bacteria, potassium bacteria, cellulose decomposition bacteria, antibiotic-producing strain and photosynthetic bacteria. The carbon-based compound fertilizer disclosed by the invention is made of microporous biomass carbon, and thus the carbon-based compound fertilizer has extremely-strong adsorption capacity and favorable light absorbing and temperature increasing effects; in addition, the probiotics of the carbon-based compound fertilizer are high in cell viability; and the carbon-based compound fertilizer can be preserved at normal temperature for a long time, can be mixed, granulated and dried with other organic and inorganic fertilizers without being influenced and is remarkable in synergistic action.

The invention discloses a biochar base soil modifier and a preparation method thereof. The biochar base soil modifier comprises the following components in percentage by weight: 95.5-98.5% of biomass carbon black and 1.5-4.5% of probiotics agent. Agricultural waste serves as a biomass raw material to carry out low-temperature carbonization to form the porous biomass carbon black; beneficial microorganism is enlarged and cultivated and is fermented into probiotics liquid; after mixing, solid and liquid separation, flash evaporation and drying are carried out to obtain the probiotics agent; the beneficial microorganism is selected from one or more of paenibacillus polymyxa, trichoderma strains, nitrogen-fixing bacteria, rhizobium, phosphate solubilizing bacteria, potassium bacteria, cellulose decomposition bacteria, antibiotic generation bacteria and photosynthetic bacteria. The biochar base soil modifier disclosed by the invention adopts the microporous biomass carbon which has strong adsorption capability and good light absorption and temperature-increasing effect. The probiotics agent has a high survival rate and can be stored for a long time at the normal temperature, the fertilizer synergy action is obvious, and the soil borne disease can be effectively prevented and cured.

The invention discloses a complex enzyme preparation for feeding piglets. The complex enzyme preparation for feeding piglets comprises the following seven enzymes: acid protease, amylase, xylanase, beta-glucanase, cellulase, pectinase and phytase; and the enzymatic activity ratio of the seven enzymes is 1: 1: (8-10): (3.3-4): 1: (0.5-0.55): (0-0.02). By applying the complex enzyme preparation disclosed by the invention, various anti-nutritional factors in feed can be degraded, the viscosity of chyme in an intestinal tract can be reduced, and the metabolic energy of the feed can be improved; the protein and starch digestibility of the piglets can be improved; excessive reproduction of harmful microorganisms in the intestinal tract can be reduced, damage to the intestinal wall can be reduced, and the microecological balance of the intestinal tract can be regulated; the survival rate and disease resistance of the piglets can be improved, the diarrhea rate can be reduced, and the overall uniformity is improved; and the weight gaining of the piglets can be promoted, and the cultivation cost is reduced.

The invention discloses an ecological breeding method of domestic chickens. The method comprises the following steps of (1) selecting and arranging a farm; (2) selecting breeding chickens; (3) breeding and managing; (4) preventing diseases. The domestic chickens bred by adopting the ecological breeding method have the advantages of strong autoimmunity, low morbidity, delicious meat and nutrient enrichment and meet the requirements of green food.