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4 results about "Genetic vaccination" patented technology
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Vaccines at Work. The merits of genetic immunization become most apparent when the actions of traditional vaccines are understood. Traditional preparations consist primarily of a killed or a weakened version of a pathogen (disease-causing agent) or of some piece (subunit) of the agent.
Artificial nucleic acid molecules for improved protein or peptide expression
The invention relates to an artificial nucleic acid molecule comprising at least one 5′ UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and / or a 3′ UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and / or genetic vaccination.
Owner:CUREVAC SE
Artificial nucleic acid molecules
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3-untranslated region element (3′-UTR element) and / or at least one 5-untranslated region element (5′-UTR element), wherein said artificial nucleic acid molecule is characterized by high translation efficiency. The translation efficiency is contributed, at least in part, by the 5′-UTR element or the 3′-UTR element, or both of the 5′-UTR element and the 3′-UTR element. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and / or genetic vaccination. Furthermore, novel 3′-UTR elements and 5′-UTR elements are provided.
Owner:CUREVAC SE
Engineered mRNA and use thereof
Provided are an engineered mRNA and a method for improving protein expression using same. Also provided is the use of such engineered mRNA in gene therapy and / or genetic vaccination.
Owner:XIANWEI (HAINAN) BIOTECHNOLOGY CO LTD
Artificial nucleic acid molecules for improved protein or peptide expression
The invention relates to an artificial nucleic acid molecule comprising at least one 5′UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and / or a 3′UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and / or genetic vaccination.
Owner:CUREVAC SE