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1301results about "Microencapsulation based" patented technology
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Lipid formulations for nucleic acid delivery
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and / or administering the SNALP.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Lipid encapsulated interfering RNA
InactiveUS20060008910A1Inhibit aggregationReduce overexpressionBiocideOrganic active ingredientsLipid formationLipid particle
The present invention provides lipid-based formulations for delivering, e.g., introducing, nucleic acid-lipid particles comprising an interference RNA molecule to a cell, and assays for optimizing the delivery efficiency of such lipid-based formulations.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Cationic lipids and methods of use
ActiveUS20060083780A1Increase flexibilityImprove propertiesUltrasonic/sonic/infrasonic diagnosticsNervous disorderLipid formationLipid particle
The present invention provides compositions comprising cationic lipids, liposomes and nucleic acid-lipid particles comprising the cationic lipids, and methods of using such compositions, liposomes, and nucleic acid-lipid particles.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Modified siRNA molecules and uses thereof
ActiveUS20070135372A1Decrease immunostimulatory propertyImmunostimulatory activity of siRNA can be abolishedOrganic active ingredientsSugar derivativesLipid formationLipid particle
The present invention provides chemically modified siRNA molecules and methods of using such siRNA molecules to silence target gene expression. Advantageously, the modified siRNA of the present invention is less immunostimulatory than its corresponding unmodified siRNA sequence and retains RNAi activity against the target sequence. The present invention also provides nucleic acid-lipid particles comprising a modified siRNA, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. The present invention further provides methods of silencing gene expression by administering a modified siRNA to a mammalian subject. Methods for identifying and / or modifying an siRNA having immunostimulatory properties are also provided.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Nucleic Acid-Lipopolymer Compositions
InactiveUS20090042829A1Increase efficiency and dosing flexibilityEfficiently be lyophilizedSpecial deliveryPeptide/protein ingredientsCholesterolFiller Excipient
Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg / ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
Owner:CLSN LAB
Lipid encapsulated interfering RNA
ActiveUS20060240093A1Inhibit aggregationMetabolism disorderMicroencapsulation basedLipid formationLipid particle
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Lipid encapsulated interfering RNA
InactiveUS20050064595A1Inhibit aggregationMetabolism disorderMicroencapsulation basedLipid formationLipid particle
The present invention provides compositions and methods for silencing gene expression by delivering nucleic acid-lipid particles comprising a siRNA molecule to a cell.
Owner:PROTIVA BIOTHERAPEUTICS
Cationic lipids and methods for the delivery of therapeutic agents
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
Owner:PROTIVA BIOTHERAPEUTICS
Systems and methods for manufacturing liposomes
ActiveUS20070042031A1Fast preparationOrganic active ingredientsMicroencapsulation basedLipid formationBuffer solution
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Lipid formulations for nucleic acid delivery
ActiveUS8283333B2Improve effectivenessHigh activityOrganic active ingredientsSugar derivativesLipid particleActive agent
The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and / or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Lipid encapsulated interfering RNA
The present invention provides lipid-based formulations for delivering, e.g., introducing, nucleic acid-lipid particles comprising an interference RNA molecule to a cell, and assays for optimizing the delivery efficiency of such lipid-based formulations.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Cationic lipids and methods of use
ActiveUS7745651B2Increase flexibilityGood fluidityUltrasonic/sonic/infrasonic diagnosticsBiocideLipid particleLiposome
The present invention provides compositions comprising cationic lipids, liposomes and nucleic acid-lipid particles comprising the cationic lipids, and methods of using such compositions, liposomes, and nucleic acid-lipid particles.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Polyethyleneglycol-modified lipid compounds and uses thereof
ActiveUS7803397B2Improve stabilityImprove propertiesNervous disorderOrganic chemistryPolyethylene glycolLiposome
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Biodegradable poly(β-amino esters) and uses thereof
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer / polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
Owner:MASSACHUSETTS INST OF TECH
Cationic lipids and methods for the delivery of therapeutic agents
InactiveUS20120202871A1Cyclic stabilitySize requirementBiocideOrganic active ingredientsLipid formationLipid particle
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
Owner:PROTIVA BIOTHERAPEUTICS
Modified nucleoside, nucleotide, and nucleic acid compositions
InactiveUS20130156849A1Therapeutically effectiveRaise hemoglobinOrganic active ingredientsPowder deliveryProtein precursorNucleotide
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and / or activity.
Owner:MODERNA THERAPEUTICS INC
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
Owner:TEKMIRA PHARMA CORP +1
Method of preventing aggregation of a lipid:nucleic acid complex
InactiveUS6858224B2Microencapsulation basedGenetic material ingredientsLipid formationPolyethylene glycol
Particle aggregation of lipid:nucleic acid complex particles is prevented by incorporating a non-cationic lipid into lipid:nucleic acid complex particles containing a cationic lipid and a nucleic acid polymer. The non-cationic lipid is a polyethylene glycol-based polymer.
Owner:TEKMIRA PHARMA CORP +1
Novel low molecular weight cationic lipids for oligonucleotide delivery
ActiveUS20130178541A1Good curative effectReduce liver toxicityBiocideMicroencapsulation basedTolerabilityNanoparticle
The instant invention provides for novel catiomc lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Owner:SIRNA THERAPEUTICS INC
Histidine copolymer and methods for using same
InactiveUS7163695B2Prolong half-life in vivoEnhanced transfectionPowder deliveryPeptide/protein ingredientsHistidine residueCopolymer
The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues, having from about 5 to 100% histidine residues, and optionally having from 0 to about 95% non-histidine amino acid residues; (ii) at least one pharmaceutical agent; and optionally (iii) one or more intracellular delivery components in association with the transport polymer. The invention also provides methods for using such composition to deliver the pharmaceutical agent to the interior of cells.
Owner:MIXSON A JAMES
Nucleic acid-containing lipid particles and related methods
ActiveUS20120276209A1Avoid mixingPowder deliveryOrganic active ingredientsLipid formationLipid particle
Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
Owner:THE UNIV OF BRITISH COLUMBIA
Novel lipid formulations for nucleic acid delivery
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and / or administering the SNALP.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Emulsions and methods of making nanocarriers
This invention relates, in part, to methods of using emulsions for making synthetic nanocarriers and the synthetic nanocarriers formed by such methods.
Owner:SELECTA BIOSCI
Branched histidine copolymers and methods for using same
InactiveUS7070807B2Prolong half-life in vivoEnhanced transfectionPowder deliveryPeptide/protein ingredientsIn vivoLocal injection
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches. The branched transport polymer may be associated with a pharmaceutical agent to form a pharmaceutical agent delivery composition useful for in vivo therapies based on local injection.
Owner:MIXSON A JAMES
Self-assembling nanoparticle drug delivery system
InactiveUS20090226525A1High binding affinityHigh affinityPowder deliveryMicroencapsulation basedLipid formationMedicine
A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the bioactive agent, a lipid layer or lipid / cholesterol layer coat and targeting or facilitating molecules anchored in the lipid layer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
Owner:CHIMEROS
Lipid vesicle compositions and methods of use
ActiveUS20120177724A1Increase load capacityImprove the level ofPeptide/protein ingredientsMicroencapsulation basedAntigenVesicle/vacuole
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and / or internally.
Owner:MASSACHUSETTS INST OF TECH +1
Novel cationic lipids and methods of use thereof
ActiveUS20130064894A1Cyclic stabilitySize requirementPowder deliveryBiocideLipid formationLipid particle
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
Owner:PROTIVA BIOTHERAPEUTICS
Polyethyleneglycol-modified lipid compounds and uses thereof
ActiveUS20050175682A1Improve stabilityImprove propertiesOrganic active ingredientsNervous disorderLipid formationPolyethylene glycol
Owner:ARBUTUS BIOPHARMA CORPORAT ION
Compositions and methods for delivering messenger RNA
InactiveUS20160151284A1Symptoms improvedLower Level RequirementsPowder deliveryOrganic active ingredientsDiseaseLipid particle
The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.
Owner:ARBUTUS BIOPHARMA CORPORAT ION
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