310results about "Phosphorus organic compounds" patented technology

The present invention relates to aqueous compositions, and more specifically aqueous compositions for replicating a nucleic acid template, wherein the composition comprises D2O, as well as to methods and uses relating to such compositions. The composition can be used, for example, in a method of storing the composition, or a method for replicating a nucleic acid template, for instance for the synthesis of Xpandomers for sequencing by expansion.

The invention discloses a dual-band dianthracene photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The novel 2, 9 '-dianthracene photocatalyst is designed and synthesized, the compatibility at the two wavebands of 365 nm and 405 nm is good, the tetrahydroisoquinoline phosphoramidite can be induced by light, and a new thought is provided for preparing an alpha-phosphoramidate compound; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

To provide an industrially usable novel production method regarding type β lysophosphatidic acid, and a novel application of type β lysophosphatidic acid.SOLUTION: A production method including the following processes (1) to (3) is used. Because type β lysophosphatidic acid obtained by the production method has various physiological activity, it can be preferably used for a cosmetic or an external preparation for skin. (1) a process of allowing phospholipase A2 to work for lecithin containing phosphatidylcholine in the water or in a mixed solution of water and organic solvent; (2) a process of allowing phospholipase D to work for a product obtained in the process (1) in the water or in a mixed solution of water and organic solvent; and (3) a process of hydrolyzing a product obtained in the process (2) under an acidic condition in the water or in a mixed solution of water and organic solvent.SELECTED DRAWING: None

The application provides a triarylmethane derivative, a pigment dispersion liquid, a preparation method thereof and a photoresist, and relates to the field of photoresists. The structural general formula of the triarylmethane derivative is: wherein X1 is selected from one of long-chain alkyl groups with a length of C1-C12, X2 is selected from hydrogen or an alkyl group, X3 is selected from one of H, an alkyl group and an aromatic group, and Q is selected from one of a carboxyl group, a sulfonic acid group and a phosphoric acid group. The triarylmethane derivative can generate strong van der Waals force and pi-pi conjugation effect with pigment molecules in a colorant by virtue of the large-plane conjugated triarylmethane skeleton, so as to be firmly anchored on the surface of the pigment particles; the strong polar functional groups such as the sulfonic acid group in the molecular structure of the triarylmethane derivative are combined with the alkaline dispersant, the side long-chain alkyl groups fully act on the dispersion medium, and the re-aggregation of the nano pigment particles is effectively prevented through strong steric hindrance and electrostatic stabilization mechanism, so that the problem of poor dispersion stability is solved.

The present invention provides IP5-substituted compounds of general formula I, methods for their synthesis, and their use. The IP5-substituted compounds of the present invention have -O(alkyl) at the positions of R1, R2, R4, and R5 n X and -O(alkyl) y Cy(alkyl) y’ -Z chain. Methods, pharmaceutical compositions and formulations, methods of use, products, and kits for the treatment of diseases and disorders, such as those associated with pathological crystallization, are also provided.

The present invention relates to a stable monomer composition comprising a phosphorous-containing methacrylate and 2,4-dimethyl-6-tert-butylphenol.

In certain embodiments, Formula I: 【Chemical 1】 Compounds of JPEG2025520456000046.jpg5339 or pharmaceutically acceptable salts or solvates thereof, compositions comprising a compound of Formula I or a pharmaceutically acceptable salt or solvate thereof, and their use in the treatment of certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation) etc. are provided herein.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of N-palmitoyl-O-phosphorylcholine serine and a deuterated substance thereof. The N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof are obtained by taking L-serine methyl ester hydrochloride and palmitic acid as raw materials through amidation reaction, phosphate esterification reaction, quaternization reaction, oxidation reaction, reduction reaction and the like. The invention provides an approach for industrial production of the N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof, and is very important for standardization of the detection method of the N-palmitoyl-O-phosphorylcholine serine.

The invention introduces novel chemical modifications to sphingomyelin and ceramide molecules, making them readily available for targeted staining and detection techniques, such as click chemistry.

Provided herein are 2-substituted benzyloxyphosphate (phosphonate) compounds, their preparation, and their uses, for example, to treat diseases or conditions of the liver.

The invention discloses a dope solution for membrane fabrication comprising a blend of TEP with NMP as a solvent system in a process to make PVDF membranes, where PVDF resin comprises a homopolymer resin, or a copolymer of VDF and at least one of hexafluoroprdpylene, trifluoroethylene, chlorotrifluoroethylene, or a tetrafluoropropene.

The invention discloses a preparation method of high-purity magnesium glycerophosphate, and belongs to the technical field of organic salt synthesis. According to the method, glycerol and phosphoric acid which are low in cost and easy to obtain are taken as starting raw materials, esterification reaction is firstly carried out under the action of a specific catalyst to generate glycerophosphate, then a magnesium source is added for salt forming reaction, and a high-purity magnesium glycerophosphate product is finally obtained by regulating and controlling the type of the catalyst, the reaction temperature, the pH value and the reaction time and combining a step-by-step purification process. The method has the advantages of easily available raw materials, recyclable catalyst, mild reaction conditions, simple process flow, high product purity, no generation of harmful impurities and the like, solves the problems of high raw material cost, complex process, difficulty in ensuring the product purity and the like in the existing magnesium glycerophosphate synthesis method, and is suitable for industrial large-scale production.

Provided are a difluoroalkylphosphorylcholine compound and an intermediate thereof. Specifically provided is a compound represented by formula I or a salt thereof. The compound represented by formula I or a salt thereof exhibits good surface activity, good solubility and good environmental friendliness and biofriendliness, is easy to store at a high concentration and convenient to transport, and has good application prospects.

The present application relates to a kind of water-based sprayable self-drying type acrylate adhesive and its preparation method, belong to polymer adhesive technical field.First, the core layer emulsion formed by hard monomer and multi-functional crosslinking monomer is prepared;Then drop the shell monomer including soft monomer, hydrophilic functional monomer and the functional monomer containing beta-dicarbonyl structure on it, form core-shell structure emulsion;Finally, by pH adjustment, add rheological modifier, film-forming aid and the coordination crosslinking agent containing polyvalent metal ions are prepared.The present application combines core-shell structure with beta-dicarbonyl / metal ion room temperature coordination crosslinking system, wherein the core layer provides rigid support, shell layer promotes rapid film formation, functional monomer and metal ion form strong coordination bond network after moisture volatilization.At the same time, self-made bifunctional monomer containing phosphate and silane significantly improves the universal adhesion of adhesive to different substrates.The prepared adhesive has excellent spray atomization, self-drying, high bonding strength and stability.

The present invention discloses a compound of formula (I); specifically, the invention relates to a compound shown as a formula (I) or pharmaceutically acceptable salt, stereoisomer, prodrug, deuterated derivative or solvate, and application of the compounds in drugs for treating or preventing pain, gout, epilepsy, insomnia, anxiety disorder, depression, Parkinson's syndrome and other related diseases.

Provided is a fluidity improver for a thermoplastic resin, the fluidity improver containing one or more compounds represented by general formula (1). In general formula (1), R1 represents an alkyl group having 26 to 40 carbon atoms, an alkenyl group having 26 to 40 carbon atoms, or a group represented by general formula (2), and n represents an integer of 1 or 2. When n is 2, the plurality of R1 moieties may be the same as or different from each other. In general formula (2), R2 represents a hydrogen atom or an alkyl group having 1 to 18 carbon atoms, R3 represents an alkylene group having 2 to 6 carbon atoms, m represents an integer so that the number average molecular weight of the group represented by general formula (2) becomes 100 to 10,000, and * indicates a bond.

Disclosed are Group V element-containing precursors, methods for their synthesis, and methods for their use in film deposition. The precursor is (SiR3) 3-m A(Si a H 2a+1 ) m , (SiR3) 3-n-p A(Si a H 2a+1 ) n (Si b H 2b+1 ) p , or A(Si a H 2a+1 )(Si b H 2b+1 )(Si c H 2c+1 ) (wherein a=1-6; b=1-6; c=1-6; a≠b≠c; m=1-3; n=1-2, p=1-2, n+p=2-3; A=As, P, Sb, Bi; R is C1-C 10 (A is selected from linear, branched, or cyclic alkyl, alkenyl, alkynyl groups of A). Synthesis methods include one-step, two-step, or three-step reaction between halo(poly)silanes and tris(trialkylsilyl) derivatives of A, or one-pot mixture reaction of two or three halo(poly)silanes with a mixture of tris(trialkylsilyl) derivatives of A. Deposition methods include CVD, PECVD, ALD, PEALD, flowable CVD, HW-CVD, epitaxy, etc.

The invention discloses an alpha-aminophosphoryl derivative as well as a preparation method and application thereof. The method comprises the following steps: by taking a quinoline derivative as a raw material and tetrahydrofuran (THF) as a solvent, adding boron trifluoride diethyl etherate in a nitrogen system at the reaction temperature of 0 DEG C, stirring for 15 minutes, reducing the temperature of the reaction system to T1 (-60 DEG C to-30 DEG C), adding a Grignard reagent into the reaction system, and reacting for 30 minutes to obtain a solution A; dissolving a phosphorus reagent in the organic solvent at room temperature in a nitrogen atmosphere to obtain a solution B; and adding the solution A into the solution B, reacting for 6-15 hours at the reaction temperature T2 (0-50 DEG C), and after the reaction is finished, extracting, concentrating and carrying out column chromatography to obtain the target product alpha-aminophosphoryl derivative. The invention provides a novel synthetic route for preparing the alpha-aminophosphonyl derivative, and various phosphorus reagents such as diaryl phosphorus oxide and phosphite ester can be compatible with the reaction. The alpha-aminophosphoryl derivative synthesized by the invention has a good antibacterial effect on gram-positive bacteria, especially staphylococcus aureus.

Compounds of formula (I): [Case 1] JPEG2025503945000103.jpg3250 or a pharma- ceutically acceptable salt, tautomer, stereoisomer, or deuterated analog thereof, 2 , R 3 , R 4 , Y 1 , Y 2 , X and Z are as described in any of the embodiments described in this disclosure); compositions thereof; and uses thereof.

The present invention relates to a heterocyclic compound, a pharmaceutical composition containing the same, and a method for preparing the heterocyclic compound, and further relates to the use of the compound in the preparation of a drug for treating thromboembolic diseases.

Disclosed herein is an isoquinolin-1 (2H) -one derivative of Formula (I) : or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., L2A, R1, R2A, R3, R4A, R4B, R4C, R4D, Q2, Q3, Q4) are as described herein. Also disclosed is a pharmaceutical composition comprising such derivative, and a method for treating or preventing a disorder or a disease responsive to the inhibition of PI3Kα activity in a subject using such derivative.

Provided herein are compounds of formula (I), (I), a compound selected from any one of the compounds in Table 1, Table 2, Table 3, or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3, and R4 are as defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or a compound selected from any of the compounds in Table 1, Table 2, Table 3, or a pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of Formula (I) or a pharmaceutically acceptable salt or deuterated form thereof, for example, in the treatment of a 5-HT2A receptor associated disease or disorder.

To provide a compound or a salt thereof which is rapidly metabolized to produce fulvestrant in the body.SOLUTION: The compound is a compound of formula (IV), an enantiomer, a diastereomer, a racemate, a pharmaceutically acceptable salt or a solvate thereof: Wherein R7 comprises certain phosphorus-containing esters and R8 represents certain substituents.SELECTED DRAWING: None

The present disclosure provides compounds and pharmaceutical compositions comprising the same. The compounds, pharmaceutical compositions thereof, and methods of using the same have a range of utilities as therapeutics, diagnostics, and research tools. The subject compositions and methods are particularly useful for potentiating immune response and / or for treating cancer and other diseases.

To provide a compound which can be used for prevention, treatment and control of aquaporin-mediated conditions such as diseases of water imbalance, for example, cerebral edema, a pharmaceutical composition, and a method for producing the same.SOLUTION: There is provided a hydrate of 2 - {[3, 5-bis (trifluoromethyl) phenyl] carbamoyl} - 4-chlorophenyl dihydrogen phosphate represented by the following structure, which exhibits an XRPD pattern comprising at least five 2 θ (°) values selected from the group consisting of 8.8, 9.5, 11.1, 15.2, 15.5, 16.4, 20.2, 20.6, 23.6, 24.0, 24.9 and 27.2, wherein the XRPD is measured using an incident beam of CuK α radiation of 1.54059 Å.SELECTED DRAWING: None

The invention discloses a halogen-free alkyl phosphate oligomer organic flame retardant and a synthesis method, the halogen-free alkyl phosphate oligomer flame retardant (PNX) is a phosphate oligomer, is often used as an additive flame retardant of polyurethane foam, and has the advantages of no halogen, high phosphorus content, high flame retardant efficiency, low VOC (volatile organic compound) value and the like. The flame retardant is synthesized by the following method: firstly, pre-cooling phosphorus oxychloride, then slowly dropwise adding ethanol in a negative pressure state, and heating for reaction to obtain an ethyl dichlorophosphate intermediate; slowly dropwise adding the ethyl dichlorophosphate intermediate into one third of precooled ethylene glycol, stirring, heating and reacting for a period of time, continuously dropwise adding the rest ethyl dichlorophosphate, reacting for a period of time, and dropwise adding ethanol for blocking to obtain a PNX product. The method has the advantages of simple synthesis process, mild conditions, fast reaction, common and easily available raw materials, no use of a catalyst, no introduction of metal ions, and no need of post-treatment. The large-scale industrial production is easy to realize.

This relates to an inositol derivative and its uses. Specifically, a compound is provided comprising two or more portions of formula (D) connected by a common central linker L2, as shown below.

The invention provides powdery phospholipid with good free-running property and rich phosphatidylcholine as well as a preparation method and application of the powdery phospholipid, and belongs to the technical field of deep processing of phospholipid. According to the method, the crude phospholipid is sequentially subjected to absolute ethyl alcohol purification and acetone refining, the refining frequency is controlled, it is guaranteed that the PC content is 40 wt% or above, meanwhile, the isomaltitol is added in the last time of refining, and the isomaltitol serves as sugar alcohol which is low in hygroscopicity and easy to crystallize, so that the purity of the product is greatly improved. At the moment, a special co-dispersion system which can form with phospholipid in an acetone medium is added, and in the subsequent drying process, the phospholipid particles can be accurately filled and an isolation layer is formed, so that the physical structure of the product is fundamentally changed, and particle adhesion is prevented from internal anti-caking and internal isomaltitol is used as a skeleton; an anti-caking agent is arranged outside to serve as a'ball 'to further reduce friction, and the dual-action mechanism ensures that the final product has extremely excellent flowability and long-term storage stability.