572results about "Phosphorus organic compounds" patented technology

A surface treatment agent containing a hydrocarbon-terminal-group-containing compound of the following formula makes it possible to form a cured film that is exceptional in water repellency, slipperiness, dirt removability, and abrasion resistance, particularly steel wool abrasion resistance and wet abrasion resistance. (R1 is a C12-80 monovalent hydrocarbon group that includes a C12 or higher monovalent or divalent linear unsubstituted aliphatic saturated hydrocarbon group and does not contain a hydrocarbon branched structure, R2 is H, a halogen atom, a hydroxyl group, a siloxy group, an -OSi(CH3)3 group, an -OSi(C2H5)3 group, an amino group, an SH group, a monovalent hydrocarbon group, R1, -V-Z-(Y-A)m, or -Y-A, U is a single bond, C, or a trivalent or tetravalent organic group, V is a single bond or a divalent hydrocarbon group, Z is a single bond, C, Si, N, S, or a trivalent to octavalent organic group, Y is a single bond or a divalent hydrocarbon group, A is a monovalent reactive group, k is 0, 1, or 2, and m is 1-7.)

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

Intermolecular interactions and molecular chain mobility are improved when a hydrocarbon-terminal-group-containing compound represented by formula (1) is used as a surface protective agent for a non-fluorine-based material, and a surface treatment agent containing the compound can form a cured coating film having excellent water repellency, slipperiness, ease of soil removal, and abrasion resistance, in particular, steel wool abrasion resistance. (R is a C1-60 monovalent hydrocarbon group, Z is a divalent connecting functional group containing at least one selected from O, N, S, and Si, Y is a C1-30 divalent hydrocarbon group, A is a monovalent reactive group, and k is 1-3.)

The present invention discloses therapeutic compounds capable of targeting a wide range of tumor cells. The disclosure is further directed to compositions comprising the therapeutic compounds, methods for producing the therapeutic compounds, and methods for treating cancer comprising administering the therapeutic compounds.

The invention relates to the field of synthetic phospholipids, in particular to a synthetic phosphatidylcholine-like refining method which comprises the following steps: A, dissolving: adding a mixed solvent into synthetic phosphatidylcholine-like, and stirring for dissolving to obtain a crude product solution; b, complexing: adding a metal salt into the crude product solution, mixing, and continuously stirring for dissolving to obtain a primary refined solution; c, crystallization: adding an indissolvable organic solvent into the primary refined liquid, then cooling for crystallization, and carrying out solid-liquid separation to obtain solid crystals; and D, cleaning: rinsing and drying the solid crystal to obtain a refined phosphatidylcholine product. The refining method provided by the invention is green in process and low in cost, and high-purity synthetic phosphatidylcholine with the purity of 98% or above is obtained.

Provided is a compound and so on having aldehyde dehydrogenase 2 (ALDH2) activation effect. A compound, a pharmaceutically acceptable salt of the compound, or a prodrug of the compound or the salt, the compound being represented by the following formula (1):whereinA is a heterocycle,R1 and R2 are each independently hydrogen, an alkyl, an alkenyl, or an alkynyl,R3 is an alkyl, an alkenyl, or an alkynyl, andX1 and X2 are each independently a halogen.

The present invention relates to aqueous compositions, and more specifically aqueous compositions for replicating a nucleic acid template, wherein the composition comprises D2O, as well as to methods and uses relating to such compositions. The composition can be used, for example, in a method of storing the composition, or a method for replicating a nucleic acid template, for instance for the synthesis of Xpandomers for sequencing by expansion.

The invention discloses a dual-band dianthracene photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The novel 2, 9 '-dianthracene photocatalyst is designed and synthesized, the compatibility at the two wavebands of 365 nm and 405 nm is good, the tetrahydroisoquinoline phosphoramidite can be induced by light, and a new thought is provided for preparing an alpha-phosphoramidate compound; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

Provided are novel formulations of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate as described below and uses thereof.

The invention relates to a nitrogen-phosphorus flame-retardant antibacterial agent, a flame-retardant antibacterial cotton fabric and a preparation method of the nitrogen-phosphorus flame-retardant antibacterial agent. The structural formula of the nitrogen-phosphorus flame-retardant antibacterial agent is as shown in formula I in the specification. The flame-retardant antibacterial cotton fabric is prepared by rinsing a cotton fabric in a sodium hydroxide solution, then washing the cotton fabric with deionized water, and grafting the nitrogen-phosphorus flame-retardant antibacterial agent onto the cotton fabric under the catalytic action of dicyandiamide. The flame-retardant antibacterial cotton fabric prepared in the invention not only has a flame-retardant function and an antibacterial function, but also the used nitrogen-phosphorus flame-retardant antibacterial agent does not contain halogen and is environment-friendly.

A compound presented by the general formula (1), its racemic form, or their salt thereof (in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a-Y-R1b (wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom), R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.).

The present invention discloses a low-odor phosphazene catalyst and its use. The catalyst comprises a phosphazene cation represented by the general formula (I) and an alkali metal salt compound anion. The catalyst is prepared by dissolving a phosphorus pentahalide and a guanidine compound in a non-benzene-based organic solvent and reacting them under heated conditions to obtain an organic phosphonium salt solution containing the organic solvent and the phosphorus halide compound. An alkali metal salt compound is then added and reacted under heated conditions in an inert atmosphere to obtain a purified phosphazene catalyst through filtration, reduced-pressure distillation, purification, and vacuum drying. The catalyst can be used in the production of polyether polyols and polyurethane foams. The phosphazene catalyst of the present invention employs a non-benzene-based inert solvent that does not participate in the reaction during production, eliminating the need for frequent solvent changes. Using the same solvent eliminates steps such as extraction and distillation, reducing energy consumption and wastewater generation during the process. The continuous production method for the phosphazene catalyst is efficient and environmentally friendly.

To provide an industrially usable novel production method regarding type β lysophosphatidic acid, and a novel application of type β lysophosphatidic acid.SOLUTION: A production method including the following processes (1) to (3) is used. Because type β lysophosphatidic acid obtained by the production method has various physiological activity, it can be preferably used for a cosmetic or an external preparation for skin. (1) a process of allowing phospholipase A2 to work for lecithin containing phosphatidylcholine in the water or in a mixed solution of water and organic solvent; (2) a process of allowing phospholipase D to work for a product obtained in the process (1) in the water or in a mixed solution of water and organic solvent; and (3) a process of hydrolyzing a product obtained in the process (2) under an acidic condition in the water or in a mixed solution of water and organic solvent.SELECTED DRAWING: None

The application provides a triarylmethane derivative, a pigment dispersion liquid, a preparation method thereof and a photoresist, and relates to the field of photoresists. The structural general formula of the triarylmethane derivative is: wherein X1 is selected from one of long-chain alkyl groups with a length of C1-C12, X2 is selected from hydrogen or an alkyl group, X3 is selected from one of H, an alkyl group and an aromatic group, and Q is selected from one of a carboxyl group, a sulfonic acid group and a phosphoric acid group. The triarylmethane derivative can generate strong van der Waals force and pi-pi conjugation effect with pigment molecules in a colorant by virtue of the large-plane conjugated triarylmethane skeleton, so as to be firmly anchored on the surface of the pigment particles; the strong polar functional groups such as the sulfonic acid group in the molecular structure of the triarylmethane derivative are combined with the alkaline dispersant, the side long-chain alkyl groups fully act on the dispersion medium, and the re-aggregation of the nano pigment particles is effectively prevented through strong steric hindrance and electrostatic stabilization mechanism, so that the problem of poor dispersion stability is solved.

The present invention provides IP5-substituted compounds of general formula I, methods for their synthesis, and their use. The IP5-substituted compounds of the present invention have -O(alkyl) at the positions of R1, R2, R4, and R5 n X and -O(alkyl) y Cy(alkyl) y’ -Z chain. Methods, pharmaceutical compositions and formulations, methods of use, products, and kits for the treatment of diseases and disorders, such as those associated with pathological crystallization, are also provided.

The present invention relates to a stable monomer composition comprising a phosphorous-containing methacrylate and 2,4-dimethyl-6-tert-butylphenol.

In certain embodiments, Formula I: 【Chemical 1】 Compounds of JPEG2025520456000046.jpg5339 or pharmaceutically acceptable salts or solvates thereof, compositions comprising a compound of Formula I or a pharmaceutically acceptable salt or solvate thereof, and their use in the treatment of certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation) etc. are provided herein.

An object of the present invention is to provide a compound having a high molar absorption coefficient in a maximum absorption wavelength (λmax) within a range of 600 to 750 nm and good stability before and after post-baking when a color filter is produced. The present invention relates to a compound represented by formula (I): wherein Z1 and Z2 each independently represent a group represented by formula (i), R3 represents a hydrocarbon group optionally having a substituent, an aromatic heterocyclic group optionally having a substituent, or a group in which a hydrocarbon group optionally having a substituent and an aromatic heterocyclic group optionally having a substituent are combined, and -CH2- contained in the hydrocarbon group is optionally replaced with -O-, -CO-, -NR6-, -S-, -SO-, or -SO2-, wherein R7 represents a hydrogen atom, a hydrocarbon group optionally having a substituent, or a group represented by formula (ii), and a1 represents 0 or 1.

The present disclosure deals about an electrolyte comprising a non-aqueous organic solvent, a lithium salt, and an additive represented by Chemical Formula 1. A detailed description of Chemical Formula 1 is given in this disclosure.

The invention relates to the technical field of solar cells, in particular to a self-assembled monomolecular hole transport material, a preparation method and application thereof, a perovskite solar cell, a preparation method thereof and a photovoltaic module. The self-assembled monomolecular hole transport material provided by the invention has a structure as shown in a formula I. In the formula I, A1, A2 and A3 are respectively and independently anchor groups or hydrogen atoms; the anchoring groups are independently selected from phosphate groups respectively; g is selected from a substituted or unsubstituted carbazolyl group, a substituted or unsubstituted acridinyl group, a substituted or unsubstituted phenothiazinyl group, and a substituted or unsubstituted phenoxazinyl group. The self-assembled monomolecular hole transport material provided by the invention has stronger anchoring binding capacity, conjugation in molecules is enhanced through the aromatic connection unit, and transport of carriers is facilitated; polyphosphonic acid anchoring in the self-assembled monomolecular hole transport material provided by the invention can enhance adsorption and uniformity of molecules, and a formed hole transport interface has better charge transport and defect passivation effects.

Disclosed herein is an isoquinoline-1 (2H)-one derivative of formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof wherein the values of the variables (e.g., L2A, R1, R2A, R3, R4A, R4B, R4C, R4D, Q2, Q3, Q4) are as described herein. Also disclosed is a pharmaceutical composition comprising such derivatives, and a method of using such derivatives to treat or prevent a condition or disease responsive to inhibition of PI3K [alpha] activity in a subject.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of N-palmitoyl-O-phosphorylcholine serine and a deuterated substance thereof. The N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof are obtained by taking L-serine methyl ester hydrochloride and palmitic acid as raw materials through amidation reaction, phosphate esterification reaction, quaternization reaction, oxidation reaction, reduction reaction and the like. The invention provides an approach for industrial production of the N-palmitoyl-O-phosphorylcholine serine and the deuterated substance thereof, and is very important for standardization of the detection method of the N-palmitoyl-O-phosphorylcholine serine.

The invention introduces novel chemical modifications to sphingomyelin and ceramide molecules, making them readily available for targeted staining and detection techniques, such as click chemistry.

The invention discloses an alcohol-based phosphorus-boron-nitrogen intumescent flame retardant as well as a preparation method and application thereof. The preparation method comprises the following specific preparation processes: carrying out reaction on glycerol and phosphoric acid in a reaction container additionally provided with a water segregator at 100-115 DEG C to prepare glycerol triphosphate; the preparation method comprises the following steps: adding boric acid into a glycerol triphosphate reaction container, and reacting at 100-115 DEG C to obtain glycerol triphosphate boric acid ester; and adding urea into a reaction container of glycerol triphosphate boric acid ester, and reacting at 110-135 DEG C to obtain the alcohol-based phosphorus-boron-nitrogen intumescent flame retardant. The limit oxygen index (LOI) of the cotton fabric finished in the flame retardant finishing liquid with the flame retardant concentration of 200g / L can reach 52%, and the flame retardant grade is gt; 42, the flame retardant property is good. The synthesis process is simple, the raw materials are green, environment-friendly, cheap and easily available, the production process is simple, large-scale production can be realized, and secondary pollution is avoided.

Provided herein are 2-substituted benzyloxyphosphate (phosphonate) compounds, their preparation, and their uses, for example, to treat diseases or conditions of the liver.

The invention discloses a dope solution for membrane fabrication comprising a blend of TEP with NMP as a solvent system in a process to make PVDF membranes, where PVDF resin comprises a homopolymer resin, or a copolymer of VDF and at least one of hexafluoroprdpylene, trifluoroethylene, chlorotrifluoroethylene, or a tetrafluoropropene.

Compounds, compositions, and methods for inhibiting ENPP1 are provided. Embodiments of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell-impermeable. The ENPP1 inhibitor compound can act extracellularly and block the degradation of cGAMP. Similarly, pharmaceutical compositions and methods for treating cancer are provided. Embodiments of the method include administering a therapeutically effective amount of an ENPP1 inhibitor to a subject to treat the cancer in the subject. In certain cases, the cancer is a solid tumor cancer. Similarly, methods are provided in which radiation therapy is administered to a subject in conjunction with administering an ENPP1 inhibitor to the subject. In the subject methods, radiation therapy can be administered at a dosage and / or frequency effective to reduce radiation damage to the subject while still eliciting an immune response.

The invention discloses a preparation method of high-purity magnesium glycerophosphate, and belongs to the technical field of organic salt synthesis. According to the method, glycerol and phosphoric acid which are low in cost and easy to obtain are taken as starting raw materials, esterification reaction is firstly carried out under the action of a specific catalyst to generate glycerophosphate, then a magnesium source is added for salt forming reaction, and a high-purity magnesium glycerophosphate product is finally obtained by regulating and controlling the type of the catalyst, the reaction temperature, the pH value and the reaction time and combining a step-by-step purification process. The method has the advantages of easily available raw materials, recyclable catalyst, mild reaction conditions, simple process flow, high product purity, no generation of harmful impurities and the like, solves the problems of high raw material cost, complex process, difficulty in ensuring the product purity and the like in the existing magnesium glycerophosphate synthesis method, and is suitable for industrial large-scale production.