840results about "Phosphorus organic compounds" patented technology

Among other things, the present disclosure provides oligonucleotide compositions and methods thereof. In some embodiments, oligonucleotides comprise various chemical modifications. In some embodiments, the present disclosure provides technologies useful for manufacturing oligonucleotides.

The invention relates to an organic compound, a solar cell and application thereof. The organic compound is shown as a formula (1), wherein Ar is selected from any one of substituted or unsubstituted aryl with the ring-forming atom number of 6-50, substituted or unsubstituted heteroaryl with the ring-forming atom number of 5-50, a group shown as a formula (A) and a group shown as a formula (B), Ar'is selected from an electrically neutral organic group, and L is selected from a paraffin subunit with the carbon atom number of 1-10; r1 is an oxyacid group; n1 is selected from any integer of 1-3, and m1 is selected from any integer of 1-10; or the organic compound is an oxyacid radical salt of the compound as shown in the formula (1). The organic compound not only can be used as a passivation material, but also can be used as a hole transport material, and can improve the photoelectric conversion efficiency of a solar cell when being applied to preparation of the solar cell.

A surface treatment agent containing a hydrocarbon-terminal-group-containing compound of the following formula makes it possible to form a cured film that is exceptional in water repellency, slipperiness, dirt removability, and abrasion resistance, particularly steel wool abrasion resistance and wet abrasion resistance. (R1 is a C12-80 monovalent hydrocarbon group that includes a C12 or higher monovalent or divalent linear unsubstituted aliphatic saturated hydrocarbon group and does not contain a hydrocarbon branched structure, R2 is H, a halogen atom, a hydroxyl group, a siloxy group, an -OSi(CH3)3 group, an -OSi(C2H5)3 group, an amino group, an SH group, a monovalent hydrocarbon group, R1, -V-Z-(Y-A)m, or -Y-A, U is a single bond, C, or a trivalent or tetravalent organic group, V is a single bond or a divalent hydrocarbon group, Z is a single bond, C, Si, N, S, or a trivalent to octavalent organic group, Y is a single bond or a divalent hydrocarbon group, A is a monovalent reactive group, k is 0, 1, or 2, and m is 1-7.)

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

Exemplary olfactory delivery scaffolds may include 1) an olfactory targeting component, stimulant, or odorant that is recognized by the olfactory nerves via, for example, a smell response, 2) a molecule with biological activity, a therapeutic component, and / or drug (sometimes collectively referred to herein as a “therapeutic component”), and 3) a linker component that links the olfactory targeting component and therapeutic component together. The olfactory delivery scaffolds may be used to deliver a molecule with biological activity and / or a therapeutic component to a subject's neurological system through the olfactory pathway and pharmaceutical compositions useful in the treatment of neurological and / or neurodegenerative diseases.

The invention provides an antistatic agent for fuel oil and a preparation method thereof, and belongs to the technical field of petrochemical engineering, and the preparation method comprises the following steps: S1, adding soybean lecithin and chlorosulfonic acid into dichloroethane, uniformly mixing, under the protection of nitrogen, heating and stirring for reaction, neutralizing reaction liquid, and performing rotary evaporation to obtain sulfonated soybean lecithin; the preparation method comprises the following steps: adding sulfonated soybean lecithin and ethidene diamine into absolute ethyl alcohol, then adding p-toluenesulfonic acid, heating and stirring for reaction, and carrying out reduced pressure distillation to obtain modified soybean lecithin; s2, dispersing the SiO2 particles in absolute ethyl alcohol, adding KH-550, and performing ultrasonic treatment, centrifugation and drying to obtain pretreated SiO2 particles; and uniformly mixing the modified soybean lecithin and the pretreated SiO2 particles, adding the mixture into a supercritical fluid reactor, heating and pressurizing, ultrasonically dispersing, and drying to obtain the antistatic agent. The antistatic agent has the advantages of good dispersibility, strong stability and strong antistatic capability.

Intermolecular interactions and molecular chain mobility are improved when a hydrocarbon-terminal-group-containing compound represented by formula (1) is used as a surface protective agent for a non-fluorine-based material, and a surface treatment agent containing the compound can form a cured coating film having excellent water repellency, slipperiness, ease of soil removal, and abrasion resistance, in particular, steel wool abrasion resistance. (R is a C1-60 monovalent hydrocarbon group, Z is a divalent connecting functional group containing at least one selected from O, N, S, and Si, Y is a C1-30 divalent hydrocarbon group, A is a monovalent reactive group, and k is 1-3.)

The present invention discloses therapeutic compounds capable of targeting a wide range of tumor cells. The disclosure is further directed to compositions comprising the therapeutic compounds, methods for producing the therapeutic compounds, and methods for treating cancer comprising administering the therapeutic compounds.

A compound of formula (I): A-B-C wherein A has the following formula (AA) and X1 is selected from O, S or NH; x2 is N or C-H; x3 is N or C-RA3; wherein if X1 is NH and X2 is C-H, then X3 is C-RA3; b has the formula (B-1) or (B-2); c is selected from the group consisting of optionally substituted C6-10 carbon aryl, C5-6 heteroaryl or C5-10 heterocyclyl, and their use as PCSK9 inhibitors. # imgabs0 #

[Problem] To provide: a flame retardant which has excellent flame retardancy and contains, as an active ingredient, an organic phosphoric acid compound reduced in environmental burden; a flame-retardant polyurethane resin composition containing the flame retardant; and a synthetic leather obtained using the flame-retardant polyurethane resin composition.　[Solution] A polyurethane resin composition containing a flame retardant that contains, as an active ingredient, an organophosphorus compound which is a salt obtained by reacting phytic acid with an aliphatic polyamine, preferably an aliphatic polyamine represented by R-(NH2)x (wherein R is a C2-C12 linear aliphatic hydrocarbon group and X is an integer of 2-4).　

The present disclosure provides for improved compositions of ionizable lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids are engineered with improved stability to oxidative degradation while in storage, while retaining high transfection activity or potency in cells. These lipids are designed to be biodegradable, thus improving the tolerability of nanoparticles formed with them in vivo. In addition, targeting of these nanoparticles in a highly specific manner to dendritic cells is provided for through inclusion of antibody conjugates directed against cell surface receptors.

The invention relates to the field of synthetic phospholipids, in particular to a synthetic phosphatidylcholine-like refining method which comprises the following steps: A, dissolving: adding a mixed solvent into synthetic phosphatidylcholine-like, and stirring for dissolving to obtain a crude product solution; b, complexing: adding a metal salt into the crude product solution, mixing, and continuously stirring for dissolving to obtain a primary refined solution; c, crystallization: adding an indissolvable organic solvent into the primary refined liquid, then cooling for crystallization, and carrying out solid-liquid separation to obtain solid crystals; and D, cleaning: rinsing and drying the solid crystal to obtain a refined phosphatidylcholine product. The refining method provided by the invention is green in process and low in cost, and high-purity synthetic phosphatidylcholine with the purity of 98% or above is obtained.

Provided is a compound and so on having aldehyde dehydrogenase 2 (ALDH2) activation effect. A compound, a pharmaceutically acceptable salt of the compound, or a prodrug of the compound or the salt, the compound being represented by the following formula (1):whereinA is a heterocycle,R1 and R2 are each independently hydrogen, an alkyl, an alkenyl, or an alkynyl,R3 is an alkyl, an alkenyl, or an alkynyl, andX1 and X2 are each independently a halogen.

Provided in the present invention are a phosphorus-containing compound, a pharmaceutical composition and the use thereof. Specifically, provided are a compound as represented by formula I, a pharmaceutically acceptable salt, an ester, a stereoisomer, a tautomer, a polymorph, a solvate, a metabolite, an isotopic derivative or a prodrug thereof. The phosphorus-containing compound of the present invention can effectively treat diseases and conditions mediated by TEAD, such as cancer.

The invention discloses a film-forming flame-retardant additive and a preparation method thereof, an electrolyte, a lithium ion battery and a power utilization device, the film-forming flame-retardant additive has a structure as shown in a formula I. The film-forming flame-retardant additive is used in the electrolyte of the lithium ion battery, can stabilize a positive electrode / electrolyte interface under high voltage, and improves the safety of the battery at the same time. # imgabs0 #

The invention discloses a method for efficiently preparing a high-stability TCPP flame retardant. The method comprises the following steps: adding a metal-loaded catalyst and phosphorus oxychloride into a reaction kettle, wherein the addition amount of the catalyst is 1.5-7.5% of the mass of phosphorus oxychloride; stirring is started, heating is conducted, epoxypropane is slowly fed, a reaction is conducted for a period of time after feeding is completed, the catalyst and excessive epoxypropane are removed, and the TCPP flame retardant is obtained. According to the scheme provided by the invention, the catalytic reaction can be carried out towards the main isomer, so that the product has high stability.

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with liver X receptors, comprising bis-octahydrophenanthrenecarboxamides and protein (e.g., antibody) drug conjugates thereof. [Selected figure] Figure 11

Disclosed are a nitrogen-containing fused ring compound as shown informula (I), an intermediate thereof, a preparation method therefor and the use thereof. The compound has a DNA polymerase θ inhibitory activity, and can be used for treatingdiseases mediated by the DNA polymerase θ, such as tumors.

The present invention relates to aqueous compositions, and more specifically aqueous compositions for replicating a nucleic acid template, wherein the composition comprises D2O, as well as to methods and uses relating to such compositions. The composition can be used, for example, in a method of storing the composition, or a method for replicating a nucleic acid template, for instance for the synthesis of Xpandomers for sequencing by expansion.

The invention belongs to the photovoltaic field, and particularly relates to a hole transport layer compound, a hole transport layer, a photovoltaic device and a preparation method. The hole transport layer compound disclosed by the invention has a structure as shown in a formula I, wherein the definitions of X1, X2, A and L are described in the specification. The hole transport layer compound provided by the invention is an acridine derivative, has better film forming uniformity as a hole transport material, can improve the performance of a large-size perovskite photovoltaic device, and has very high commercial application prospects. # imgabs0 #

Provided are a hole transport material and a use thereof. The hole transport material is used in the preparation of a perovskite solar battery, and can improve the efficiency and stability of the battery.

The invention discloses a dual-band dianthracene photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The novel 2, 9 '-dianthracene photocatalyst is designed and synthesized, the compatibility at the two wavebands of 365 nm and 405 nm is good, the tetrahydroisoquinoline phosphoramidite can be induced by light, and a new thought is provided for preparing an alpha-phosphoramidate compound; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

Provided are novel formulations of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate as described below and uses thereof.

To provide therapeutic compounds capable of targeting a broad range of tumor cells.SOLUTION: The present disclosure is directed to compositions comprising therapeutic compounds, methods of manufacturing therapeutic compounds, and methods of treating cancer comprising administering therapeutic compounds.SELECTED DRAWING: None

The present invention includes a method of reducing or eliminating cardiac toxic effects or cardiac pathological effects of one or more active agents comprising administering to a subject in need thereof an effective amount of one or more lipids that reduce or eliminate cardiac toxic effects of one or more active agents wherein the lipids have the formula: # imgabs0 #.

The invention discloses a pure organic scintillator material and a preparation method and application thereof, and belongs to the technical field of organic photoelectric functional materials, and the pure organic scintillator material provided by the invention is obtained by taking diphenyl phosphorus chloride as a raw material through two-step reaction and crystal culture. The preparation method has the advantages of mild reaction conditions, simple synthesis, cheap raw materials, easy product purification and the like, and provides a new idea for preparing the organic scintillator. A pure organic scintillator material is ground and then doped with polyvinyl alcohol to prepare the scintillation screen, and the prepared scintillation screen has the advantages of radiative brightness, high imaging resolution, low detection limit, bendability, crimpability and the like, and successfully realizes static, curved, three-dimensional and dynamic X-ray imaging.

The invention provides a method for extracting perfluorophosphoric acid in soil through coupling of an acid-base extracting agent, and relates to the technical field of soil pollutant extraction. The soil is subjected to alkaline extraction by using alkaline methanol, and then is subjected to acidic extraction by using acidic methanol. Perfluorophosphoric acid in soil tends to be strongly combined with soil organic matters. According to the method disclosed by the invention, the alkaline methanol and the acidic methanol are used for carrying out acid-alkali extractant coupling extraction, so that the perfluorophosphoric acid combined with the organic matter can be more sufficiently released, the extraction rate of the perfluorophosphoric acid is high, the recovery rate of each perfluorophosphoric acid is greater than 60%, and the average recovery rate is 75.7%. Compared with alkaline methanol, acidic methanol and pure methanol as extractants, the acid-base extractant coupling method provided by the invention has the advantages that the comprehensive extraction effect on the perfluorophosphoric acid in the soil is obviously improved, and a powerful guarantee is provided for screening and management and control of the perfluorophosphoric acid in the soil.