The present invention discloses 3-vinyl-quinoxaline-2(1H)-one derivative acting on FGFR-1, a preparation method and uses thereof, and belongs to the field of pharmaceutical chemistry. According to the present invention, o-phenylenediamine and pyruvic acid are adopted as raw materials and are subjected to cyclization to obtain 3-methyl quinoxaline-2(1H)-one, the 3-methyl quinoxaline-2(1H)-one reacts with different substituted aldehydes to obtain 3-substituted quinoxaline derivatives, and the 3-substituted quinoxaline derivatives are adopted as the intermediate products and are subjected to substitution to obtain other types of the target compounds, wherein the 6 new compounds are prepared; and the 3-vinyl-quinoxaline-2(1H)-one derivatives of the present invention have a certain inhibition effect for experiment cells, show a certain anti-tumor activity, and further have characteristics of cell selectively, good safety, and kinase inhibition activity.