6 results about "Pioglitazone" patented technology

The present invention is directed to a combination therapy involving Pioglitazone and a MEK inhibitor for the treatment of a cancer patient in need of such a therapy.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an endocrine drug-derived anti-cancer composition as well as a preparation method and application thereof. The composition comprises a composite solid dispersion composed of an endocrine disease treatment drug metformin, pioglitazone or sitagliptin, a hydrophilic carrier material and a pretreated functional ion exchange resin. The preparation method mainly comprises the following steps: carrying out alkaline swelling and surface modification pretreatment on ion exchange resin, forming a uniform compound from the medicine, the carrier and the resin through a melting-adsorption-curing process, and carrying out nanocrystallization treatment and structure stabilization drying to obtain the nano composite powder. The composition can be used for preparing an oral solid preparation for inhibiting breast cancer, prostatic cancer, endometrial cancer or colorectal cancer, and has the potential advantage of improving drug dissolution and release behaviors by utilizing a composite structure; the preparation method can effectively guarantee the structural integrity and the performance consistency of the preparation, and the operation controllability is high.

1. Name of the design product: packaging box (metformin hydrochloride and pioglitazone hydrochloride tablet). 2. Use of the design product: the design product is used for the packaging of medicines. 3. Design points of the design product: the combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The present invention is directed to a combination therapy involving Pioglitazone and a MEK inhibitor for the treatment of a cancer patient in need of such a therapy.

Provided herein are crystalline forms of deuterium-enriched (R)-pioglitazone and compositions thereof. Also provided herein are methods of using the crystalline forms of deuterium-enriched (R)-pioglitazone and compositions thereof.

The utility model discloses a granulating device for producing pioglitazone and metformin tablets, and relates to the technical field of medicine production. A top cover is clamped to the top of the raw material box, a first rotating motor is fixedly clamped to the top of the top cover, lifting air cylinders are arranged on the periphery of the bottom of the raw material box, a granulation pressing plate is arranged in the center of the bottom of the raw material box, a cutting knife is slidably clamped to the bottom of the granulation pressing plate, and the net-shaped conveying belt is arranged at the bottom of the raw material box. By arranging the raw material box and the net-shaped conveying belt, the problems that when a cutting knife is used for directly cutting particles, due to the fact that metformin raw materials are high in humidity and viscosity, when the cutting knife is used for directly cutting the particles, a large number of particles are likely to be stacked and bonded and are inconvenient to dry subsequently, and when the cutting knife is too slow, the particles are likely to be attached to the surface of the cutting knife, and the cutting efficiency is poor are solved. And when particles of different sizes need to be extruded, an extrusion plate needs to be replaced, and time and labor are wasted in operation.