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Application of ferroptosis inhibitor

A ferroptosis, inhibitor technology, applied in the medical field

Active Publication Date: 2019-03-12
JINSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above problems, the inventors found that radiation lung injury is caused by ferroptosis in cells, therefore, ferroptosis inhibitors can be used to treat radiation lung injury diseases, and there is no report on this research content at home and abroad.

Method used

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  • Application of ferroptosis inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Pre-experiment

[0032] 1 Materials and Grouping

[0033] 1.1 Experimental animals

[0034] 120 C57 / BL male mice (purchased from Shanghai Jiesijie Experimental Animal Co., Ltd.).

[0035] 1.2 Experimental equipment

[0036] Medical linear accelerator (Varian accelerator in the United States): It can generate X-rays with an energy mode of 6MV, a source-to-skin distance of 100cm, and a single dose of 15Gy.

[0037] 1.3 Grouping

[0038] 120 C57 / BL male mice purchased from Shanghai Jiesijie Experimental Animal Co., Ltd. were divided into two groups according to the method of random number table, divided into blank group and irradiation group, 59 mice in the blank group, and 59 mice in the irradiation group. 61 only.

[0039] 1.4 Establishment of mouse animal model of radiation-induced lung injury

[0040] The mice in the irradiation group were treated as follows: use 3% pentobarbital sodium (40mg / Kg body weight) to anesthetize each mouse in the irradiati...

Embodiment 2

[0063] Example 2 Verification of new uses of ferroptosis inhibitors

[0064] 1 Materials and Grouping

[0065] 1.1 Experimental animals

[0066] 120 C57 / BL male mice (purchased from Shanghai Jiesijie Experimental Animal Co., Ltd.).

[0067] 1.2 Experimental equipment

[0068] Medical linear accelerator (Varian accelerator in the United States): It can generate X-rays with an energy mode of 6MV, a source-to-skin distance of 100cm, and a single dose of 15Gy.

[0069] 1.3 Grouping

[0070] 120 C57 / BL male mice were divided into four groups according to the method of random number table, which were blank group, simple irradiation group (RT group), radiation combined with ferroptosis specific inhibitor treatment group (RT+F group) and In the radiation combined with glucocorticoid treatment group, there were 30 mice in the blank group, 26 mice in the RT group, 32 mice in the RT+F group, and 32 mice in the radiation combined with glucocorticoid treatment group.

[0071] 1.4 Esta...

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Abstract

The invention relates to the technical field of medical science, in particular to new application of a ferroptosis inhibitor. The ferroptosis inhibitor is prepared from Liproxstatin-1, Ferrostatin-1,rosiglitazone, pioglitazone, troglitazone and Zileuton. The new application refers to that the inhibitor is applied to treating radiation-induced pulmonary injury diseases. The application has the advantages that (1) radioactive rays trigger radiation-induced pulmonary injury by mediating pulmonary alveoli epithelial cells to have ferroptosis, the ferroptosis specificity inhibitor can be used to prevent and treat radiation-induced pulmonary injury, and has the important meaning on development of new drug for preventing and treating radiation-induced pulmonary injury; and (2) it is found that radioactive rays can cause cell death through the mode of ferroptosis, and application of the ferroptosis inhibitor also has the significant theoretical meaning on guiding research for guiding radioactive rays to treat cancer mechanism.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the new application of a ferroptosis inhibitor in the treatment of radiation-induced lung injury. Background technique [0002] Radiation therapy, as one of the most important treatment methods for malignant tumors, plays an important role in the treatment of thoracic tumors. The lung is a moderately radiation-sensitive organ and is easily damaged after being irradiated. As early as the 1960s, Rubin et al. proposed the concept of radiation pneumonitis. Radiation-induced lung injury is one of the common complications after radiotherapy for thoracic tumors. It has been reported in the literature that the incidence of radiation-induced lung injury during radiotherapy for thoracic tumors ranges from 16.7% to 50.3%. The inventor collected chest tumor radiotherapy patients from Jinshan Hospital Affiliated to Fudan University from January 2018 to June 2018, and the overall incidence o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/499A61K31/216A61P11/00A61P35/00
CPCA61K31/216A61K31/499A61P11/00A61P35/00
Inventor 李轩段立洁
Owner JINSHAN HOSPITAL FUDAN UNIV
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