38 results about "Radiation Pneumonitis" patented technology

The invention relates to a traditional Chinese medicine for treating radiation pneumonia, which is characterized by being prepared from the following medicinal materials by weight: 8-12g of dangshen, 8-12g of astragalus root, 8-10g of angelica sinensis, 8-12g of radix scrophulariae, 6-8g of ophiopogon root, 6-9g of cortex phellodendri, 3-6g of plaster, 6-8g of rhizoma anemarrhenae, 4-6g of peach kernels, 6-8g of radix rehmanniae, 6-8g of tendril-leaved fritillary bulb, 6-8g f platycodon grandiflorum, 6-8g of Chinese gall, 8-10g of houttuynia cordata, 6-8g of radix paeoniae rubra, 4-6g of caulis spatholobi, 6-8g of dendrobium nobile and 3-6g of radix liquiritiae. The traditional Chinese medicine is decocted, one dose is divided to be administrated in every morning and evening, ten days is a treatment course, and drug discontinuance is carried out for two days between the two treatment courses. The radiation pneumonia is recovered by the traditional Chinese treatment, the rules of treatment are to strengthen healthy energy, tonify qi, nourish blood, nourish Yin and clear heat, moisten lung and generate a body fluid, and activate blood circulation and dispel blood stasis, and diagnosis and treatment based on overall analysis of the illness and the condition of the patient are carried out clinically. Proven by clinical application trials for many years, the traditional Chinese medicine can be used for effectively treat acute and chronic radiation pneumonia, the effective rate can achieve 91.1 percent, the recovery rate can reach 82.3 percent and no toxic and side effects exist.

The invention relates to the field of lung cancer treatment, in particular to genetic biomarkers for predicting or assisting in predicting the risk of radiation pneumonitis after pulmonary radiation,and application of the genetic biomarkers. The genetic biomarkers comprise single-nucleotide polymorphic sites from RP2-01 to RP2-31; and the group of the genetic biomarkers fills in the absence of abiomarker which can be used for predicting the risk of radiation pneumonitis after the pulmonary radiation in patients in the prior art. The group of the single-nucleotide polymorphic sites is of different genotypes in different individuals; the different genotypes can affect the sensitivity of normal lung tissues to radiation; by detecting and evaluating the sites, a prognosis can be assisted; and the genetic biomarkers are of great significance to guide the monitoring and treatment of patients with a lung cancer after radiotherapy.

The invention discloses a radiation pneumonitis CT (Computed Tomography) quantitative detection method used for a radiobiology experiment. Through a CT low-dosage scanning parameter, a scanning imageis subjected to three-dimensional reconstruction, then, a CT three-dimensional segmentation image pixel histogram is obtained on the basis of an automatic region growth lung image matrix three-dimensional segmentation technology, a pneumonitis index algorithm is adopted through a pneumonitis degree quantitative criterion, and a mouse pneumonitis index is obtained to finish noninvasive quantitativedetection. The method effectively appears in noninvasive quantitative detection methods which aim at the mouse radiation pneumonitis model at home and abroad for the first time, and is an experimentdetection method which can objectively and accurately quantify the generation and the development of the mouse pneumonitis in real time, and the accuracy, the simplification, the stability and the efficiency of radiation inducibility mouse pneumonitis detection can be obviously improved. While experiment cost and vigor can be greatly reduced, the dependency of small animal minitype CT is reduced,experience cost is lowered, and the method has the obvious advantages of no trauma, high speed in scanning, high accuracy, good repeatability and the like.

An embodiment of the invention provides application of a bone marrow mesenchymal stem cell to prevention of radiation-induced lung injury. The application of the bone marrow mesenchymal stem cell to prevention of the radiation-induced lung injury is the use of the bone marrow mesenchymal stem cell for prevention of radiation pneumonitis and advanced fibrosis and the improvement of the survival rate of the radiation-induced lung injury. Through experiments, the effectiveness of the bone marrow mesenchymal stem cell in preventing radiation-induced lung injury, including radiation pneumonitis andadvanced fibrosis, is verified. The new medical use of the bone marrow mesenchymal stem cell is developed, the bone marrow mesenchymal stem cell is applied to preventing radiation-induced lung injury, including radiation pneumonitis and advanced pulmonary fibrosis, in a groundbreaking way, and a new choice is provided for clinical treatment.

The invention discloses a traditional Chinese medicine preparation and its preparation and application. The preparation is made from the following raw materials by weight: 20-30 parts of Astragalus root, 20-30 parts of Nansha ginseng, 20-30 parts of Beisha ginseng, and 10-30 parts of Lily Radix. 20 servings, 5-15 servings of dendrobium, 10-20 servings of aster, 10-20 servings of loquat leaves, 10-20 servings of bitter almond, 10-20 servings of Bai Bu, and 10-20 servings of angelica. It has the functions of clearing the lungs, relieving cough and relieving asthma, nourishing qi, nourishing yin and promoting blood circulation. After taking, the drug can directly act on the lesions of radiation pneumonia, inhibit the exudation of inflammatory cells in the alveolar wall, pulmonary interstitial congestion, hemorrhage, edema and alveolar structure damage, reduce the TLR4 signaling pathway signaling molecule protein and local lung. The expression of cytokines in tissue-related cells can reduce the inflammatory response of the lungs and achieve the purpose of delaying or treating radiation pneumonitis.

The invention discloses a traditional Chinese medicine composition for treating radiation pneumonitis. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: 20-30g of Indian buead, 10-20g of fresh ginger, 10-20g of English walnut seed, 10-20g of dried human placenta, 10-20g of platycodon root, 10-20g of ginseng, 10-20g of Chinese angelica, 10-20g of cassia twig, 10-20g of radix notoginseng, 8-15g of Chinese magnoliavine fruit, 8-12g of herb of christina loosestrife, 8-12g of indigowoad leaf, 8-12g of perilla fruit, 8-12g of malaytea scurfpea fruit, 8-12g of turmeric root-tuber, 8-12g of heartleaf houttuynia herb and 3-5g of cicada slough. All the medicinal materials are excellent in compatibility and reasonable in formula to achieve the effects of clearing away heat and toxic materials, removing blood stasis and dispersing lung, resolving carbuncle and expulsing boil, tonifying the lung and invigorating primordial Qi, warming the spleen and stomach to promote transportation of the spleen, regulating the flow of qi to stop coughing and the like, and has unique advantages in the aspects of improving clinical symptoms of radiation pneumonitis patients, improving the quality of life, prolong the survival time and the like.

The present invention relates to the field of lung cancer treatment. Specifically, it provides a kit for predicting or assisting in predicting the risk of radiation pneumonitis after lung radiation. A system for detecting the genotypes of genetic biomarkers for grade 2 or above radiation pneumonitis, in which a total of 31 genetic biomarkers can be used as detection and evaluation targets. The kit can accurately and effectively predict whether a patient’s chest tumor will cause radiation pneumonitis of grade 2 or above after receiving radiation therapy. It is easy to use, easy to operate, and the result is reliable. important guiding significance.

The invention discloses a traditional Chinese medicine composition for treating radiation pneumonitis, belonging to the technical field of traditional Chinese medicines. Aiming at the pathogenesis of radiation pneumonitis, the following traditional Chinese medicines with the effects of nourishing yin to moisten dryness, clearing away heat and toxic materials as well as activating blood circulation and resolving phlegm are selected to be prepared into a decoction: wilson begonia rhizome, evergreen mucuna root and leaf, radix asparagi, dendrobium, grassleaf eria herb, ovateleaf coelogyne herb, Japanese platanthera herb, elongated screwtree herb, oroxylum seed, fermented Chinese gall herb and tea leaves, perny holly root, woody hawksbeard root, laxflower embelia root, European white birch bark and thin evodia root. Clinical tests prove that the total effective rate reaches 93.6%.

The invention belongs to the field of disease risk prediction, and relates to a construction and verification method of a novel predictive factor for lung cancer stereotactic radiotherapy radiation pneumonitis risk, which comprises the following steps: A, case collection; b, performing 4DCT simulation positioning scanning; c, sketching a target region and an organ at risk; d, designing a radiotherapy plan; e, extracting tumor related parameters; f, calculating the occurrence probability of the concurrent radiation pneumonitis; g, screening predictive factors; and H, obtaining an intercept point. According to the invention, a novel predictive factor Lung / PTVL which has the highest correlation with RP greater than or equal to 2 in lung cancer SBRT treatment is screened out by using a radioactive biological model for the first time; the intercept point value of the novel predictive factor is obtained for the first time. The novel predictive factor can help clinicians to distinguish patients with high and low RP occurrence risks greater than or equal to 2 levels, and the clinicians can adopt appropriate treatment strategies according to the RP occurrence risks of the patients, so that the RP occurrence probability is reduced, and individualized precise radiotherapy is realized.

The invention discloses an astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis. The astragalus polysaccharide sustained release microsphere comprises the following components in parts by weight: 1 part of astragalus polysaccharide and 3-7 parts of chitosan, wherein the degree of polymerization of chitosan is 30CPS, 50CPS and 130 CPS. The invention simultaneously discloses a preparation method of the astragalus polysaccharide sustained release microsphere. The astragalus polysaccharide sustained release microsphere prepared by virtue of the preparation method has an ideal targeting effect, can slowly release after being administrated, is long in action time and is capable of increasing the concentration of astragalus polysaccharide in target organs, and the high local blood concentration is avoided; the astragalus polysaccharide sustained release microsphere is safe and environmentally friendly and has high treatment effect to radiation pneumonitis and little side effect; the operation is simple and convenient, a process is stable, and industrial production is easily realized; the astragalus polysaccharide sustained release microsphere is high in encapsulation efficiency and drug loading capacity; the skin of a patient is smooth and fine after the administration.

The invention belongs to the field of traditional Chinese medicines and discloses a traditional Chinese medicine for radiation pneumonitis caused by malignant tumor radiotherapy and a preparation method of the traditional Chinese medicine for radiation pneumonitis caused by malignant tumor radiotherapy. Active ingredients of the traditional Chinese medicine include radix ilicis asprellae, viola acuminata, Chinese forgetmenot root, rhizoma polygonati, herba pholidotae chinensis, selaginella delicatula, perfoliote knotweed herb, northern bedstraw, fiveleaf gynostemma herb, herb of glabrous torenia, root of Chinese eriosema, poria cocos, parochetus communis buch, disporum calcaratum, mulberry fruit, angelica sinensis, picrarrhiza kurroa royle, chlorephytum capense var variegatum hort, radix asparagi, lilies, radix cynanchi, aernaria przewalskii maxim, radix ophiopogonis, radix glycyrrhizae, root of axillaryflower twistedstalk, begonia fimbristipula, tremella and rhizoma menispermi. By symptomatic treatment, the traditional Chinese medicine for radiation pneumonitis caused by malignant tumor radiotherapy has efficacies of Qi tonifying, Yin nourishing, heat clearing, detoxifying, blood circulation promoting, stasis removing, lung moisturizing, cough relieving, sputum reducing, body fluid production promoting, moistening, mind calming and nerve soothing and has the advantages of excellent absorption effects, remarkable curative effects, avoidance of toxic and side effects and clinical adverse reaction and high cure rate of radiation pneumonitis according to clinical verification.

The invention discloses a Chinese medicinal preparation for treating radiation pneumonitis. The radiation pneumonitis belongs to the categories of 'cough' and 'consumptive lung disease' considered by the traditional Chinese medicine, belongs to the evil of toxic heat burns fluid for the irradiation of the radioactive rays and harms the human body vital Qi and Yin blood; and the pathogenesis is heat toxin, Yin deficiency, Qi deficiency, phlegm dampness and blood stasis. Therefore, peristrophe, rhizoma panacis majoris, lignum dalbergiae odoriferae, chicken with yellow feet, adenophora tetraphylla, Ilex cornuta lindl, tricuspid cudrania bark, Chinese pulsatilla root, cacumen biotae, radix tetrastigme, dandelion, gynostemma pentaphyllum, callicarpa bodinieri, argentina anserine, white atractylodes rhizome and licorice are decocted by using water. Clinical experiments in the hospital prove that the total effective rate is 95.3% and the Chinese medicinal preparation is worthy of clinical popularization and application.

Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of susceptibility. The method involves measuring SOD and GPX activity levels. A high SOD or low GPX activity, or a combination thereof, is indicative that the individual is likely to be susceptible to radiation pneumonitis.